Article
Biology
Andrea Monti Hughes, Jessica A. Goldfinger, Monica A. Palmieri, Paula Ramos, Iara S. Santa Cruz, Luciana De Leo, Marcela A. Garabalino, Silvia Thorp, Paula Curotto, Emiliano C. C. Pozzi, Kazuki Kawai, Shinichi Sato, Maria E. Itoiz, Veronica A. Trivillin, Juan S. Guidobono, Hiroyuki Nakamura, Amanda E. Schwint
Summary: This study evaluated the distribution and therapeutic effect of MID:BSA in a hamster cheek pouch oral cancer model, demonstrating that the 15 mg B/kg dose reached therapeutically useful boron concentration values in the tumor and was well-tolerated, while the 30 mg B/kg dose induced high toxicity.
Article
Engineering, Chemical
Mizuki Kitamatsu, Ken Inoue, Naoki Yamagata, Hiroyuki Michiue
Summary: This study assessed the reactivity between chloroacetyl-modified tripeptides with different amino acid residues and mercaptoundecahydrododecaborate. The results showed that the reactivity varied with the type and number of amino acid residues as well as the length of the alkyl linker. The electrostatic attraction between positively charged amino acid residues and negatively charged mercaptoundecahydrododecaborate was found to play a key role in the accelerated reaction.
Article
Biochemistry & Molecular Biology
Natalya Gubanova, Alphiya R. Tsygankova, Evgenii L. Zavjalov, Alexander Romashchenko, Yuriy L. Orlov
Summary: Boron neutron capture therapy (BNCT) is a treatment that relies on the ability of boron-10 isotope to capture epithermal neutrons and destroy cells in tumors. This study evaluated the concentration of boron in human glioma U87MG cell grafts and normal tissues in mice, showing variations in boron accumulation in different tissues and the limitations of current administration protocols for successful BNCT in a glioma mouse model.
Article
Oncology
Amir R. Jalilian, Arman Shahi, Ian P. Swainson, Hiroyuki Nakamura, Meera Venkatesh, Joao A. Osso
Summary: Boron neutron capture therapy (BNCT) is a widely practiced treatment method that uses drugs containing boron atoms to target specific tumors. The recent use of therapeutic radiopharmaceuticals has opened up possibilities for the development of new tumor-specific BNCT agents that can be used for both imaging and therapeutic applications.
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
(2022)
Review
Cell Biology
Hiroshi Fukuda
Summary: Boron neutron capture therapy (BNCT) is a cancer-selective radiotherapy using B-10 compounds, which can minimize damage to normal tissues within tolerable limits. Evaluation of normal tissue response to BNCT is crucial, with BPA and BSH having different effects on CBE values.
Article
Chemistry, Inorganic & Nuclear
Makoto Shirakawa, Kei Nakai, Yuhki Sato, Shunji Nakamura, Mari Harada, Kazuki Ishihara, Fumiyo Yoshida, Akira Matsumura, Hisao Tomida
Summary: By adjusting the concentrations of lipids and BSH, the boron content in liposomes can be significantly increased, which helps to improve the encapsulation efficiency of BSH.
APPLIED RADIATION AND ISOTOPES
(2021)
Review
Oncology
Danushka Seneviratne, Pooja Advani, Daniel M. Trifiletti, Saranya Chumsri, Chris J. Beltran, Aaron F. Bush, Laura A. Vallow
Summary: BNCT is a biologically targeted radiation therapy that can effectively treat tumors while reducing damage to normal tissues. This review discusses the potential use of BNCT in breast cancer treatment and summarizes the physical and biological properties of various boronated compounds.
Article
Radiology, Nuclear Medicine & Medical Imaging
Giovanni Romanelli, Silvia Capuani, Dalila Onorati, Pierfrancesco Ulpiani, Enrico Preziosi, Carla Andreani, Roberto Senesi
Summary: This study provides a modeling of the thermal neutron cross section of BPA and quantifies the competing contributions of boron absorption against hydrogen scattering. The results suggest that fluorine-rich variants of BPA increase the probability of neutrons being captured by the molecule, thus improving the efficiency of boron neutron capture treatment.
