Article
Chemistry, Analytical
Filippo Amadeo, Prithviraj Mukherjee, Hua Gao, Jian Zhou, Ian Papautsky
Summary: Soft lithography for microfluidic devices is popular due to its simplicity and low cost, but PDMS masters can be expensive and fragile. This study presents an optimized method using PC sheets on PDMS molds for replication, successfully replicating various microfluidic devices with different aspect ratios. It is a cost-effective, fast, and simple approach for long-term preservation of soft lithography masters.
Article
Nanoscience & Nanotechnology
Jinjian Lin, Yanmiao Fan, Daniel J. Hutchinson, Michael Malkoch
Summary: Composites of TATO thiol-ene networks and HA have great potential as fixation materials for bone fractures due to their high flexural modulus, biocompatibility, and insusceptibility to forming soft-tissue adhesions. By designing new TATO monomers and utilizing TEC or TYC chemistry, soft composites with a range of mechanical properties have been successfully synthesized. The most promising composite shows excellent softness and can be used for biomedical applications.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Chemistry, Multidisciplinary
Daniela Maria Correia, Liliana Correia Fernandes, Margarida Macedo Fernandes, Bruno Hermenegildo, Rafaela Marques Meira, Clarisse Ribeiro, Sylvie Ribeiro, Javier Reguera, Senentxu Lanceros-Mendez
Summary: Ionic liquids (ILs) have been extensively explored and applied in various fields, especially in biomedicine. They have unique properties that allow for the development of materials with specific functionalities, including improved dissolution and processability, when combined with natural and synthetic polymers. This review focuses on the recent advances of ILs in developing biomaterials for biomedical applications such as drug delivery, cancer therapy, tissue engineering, antimicrobial agents, and biosensing.
Article
Materials Science, Multidisciplinary
Jianxing Liu, Dongjia Yan, Wenbo Pang, Yihui Zhang
Summary: Soft network materials, with well-organized microarchitectures inspired by biological tissues, offer a unique combination of properties and design flexibility for customized mechanical performance, leading to a range of promising applications in cutting-edge technologies like bio-integrated electronics and regenerative medicine. Perspectives on remaining challenges and open opportunities are also provided.
Article
Biochemical Research Methods
Qi Zhang, Feng Ruan, Maonan Yang, Qinghui Wen
Summary: There is an urgent need for potential pharmaceutics for lung cancer treatment due to the increased number of lung cancer deaths and the resistance of cancer cells to present therapeutics. The present work aims to discover the anticancer potential of the natural compound chaetocin as a therapeutic for lung cancer treatment. Experimental results suggested that chaetocin induces A549 cell apoptosis, by causing ROS and nuclear damage activation pathways. In the future, chaetocin might be an effective bio-safe anticancer agent for lung cancer treatments.
IET NANOBIOTECHNOLOGY
(2023)
Review
Polymer Science
Zhuonan Yu, Kuo-Kang Liu
Summary: Soft polymers play a crucial role in biomedical engineering for sensing cellular forces and maintaining normal cell functions. Various techniques for soft polymer fabrication have been developed, focusing on quantitativeness and cell-friendliness. Future trends include designing new technologies and processes for cellular force measurement.
Review
Polymer Science
Fawad Ali, Muammer Koc
Summary: Three-dimensional (3D) printing is a promising manufacturing platform in biomedical engineering. Polymer piezoelectric materials, with their controllable and reproducible properties, have opened new possibilities for integration into biomedical fields such as sensors, drug delivery systems, and tissue engineering.
Review
Chemistry, Physical
Shiyun Meng, Mahmoud Rouabhia, Ze Zhang
Summary: This work reviews the research on the cellular response to electrical stimulation (ES) and its mechanisms, focusing on potential clinical applications. Different techniques and methodologies have been developed, leading to complications in interpreting and comparing experimental outcomes. The review categorizes these techniques and comments on their strengths and weaknesses. The study finds that ES can enhance cell proliferation, growth, migration, and stem cell differentiation, showing potential for manipulating cellular activities. However, inappropriate parameters or setup can have negative effects, and comparing different parameter sets is challenging. Mechanistic studies are rare and much needed. Despite this, ES combined with advanced materials and nanotechnology is gaining momentum in biomedical research and regenerative medicine.
