4.4 Article

Characterization of breast tissue using energy-dispersive X-ray diffraction computed tomography

Journal

APPLIED RADIATION AND ISOTOPES
Volume 68, Issue 10, Pages 1980-1987

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.apradiso.2010.04.027

Keywords

Tissue characterization; X-ray diffraction; Computed tomography; Breast imaging

Funding

  1. Marie Curie Intra-European Fellowship [MEIF-CT-2004-007206]
  2. EPSRC [EP/D048737/1] Funding Source: UKRI
  3. Engineering and Physical Sciences Research Council [EP/D048737/1] Funding Source: researchfish

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A method for sample characterization using energy-dispersive X-ray diffraction computed tomography (EDXRDCT) is presented. The procedures for extracting diffraction patterns from the data and the corrections applied are discussed. The procedures were applied to the characterization of breast tissue samples, 6 mm in diameter. Comparison with histological sections of the samples confirmed the possibility of grouping the patterns into five families, corresponding to adipose tissue, fibrosis, poorly differentiated cancer, well differentiated cancer and benign tumour. (C) 2010 Elsevier Ltd. All rights reserved.

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