Article
Oncology
Song Wang, Zhengchao Zhang, Lele Miao, Jiaxing Zhang, Futian Tang, Muzhou Teng, Yumin Li
Summary: Boron Neutron Capture Therapy (BNCT) is a new binary radiation therapy that uses neutron capture reaction to kill tumor cells. It has been included in the clinical backup program for the treatment of glioma, melanoma, and other diseases. However, the key challenge of BNCT lies in developing more efficient boron delivery agents to improve targeting and selectivity.
FRONTIERS IN ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Yaxin Shi, Zhibin Guo, Qiang Fu, Xinyuan Shen, Zhongming Zhang, Wenjia Sun, Jinqiang Wang, Junliang Sun, Zizhu Zhang, Tong Liu, Zhen Gu, Zhibo Liu
Summary: Boron neutron capture therapy (BNCT) is a clinically approved radiotherapy that selectively deposits deadly particles within cancer cells, but its abscopal anti-tumour effect has been limited. In this study, a boron capsule was engineered to synergize BNCT with controlled immune adjuvants release, promoting a potent anti-tumour immune response. The study revealed that the nuclear reaction in the boron capsule enhances drug release and uncovered the mechanism of BNCT-induced heat on anti-tumour immunity. In preclinical cancer models, BNCT and controlled drug release led to significant regression of both primary and distant tumour grafts.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Physical
Dawid Kozien, Paulina Zeliszewska, Bozena Szermer-Olearnik, Zbigniew Adamczyk, Anna Wroblewska, Agnieszka Szczygiel, Katarzyna Wegierek-Ciura, Jagoda Mierzejewska, Elzbieta Pajtasz-Piasecka, Tomasz Tokarski, Grzegorz Cios, Stanislaw Cudzilo, Zbigniew Pedzich
Summary: This research presents the synthesis of B4C nanoparticles via vapor deposition and investigates their characteristics. The study evaluates the cytotoxicity effect of the synthesized nanoparticles on various cell lines, providing insights into their potential application in boron neutron capture therapy.
Review
Pharmacology & Pharmacy
Anne-Marie Caminade, Max Milewski, Evamarie Hey-Hawkins
Summary: The use of boron clusters in nanoparticles for cancer treatment, particularly in dendrimers, is highlighted in this review. The synthesis methods and biological properties of boronated dendritic structures are discussed, along with their efficiency in animal models and potential for boron neutron capture therapy (BNCT) experiments.
Article
Biology
Tsubasa Watanabe, Yu Sanada, Yoshihide Hattori, Minoru Suzuki
Summary: The study revealed that the strength of LAT1 expression strongly influenced the ability of tumor cells to uptake BPA. Squamous cell carcinomas consistently exhibit high levels of LAT1 expression regardless of the primary tumor site. Higher LAT1 expression in tumors was associated with higher expression of cell proliferation markers and poorer patient prognosis.
JOURNAL OF RADIATION RESEARCH
(2023)
Article
Biology
Shoji Imamichi, Lichao Chen, Tasuku Ito, Ying Tong, Takae Onodera, Yuka Sasaki, Satoshi Nakamura, PierLuigi Mauri, Yu Sanada, Hiroshi Igaki, Yasufumi Murakami, Minoru Suzuki, Jun Itami, Shinichiro Masunaga, Mitsuko Masutani
Summary: This study investigated whether high mobility group box 1 (HMGB1) could serve as a potential biomarker for evaluating the therapeutic response during boron neutron capture therapy (BNCT). The results showed that there was an increased release of extracellular HMGB1 in cancer cells 24 hours after BNCT irradiation, compared to gamma-ray irradiation. High levels of plasma HMGB1 were also detected in a xenograft mouse model at 3 days post-BNCT irradiation, even when the size of the tumor decreased. These findings suggest that HMGB1 could be a potential biomarker for evaluating the therapeutic efficacy of BNCT.
