Journal
APPLIED SURFACE SCIENCE
Volume 262, Issue -, Pages 227-230Publisher
ELSEVIER
DOI: 10.1016/j.apsusc.2012.06.041
Keywords
Scaffolds; Carbon nanotube; Hydroxyapatite; Composites; Superparamagnetism
Categories
Funding
- National Basic Research Program of China (973 Program) [2012CB933602]
- National Natural Science Foundation of China [51172188]
- Fundamental Research Funds for the Central Universities [SWJTU12CX013, SWJTU11ZT05]
- National SRTP project, China [SWJTU201210613008]
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In this paper, the foam-like composite scaffolds composed of hydroxyapatite (HA) and carbon nanotubes (CNTs) were prepared by a new method, where a polymer impregnating method was used for porous HA-based scaffold and a chemical vapor deposition (CVD) method was used for the growth of CNTs from the HA-based scaffold. The process produces the CNTs/HA scaffolds that have a foam-like structure with better mechanical property, better microstructure and a high degree of interconnection. A favorable pore size with big pores of 1-2 mm and small pores of 20-300 mu m for osteoconduction and bone ingrowth is presented in these scaffolds. About 2 wt% multi-walled CNTs with the diameter of 60-100 nm are observed to be in situ grown from deficient nano-HA crystallites. Magnetic measurement exhibits these scaffolds are superparamagnetic with a saturation magnetization of 1.14 emu g(-1) at a room temperature, benefiting the scaffolds to take up growth factors in vivo, stem cell or other bioactive molecules easily. This new type of CNTs/HA scaffolds is expected to have a promising applications in bone tissue engineering, targeted drug delivery system and other biomedical fields. (c) 2012 Elsevier B.V. All rights reserved.
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