4.6 Article

Flow-enhanced transient response in whispering gallery mode biosensors

Journal

APPLIED PHYSICS LETTERS
Volume 99, Issue 25, Pages -

Publisher

AMER INST PHYSICS
DOI: 10.1063/1.3669698

Keywords

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Funding

  1. Jacobs Institute for Molecular Engineering for Medicine at the California Institute of Technology

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Whispering gallery mode (WGM) optical resonator sensors are an extremely sensitive label-free technology for detecting the binding of biomolecules in solution. To better understand the fast transient response observed with these devices, we model mass transfer to spherical and toroidal WGM sensors of identical outer radius. Finite element simulations predict a 3-10 fold higher binding frequency for toroidal sensors. These results agree to within an order of magnitude with experimental data from the literature and suggest a design strategy to improve the transient response of a sensor by making the device small only in the dimension that governs boundary layer development. (C) 2011 American Institute of Physics. [doi: 10.1063/1.3669698]

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