Application of single-vial ready-for-use formulation of 111In- or 177Lu-labelled somatostatin analogs

For the sake of safety it would be desirable to store and transport the ready-for-use liquid formulation (diagnostics and therapeutics) of radiolabelled peptides. The use of ethanol, in combination with a mixture of gentisic- and ascorbic acid, has superior effects on stabilizing radiolabelled somatostatin analogs. As a consequence, In-111- and Lu-177-labelled somatostatin analogs can be stored and transported in a single-vial ready-for-use liquid formulation up to 7 days after radiolabelling. (C) 2013 Elsevier Ltd. All rights reserved.