Article
Chemistry, Multidisciplinary
Harjeet S. Soor, Diego B. Diaz, Katherine I. Burton, Andrei K. Yudin
Summary: The ongoing search for underdeveloped functional group combinations has led to the discovery of alpha-fluorinated aminoalkylboronic acids, a new class of molecules featuring the B-CF linkage. These compounds can be generated through electrophilic fluorination and show stability and unique structural properties.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Isabelle Nathalie-Marie Leibler, Shivaani S. Gandhi, Makeda A. Tekle-Smith, Abigail G. Doyle
Summary: This Perspective article provides an overview of the progress and current limitations of nucleophilic fluorination methodologies. Despite the challenges, researchers have been actively studying and developing this transformation to gain a better understanding of its mechanism, create user-friendly fluorination reagents, and contribute to the invention of synthetic methods for radiofluorination. The article discusses studies from the Doyle group and others in the field, highlighting developments in fluoride reagent development and the mechanistic implications of reagent identity. It also outlines the inaccessible chemical space and future directions for filling the existing gaps in synthetic technologies.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Inorganic & Nuclear
Nathanael Allison, Mehrdad Balandeh, Travis Holloway, Adrian Gomez, Alejandra Rios, Christopher M. Waldmann, Artem Lebedev, Saman Sadeghi
Summary: We report a no-carrier-added radiofluorination method for thioethers, successfully producing over 100 MBq of F-18-fluorinated thioethers by electrochemical radiofluorination in the absence of non-radioactive fluorination agents. This unexpected achievement eliminates the need for high amounts of stable [F-19]fluoride, providing a new approach for radiolabeling thioethers.
JOURNAL OF FLUORINE CHEMISTRY
(2022)
Article
Chemistry, Organic
German Fuentes, Maria F. Garcia, Hugo Cerecetto, Guzman alvarez, Marcos Couto, Angel H. Romero
Summary: Favipiravir has emerged as an important selective antiviral against COVID-19, but its conventional synthesis methods have limitations. This study presents a one-step protocol for the synthesis of favipiravir using a direct fluorination reaction, which is simple, economical, eco-friendly, and scalable. The use of ionic liquid BF4-BMIM helps to overcome the chemical limitations of the substrate and improve the yield of favipiravir to 50%.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Jay S. Wright, Richard Ma, E. William Webb, Wade P. Winton, Jenelle Stauff, Kevin Cheng, Allen F. Brooks, Melanie S. Sanford, Peter J. H. Scott
Summary: This report presents the development of a Zn(OTf)(2)-mediated method for converting alpha-tertiary haloamides to the corresponding alpha-tertiary fluoroamides. Under optimized conditions, high radiochemical conversion can be achieved. This method has been successfully applied to prepare various model radiofluorides.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Jin Young Chai, Hyojin Cha, Sung-Sik Lee, Young-Ho Oh, Sungyul Lee, Dae Yoon Chi
Summary: The synthesis of fluorine-18 labeled fluoroform with high molar activity is essential for the development of fluorine-18 labeled aryl-CF3 radiopharmaceuticals for PET imaging. The study proposed a strategy for synthesizing fluoroform and elucidated the mechanism of the fluorination reaction, showing the superiority of the S(N)2 pathway. The research demonstrated the potential for preparing fluorine-18 labeled fluoroform with high molar activity through experimental and theoretical studies.
Article
Chemistry, Inorganic & Nuclear
Chun-Xiang Guo, Sivathmeehan Yogendra, Rosa M. Gomila, Antonio Frontera, Felix Hennersdorf, Johannes Steup, Kai Schwedtmann, Jan J. Weigand
Summary: The study successfully synthesized a family of electrophilic fluorophosphonium cations as triflate salts by in situ electrophilic fluorination of phosphanes, followed by subsequent methylation of the anion. These fluorophosphonium triflate salts exhibit remarkable Lewis acidity and form isolable adducts in stoichiometric reactions with suitable donors. Additionally, their catalytic capabilities were tested in a specific transformation reaction and validated by DFT calculations.
INORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Applied
Tsugio Kitamura, Daichi Kitamura, Juzo Oyamada, Masahiro Higashi, Yosuke Kishikawa
Summary: A new N-F reagent, N,N'-difluoro-2,2';-bipyridinium bis(tetrafluoroborate), for iodoarene-catalyzed fluorination reactions as a terminal oxidant is reported. This reaction is effective for the fluorination of simple alkenes, aromatic alkenes and 1,3-dicarbonyl compounds, giving 1,2-difluorinated alkanes, geminal difluorinated compounds, 2-fluorinated-1,3-dicarbonyl compounds in good to high yields, respectively. The present N-F reagent can be recovered as 2,2'-bipyridine.
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Article
Chemistry, Organic
Zhuyong Zhang, Junfei Luo, Hongyin Gao
Summary: A new strategy for the synthesis of fluorinated anilides without the use of metals and oxidants has been developed, resulting in moderate to good yields of ortho- or para-fluorinated aromatic amine products. This method allows for the efficient construction of structurally diverse fluorinated anilides, including heterocyclic and pharmaceutically relevant molecules.
Article
Chemistry, Multidisciplinary
Rui Wang, Long Lu, Qilong Shen
Summary: A new electrophilic monofluoromethylthiolating reagent, N-fluoromethylthiophthalimide PhthSCH(2)F 1, was easily synthesized from benzyl mercaptan and CH2FCl in three steps. This reagent enables the monofluoromethylthiolation of a wide range of nucleophiles, including alkynes, aryl/vinyl boronic acids, electron-rich heteroarenes, beta-ketoesters and oxindoles, as well as thiols, under mild conditions.
CHINESE JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Applied
Takuma Tagami, Yusuke Mitani, Shintaro Kawamura, Mikiko Sodeoka
Summary: Given the significance of difluoromethylated molecules in drug and agrochemical development, the establishment of synthetic protocols for their synthesis has gained much attention. This study reports a general and practical Cu-catalyzed method for the difluoromethylation of alkenes using difluoroacetic anhydride (DFAA) as a CF2H source. The reaction proceeds via the in situ generation of bis(difluoroacetyl) peroxide (BDFAP) from DFAA and H2O2. The obtained results enable the simple and efficient synthesis of a wide range of difluoromethylated species for their practical applications in medicinal and agricultural chemistry.
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Article
Chemistry, Applied
Paula Casasus, Jordi Mestre, Miguel Bernus, Sergio Castillon, Omar Boutureira
Summary: Two saccharine-based electrophilic reagents have been developed for the direct introduction of SCH2CF3 and SCH2CF2H motifs via a C-S bond forming reaction. Large-scale preparation and reactivity performance have been examined, enabling access to a series of indoles through open-flask reactions. Sulfone and sulfoxide analogs (S(O)(n)CH2RF, n=1,2) are also accessible by sequential oxidation reactions.
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Article
Nanoscience & Nanotechnology
Benyuan Huang, Yang Liu, Jiawei Duan, Xin Li, Yulong Li, Rui Qin, Xu Wang, Yongbing Zhuang, Xiangyang Liu
Summary: This study develops a fluorination strategy with an atomic fluorination mechanism to modify graphene, which enables the preparation of graphene with a higher fluorination degree and relatively homogeneous fluorine distribution. The resulting fluorinated graphene possesses higher thermal stability, thermal conductivity, and electrical insulation, demonstrating its potential applications in thermal conduction and electrical insulation for microelectronics.
ACS APPLIED NANO MATERIALS
(2022)
Article
Chemistry, Analytical
Alexander Mansel, Karsten Franke
Summary: The chemical separation of zirconium from lanthanides using liquid-liquid extraction is challenging but critical. By optimizing the process with the radiotracer technique, Zr-89 was successfully separated in a sulfuric acid solution and used in solvent extraction tests for the efficient separation and purification of lanthanides.
