Journal
APPLIED SPECTROSCOPY
Volume 68, Issue 9, Pages 949-954Publisher
SAGE PUBLICATIONS INC
DOI: 10.1366/13-07293
Keywords
Laser-induced breakdown spectroscopy; LIBS; Femtosecond phenomena; Ultra-short pulsed laser; Optical diagnostics for medicine; Chemical analysis; Laser materials processing
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Funding
- National Science Foundation (NSF) through Center for Biophotonics Science and Technology
- NSF Science and Technology Center [PHY 0120999]
- NSF Program Accelerating Innovation Research: Creation of an Ecosystem for Biophotonics Innovation [1127888]
- Div Of Industrial Innovation & Partnersh
- Directorate For Engineering [1127888] Funding Source: National Science Foundation
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We characterize the femtosecond laser-induced breakdown spectroscopy (fsLIBS) signal for biological tissues as a function of different excitation parameters with femtosecond laser systems. These parameters include laser energy, depth of focus, and number of pulses per focal volume. We used femtosecond laser pulses of 800 nm and energy between 25 and 123 mu J to generate LIBS signals in biological tissues. As expected, we observed a linear increase in the fsLIBS intensity as a function of the laser energy. In addition, we show that moving the beam out of focus and the presence of overlapping pulses on the same focal area leads to a decrease in fsLIBS intensity due to changes in focal spot size. We also demonstrate that fsLIBS can distinguish between different biological tissue samples.
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