Article
Biochemistry & Molecular Biology
Daniel A. F. de Oliveira, Susana N. Diniz, Regina M. S. Pereira, Ivair D. Goncalves, Andre L. Renno, Renata Gorjao, Eduardo G. Vieira, Ana M. C. Ferreira, Cristina E. Okuyama
Summary: The new rutin copper(II) complex shows potential in preventing hypercholesterolemia by reducing blood lipid levels, decreasing inflammation, and protecting against liver damage. Both rutin and R-Cu2 demonstrate effects, but R-Cu2 shows more noticeable results in some aspects, suggesting it could be a nutraceutical option for preventing hypercholesterolemia.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Azza A. A. Attia, Jehan M. M. Sorour, Neama A. A. Mohamed, Tagreed T. T. Mansour, Rasha A. A. Al-Eisa, Nahla S. S. El-Shenawy
Summary: This study aimed to investigate the protective role of vitamin E in improving cardiotoxicity induced by cyclophosphamide in rats. The results showed that vitamin E could attenuate the elevation of cardiac markers, increase in lipid profiles, reduction in antioxidant enzyme activities, and increase in lipid peroxidation. In addition, vitamin E was found to improve the histopathological alterations caused by cyclophosphamide.
Article
Food Science & Technology
Phung Diep Huy Vu, Akkaratch Rodklongtan, Pakamon Chitprasert
Summary: The study found that the encapsulant weight ratio of whey protein isolate-lignin complex significantly affects the survival rate of spray-dried probiotics, with the 9:1 ratio offering the best protection. Lignin improves the survival of probiotics by enhancing the structure and antioxidant properties of WPI.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Alireza Behnamifar, Shaban Rahimi, Mohammad Amir Karimi Torshizi, Mohsen Sharafi, J. L. Grimes
Summary: This study investigated the effects of alpha-lipoic acid supplementation on the semen quality and fertility parameters of aging breeder roosters, finding that appropriate levels of ALA can improve sperm quality, while higher doses do not result in further improvement.
Review
Biochemistry & Molecular Biology
Onchuma Mueangson, Aongart Mahittikorn, Nsoh Godwin Anabire, Wanida Mala, Manas Kotepui
Summary: This study examined the relationship between malondialdehyde (MDA) concentrations and Plasmodium infections. The results showed that MDA concentrations were significantly elevated in patients with malaria compared to uninfected controls, indicating an increase in oxidative stress and lipid peroxidation. MDA levels can be a valuable biomarker for evaluating these processes in individuals with malaria.
Article
Medicine, Research & Experimental
Luis Alberto Ayala-Ruiz, Luis Gerardo Ortega-Perez, Jonathan Saul Pinon-Simental, Oliver Rafid Magana-Rodriguez, Esperanza Melendez-Herrera, Patricia Rios-Chavez
Summary: This study reveals that 1,8-Cineole, limonene and alpha-terpineol found in Callistemon citrinus attenuated oxidative stress through antioxidant and anti-inflammatory mechanisms in rats fed with a high-fat-sucrose diet. These terpenes showed different effects on hepatic cells and oxidative biomarkers, but exhibited the same positive effects on pro-inflammatory cytokines. The findings highlight the significant anti-inflammatory effects of these terpenes and their importance in the activities of Callistemon citrinus.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biotechnology & Applied Microbiology
Huan Xiao, Shitao Peng, Xianbin Liu, Jianna Jia, Han Wang
Summary: The study investigated the integrated influence of pollutant concentrations on phytoremediation efficiency by aquatic macrophytes. Results showed that COD removal efficiency increased with pollutant concentration, while TN, NH4+-N and TP purification efficiencies were inhibited at high concentration levels. Physiological responses in submerged macrophytes were explored to estimate the correlation between them and pollutant concentrations, with oxidative stress proved by higher MDA content. Antioxidant enzyme responses were induced to maintain plant health, but were inhibited in high pollutant concentration levels, leading to unhealthy symptoms in plants. The study concludes that excessive concentrations of organics and nutrients may inhibit adaptive physiological regulations and reduce phytoremediation efficiency.
