Article
Chemistry, Medicinal
Binod Timalsina, Md Nazmul Haque, Ho Jin Choi, Raju Dash, Il Soo Moon
Summary: This study investigates the therapeutic potential of Tachyspermum ammi seed extract (TASE) and its principal component thymol for the treatment of Alzheimer's disease (AD) in a mouse model. The findings suggest that TASE and thymol can reduce oxidative stress, enhance learning and memory, decrease A beta 1-42 accumulation, and promote neurogenesis, indicating their potential as natural therapeutic agents for neurodegenerative disorders.
PHYTOTHERAPY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Binod Timalsina, Md Nazmul Haque, Raju Dash, Ho Jin Choi, Nisha Ghimire, Il Soo Moon
Summary: TASE and thymol have potent capacities in promoting neuronal development and reconstruction, which are crucial for neurodegenerative disorders and acute brain injuries.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Kesavan Subaharan, Periyasamy Senthamarai Selvan, Thagare Manjunatha Subramanya, Rajendran Senthoorraja, Sowmya Manjunath, Tania Das, Vppalayam Shanmugam Pragadheesh, Nandagopal Bakthavatsalam, Muthu Gounder Mohan, Sengottayan Senthil-Nathan, Sreehari Uragayala, Paulraj Philip Samuel, Renu Govindarajan, Muthuswamy Eswaramoorthy
Summary: This study successfully developed nanoemulsions of Trachyspermum ammi essential oil and thymol and demonstrated their superior larvicidal effect against Aedes aegypti. These nanoemulsions can serve as an alternative control measure for this mosquito vector.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Chemistry, Medicinal
Eugenia Mazzara, Serena Scortichini, Dennis Fiorini, Filippo Maggi, Riccardo Petrelli, Loredana Cappellacci, Giuseppe Morgese, Mohammad Reza Morshedloo, Giovanni Filippo Palmieri, Marco Cespi
Summary: In this study, the extraction of ajowan essential oil using microwave-assisted extraction was optimized through a design of experiment approach, resulting in higher yield and thymol concentration of the essential oil compared to standard hydrodistillation.
Article
Chemistry, Applied
Atia-tul-Wahab, Qibtiya Ilyas, Saba Farooq, Sumaira Javaid, Shakil Ahmed, Atta-ur-Rahman, M. Lqbal Choudharya
Summary: The study evaluated the antifungal activity of Trachyspermum ammi seeds against Candida albicans, showing promising results in both in-vitro and in-vivo experiments. The hexanes fraction had a minimal inhibitory concentration of 225 mu g/mL, and the ointment containing the extract and fraction led to 90-100% recovery in mice with cutaneous candidiasis. GC/MS analysis revealed the presence of major components in the hexanes extract, indicating the potential for development of novel antifungal agents.
NATURAL PRODUCT RESEARCH
(2021)
Article
Environmental Sciences
Musrat Ali, Xiukang Wang, Urooj Haroon, Hassan Javed Chaudhary, Asif Kamal, Qurban Ali, Muhammad Hamzah Saleem, Kamal Usman, Aishah Alatawi, Shafaqat Ali, Muhammad Farooq Hussain Munis
Summary: The study aimed to diagnose and control the fruit rot disease of grapefruit using zinc oxide green nanoparticles (ZnO NPs). Results showed that ZnO NPs exhibited excellent antifungal activity, with the most significant fungal growth inhibition observed at a concentration of 1.0 mg/ml. Characterization and analysis of ZnO NPs confirmed the effectiveness and cost-effectiveness of this method in controlling grapefruit fruit rot disease.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Food Science & Technology
Gita Mirniyam, Mehdi Rahimmalek, Ahmad Arzani, Adam Matkowski, Shima Gharibi, Antoni Szumny
Summary: This study evaluated the seed yield, essential oil constituents, polyphenolic composition, and antioxidant capacity of ajowan populations under different water irrigation regimes. The results showed that water stress significantly reduced both essential oil and seed yield. Different populations of ajowan also exhibited variations in chemical composition and antioxidant capacity.