Review
Oncology
Timothy D. Malouff, Danushka S. Seneviratne, Daniel K. Ebner, William C. Stross, Mark R. Waddle, Daniel M. Trifiletti, Sunil Krishnan
Summary: Boron neutron capture therapy (BNCT) is an emerging treatment modality that utilizes boron-10 to target tumors and has shown promising results in various cancer types in clinical studies.
FRONTIERS IN ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
R. O. Farias, M. A. Garabalino, S. Ferraris, J. Santa Maria, O. Rovati, F. Lange, V. A. Trivillin, A. Monti Hughes, E. C. C. Pozzi, S. I. Thorp, P. Curotto, M. E. Miller, G. A. Santa Cruz, S. Bortolussi, S. Altieri, A. M. Portu, G. Saint Martin, A. E. Schwint, S. J. Gonzalez
Article
Nuclear Science & Technology
J. L. Tripp, J. D. Law, T. E. Smith, V. J. Rutledge, W. F. Bauer, R. D. Ball, P. A. Hahn
NUCLEAR TECHNOLOGY
(2015)
Article
Biology
Veronica A. Trivillin, Leandro J. Bruno, David A. Gatti, Mariela Stur, Marcela A. Garabalino, Andrea Monti Hughes, Jorge Castillo, Emiliano C. C. Pozzi, Luis Wentzeis, Hugo Scolari, Amanda E. Schwint, Sara Feldman
RADIATION AND ENVIRONMENTAL BIOPHYSICS
(2016)
Article
Biology
Veronica A. Trivillin, Emiliano C. C. Pozzi, Lucas L. Colombo, Silvia I. Thorp, Marcela A. Garabalino, Andrea Monti Hughes, Sara J. Gonzalez, Ruben O. Farias, Paula Curotto, Gustavo A. Santa Cruz, Daniel G. Carando, Amanda E. Schwint
RADIATION AND ENVIRONMENTAL BIOPHYSICS
(2017)
Article
Biology
Andrea Monti Hughes, Juan Longhino, Esteban Boggio, Vanina A. Medina, Diego J. Martinel Lamas, Marcela A. Garabalino, Elisa M. Heber, Emiliano C. C. Pozzi, Maria E. Itoiz, Romina F. Aromando, David W. Nigg, Veronica A. Trivillin, Amanda E. Schwint
RADIATION AND ENVIRONMENTAL BIOPHYSICS
(2017)
Article
Biology
Veronica Andrea Trivillin, Ayelen Serrano, Marcela A. Garabalino, Lucas Luis Colombo, Emiliano Cesar Pozzi, Andrea Monti Hughes, Paula M. Curotto, Silvia Ines Thorp, Ruben O. Farias, Sara J. Gonzalez, Silva Bortolussi, Saverio Altieri, Maria E. Itoiz, Romina F. Aromando, David W. Nigg, Amanda E. Schwint
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2019)
Article
Biology
Marcela A. Garabalino, Nahuel Olaiz, Agustina Portu, Gisela Saint Martin, Silvia Thorp, Emiliano C. C. Pozzi, Paula Curotto, Maria E. Itoiz, Andrea Monti Hughes, Lucas L. Colombo, David W. Nigg, Veronica A. Trivillin, Guillermo Marshall, Amanda E. Schwint
RADIATION AND ENVIRONMENTAL BIOPHYSICS
(2019)
Article
Dentistry, Oral Surgery & Medicine
Iara S. Santa Cruz, Marcela A. Garabalino, Veronica A. Trivillin, Maria E. Itoiz, Emiliano C. C. Pozzi, Silvia Thorp, Paula Curotto, Juan S. Guidobono, Elisa M. Heber, David W. Nigg, Amanda E. Schwint, Andrea Monti Hughes
Article
Biology
Amanda E. Schwint, Andrea Monti Hughes, Marcela A. Garabalino, Gustavo A. Santa Cruz, Sara J. Gonzalez, Juan Longhino, Lucas Provenzano, Paulina Ona, Monica Rao, Maria de los Angeles Cantarelli, Andrea Leiras, Maria Silvina Olivera, Veronica A. Trivillin, Paula Alessandrini, Fabricio Brollo, Esteban Boggio, Hernan Costa, Romina Ventimiglia, Sergio Binia, Emiliano C. C. Pozzi, Susana I. Nievas, Iara S. Santa Cruz