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
(2021)
Article
Chemistry, Organic
Long-Yu Ran, Xue Ding, Xue-Ping Yan, Cheng-Pan Zhang
Summary: This article describes the synthesis of alkyl fluorides and carbonates via divergent dehydroxyfluorination and carbonation of alcohols with trifluoromethyl trifluoromethanesulfonate (CF3SO2OCF3). Reactions with BTMG in THF yielded alkyl fluorides in good yields, while reactions of two different alcohols with Et3N in DCM formed asymmetric carbonates in moderate to excellent yields. CF3SO2OCF3 was shown to serve as either a F or a CO reagent in the reactions by changing the base, enabling the selective construction of alkyl fluorides and carbonates with high efficiency. Notably, the synthesis of fluorine-containing asymmetric carbonates, which are difficult to prepare by other methods, was comprehensively achieved by this method, demonstrating its significant application potential in both academia and industry.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Feng Gao, Wiebke Sihver, Christoph Jurischka, Ralf Bergmann, Cathleen Haase-Kohn, Birgit Mosch, Joerg Steinbach, Davide Carta, Cristina Bolzati, Andrea Calderan, Jens Pietzsch, Hans-Juergen Pietzsch
Article
Medicine, Research & Experimental
Alexander Scholz, Patrick N. Harter, Sebastian Cremer, Burak H. Yalcin, Stefanie Gurnik, Maiko Yamaji, Mariangela Di Tacchio, Kathleen Sommer, Peter Baumgarten, Oliver Baehr, Joachim P. Steinbach, Joerg Trojan, Martin Glas, Ulrich Herrlinger, Dietmar Krex, Matthias Meinhardt, Astrid Weyerbrock, Marco Timmer, Roland Goldbrunner, Martina Deckert, Christian Braun, Jens Schittenhelm, Jochen T. Frueh, Evelyn Ullrich, Michel Mittelbronn, Karl H. Plate, Yvonne Reiss
EMBO MOLECULAR MEDICINE
(2016)
Article
Oncology
Congcong Zhang, Michael C. Burger, Lukas Jennewein, Sabrina Genssler, Kurt Schoenfeld, Pia Zeiner, Elke Hattingen, Patrick N. Harter, Michel Mittelbronn, Torsten Tonn, Joachim P. Steinbach, Winfried S. Wels
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2016)
Article
Oncology
Congcong Zhang, Michael C. Burger, Lukas Jennewein, Sabrina Genssler, Kurt Schoenfeld, Pia Zeiner, Elke Hattingen, Patrick N. Harter, Michel Mittelbronn, Torsten Tonn, Joachim P. Steinbach, Winfried S. Wels
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2016)
Article
Chemistry, Inorganic & Nuclear
Sven Roetering, Matthias Scheunemann, Robert Guenther, Reik Loeser, Achim Hiller, Dan Peters, Peter Brust, Steffen Fischer, Joerg Steinbach
APPLIED RADIATION AND ISOTOPES
(2016)
Article
Biochemical Research Methods
Sally Wagner, Rodrigo Teodoro, Winnie Deuther-Conrad, Mathias Kranz, Matthias Scheunemann, Steffen Fischer, Barbara Wenzel, Ute Egerland, Norbert Hoefgen, Joerg Steinbach, Peter Brust
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
(2017)
Article
Multidisciplinary Sciences
Falco Reissig, Constantin Mamat, Joerg Steinbach, Hans-Juergen Pietzsch, Robert Freudenberg, Carlos Navarro-Retamal, Julio Caballero, Joerg Kotzerke, Gerd Wunderlich
Article
Oncology
Christina Jentsch, Ralf Bergmann, Kerstin Bruechner, Birgit Mosch, Ala Yaromina, Mechthild Krause, Daniel Zips, Esther G. C. Troost, Steffen Loeck, Joerg Kotzerke, Joerg Steinbach, Howard Thames, Michael Baumann, Bettina Beuthien-Baumann
RADIOTHERAPY AND ONCOLOGY
(2016)
Article
Medicine, Research & Experimental
Christoph Tondera, Sandra Hauser, Anne Krueger-Genge, Friedrich Jung, Axel T. Neffe, Andreas Lendlein, Robert Klopfleisch, Joerg Steinbach, Christie Neuber, Jens Pietzsch
Article
Radiology, Nuclear Medicine & Medical Imaging
Ralf Bergmann, Marian Meckel, Vojtech Kubicek, Jens Pietzsch, Joerg Steinbach, Petr Hermann, Frank Roesh
Correction
Chemistry, Multidisciplinary
Matthew Gott, Joerg Steinbach, Constantin Mamat
Article
Chemistry, Multidisciplinary
Matthew Gott, Joerg Steinbach, Constantin Mamat
Article
Multidisciplinary Sciences
Roberta Aliperta, Petra B. Welzel, Ralf Bergmann, Uwe Freudenberg, Nicole Berndt, Anja Feldmann, Claudia Arndt, Stefanie Koristka, Marcello Stanzione, Marc Cartellieri, Armin Ehninger, Gerhard Ehninger, Carsten Werner, Jens Pietzsch, Joerg Steinbach, Martin Bornhaeuser, Michael P. Bachmann
SCIENTIFIC REPORTS
(2017)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
T. Kniess, N. Bechmann, J. Steinbach, J. Pietzsch
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2016)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
R. Bergmann, A. Feldmann, C. Arndt, S. Koristka, M. Cartellieri, A. Ehninger, J. Pietzsch, J. Steinbach, D. Mathe, M. Bachmann
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2016)
Article
Chemistry, Inorganic & Nuclear
R. Galea, K. Moore
Summary: In this study, the solution of 225Ac was standardized using the TDCR method. The counting efficiencies were calculated to be approximately 500% for the NRC TDCR system. The relative uncertainty for the activity concentration was determined to be 0.25%. The measured half-life of 225Ac was found to be consistent with previous measurements.