Review
Polymer Science
Danielle M. Fitzgerald, Yolonda L. Colson, Mark W. Grinstaff
Summary: Pressure sensitive adhesives are widely used in everyday products and have the potential for greater use in medicine. The strength of adhesion depends on the chemical and material properties of the adhesive formulation and its interaction with the surface. This review focuses on the structure-property relationships of polymer architecture and pressure sensitive adhesion, specifically in the context of durable, removable, and biocompatible adhesion to wet surfaces like tissue. Challenges in biomedical wound closure are also discussed, along with innovative strategies to address them.
PROGRESS IN POLYMER SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Hritwick Banerjee, Andreas Leber, Stella Laperrousaz, Remi La Polla, Chaoqun Dong, Syrine Mansour, Xue Wan, Fabien Sorin
Summary: Magnetically responsive soft materials are used as building blocks for soft robotics, prosthesis, surgical tools, and smart textiles. However, the fabrication of highly integrated magnetic fibers remains challenging. This study proposes multimaterial thermal drawing as a platform to fabricate long, soft, ultrastretchable, and resilient magnetic fibers with extreme aspect ratios and demonstrates their potential applications.
ADVANCED MATERIALS
(2023)
Review
Biochemical Research Methods
Sachin Kumar, Karan Veer
Summary: With the rapid development of high-volume and complex data analysis, machine learning has become a critical tool for classification and prediction. This study reviews the methods of machine learning and deep learning for the classification and prediction of biological signals and conducts a systematic review on their applications in different biomedical signals from 2015 to 2022. The findings show a clear shift towards deep learning techniques in the classification of biomedical signals compared to machine learning.
CURRENT BIOINFORMATICS
(2023)
Article
Chemistry, Multidisciplinary
Rachel S. Bang, Sangchul Roh, Austin H. Williams, Simeon D. Stoyanov, Orlin D. Velev
Summary: A universal method based on polymer precipitation templated by fluid streamlines in multiphasic flow is explored for fabricating diverse nano- and micro-scale morphologies. By systematically investigating the process conditions, 12 distinct classes of polymer micro- and nano-structures are identified. The liquid shear-based technique shows potential as a versatile and scalable nanofabrication tool.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Sirawit Pruksawan, Heng Li Chee, Zizhen Wang, Ping Luo, Yi Ting Chong, Warintorn Thitsartarn, FuKe Wang
Summary: This article reports on the use of methacrylated cellulose nanocrystals as a macro-cross-linking agent in poly(2-hydroxyethyl methacrylate) hydrogels for 3D printing of auxetic structures. The developed hydrogels exhibit significant improvements in mechanical properties and stretchability compared to traditional hydrogels.
CHEMISTRY-AN ASIAN JOURNAL
(2022)
Review
Biotechnology & Applied Microbiology
Meiwen Chen, Rui Jiang, Niping Deng, Xiumin Zhao, Xiangjuan Li, Chengchen Guo
Summary: This article provides a comprehensive review of recent progress on natural polymer-based scaffolds for soft tissue repair, focusing on clinical translation and materials design. The limitations and challenges, such as unsatisfactory mechanical properties and unfavorable biological responses, are discussed to advance the development of novel scaffolds for soft tissue repair and regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Sinan Akgol, Fulden Ulucan-Karnak, Cansu Ilke Kuru, Kevser Kusat
Summary: Nanotechnology has been continuously developing in biomedical applications, particularly in the design of composite nanomaterials with exceptional properties. These composite nanomaterials are widely used in textile, chemical, energy, defense industry, electronics, and biomedical engineering, impacting human health significantly.