Article
Radiology, Nuclear Medicine & Medical Imaging
Veronica A. Trivillin, Yanina Langle, Monica A. Palmieri, Emiliano C. C. Pozzi, Silvia Thorp, Debora N. Benitez Frydryk, Marcela A. Garabalino, Andrea Monti Hughes, Paula M. Curotto, Lucas L. Colombo, Iara S. Santa Cruz, Paula S. Ramos, Maria E. Itoiz, Claudia Arguelles, Ana M. Eijan, Amanda E. Schwint
Summary: This study evaluated the local, regional, and abscopal effects of Boron Neutron Capture Therapy (BNCT) combined with Bacillus Calmette-Guerin (BCG) in a colon cancer model. The results showed that the combination therapy induced significant anti-tumor responses locally and reduced metastatic spread to lymph nodes, suggesting a potential comprehensive approach for cancer treatment.
BRITISH JOURNAL OF RADIOLOGY
(2021)
Article
Biology
Andrea Monti Hughes, Jessica A. Goldfinger, Monica A. Palmieri, Paula Ramos, Iara S. Santa Cruz, Luciana De Leo, Marcela A. Garabalino, Silvia Thorp, Paula Curotto, Emiliano C. C. Pozzi, Kazuki Kawai, Shinichi Sato, Maria E. Itoiz, Veronica A. Trivillin, Juan S. Guidobono, Hiroyuki Nakamura, Amanda E. Schwint
Summary: This study evaluated the distribution and therapeutic effect of MID:BSA in a hamster cheek pouch oral cancer model, demonstrating that the 15 mg B/kg dose reached therapeutically useful boron concentration values in the tumor and was well-tolerated, while the 30 mg B/kg dose induced high toxicity.
Article
Cell Biology
Nahuel Olaiz, Andrea Monti Hughes, Emiliano C. C. Pozzi, Silvia Thorp, Paula Curotto, Veronica A. Trivillin, Paula S. Ramos, Monica A. Palmieri, Guillermo Marshall, Amanda E. Schwint, Marcela A. Garabalino
Summary: Electroporation improves the therapeutic efficacy of GB-10/BNCT in vivo in the hamster cheek pouch oral cancer model without increasing the radiotoxicity.
Article
Pharmacology & Pharmacy
Andrea Monti Hughes, Jessica A. Goldfinger, Lara S. Santa Cruz, Emiliano C. C. Pozzi, Silvia Thorp, Paula Curotto, Marcela A. Garabalino, Maria E. Itoiz, Monica A. Palmieri, Paula Ramos, Elisa M. Heber, Romina F. Aromando, David W. Nigg, Hanna Koivunoro, Veronica A. Trivillin, Amanda E. Schwint
THERAPEUTIC DELIVERY
(2019)
Article
Engineering, Biomedical
S. J. Gonzalez, E. C. C. Pozzi, A. Monti Hughes, L. Provenzano, H. Koivunoro, D. G. Carando, S. I. Thorp, M. R. Casal, S. Bortolussi, V. A. Trivillin, M. A. Garabalino, P. Curotto, E. M. Heber, G. A. Santa Cruz, L. Kankaanranta, H. Joensuu, A. E. Schwint
PHYSICS IN MEDICINE AND BIOLOGY
(2017)
Article
Chemistry, Multidisciplinary
Christopher A. Zarzana, Dean R. Peterman, Gary S. Groenewold, Lonnie G. Olson, Rocklan G. McDowell, William F. Bauer, Sabrina J. Morgan
SEPARATION SCIENCE AND TECHNOLOGY
(2015)
Article
Chemistry, Inorganic & Nuclear
R. Galea, K. Moore
Summary: In this study, the solution of 225Ac was standardized using the TDCR method. The counting efficiencies were calculated to be approximately 500% for the NRC TDCR system. The relative uncertainty for the activity concentration was determined to be 0.25%. The measured half-life of 225Ac was found to be consistent with previous measurements.
