Article
Food Science & Technology
Mustafa Fevzi Karagoz, A. Gulcin Sagdicoglu Celep
Summary: Energy restriction, a non-genetic intervention, increases life expectancy by stimulating NAD+ and AMP levels, activating SIRT enzymes and AMPK. These enzymes regulate various mechanisms, including enhancing resistance to oxidative stress, inducing apoptosis, and suppressing tumor growth. Energy restriction also stimulates autophagy, mitophagy, and mitochondrial biogenesis, while regulating lipid metabolism and inflammatory response through genetic pathways.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Article
Multidisciplinary Sciences
Elite Possik, Laura-Lee Klein, Perla Sanjab, Ruyuan Zhu, Laurence Cote, Ying Bai, Dongwei Zhang, Howard Sun, Anfal Al-Mass, Abel Oppong, Rasheed Ahmad, Alex Parker, S. R. Murthy Madiraju, Fahd Al-Mulla, Marc Prentki
Summary: Excess nutrients can accelerate aging, but the newly discovered enzyme G3PP can counter metabolic stress and promote healthy aging in C. elegans. Overexpression of the C. elegans G3PP homolog, PGPH-2, decreases fat levels and mimics the effects of calorie restriction, particularly in glucotoxicity conditions, without reducing food intake. This overexpression depletes glycogen stores and activates AMPK, HLH-30, and autophagy, promoting healthy aging.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, Research & Experimental
Evelyn Lopez Soares, Fabio Andre dos Santos, Tayline Mroczek, Debora Cristina de Lima, Hemily Victoria Bardini Josefino, Luise Adrieli Bochenek da Silva, Leomar Emanuel Almeida Mecca, Gilson Cesar Nobre Franco
Summary: The study found that caloric restriction reduced alveolar bone loss, improved the glycemic profile, and alleviated gingival inflammation in rats with experimental periodontitis.
Article
Medicine, Research & Experimental
Evelyn Lopez Soares, Fabio Andre dos Santos, Tayline Mroczek, Debora Cristina de Lima, Hemily Victoria Bardini Josefino, Bruna Carolina Mehret Scorsin, Dionizia Xavier Scomparin, Gilson Cesar Nobre Franco
Summary: The study suggests that caloric restriction can reduce alveolar bone loss in obese rats with experimental periodontitis, while also benefiting glycemic profile and clinical periodontal measures.
Article
Plant Sciences
Jing Xu, Chaofan Fu, Tao Li, Xiaoyan Xia, Huixing Zhang, Xude Wang, Yuqing Zhao
Summary: The study found that AE inhibited apoptosis and increased antioxidant levels in STZ-induced MIN6 cells. In the diabetic rat model, the AE group showed lower blood glucose levels, increased insulin secretion, and alleviated weight loss.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biology
Bernd Niemann, Ruping Pan, Hassan Issa, Andreas Simm, Rainer Schulz, Susanne Rohrbach
Summary: This study investigated the impact of caloric restriction on heart failure progression and found that caloric restriction inhibits the loss of heart function, even in established heart failure. These findings deepen our understanding of the mechanisms behind the cardioprotective effects of caloric restriction.
Article
Nutrition & Dietetics
Chanisa Thonusin, Patcharapong Pantiya, Aphisek Kongkaew, Wichwara Nawara, Busarin Arunsak, Sirawit Sriwichaiin, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: Exercise and caloric restriction have different effects on skeletal muscle metabolism during aging. Exercise is more effective in improving fatty acid oxidation and oxidative phosphorylation, while caloric restriction reduces oxidative stress in skeletal muscle.
Article
Endocrinology & Metabolism
Kayla Rapps, Tatiana Kisliouk, Asaf Marco, Aron Weller, Noam Meiri
Summary: KDM4D plays a role in energy balance by regulating the expression of AgRP. Downregulation of Kdm4d mRNA results in enrichment of H3K9me2 on the AgRP promoter and transcriptional repression of AgRP. Upregulation of Kdm4d mRNA in calorically restricted rats leads to demethylation of H3K9 on the AgRP promoter and transcriptional increase of AgRP. Inhibition of KDM4D activity leads to transcriptional repression of AgRP, inhibiting hunger.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biology
Madelene Ericsson, Par Steneberg, Rakel Nyren, Helena Edlund
Summary: Age is associated with deteriorating metabolic, cardiac, and vascular function, as well as reduced mobility and quality of life. Although exercise has positive effects on age-related dysfunctions, many elderly individuals are unable to engage in regular physical activity for various reasons. Developing pharmacological treatments that mimic the beneficial effects of exercise is highly desirable. The pan-AMPK activator O304 has shown in preclinical studies to prevent and reverse age-related hyperinsulinemia and insulin resistance, and improve cardiac function and exercise capacity in aged mice, indicating its potential as an exercise mimetic for improving metabolic dysfunction and quality of life in the elderly.