BIOTECHNOLOGY AND BIOENGINEERING
(2021)
Review
Materials Science, Multidisciplinary
Yanxia Wu, Shengxi Wang, Kyriakos Komvopoulos
JOURNAL OF MATERIALS RESEARCH
(2020)
Article
Materials Science, Multidisciplinary
Xiao-Guang Ma, Kyriakos Komvopoulos
JOURNAL OF MATERIALS RESEARCH
(2020)
Article
Mechanics
J. Yang, K. Komvopoulos
INTERNATIONAL JOURNAL OF SOLIDS AND STRUCTURES
(2020)
Article
Mechanics
Z. Vangelatos, K. Komvopoulos, J. Spanos, M. Farsari, C. Grigoropoulos
INTERNATIONAL JOURNAL OF SOLIDS AND STRUCTURES
(2020)
Article
Materials Science, Multidisciplinary
Shengxi Wang, Kyriakos Komvopoulos
Article
Engineering, Mechanical
Yanxia Wu, Shujiao Zhang, Jie Meng, Shengxi Wang, Shengwang Yu, Yong Ma, Bin Tang, Ying Liu, Kyriakos Komvopoulos
TRIBOLOGY TRANSACTIONS
(2020)
Article
Engineering, Mechanical
Zacharias Vangelatos, Chenyang Li, Costas Grigoropoulos, Kyriakos Komvopoulos
EXTREME MECHANICS LETTERS
(2020)
Article
Mechanics
J. Cen, K. Komvopoulos
INTERNATIONAL JOURNAL OF SOLIDS AND STRUCTURES
(2020)
Article
Materials Science, Multidisciplinary
Maria I. Echeverria Molina, Kyriakos Komvopoulos
Summary: This paper emphasizes the importance of understanding the deposition process of electrospun fibers and presents an analysis of how electric potential intensity and directionality affect the deposition of fibers. The study provides guidance for designing electrospinning setups capable of producing microfibrous constructs with tailored morphologies.
Review
Materials Science, Multidisciplinary
Anurag Roy, Shengxi Wang, Kyriakos Komvopoulos
Summary: Amorphous carbon films are widely used as protective coatings due to their unique thermophysical properties and strong adherence. To meet the demands of device miniaturization, thinning a-C films to a few nanometers while preserving important properties is crucial. This article provides a comprehensive assessment of effective deposition techniques for synthesizing ultrathin films, particularly a-C films, and discusses microanalysis methods and technological challenges in the field.
JOURNAL OF MATERIALS RESEARCH
(2023)
Article
Chemistry, Physical
Maria I. Echeverria I. Molina, Chi-An Chen, Jeniree Martinez, Perry Tran, Kyriakos Komvopoulos
Summary: Fully functional skin regeneration is still difficult after decades of research. Scaffold engineering, a leading field in skin substitutes, can optimize the biomolecular exchange to promote the formation of high-quality tissue. This study designed and evaluated a new class of three-dimensional fibrous scaffolds that induce keratinocyte differentiation through calcium leaching, demonstrating their potential for tissue engineering.
Article
Biophysics
Maria I. Echeverria Molina, Kyriakos Komvopoulos
Summary: Polymer degradation and mechanical properties play a crucial role in tissue engineering. In this study, the degradation behavior of electrospun PLLA bilayer microfibrous scaffolds in a pH-neutral medium was investigated. The interplay between chain scission and orderly chain rearrangement during degradation was found to be critical. The bilayer PLLA scaffolds with adequate matrix stiffness showed potential for tissue engineering and drug delivery applications.
JOURNAL OF BIOMECHANICS
(2023)
Article
Materials Science, Multidisciplinary
Tianzong Xu, Kyriakos Komvopoulos
Summary: The nucleation and growth of diamond from submicron clusters consisting of amorphous carbon phase and diamond nanocrystallites were investigated. The carbon clusters were created by exposing a highly sp(3)-hybridized carbon thin film to a low-temperature, methane-rich hydrogen plasma. Diamond nanocrystallites inside the carbon clusters acted as nucleation sites. The results provided insights into the structure and composition of the carbon clusters, diamond nanocrystallites, and amorphous interlayers at the interfaces.
JOURNAL OF MATERIALS RESEARCH
(2023)
Article
Mechanics
Rui Xu, Kyriakos Komvopoulos
Summary: This study aims to develop an effective computational mechanics framework for analyzing the stress distribution of dynamic microdevices with different polycrystalline microstructures. Dynamic finite element analysis and steady-state finite element analysis were performed to investigate the effect of material damping on the dynamic response and the influence of texture anisotropy on stress distribution. Probabilistic stress analysis was conducted to explore the stochastic nature of stress in the critical region due to variations in grain geometry, size, and orientation.
Article
Engineering, Mechanical
Rui Xu, Kyriakos Komvopoulos
Summary: This study analyzed fatigue crack growth in polysilicon under multi-axial loading using the finite element method, revealing the significant effect of local grain orientation on crack growth direction and rate.
INTERNATIONAL JOURNAL OF FATIGUE
(2023)