ENVIRONMENTAL TECHNOLOGY & INNOVATION
(2021)
Article
Biochemistry & Molecular Biology
Sung Ho Lim, Chang-Ik Choi
Summary: Oxidative stress is linked to various diseases, and studies have shown that raspberry ketone exhibits antioxidant properties by increasing total antioxidant capacity, upregulating antioxidant enzymes, and improving lipid peroxidation. Further clinical studies are needed to verify its value as an effective antioxidant and therapeutic agent.
Article
Biochemistry & Molecular Biology
Liaisan Arslanbaeva, Giovanni Tosi, Marco Ravazzolo, Manuela Simonato, Francesco A. Tucci, Salvatore Pece, Paola Cogo, Massimo M. Santoro
Summary: This study demonstrates that the expression of UBIAD1 is associated with poor overall survival in human melanoma patients, and UBIAD1 and CoQ10 levels are upregulated in melanoma cells. The study also shows that UBIAD1 and plasma membrane CoQ10 sustain melanoma cell survival and proliferation by preventing lipid peroxidation and cell death.
Article
Cardiac & Cardiovascular Systems
Rajat Gupta, Yan Lin, Karla Luna, Anjali Logue, Alexander J. Yoon, Kacey P. Haptonstall, Roya Moheimani, Yasmine Choroomi, Kevin Nguyen, Elizabeth Tran, Yifang Zhu, Kym F. Faull, Theodoros Kelesidis, Jeffrey Gornbein, Holly R. Middlekauff, Jesus A. Araujo
Summary: The study found that chronic users of electronic cigarettes (EC) and tobacco cigarettes (TC) exhibit differences in blood lipid peroxidation and antioxidant defense. EC users and TC smokers have lower concentrations of arachidonic acid and linoleic acid, lower levels of oxidized linoleic acid metabolites, and higher total antioxidant capacity and bilirubin compared to non-users.
CIRCULATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Hanna Lesiewska, Alina Wozniak, Pawel Reisner, Krzysztof Czosnyka, Joanna Stachura, Grazyna Malukiewicz
Summary: Oxidative stress and depletion of antioxidant defenses may contribute to cataract incidence in patients under 60 years. This study measured antioxidant enzyme activity, vitamin concentrations, and oxidative stress markers in cataract patients and controls. The results showed lower activity of antioxidant enzymes and lower concentrations of vitamins A and E in cataract patients. Additionally, higher levels of lipid peroxidation and protein oxidation were observed, indicating increased oxidative stress in cataract patients. Supplementation with antioxidants could be beneficial for this group of patients.
Article
Multidisciplinary Sciences
Shan-Shan Xie, Yan Deng, Sheng-lan Guo, Jia-quan Li, Ying-chuan Zhou, Juan Liao, Dan-dan Wu, Wei-Fang Lan
Summary: This study found that pulmonary artery endothelial cell ferroptosis plays an important role in pulmonary hypertension. Ferroptosis triggers an inflammatory response through the HMGB1/TLR4/NLRP3 inflammasome signaling pathway, which further leads to pulmonary vascular remodelling. The use of a ferroptosis inhibitor, Fer-1, may be a promising therapeutic strategy for treating pulmonary hypertension.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Priscila Ortega, Hector Aguilar Vitorino, Shadaesha Green, Flavia P. Zanotto, J. Sook Chung, Renata G. Moreira
Summary: The study showed that in crabs from highly contaminated areas, cadmium bioaccumulation, oxidative stress, and hormone levels were higher compared to those from lightly contaminated areas, while the transcripts of crustacean hyperglycemic hormone and molt-inhibiting hormone decreased.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2022)
Article
Environmental Sciences
Abdul Qader, Kanwal Rehman, Muhammad Sajid Hamid Akash
Summary: This study investigated the impairment of lipid metabolism induced by lead (Pb) and its amelioration through plant-based therapeutic interventions. Pb-induced hepatotoxicity disrupted the normal levels of antioxidant enzymes, leading to lipid peroxidation. Additionally, Pb toxicity altered the regulation of hormones involved in the synthesis of HMG-CoA reductase, resulting in abnormal levels of serum cholesterol and other lipid molecules. The administration of resveratrol effectively treated Pb toxicity. Overall, this study demonstrated the therapeutic effect of resveratrol in improving Pb-induced lipid metabolism impairment by using vitamin C as a standard intervention.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Fisheries
Hongjian Lu, Zhengxi Wang, Yuwei Ding, Xue Feng, Chunxian Zhao, Linghan Chen, Weizhi Yao, Dan Xi, Mei Fu
Summary: In this study, it was found that injection of Calcein (CAL) could induce a strong oxidative stress response in juvenile silver carp. The severity of oxidative stress was correlated with the injection dose and time after injection. Higher CAL doses could lead to greater toxicity in the fish. When using CAL for fluorescent labeling, the injection dose should be restricted to 25 mg/kg or less and the injected fish should be reared for at least 16 days.
