Article
Hematology
Nicolas Gendron, Mickael Rosa, Adeline Blandinieres, Yoann Sottejeau, Elisa Rossi, Eric Van Belle, Salim Idelcadi, Severine Lecourt, Andre Vincentelli, Audrey Cras, Ramadan Jashari, Richard Chocron, Yael Baudouin, Thibault Pamart, Ivan Bieche, Nathalie Nevo, Bernard Cholley, Jeanne Rancic, Bart Staels, Pascale Gaussem, Annabelle Dupont, Alain Carpentier, Sophie Susen, David M. Smadja
Summary: The study demonstrated that human VICs isolated from patients with calcific aortic valve disease have the potential to participate in aortic valve angiogenesis by differentiating into perivascular cells and exerting paracrine effects of VEGF-A. These findings suggest a novel function of VICs in valve vascularization during calcific aortic valve disease and highlight the importance of targeting perivascular differentiation and VEGF-A in slowing disease progression.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Rasool Erfani, Cameron Carmichael, Thea Sofokleous, Qiuyu Wang
Summary: Plasma therapy is an exciting and novel cancer treatment method that can be influenced by treatment time and different parameters. Changing the polarity of the reactor can alter the plasma discharge regime, thereby directly affecting the treatment effectiveness. This treatment method can induce cell death, which is not completely counteracted by N-acetyl cysteine. Gene expression analysis also identified key genes associated with plasma-induced cell death.
SCIENTIFIC REPORTS
(2022)
Article
Cell & Tissue Engineering
Zhuangzhuang Yang, Miao Yu, Xuechun Li, Yuanyuan Tu, Chunyan Wang, Wei Lei, Min Song, Yong Wang, Ying Huang, Fengyue Ding, Kaili Hao, Xinglong Han, Xuan Ni, Lina Qu, Zhenya Shen, Shijun Hu
Summary: This study demonstrates that retinoic acid inhibits angiogenesis and suppresses glycolysis in human embryonic stem cell-derived endothelial cells. The inhibitory effect is mediated by upregulation of fructose-1,6-bisphosphatase 1 (FBP1), a key enzyme in gluconeogenesis, and is dependent on the retinoic acid receptor (RAR). These findings suggest that FBP1 may serve as a novel therapeutic target for pathological angiogenesis.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Physics, Applied
Shota Sasaki, Shion Osana, Takahiro Kubota, Mutsuo Yamaya, Hidekazu Nishimura, Ryoichi Nagatomi, Toshiro Kaneko
Summary: The recent global COVID-19 pandemic has led to a high demand for an effective virus inactivation method. This study evaluated the potential and mechanism of human coronavirus inactivation using atmospheric pressure plasma (APP) technology. The results showed that a 30-second exposure to APP significantly reduced the HCoV-229E titers, indicating strong virus-inactivation efficacy. It was found that the production of reactive oxygen and nitrogen species (RONS), particularly O-2 (center dot-), played a crucial role in the inactivation process. These findings provide new insights into a more efficient method for inactivating human coronaviruses using APPs.
JOURNAL OF PHYSICS D-APPLIED PHYSICS
(2022)
Article
Physics, Applied
K. Gazeli, M. Hadjicharalambous, Eleftherios Ioannou, O. Gazeli, C. Lazarou, C. Anastassiou, P. Svarnas, V. Vavourakis, G. E. Georghiou
Summary: We developed an in silico model to simulate the response of B16F10 melanoma cells to a helium atmospheric pressure plasma jet (APPJ) and doxorubicin drug (DOX). The simulation results showed that increasing plasma duration and DOX concentration resulted in increased cytotoxicity and a higher apoptosis probability compared to mitosis probability. Furthermore, combining plasma treatment and drug application enhanced cell cytotoxicity. This in silico model is valuable in the field of plasma medicine for understanding the response of different cancers to APPJ and cancer drugs.
APPLIED PHYSICS LETTERS
(2022)
Article
Chemistry, Medicinal
Amirfarbod Yazdanyar, Charles L. Cai, Jacob V. Aranda, Eric Shrier, Kay D. Beharry
Summary: This study found that Eylea is not as effective as Avastin in promoting angiogenesis, although the lower dose of Eylea may be more effective than the higher dose. Additionally, Eylea may promote normal vascular development by regulating the expression of factors such as VEGFR-1 and Notch/Jagged-1.