Article
Immunology
Abolghasem Siyadatpanah, Roghayeh Norouzi, Farzaneh Mirzaei, Bibi Fatemeh Haghirosadat, Veeranoot Nissapatorn, Watcharapong Mitsuwan, Muhammad Nawaz, Maria Lourdes Pereira, Seyed Abdollah Hosseini, Mahbobeh Montazeri, Mohammad Majdizadeh, Ray S. Almeida, Mahdie Hemati, Polrat Wilairatana, Henrique Douglas Melo Coutinho
Summary: This study evaluated the efficacy of liposomes containing essential oils from two herbal plants against Trichomonas vaginalis in vitro. The results indicated that these liposomes exhibited strong inhibition against the protozoan, suggesting their potential use as alternative treatments for Trichomonas infection.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2023)
Article
Agricultural Engineering
Mansour A. Balkhyour, Abdurazag M. S. Tammar, Ahmed Saleh Summan, Abdelrahim H. A. Hassan
Summary: The research demonstrates that laser irradiation treatment significantly enhances biomass accumulation, photosynthesis, metabolism of coumarins and essential oils, and improves antibacterial properties of ajwain sprouts.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Agronomy
Abdelrahim H. A. Hassan, Mohammad K. Okla, Saud A. Al-amri, Mohamed A. El-Tayeb, Ihab M. Moussa, Yahaya B. Elbadawi, Mostafa A. Adel-Maksoud, Fatma H. M. Ali, Khalid S. Almaary, Samy Selim, Hamada AbdElgawad
Summary: Elevated atmospheric CO2 can enhance plant metabolism and improve nutritional quality, showing positive effects on growth, chemical composition, and biological properties of ajwain during sprouting.
Article
Biochemistry & Molecular Biology
Kahkashan Perveen, Fohad Mabood Husain, Faizan Abul Qais, Altaf Khan, Suhail Razak, Tayyaba Afsar, Pravej Alam, Ali M. Almajwal, Mahmoud M. A. Abulmeaty
Summary: The study utilizes plant extracts to synthesize gold nanoparticles that demonstrate significant efficacy against drug-resistant biofilms and cancer cells, presenting a new eco-friendly approach for various biomedical applications.
Article
Chemistry, Physical
Saeida Saadat, Deepak Rawtani, Vincent Braganza
Summary: Ajwain seed oil (ASO) was loaded into treated Halloysite nanotubes (Hal) and further incorporated with chitosan to develop an innovative antimicrobial food packaging nanocomposite film. The nanocomposite film exhibited excellent antimicrobial properties against various bacteria and fungi.
APPLIED CLAY SCIENCE
(2022)
Article
Agriculture, Multidisciplinary
Maryamolsadat Hashemi, Bita Behboodian, Ehsan Karimi, Ehsan Oskoueian
Summary: The study found that the combination of plant growth-promoting bacteria A. chroococcum with slight drought stress can significantly increase the essential oil yield, total phenolic, total flavonoid content, and antioxidant activity of T. ammi seeds. Gene expression analysis in developing seeds confirmed up-regulation of antioxidant-related gene (SOD) and thymol synthesis gene (TSG) upon treatment with A. chroococcum bacteria combined with slight drought stress. The toxicity study showed no significant signs of toxicity in mice after oral administration of essential oil for 28 days at a dose of up to 100 mg/kg body weight.
CHEMICAL AND BIOLOGICAL TECHNOLOGIES IN AGRICULTURE
(2022)
Article
Biochemistry & Molecular Biology
Vishal Kumar, Ashutosh Bahuguna, Myunghee Kim
Summary: The study showed that six compounds from Trachyspermum ammi, particularly carvacrol and thymol, exhibited binding affinity and stability with PD-1. These findings suggest that carvacrol and thymol have the potential to inhibit the PD-1/PD-L1 pathway.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Endocrinology & Metabolism
Maandvi Sharma, Alok Shiomurti Tripathi, Tabinda Hasan, Mohammad Yasir, Kavitha Ganesh, Najwa Abdur Rashid, Himani Awasthi, Priya Pathak, Lucy Mohapatra, Rahul Kumar Maurya
Summary: Present study investigates the neuroprotective effect of Trachyspermum ammi essential oil (TAEO) against monosodium glutamate-induced excitotoxicity in rats. The results show that TAEO improves motor and cognitive function, reduces oxidative stress, and decreases formation of ss-Amyloid plaque by targeting NMDA receptor.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Mycology
A. Sharifzadeh, H. Shokri, S. Abbaszadeh
JOURNAL DE MYCOLOGIE MEDICALE
(2019)
Article
Environmental Sciences
Ali Abdulkhani, Elaheh Amiri, Aghil Sharifzadeh, Sahab Hedjazi, Peyman Alizadeh
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2019)
Article
Veterinary Sciences
Aghil Sharifzadeh, Hojjatollah Shokri
Summary: The study demonstrated synergistic effects of eugenol in combination with voriconazole against genital Candida isolates, providing potential therapeutic implications for cases of azole resistance.