Article
Pharmacology & Pharmacy
Imran Khan Burki, Muhammad Khalid Khan, Barkat Ali Khan, Bushra Uzair, Valdir A. Braga, Qazi Adnan Jamil
Review
Pharmacology & Pharmacy
Thyago M. de Queiroz, Navya Lakkappa, Eric Lazartigues
FRONTIERS IN PHARMACOLOGY
(2020)
Article
Education, Scientific Disciplines
Atalia Ferreira Lima Flor, Francineide Fernandes Costa, Joao Marcos Lima Garcia, Valdir A. Braga, Josiane Campos Cruz
ADVANCES IN PHYSIOLOGY EDUCATION
(2020)
Article
Pharmacology & Pharmacy
Barkat Ali Khan, Shafi Ullah, M. Khalid Khan, Sultan M. Alshahrani, Valdir A. Braga
SAUDI PHARMACEUTICAL JOURNAL
(2020)
Article
Pharmacology & Pharmacy
Barkat Ali Khan, Afnan Khan, Muhammad Khalid Khan, Valdir A. Braga
Summary: This study focused on the preparation of PVA/Chitosan blend topical hydrogel films, which showed good swelling index and skin suitability, efficient drug release, and promotion of wound healing. In vivo studies demonstrated superior efficacy of the hydrogel compared to the control group.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Nutrition & Dietetics
Francisco A. O. Junior, Clara R. Ruiz, Yohanna de Oliveira, Marco A. Barros, Alexandre S. Silva, Maria S. B. Santos, Vinicius J. B. Martins, Camille M. Balarini, Valdir A. Braga
Summary: This study tested the effect of coconut oil on the management of hypertension, and found that neither coconut oil alone nor combined with exercise training reduced blood pressure or had an effect on blood pressure variability and oxidative stress in hypertensive patients. Despite promising pre-clinical studies, the current clinical trial did not provide evidence to support the use of coconut oil as an adjuvant in hypertension management.
Article
Biochemistry & Molecular Biology
Gensheng Zhang, Huirong Han, Zhengbing Zhuge, Fang Dong, Shan Jiang, Wenwen Wang, Drielle D. Guimaraes, Tomas A. Schiffer, En Yin Lai, Lucas Rannier Ribeiro Antonino Carvalho, Ricardo Barbosa Lucena, Valdir A. Braga, Eddie Weitzberg, Jon O. Lundberg, Mattias Carlstrom
Summary: Boosting the nitrate-nitrite-NO pathway shows therapeutic potential in ameliorating renal and cardiovascular dysfunction induced by renal ischemia-reperfusion injury, reducing oxidative stress and injuries.
Article
Biology
F. A. de Oliveira Junior, R. A. Pereira, A. S. Silva, J. L. de Brito Alves, J. H. Costa-Silva, V. A. Braga, C. M. Balarini
Summary: The study compared data obtained simultaneously with ECG, APP, and chest heart rate transmitters. While there was a high correlation for HRV variables in the time domain, the correlation decreased in the frequency domain when two software programs were used. Differences were also found in the spectral analysis parameters when HRV data were analyzed separately in each device.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2022)
Article
Peripheral Vascular Disease
Mickael S. Luz, Danilo D. A. Gadelha, Kaio J. S. Andrade, Renata A. Travassos, Juliene D. Ribeiro, Alynne Carvalho-Galvao, Josiane C. Cruz, Camille M. Balarini, Valdir A. Braga, Maria S. Franca-Falcao
Summary: This study evaluated the effects of borneol on normotensive and hypertensive rats, and found that it has the ability to improve blood pressure, autonomic function, and baroreflex sensitivity. Borneol also has a vasorelaxant effect by reducing vascular constriction and an antioxidant effect.