Article
Chemistry, Multidisciplinary
Elias Abedelnour, Stephanie Ognier, Mengxue Zhang, Laurent Schio, Olivier Venier, Janine Cossy, Michael Tatoulian
Summary: The direct N-acylation of amines by esters in a microreactor using argon plasma is presented, resulting in high yields of amides.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Jacob Manzi, Ariel E. E. Weltner, Tony Varghese, Nicholas McKibben, Mia Busuladzic-Begic, David Estrada, Harish Subbaraman
Summary: This paper demonstrates the use of plasma-jet printing (PJP) to deposit thermoelectric nanoflakes onto flexible substrates at room temperature, with substantial improvements in material adhesion and flexibility observed. The printed films exhibit electrical conductivity of 2.5 x 10(3) S m(-1) and a power factor of 70 mu W m(-1) K-2 at room temperature. This advancement in plasma jet printing promotes not only the development of energy harvesting but also large-scale flexible electronics and sensors for space and commercial applications.
Article
Multidisciplinary Sciences
Ke Ma, Sitong Liu, Hongyue Liang, Guan Wang, Tianyu Wang, Shuya Luo, Kuan Gao, Hui Wang, Mei Liu, Lichuan Bai, Qinghuan Xiao
Summary: This study reveals a novel mechanism of cholesterol-mediated TMEM16A inhibition, by which cholesterol reduces TMEM16A expression via DNMT1-mediated methylation and directly inhibits channel activities. TMEM16A channel inhibition promotes endothelial cell angiogenesis.
JOURNAL OF ADVANCED RESEARCH
(2021)
Article
Multidisciplinary Sciences
Alan Max T. Souza, Janine Karla F. da Silva Braz, Gabriel M. Martins, Jussier de Oliveira Vitoriano, Aurelio G. A. Neto, David M. Nery, Vladimir G. Sabino, Eudes E. de Souza Lucena, Hugo Alexandre de Oliveira Rocha, Carlos Augusto G. Barboza, Clodomiro A. Junior, Carlos Eduardo B. de Moura
Summary: This study evaluated the effects of cold atmospheric plasma (CAP) and thermal plasma methods on the biocompatibility of titanium surfaces. The results showed that CAP treatment improved the hydrophilicity and reduced the roughness of the titanium surface, enhancing the biocompatibility of endothelial cells. This technique has the potential for biomedical applications due to its low cost and ease of use.
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
(2023)
Article
Plant Sciences
Marzieh Moeenfard, Maria Joao Pena, Pedro Barata, Raquel Soares, Raquel Costa
Summary: The study found that both raw and roasted date seed polyphenols extracts can inhibit angiogenesis features, possess antioxidant activity, and show potential anti-angiogenic properties.
PLANT FOODS FOR HUMAN NUTRITION
(2022)
Article
Cell & Tissue Engineering
Tao Li, Kelsey L. Conroy, Amy M. Kim, Julian Halmai, Kewa Gao, Emily Moreno, Aijun Wang, Anthony G. Passerini, Jan A. Nolta, Ping Zhou
Summary: Human induced pluripotent stem cells (hiPSCs) have great potential as a source of vascular cells for therapy and as a model for studying vascular cell differentiation and functionality. This study found that the MEF2C transcription factor was significantly upregulated during the differentiation of vascular progenitors and endothelial cells (ECs) from hiPSCs. Vascular endothelial growth factors (VEGF) induced MEF2C expression in endothelial lineage cells, and this upregulation was dependent on extracellular signal regulated kinase (ERK). Knockdown of MEF2C reduced the migration and tube formation capacity of hiPSC-derived ECs. The study also identified TNF-related apoptosis inducing ligand (TRAIL) and transmembrane protein 100 (TMEM100) as novel targets of MEF2C. These findings highlight the importance of MEF2C in regulating human EC functions and suggest its potential as a therapeutic target for vascular malfunction-associated diseases.
Article
Multidisciplinary Sciences
Mime Kobayashi, Kiichiro Tomoda, Hirofumi Morihara, Michio Asahi, Tetsuji Shimizu, Shinya Kumagai
Summary: Non-thermal atmospheric-pressure plasma can influence the differentiation pattern of human induced pluripotent stem cells (hiPSCs) without disrupting their genomic integrity. The findings suggest that plasma treatment can be an effective tool for directing the fate of pluripotent stem cells.