EQUINE VETERINARY JOURNAL
(2021)
Article
Food Science & Technology
Rouhollah mohammadi, Sepideh Abbaszadeh, Aghil Sharifzadeh, Mojtaba Sepandi, Maryam Taghdir, Najmeh Youseftabar Miri, Karim Parastouei
Summary: The study revealed that the simultaneous use of encapsulated and nonencapsulated forms of lactic acid bacteria can effectively inhibit the growth of toxigenic aspergilla, significantly reducing aflatoxin production.
FOOD SCIENCE & NUTRITION
(2021)
Article
Fisheries
Sina Mirmazloomi, Maryam Ghiasi, Ali Reza Khosravi
Summary: The aim of this study was to determine the chemical composition of ethanolic extracts from Sambucus ebulus and Actinidia deliciosa, and assess their antifungal activity on the mycelial growth of Saprolegnia parasitica. The results showed that both extracts inhibited the growth of Saprolegnia hyphae in vitro.
AQUACULTURE INTERNATIONAL
(2022)
Meeting Abstract
Infectious Diseases
Sivash Nikkholgh, Ivan Pchelin, Ali Zarei Mahmoudabadi, Mahbubeh Shabanzadeh-Bardar, Maral Gharaghani, Aghil Sharifzadeh, Rasoul Mohammadi, Sadegh Noripour-Sisakht, Farzad Katiraee, Ali Rezaei-matehkolaei
Meeting Abstract
Infectious Diseases
Aghil Sharifzadeh, Hojjatollah Shokri, Donya Nikaein
Meeting Abstract
Infectious Diseases
Aghil Sharifzadeh, Hojjatollah Shokri, Donya Nikaein
Article
Veterinary Sciences
Donya Nikaein, Pegah Yaghuti, Aghil Sharifzadeh, Alireza Khosravi, Asad Balal
Summary: This study investigates the incidence of dermatophytosis among rodents referred to a mycology laboratory during 2019-2021. The results show that 37.4% of rodents were affected by dermatophytosis, with rabbits having the highest prevalence. Microsporum canis was the most commonly isolated agent. Female rabbits were more susceptible, while male guinea pigs and hamsters were more likely to be infected with dermatophytosis. Rodents less than 6 months old were more susceptible to dermatophytosis.
VETERINARY MEDICINE AND SCIENCE
(2023)
Article
Veterinary Sciences
Donya Nikaein, Dariush Shirani, Aghil Sharifzadeh, Ava Alavi, Ali Reza Khosravi
Summary: This study aimed to identify yeast isolates from the oral cavity of healthy cats and evaluate their antifungal susceptibility pattern. The results showed that cats have a different oral mycoflora compared to humans and other animals, but the susceptibility patterns are similar to those seen in isolates from other species. Further studies are needed to characterize the oral mycobiota of cats and its role in oral infections.
VETERINARY MEDICINE AND SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Aghil Sharifzadeh, Hojjatollah Shokri, Farzad Katiraee
Summary: This study demonstrated the significant inhibitory properties of thymol and carvacrol on the adherence and growth of azole susceptible- and -resistant Candida isolates. Thymol showed more effective inhibition on adherence of all Candida species than carvacrol, and was more effective for preventing the adherence of yeast cells to polystyrene.
JUNDISHAPUR JOURNAL OF NATURAL PHARMACEUTICAL PRODUCTS
(2021)
Article
Oncology
Behnam Alirezaie, Ashraf Mohammadi, Arash Ghalyanchi Langeroudi, Roozbeh Fallahi, Ali Reza Khosravi
INTERNATIONAL JOURNAL OF CANCER MANAGEMENT
(2020)
Meeting Abstract
Infectious Diseases
Minoo Soltani, Aghil Sharifzadeh
Meeting Abstract
Infectious Diseases
D. Nikaein, A. R. Khosravi, A. Sharifzadeh