HYPERTENSION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Lucas Rannier R. A. Carvalho, Drielle D. Guimaraes, Atalia Ferreira L. Flor, Ericka G. Leite, Clara R. Ruiz, Juliana T. de Andrade, Matheus M. O. Monteiro, Camille M. Balarini, Ricardo Barbosa de Lucena, Valeria Cristina Sandrim, Jon O. Lundberg, Eddie Weitzberg, Mattias Carlstrom, Valdir de Andrade Braga
Summary: The study found that dietary nitrate does not affect lifespan or increase cancer incidence in rats, but may improve vascular function.
Review
Biology
Gabriela Maria da Silva, Mirelly Cunha da Silva, Deborah Victoria Gomes Nascimento, Ellen Mayara Lima Silva, Fabiola Furtado Fialho Gouvea, Luiz Gonzaga de Franca Lopes, Alice Valenca Araujo, Kelli Nogueira Ferraz Pereira, Thyago Moreira de Queiroz
Summary: Nitric oxide plays crucial physiological roles in the cardiovascular system, and its deficiency can lead to cardiovascular diseases such as hypertension. Nitric oxide donors are clinically beneficial in treating cardiovascular disorders by modulating oxidative stress and inflammation, particularly in conditions like hypertension. Novel NO donors, especially those containing metal ions, show promising potential in improving vascular function and treating hypertension.
Article
Biochemistry & Molecular Biology
Xuechen Li, Zhengbing Zhuge, Lucas Rannier R. A. Carvalho, Valdir A. Braga, Ricardo Barbosa Lucena, Shuijie Li, Tomas A. Schiffer, Huirong Han, Eddie Weitzberg, Jon O. Lundberg, Mattias Carlstrom
Summary: The study indicates that treatment with inorganic nitrate and nitrite can attenuate the development of kidney fibrosis by targeting oxidative stress and lipid metabolism. Mechanisms include modulation of AMPK and AKT-PGC1α pathways.
Review
Peripheral Vascular Disease
Matheus Vinicius Barbosa da Silva, Maria Alessandra da Silva Lima, Lizandra Henrique de Farias, Vanessa Maria dos Santos, Thyago Moreira de Queiroz
Summary: Oxidative stress is a major contributing factor in arterial hypertension, leading to vascular dysfunction. Natural antioxidants offer a promising alternative to pharmacological treatments for preventing and treating hypertension. This review explores the main antioxidants of natural origin, such as caffeic acid and curcumin, and their therapeutic effects in reducing oxidative stress, improving endothelial function, and preventing cardiovascular dysfunctions associated with hypertension.
CURRENT HYPERTENSION REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Sebastiao Vieira de Morais, Priscylla Gouveia Mendonca, Cleydlenne Costa Vasconcelos, Paloma Larissa Arruda Lopes, Joao Batista Santos Garcia, Natalia Tabosa Machado Calzerra, Thyago Moreira de Queiroz, Silvia Tereza de Jesus Rodrigues Moreira Lima, Gyl Eanes Barros Silva, Alberto Jorge Oliveira Lopes, Maria do Socorro de Sousa Cartagenes, Gerson Ricardo de Souza Domingues
Summary: This study investigated the effects of cuminaldehyde on an experimental model of osteoarthritis induced in rat knees. Cuminaldehyde was found to be as effective as indomethacin in reducing pain in all evaluated tests, including forced walking, functional disability of weight distribution on the legs, and spontaneous pain in animals with osteoarthritis. Cuminaldehyde also modulated the production of pro-inflammatory cytokines and inhibited COX-2 enzyme activity.
Article
Pharmacology & Pharmacy
Anina Tul Kobra, Asif Shahriar, Rumana Shams, Md Shamim Hossain, S. M. Mostofa Kamal, Ali Alqahtani, Valdir A. Braga, Talha Bin Emran
Summary: The study aimed to compare different methods for the rapid diagnosis of pleural TB, and found that Xpert MTB/RIF assay showed high sensitivity and specificity, especially in detecting rifampicin-resistant strains. It concluded that Xpert MTB/RIF assay is a rapid and accurate method for detecting pleural TB.
LATIN AMERICAN JOURNAL OF PHARMACY
(2021)