Journal
APPLIED RADIATION AND ISOTOPES
Volume 67, Issue 3, Pages 436-439Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.apradiso.2008.06.015
Keywords
Microbeam; Nanobeam; Non-targeted effects; Bystander effect; Radiation risk
Categories
Funding
- Cancer Research UK
- EU Marie Curie Research Training Programme (CELLION)
- Wolfson Foundation
- Research Council's UK Basic Technology Programme (BASROC)
- Engineering and Physical Sciences Research Council [EP/E032869/1, GR/S91512/01, EP/D032210/1, EP/E035728/1] Funding Source: researchfish
- EPSRC [EP/D032210/1, EP/E032869/1, EP/E035728/1] Funding Source: UKRI
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The micro-irradiation technique continues to be highly relevant to a number of radiobiological studies in vitro. In particular, studies of the bystander effect show that direct damage to cells is not the only trigger for radiation-induced effects, but that unirradiated cells can also respond to signals from irradiated neighbours. Furthermore, the bystander response can be initiated even when no energy is deposited in the genomic DNA of the irradiated cell (i.e. by targeting just the cytoplasm). (C) 2008 Published by Elsevier Ltd.
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