COMMUNICATIONS BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Johanna Y. Fleischman, Nathan R. Qi, Mary K. Treutelaar, Steven L. Britton, Lauren G. Koch, Jun Z. Li, Charles F. Burant
Summary: Caloric restriction improves metabolic health and shares similarities with high cardiorespiratory fitness in terms of adiposity reduction, enhanced cardiometabolic health, and increased longevity. This study investigates whether the mechanisms through which heritable high cardiorespiratory fitness occurs are similar to those promoting health and longevity through caloric restriction. The results suggest that caloric restriction has positive effects on physiological parameters in low cardiorespiratory fitness rats that resemble those seen in high cardiorespiratory fitness rats.
MOLECULAR METABOLISM
(2023)
Article
Nutrition & Dietetics
Josimar Macedo de Castro, Dirson Joao Stein, Helouise Richardt Medeiros, Carla de Oliveira, Iraci L. S. Torres
Summary: The study revealed that calorie restriction (CR) can lead to muscle wasting and neuroinflammation, while nicotinamide riboside (NR) can enhance cellular transformation. NR may prevent muscle mass loss in the weight loss process, suggesting a potential adjuvant for obesity treatment.
FRONTIERS IN NUTRITION
(2021)
Article
Cell Biology
Patricia Corrales, Marina Martin-Taboada, Yurena Vivas-Garcia, Lucia Torres, Laura Ramirez-Jimenez, Yamila Lopez, Daniel Horrillo, Rocio Vila-Bedmar, Eloisa Barber-Cano, Adriana Izquierdo-Lahuerta, Maria Pena-Chilet, Carmen Martinez, Joaquin Dopazo, Manuel Ros, Gema Medina-Gomez
Summary: Caloric restriction is a non-pharmacological intervention that improves metabolic defects associated with aging. MiRNA expression levels can serve as predictive tools for aging-related alterations. Specific miRNAs contribute to impaired insulin-stimulated glucose metabolism in subcutaneous white adipose tissue, and their expression is modified by caloric restriction, suggesting their potential as biomarkers for age-related metabolic alterations.
Article
Nutrition & Dietetics
Monica Serra, Fabio Marongiu, Ezio Laconi
Summary: The study found that chronic moderate caloric restriction and social isolation can synergize to induce anorexia-like behavior in rats, but restoring group-housing conditions can reverse this effect.
Review
Endocrinology & Metabolism
Olivia R. Ghosh-Swaby, Amy C. Reichelt, Paul A. S. Sheppard, Jeffrey Davies, Timothy J. Bussey, Lisa M. Saksida
Summary: This article discusses the role of metabolic hormones in neural plasticity and cognition, as well as the relationship between metabolic hormones and metabolic syndromes such as obesity and diabetes. Adjusting metabolic hormone levels can restore metabolic homeostasis and enhance cognitive function.
