4.6 Article

Cell viability monitoring using Fano resonance in gold nanoslit array

Journal

APPLIED PHYSICS LETTERS
Volume 103, Issue 13, Pages -

Publisher

AMER INST PHYSICS
DOI: 10.1063/1.4822303

Keywords

-

Funding

  1. National Science Council, Taipei, Taiwan [NSC-99-2120-M-007-009, NSC-97-3112-B-001-022]

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Cell viability is a crucial issue in biological research. We present label-free monitoring of adhesion cells viability by gold nanoslits-based Fano resonance biosensors. Plastic multiple wells with gold nanoslits substrate were made using a thermal nanoimprint method. Adhesion cells in the wells were treated with doxorubicin for inducing cell death and compared with conventional colorimetric assay. The nanoslits method shows better respones of viability tests under low concentration and short interaction time due to its high surface sensitivies. The vinculin labelling indicates that the measured signals are in good agreement with the adhesion abilities of cells. (C) 2013 AIP Publishing LLC.

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