Article
Cardiac & Cardiovascular Systems
Arne Schmidt, Maximilian Fuchs, Stevan D. Stojanovic, Chunguang Liang, Kevin Schmidt, Mira Jung, Ke Xiao, Jan Weusthoff, Annette Just, Angelika Pfanne, Jorg H. W. Distler, Thomas Dandekar, Jan Fiedler, Thomas Thum, Meik Kunz
Summary: In this study, a targeted bioinformatics approach was used to identify and validate transcription factors that regulate angiogenic signaling. The results revealed the role of KLF5 and SP1 in hypoxia sensing and inflammatory signaling, providing insights for potential therapeutic strategies in vascularization.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Nutrition & Dietetics
Hidehito Saito-Takatsuji, Yasuo Yoshitomi, Yasuhito Ishigaki, Shoko Yamamoto, Noriaki Numata, Yasuo Sakai, Masayoshi Takeuchi, Naohisa Tomosugi, Shogo Katsuda, Hideto Yonekura, Takayuki Ikeda
Summary: The study suggests that collagen tripeptide (CTP) has a protective effect on human aortic endothelial cells (HAECs) under oxidative stress by recovering downregulated gene expression, potentially playing a role in atherosclerosis by regulating this mechanism.
Article
Physics, Fluids & Plasmas
Dongho Lee, Guentae Doh, Holak Kim, Laurent Garrigues, Wonho Choe
Summary: Two distinct discharge modes were observed in a 50 W-class micro-Hall thruster plasma under different operating conditions. In mode B, the thruster showed performance improvements in terms of thrust, specific impulse, and anode efficiency, suggesting that operation is more advantageous in mode B than in mode A for the utilization of such low-power Hall thrusters.
PLASMA SOURCES SCIENCE & TECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Sanghoo Park, Wonho Choe, Hyungyu Lee, Joo Young Park, Jinwoo Kim, Se Youn Moon, Uros Cvelbar
Summary: This study investigates the impact of gas jets on a water surface and the stabilizing effect of weakly ionized gas on cavities. Experimental results demonstrate that plasma bullets generated by weakly ionized gas can exert more force on the water surface through electrohydrodynamic flow, leading to cavity expansion without destabilization.
Article
Physics, Applied
Sanghoo Park, Jinwoo Kim, Hyungyu Lee, Duksun Han, Seungil Park, Seong Bong Kim, Wonho Choe
Summary: This study proposes a new method of nonheating ozone suppression in air discharges by controlling plasma chemical kinetics through adjusting the duration and frequency of high-voltage DC pulses. Experimental results show that ozone can be quenched faster in a plasma reactor operated at 21 degrees C, leading to an irreversible chemical mode transition from an O-3-rich environment to a NO-rich environment. Findings suggest a breakthrough in expanding the usage of air discharges and their application in various fields of interest.
JOURNAL OF PHYSICS D-APPLIED PHYSICS
(2021)
Article
Instruments & Instrumentation
Seung Hun Lee, Hyun Jeong Jeon, Youbong Lim, Jun Young Kim, Wonho Choe
Summary: A novel impermeable sterile pouch is developed to improve the sterilization cycle by utilizing forced convective heating mechanism, leading to shorter sterilization time and increased efficiency, which is validated through experimental and numerical analysis.
REVIEW OF SCIENTIFIC INSTRUMENTS
(2021)
Article
Biochemical Research Methods
Jiheun Ryu, Unkyo Kang, Joon Woo Song, Junyoung Kim, Jin Won Kim, Hongki Yoo, Bomi Gweon
Summary: This article introduces a novel high-speed multimodal optical microscope system that can simultaneously observe five different microscopic contrasts, providing complementary optical information that enhances both structural and functional contrasts.
BIOMEDICAL OPTICS EXPRESS
(2021)
Article
Physics, Multidisciplinary
Kijung Kim, Jinseung Choung, Ung Hyun Ko, Ara Jung, Wonho Choe, Jennifer H. Shin, Bomi Gweon
Summary: Atmospheric pressure plasma (APP) has emerged as a potent tool for cancer therapy due to its various anti-cancer effects, including altering cancer cell morphology, suppressing migratory activity, and reducing invasiveness. By down-regulating markers associated with epithelial to mesenchymal transition (EMT), APP treatment may have the potential to suppress cancer metastasis.
FRONTIERS IN PHYSICS
(2021)
Article
Physics, Applied
Guentae Doh, Jaehong Park, Dongho Lee, Holak Kim, Wonho Choe
Summary: Information on the ionization of propellant gases is crucial for Hall thruster plasma studies because the ion beam is responsible for thrust generation. This study introduces a new method that combines laser-induced fluorescence spectroscopy and floating emissive probe measurements to identify the location of Xe+ ionization in Hall thruster plasmas. The ionization region in a annular Hall thruster was found to be located a few millimeters upstream of the maximum radial magnetic field, in agreement with simulation results. In contrast, the ionization region in a cylindrical Hall thruster was deeper inside the discharge cavity.
JOURNAL OF APPLIED PHYSICS
(2021)
Article
Physics, Applied
Holak Kim, Seunghoon Lee, Guentae Doh, Dongho Lee, Wonho Choe
Summary: By tailoring the magnetic field in a cylindrical Hall thruster, this study has demonstrated higher ion current and propellant efficiencies, reduced wall interaction, and observed a large fraction of multiply charged ions.