APPLIED RADIATION AND ISOTOPES
(2024)
Article
Chemistry, Inorganic & Nuclear
N. C. Ramirez, S. M. Collins
Summary: In this paper, the authors determined the half-life of 68Ga using ionisation chambers measurements and HPGe gamma-ray spectrometry. They reviewed the current literature and identified possible causes of inconsistency within the dataset. The findings suggest that addressing these issues could lead to a significant improvement in future evaluations of the half-life.
APPLIED RADIATION AND ISOTOPES
(2024)
Article
Chemistry, Inorganic & Nuclear
C. P. Mano, C. Chapelle, Der Mesrobian Kabakian, H. Paradis, O. Delaune, L. Patryl
Summary: CEA/DAM is developing new beta-gamma measurement systems to enhance the reliability of the Comprehensive Nuclear Test Ban Treaty's verification regime. A new spectral unmixing algorithm for full-spectrum analysis was tested to improve analysis methods for nuclear activities with low statistics.
APPLIED RADIATION AND ISOTOPES
(2024)
Article
Chemistry, Inorganic & Nuclear
Junyoung Lee, Geunsub Kim, Hyegang Chang, Sangmin Lee, Sung-Joon Ye
Summary: The study applied the convolution/superposition method to calculate the dose distribution of boron neutron capture therapy and compared it with the Monte Carlo method. The results showed that the C/S method has a fast calculation speed and reasonable accuracy.
APPLIED RADIATION AND ISOTOPES
(2024)
Article
Chemistry, Inorganic & Nuclear
Victor H. Elvira, Marie-Christine Lepy, Yves Menesguen, Stephanie Melhem
Summary: In this study, a cryogenic electrical-substitution radiometer was utilized for the primary calibration of monochromatic photon beams at a synchrotron facility, in order to determine the intrinsic efficiency and dead layer thickness of an HPGe detector. This calibration method allowed for the calculation of efficiency up to 55 keV, where the active thickness of the detector is not a determining factor. Geometrical efficiency was also determined through measurements of a radioactive source at various distances.
APPLIED RADIATION AND ISOTOPES
(2024)
Article
Chemistry, Inorganic & Nuclear
Ali Pashazadeh, Hamid Reza Baghani, Mostafa Robatjazi, Prajit Kadavil
Summary: This study investigated the effect of patch source geometric parameters on the depth dose distribution in skin tissue through Monte Carlo simulation. The results showed that increasing the source-to-skin distance, patch thickness, and patch diameter will reduce the depth dose distribution, with the source-to-skin distance having the most significant impact on dose gradient.
APPLIED RADIATION AND ISOTOPES
(2024)
Article
Chemistry, Inorganic & Nuclear
Yueli Song, Fengqun Zhou, Yajuan Hao, Xiaopeng Zhang, Pengfei Ji, Yong Li
Summary: In this study, the cross section values of the 109Ag(n,2n)108mAg reaction at different neutron energies were measured using the activation technique and off-line gamma-ray spectrometry. The results were compared with experimental data, evaluated data from libraries, and theoretical values to validate their accuracy.
APPLIED RADIATION AND ISOTOPES
(2024)
Article
Chemistry, Inorganic & Nuclear
Zhongkai Fan, Tao Hu, Xiangming Cai, Ruomei Xie, Haoxuan Li, Fengdi Qin, Shoukang Qiu, Yanliang Tan, Jian Shan
Summary: The high-precision measurement of Rn-220 is crucial for assessing and preventing thoron radiological hazards. By adding a ZnS(Ag)-coated clapboard, the issue of reduced Rn-220 concentrations due to decreased air pressure can be addressed, leading to improved detection efficiency. Experimental and simulation results provide valuable references for establishing the Rn-220 calibration factor.