FRONTIERS IN NEUROENDOCRINOLOGY
(2022)
Article
Geriatrics & Gerontology
Yuhei Mizunoe, Masaki Kobayashi, Hiroki Saito, Akifumi Goto, Ryota Migitaka, Kumi Miura, Naoyuki Okita, Yuka Sudo, Ryoma Tagawa, Miki Yoshida, Ai Umemori, Yoshimi Nakagawa, Hitoshi Shimano, Yoshikazu Higami
Summary: Research indicates that aging leads to muscle atrophy, but long-term caloric restriction can reduce this age-related muscle decline.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Cell Biology
Lucas Zangerolamo, Jean F. Vettorazzi, Carina Solon, Gabriela A. Bronczek, Daiane F. Engel, Mirian A. Kurauti, Gabriela M. Soares, Karina S. Rodrigues, Licio A. Velloso, Antonio C. Boschero, Everardo M. Carneiro, Helena C. L. Barbosa
Summary: Tauroursodeoxycholic acid (TUDCA) showed improvements in glucose tolerance and insulin sensitivity, reduced blood glucose levels, increased islet mass and beta-cell area, and enhanced glucose-stimulated insulin secretion in Alzheimer's disease (AD) models. Additionally, TUDCA also reduced neuroinflammation, decreased protein content of amyloid oligomers, improved memory, and increased protein content of insulin receptor beta-subunit in the hippocampus.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Iala Milene Bertasso, Carla Bruna Pietrobon, Rosane Aparecida Ribeiro, Gabriela Moreira Soares, Janaina Chaves de Oliveira, Ana Claudia Paiva Alegre-Maller, Antonio Carlos Boschero, Allan Cezar Faria Araujo, Ana Tereza Bittencourt Guimaraes, Maria Lucia Bonfleur, Sandra Lucinei Balbo
Summary: Maternal obesity increases the risk of nonalcoholic fatty liver disease (NAFLD) in offspring. Roux-en-Y gastric bypass (RYGB) surgery is effective for weight loss and improving NAFLD. However, this study found that RYGB can exacerbate NAFLD after pregnancy and lactation, and induce gender-related differential expression of hepatic lipogenesis pathway in the offspring, potentially increasing the risk of NAFLD in female offspring.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2022)
Article
Multidisciplinary Sciences
Gabriela Alves Bronczek, Gabriela Moreira Soares, Jaqueline Fernandes de Barros, Jean Franciesco Vettorazzi, Mirian Ayumi Kurauti, Emilio Marconato-Junior, Lucas Zangerolamo, Carine Marmentini, Antonio Carlos Boschero, Jose Maria Costa-Junior
Summary: Resistance exercise improves glucose homeostasis in healthy mice by enhancing insulin secretion, potentially driven by exercise-induced humoral factors.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Carine Marmentini, Gabriela M. Soares, Gabriela A. Bronczek, Silvano Piovan, Cecilia E. Mareze-Costa, Everardo M. Carneiro, Antonio C. Boschero, Mirian A. Kurauti
Summary: Although insulin sensitivity was unaffected in old mice, glucose tolerance appeared to increase during the intraperitoneal glucose tolerance test, accompanied by higher plasma insulin levels. The reduced insulin clearance in old mice may be related to the decreased hepatic CEACAM1 and IDE function.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cell Biology
Karina Rodrigues-dos-Santos, Gabriela M. Soares, Dimitrius S. P. S. F. Guimaraes, Thiago R. Araujo, Jean F. Vettorazzi, Lucas Zangerolamo, Emilio Marconato-Junior, Renzhi Cai, Wei Sha, Andrew Schally, Antonio C. Boschero, Helena C. L. Barbosa
Summary: Endoplasmic reticulum (ER) stress is associated with the progression of type 2 diabetes mellitus, and investigating agents like the GHRH agonist MR-409 could help alleviate oxidative stress and enhance cell survival under ER stress. However, further research is needed to understand the mechanisms by which MR-409 leads to these outcomes.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jose Maria Costa-Junior, Sandra Mara Ferreira, Mirian Ayumi Kurauti, Diana L. Bernstein, Elena G. Ruano, Vasumathi Kameswaran, Jonathan Schug, Ricardo Freitas-Dias, Claudio C. Zoppi, Antonio C. Boschero, Camila A. M. de Oliveira, Gustavo J. Santos, Everardo M. Carneiro, Klaus H. Kaestner
Summary: Paternal exercise has a positive impact on the metabolic health of offspring, which can be achieved through transgenerational inheritance. The study showed that paternal exercise improves glucose tolerance and insulin sensitivity in the offspring, and this effect may be achieved by influencing the epigenetic mechanisms of transgenerational inheritance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Carine Marmentini, Renato C. S. Branco, Antonio C. Boschero, Mirian A. Kurauti
Summary: Islet amyloid polypeptide is a hormone co-secreted with insulin by pancreatic beta-cells and is found in patients with type 2 diabetes. Investigating aspects related to amyloid formation is crucial for developing strategies towards beta-cell protection. Approaches to prevent islet amyloid cytotoxicity have shown promise in improving beta-cell function and preventing hyperglycemia.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Endocrinology & Metabolism
Patricia Cristine Borck, Sarah Rickli, Jean Franciesco Vettorazzi, Thiago Martins Batista, Antonio Carlos Boschero, Elaine Vieira, Everardo Magalhaes Carneiro
Summary: Exposure to artificial light at night, especially in conjunction with a low-protein diet, can have negative effects on energy and glucose metabolism, potentially predisposing to metabolic disorders.
JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Medicine, Research & Experimental
Ricardo Freitas-Dias, Tanes Lima, Jose Maria Costa-Junior, Luciana M. Goncalves, Hygor N. Araujo, Flavia M. M. Paula, Gustavo J. Santos, Renato Chaves Souto Branco, Kristy Ou, Klaus H. Kaestner, Leonardo R. Silveira, Camila A. M. Oliveira, Antonio C. Boschero, Claudio C. Zoppi, Everardo M. Carneiro
Summary: This study investigates whether improved skeletal muscle mitochondrial function and its association with glycemic control are multigenerational benefits of exercise. The results show that offspring from trained fathers exhibit higher endurance performance, mitochondrial oxygen consumption, glucose tolerance, and insulin sensitivity. These effects are correlated with reduced expression of NCoR1, increased activation of PGC-1 alpha target genes, and increased DNA methylation at the NCoR1 promoter.
Article
Medicine, Research & Experimental
Robson Barth, Carolina Ruoso, Sandra Mara Ferreira, Francieli Caroline de Ramos, Fernanda Barbosa Lima, Antonio Carlos Boschero, Gustavo Jorge dos Santos
Summary: Research findings indicate that DEX-induced proliferation of pancreatic beta cells relies on HNF4 alpha, leading to the expansion of beta-cell mass. Therefore, HNF4 alpha may serve as a potential therapeutic target for diabetes treatment.
Article
Anatomy & Morphology
Carolina Martinez, Daniela A. Maschio, Camila C. de Fontes, Emerielle C. Vanzela, Izabelle D. Benfato, Marcos L. Gazarini, Everardo M. Carneiro, Camila A. M. de Oliveira, Carla B. Collares-Buzato, Carolina P. F. Carvalho
Summary: This study found that a high-fat diet caused significant changes in the content of cell-to-cell junction proteins in pancreatic islet cells of prediabetic mice. The content of adherens junction-associated proteins increased while the content of gap junction proteins decreased. These changes may be associated with insulin secretion and calcium oscillation frequency in islet cells.
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
(2022)
Article
Pharmacology & Pharmacy
Carine Marmentini, Dimitrius Santiago P. S. F. Guimaraes, Tanes de Lima, Francisco Breno S. Teofilo, Natalia S. da Silva, Gabriela M. Soares, Antonio C. Boschero, Mirian A. Kurauti
Summary: The study demonstrates that rosiglitazone can improve the viability of INS-1E cells exposed to hIAPP, independent of insulin-degrading enzyme (IDE) modulation. Rosiglitazone inhibited hIAPP fibrillation and reduced hIAPP-induced expression of CHOP, ATF4, and p-eIF2a, suggesting that TZDs treatment may be a promising approach to preserve β-cell mass and function.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Gabriela Alves Bronczek, Gabriela Moreira Soares, Carine Marmentini, Antonio Carlos Boschero, Jose Maria Costa-Junior
Summary: Resistance training increases insulin secretion and beta cell function, enhancing beta cell glucose sensing and survival. In vitro experiments using a pancreatic beta cell line showed increased insulin secretion and expression of glucose transporter 2 (GLUT2) and glucokinase (GCK) when incubated with serum from trained mice. Trained serum also protected cells from cytokine-induced apoptosis. In vivo experiments using diabetic mice showed that resistance training improved muscle mass, reduced blood glucose levels, and enhanced glucose tolerance, potentially through increased insulin levels and beta cell mass.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Gabriela Moreira Soares, Luana Emanuelly Sinhori Lopes, Sandra Lucinei Balbo, Carine Marmentini, Gabriela Alves Bronczek, Mirian Ayumi Kurauti, Maria Lucia Bonfleur, Licio Augusto Velloso, Everardo Magalhaes Carneiro, Antonio Carlos Boschero, Jose Maria Costa Jr
Summary: Sleeve gastrectomy (SG) normalizes metabolic homeostasis and insulin sensitivity in obese individuals, possibly through increased insulin clearance mediated by enhanced liver IDE expression. However, IDE activity does not appear to be affected by SG surgery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Lucas Zangerolamo, Carina Solon, Gabriela M. Soares, Daiane F. Engel, Licio A. Velloso, Antonio C. Boschero, Everardo M. Carneiro, Helena Cristina L. Barbosa
Summary: TUDCA treatment in Stz mice leads to lower food intake, higher energy expenditure, improved hypothalamic leptin signaling, and reduced body weight and adiposity.
SCIENTIFIC REPORTS
(2021)