APPLIED RADIATION AND ISOTOPES
(2024)
Article
Chemistry, Inorganic & Nuclear
N. C. Ramirez, S. M. Collins
Summary: In this paper, the authors determined the half-life of 68Ga using ionisation chambers measurements and HPGe gamma-ray spectrometry. They reviewed the current literature and identified possible causes of inconsistency within the dataset. The findings suggest that addressing these issues could lead to a significant improvement in future evaluations of the half-life.
APPLIED RADIATION AND ISOTOPES
(2024)
Article
Chemistry, Inorganic & Nuclear
C. P. Mano, C. Chapelle, Der Mesrobian Kabakian, H. Paradis, O. Delaune, L. Patryl
Summary: CEA/DAM is developing new beta-gamma measurement systems to enhance the reliability of the Comprehensive Nuclear Test Ban Treaty's verification regime. A new spectral unmixing algorithm for full-spectrum analysis was tested to improve analysis methods for nuclear activities with low statistics.
APPLIED RADIATION AND ISOTOPES
(2024)
Article
Chemistry, Inorganic & Nuclear
Junyoung Lee, Geunsub Kim, Hyegang Chang, Sangmin Lee, Sung-Joon Ye
Summary: The study applied the convolution/superposition method to calculate the dose distribution of boron neutron capture therapy and compared it with the Monte Carlo method. The results showed that the C/S method has a fast calculation speed and reasonable accuracy.
APPLIED RADIATION AND ISOTOPES
(2024)
Article
Chemistry, Inorganic & Nuclear
Victor H. Elvira, Marie-Christine Lepy, Yves Menesguen, Stephanie Melhem
Summary: In this study, a cryogenic electrical-substitution radiometer was utilized for the primary calibration of monochromatic photon beams at a synchrotron facility, in order to determine the intrinsic efficiency and dead layer thickness of an HPGe detector. This calibration method allowed for the calculation of efficiency up to 55 keV, where the active thickness of the detector is not a determining factor. Geometrical efficiency was also determined through measurements of a radioactive source at various distances.
APPLIED RADIATION AND ISOTOPES
(2024)
Article
Chemistry, Inorganic & Nuclear
Ali Pashazadeh, Hamid Reza Baghani, Mostafa Robatjazi, Prajit Kadavil
Summary: This study investigated the effect of patch source geometric parameters on the depth dose distribution in skin tissue through Monte Carlo simulation. The results showed that increasing the source-to-skin distance, patch thickness, and patch diameter will reduce the depth dose distribution, with the source-to-skin distance having the most significant impact on dose gradient.
APPLIED RADIATION AND ISOTOPES
(2024)
Article
Chemistry, Inorganic & Nuclear
Yueli Song, Fengqun Zhou, Yajuan Hao, Xiaopeng Zhang, Pengfei Ji, Yong Li
Summary: In this study, the cross section values of the 109Ag(n,2n)108mAg reaction at different neutron energies were measured using the activation technique and off-line gamma-ray spectrometry. The results were compared with experimental data, evaluated data from libraries, and theoretical values to validate their accuracy.
