Journal
APPLIED PHYSICS LETTERS
Volume 102, Issue 16, Pages -Publisher
AMER INST PHYSICS
DOI: 10.1063/1.4803444
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Funding
- National Institutes of Health [DP1 EB016986, R01 CA134539, U54 CA136398, R01 CA157277, R01 CA159959]
- NATIONAL CANCER INSTITUTE [U54CA136398, R01CA159959, R01CA157277, R01CA134539] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [T32EB014855, DP1EB016986] Funding Source: NIH RePORTER
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We propose to enhance the axial resolution of photoacoustic microscopy (PAM) by reducing the speed of sound within the imaging region of interest. With silicone oil immersion, we have achieved a finest axial resolution of 5.8 mu m for PAM, as validated by phantom experiments. The axial resolution was also enhanced in vivo when mouse ears injected with silicone oil were imaged. When tissue-compatible low-speed liquid becomes available, this approach may find broad applications in PAM as well as in other imaging modalities, such as photoacoustic computed tomography and ultrasound imaging. (C) 2013 AIP Publishing LLC. [http://dx.doi.org/10.1063/1.4803444]
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