Journal
APPLIED RADIATION AND ISOTOPES
Volume 69, Issue 12, Pages 1752-1755Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.apradiso.2011.02.030
Keywords
BPA; Differentiated; Thyroid cancer; Uptake
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Funding
- CONICET
- ANPCYT
- University of Buenos Aires
- National Atomic Energy Commission
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The aim of these studies was to evaluate the possibility of treating differentiated thyroid cancer by BNCT. These carcinomas are well controlled with surgery followed by therapy with (131)I; however, some patients do not respond to this treatment. BPA uptake was analyzed both in vitro and in nude mice implanted with cell lines of differentiated thyroid carcinoma. The boron intracellular concentration in the different cell lines and the biodistribution studies showed the selectivity of the BPA uptake by this kind of tumor. (C) 2011 Elsevier Ltd. All rights reserved.
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