APPLIED RADIATION AND ISOTOPES
(2024)
Article
Chemistry, Inorganic & Nuclear
R. Han, Z. Chen, Y. Nie, B. Liu, G. Tian, X. Zhang, F. Shi, H. Sun, Z. Zhang, Y. Ding, X. Ruan, J. Ren, S. Zhang
Summary: The leakage neutron spectra of Lead samples were measured using a TOF technique, and MCNP simulations with different nuclear data libraries showed that JENDL-5.0 and JEFF-3.3 libraries have better agreement with experimental data. Differences in spectra mainly stem from variations in neutron reaction channels across the libraries, with ENDF/B-VIII.0 and CENDL-3.2 libraries being overestimated in certain energy ranges.
APPLIED RADIATION AND ISOTOPES
(2024)
Article
Chemistry, Inorganic & Nuclear
Nissren Tamam, Maryam Al Huwayz, Z. A. Alrowaili, Norah Alwadai, Khadijah Mohammedsaleh Katubi, Mohammed S. Alqahtani, I. O. Olarinoye, M. S. Al-Buriahi
Summary: This study investigates the radiation shielding properties and radiation protection applications of borotellurite glasses. The results show that the addition of TeO2 can enhance the glass's ability to absorb photons and fast neutrons, and effectively suppress photon buildup. These glasses also exhibit exceptional gamma radiation and fast neutron moderating abilities, making them suitable for designing lead-free, transparent, and efficient radiation protection structures.
APPLIED RADIATION AND ISOTOPES
(2024)
Article
Chemistry, Inorganic & Nuclear
S. Chasapoglou, M. Kokkoris, R. Vlastou, M. Diakaki, V. Michalopoulou, A. Kalamara, G. Gkatis, A. Stamatopoulos, M. Axiotis, S. Harissopulos, A. Lagoyannis, M. I. Savva, T. Vasilopoulou, C. Lederer-Woods, N. Patronis, K. Kaperoni
Summary: This study investigated the accuracy and limitations of theoretical corrections in neutron-induced reactions on isotopically enriched Ge targets. Experimental cross-section measurements were conducted on several reactions using Ge-nat and isotopically enriched Ge targets. The results showed that the methodology using isotopically enriched targets provided accurate results without the need for theoretical corrections.
APPLIED RADIATION AND ISOTOPES
(2024)
Article
Chemistry, Inorganic & Nuclear
P. G. Konstantinidis, G. S. Polymeris, E. Tsoutsoumanos, G. Kitis
Summary: This study investigates an altered version of an existing protocol to study the mechanisms and phenomena of stimulated luminescence. The protocol allows for the examination of recombination mechanisms and trapping parameters of the traps, as well as the observation of potential transitions between two different states.
APPLIED RADIATION AND ISOTOPES
(2024)
Article
Chemistry, Inorganic & Nuclear
Quanzhi Yu
Summary: This study obtained the broad neutron spectrum of the Atmospheric Neutron Irradiation Spectrometer (ANIS) through Monte Carlo simulation and provided an analytic expression. By calculating the Single Error Rate (SER) and ratio, the reliability of the ANIS neutron spectrum was evaluated.
APPLIED RADIATION AND ISOTOPES
(2024)
Article
Chemistry, Inorganic & Nuclear
D. Glavic Cindro, M. Korun, T. Petrovic, B. Vodenik, B. Zorko
Summary: In gamma-ray spectrometric measurements, the decision threshold is determined by the observed value of the measurand. However, this dependence restricts its application to measurements with non-expressive indications. To address this issue, a recalculation of the decision thresholds based on the peak widths corresponding to expressive indications is proposed.
APPLIED RADIATION AND ISOTOPES
(2024)