APPLIED RADIATION AND ISOTOPES
(2024)
Article
Chemistry, Inorganic & Nuclear
Zhongkai Fan, Tao Hu, Xiangming Cai, Ruomei Xie, Haoxuan Li, Fengdi Qin, Shoukang Qiu, Yanliang Tan, Jian Shan
Summary: The high-precision measurement of Rn-220 is crucial for assessing and preventing thoron radiological hazards. By adding a ZnS(Ag)-coated clapboard, the issue of reduced Rn-220 concentrations due to decreased air pressure can be addressed, leading to improved detection efficiency. Experimental and simulation results provide valuable references for establishing the Rn-220 calibration factor.
APPLIED RADIATION AND ISOTOPES
(2024)
Article
Chemistry, Inorganic & Nuclear
R. Han, Z. Chen, Y. Nie, B. Liu, G. Tian, X. Zhang, F. Shi, H. Sun, Z. Zhang, Y. Ding, X. Ruan, J. Ren, S. Zhang
Summary: The leakage neutron spectra of Lead samples were measured using a TOF technique, and MCNP simulations with different nuclear data libraries showed that JENDL-5.0 and JEFF-3.3 libraries have better agreement with experimental data. Differences in spectra mainly stem from variations in neutron reaction channels across the libraries, with ENDF/B-VIII.0 and CENDL-3.2 libraries being overestimated in certain energy ranges.
APPLIED RADIATION AND ISOTOPES
(2024)
Article
Chemistry, Inorganic & Nuclear
Nissren Tamam, Maryam Al Huwayz, Z. A. Alrowaili, Norah Alwadai, Khadijah Mohammedsaleh Katubi, Mohammed S. Alqahtani, I. O. Olarinoye, M. S. Al-Buriahi
Summary: This study investigates the radiation shielding properties and radiation protection applications of borotellurite glasses. The results show that the addition of TeO2 can enhance the glass's ability to absorb photons and fast neutrons, and effectively suppress photon buildup. These glasses also exhibit exceptional gamma radiation and fast neutron moderating abilities, making them suitable for designing lead-free, transparent, and efficient radiation protection structures.
APPLIED RADIATION AND ISOTOPES
(2024)
Article
Chemistry, Inorganic & Nuclear
S. Chasapoglou, M. Kokkoris, R. Vlastou, M. Diakaki, V. Michalopoulou, A. Kalamara, G. Gkatis, A. Stamatopoulos, M. Axiotis, S. Harissopulos, A. Lagoyannis, M. I. Savva, T. Vasilopoulou, C. Lederer-Woods, N. Patronis, K. Kaperoni
Summary: This study investigated the accuracy and limitations of theoretical corrections in neutron-induced reactions on isotopically enriched Ge targets. Experimental cross-section measurements were conducted on several reactions using Ge-nat and isotopically enriched Ge targets. The results showed that the methodology using isotopically enriched targets provided accurate results without the need for theoretical corrections.
APPLIED RADIATION AND ISOTOPES
(2024)
Article
Chemistry, Inorganic & Nuclear
P. G. Konstantinidis, G. S. Polymeris, E. Tsoutsoumanos, G. Kitis
Summary: This study investigates an altered version of an existing protocol to study the mechanisms and phenomena of stimulated luminescence. The protocol allows for the examination of recombination mechanisms and trapping parameters of the traps, as well as the observation of potential transitions between two different states.
APPLIED RADIATION AND ISOTOPES
(2024)
Article
Chemistry, Inorganic & Nuclear
Quanzhi Yu
Summary: This study obtained the broad neutron spectrum of the Atmospheric Neutron Irradiation Spectrometer (ANIS) through Monte Carlo simulation and provided an analytic expression. By calculating the Single Error Rate (SER) and ratio, the reliability of the ANIS neutron spectrum was evaluated.
APPLIED RADIATION AND ISOTOPES
(2024)
Article
Chemistry, Inorganic & Nuclear
D. Glavic Cindro, M. Korun, T. Petrovic, B. Vodenik, B. Zorko
Summary: In gamma-ray spectrometric measurements, the decision threshold is determined by the observed value of the measurand. However, this dependence restricts its application to measurements with non-expressive indications. To address this issue, a recalculation of the decision thresholds based on the peak widths corresponding to expressive indications is proposed.
APPLIED RADIATION AND ISOTOPES
(2024)