JOURNAL OF APPLIED PHYSICS
(2022)
Article
Physics, Applied
Guentae Doh, Holak Kim, Dongho Lee, Sanghoo Park, Stephane Mazouffre, Wonho Choe
Summary: A study was conducted on the structure of the ion acceleration region and the shape of the ion velocity distribution function in cylindrical Hall thruster plasmas, using laser-induced fluorescence spectroscopy on Xe II metastable ions. It was found that ion acceleration mostly takes place outside the discharge channel, with the IVDF close to a single Gaussian distribution inside the channel and becoming asymmetric downstream. The measured ion velocity distributions downstream were in good agreement with double Gaussian distributions, with cold and hot ion groups, showing an R-squared greater than 0.995.
JOURNAL OF PHYSICS D-APPLIED PHYSICS
(2022)
Article
Physics, Fluids & Plasmas
Hyojong Lee, Hyeonjun Lee, Yoon Seong Han, Jiheon Song, E. A. Belli, Wonho Choe, Jisung Kang, Jekil Lee, J. Candy, Jungpyo Lee
Summary: The theoretical analysis and simulation results in this study reveal that the rotation speed has a certain influence on the tungsten impurity accumulation in KSTAR experiment. Beyond a certain threshold, the rotation reduces the inward convection of impurities or changes it to outward convection, providing a means to control impurity accumulation conditionally. Additionally, the rotation amplifies the temperature screening effect. However, this effect is influenced by the radius and collisionality.
PHYSICS OF PLASMAS
(2022)
Article
Physics, Fluids & Plasmas
Jinwoo Kim, Dongho Lee, Guentae Doh, Sanghoo Park, Holak Kim, Wonho Choe
Summary: A diagnostic system was developed for spectrally resolved, three-dimensional tomographic reconstruction of Hall thruster plasmas, successfully reconstructing local intensity profiles of Xe I and Xe II emissions. The system employed 28 virtual cameras and the Phillips-Tikhonov regularization algorithm, achieving a root-mean-square error within an order of 10(-3) even for a 1% difference in azimuthal intensity distribution.
PLASMA SOURCES SCIENCE & TECHNOLOGY
(2022)
Article
Engineering, Environmental
Hyungyu Lee, Sanghoo Park, Joo Young Park, Jinwoo Kim, Wonho Choe
Summary: We numerically demonstrate that photolytic processes induced by external UV sources significantly affect the chemical properties of plasma-water systems. Exposure of plasma-treated water (PTW) to UV leads to the photolysis of long-lived species and the formation of hydroxyl radical (OH) and nitric oxide (NO). The concentration of OH and NO in PTW is greatly enhanced under UV exposure, making it an attractive approach to increase the reactivity and applicability of PTW.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Physics, Fluids & Plasmas
Dongho Lee, Jinwoo Kim, Guentae Doh, Changmin Shin, Wonho Choe
Summary: Two-dimensional electron temperature and density profiles in the plume region of a 300 W-class Hall thruster Ar plasmas were successfully obtained using tomographically reconstructed optical emission intensity profiles combined with a collisional-radiative model, and the results were in good agreement with double Langmuir probe measurements.
PLASMA SOURCES SCIENCE & TECHNOLOGY
(2022)
Article
Physics, Fluids & Plasmas
H. Shin, J. Hwang, Y. Han, G. Shin, H. Lee, K. -B. Chai, Wonho Choe
Summary: In this study, we demonstrate successful ELM suppression and mitigation using an argon-seeded discharge and a three-row resonant magnetic perturbation configuration in KSTAR. The heat flux on the divertor target was reduced by argon seeding, and the particle flux on both targets was significantly reduced. The divertor heat load was further reduced during the RMP grassy-ELM regime, and a highly localized radiation zone near the X-point was observed during divertor detachment.
Article
Materials Science, Multidisciplinary
Holak Kim, Guentae Doh, Wonho Choe
Summary: The production of multiply charged ions in Hall effect plasmas was studied by analyzing factors such as geometry, magnetic field configuration, and magnetic mirror ratio. The co-current configuration of the cylindrical Hall thruster showed the highest fractions of multiply charged ions, with the region of high magnetic flux density having a significant influence on the fraction. However, the fraction of multiply charged ions was not significantly affected by magnetic mirror ratios. The configuration with similar magnetic fields in the cylindrical Hall thruster demonstrated comparable fractions of multiply charged ions and thrust, even with different channel lengths.
CURRENT APPLIED PHYSICS
(2023)
