Article
Biochemistry & Molecular Biology
Sergio R. S. Veloso, Raquel G. D. Andrade, Valeria Gomes, Carlos O. Amorim, Vitor S. Amaral, Veronica Salgueirino, Paulo J. G. Coutinho, Paula M. T. Ferreira, Miguel A. Correa-Duarte, Elisabete M. S. Castanheira
Summary: In this study, citrate-functionalized calcium-doped manganese ferrite nanoparticles were synthesized through thermally assisted oxidative precipitation. The nanoparticles showed good dispersibility and their microstructure and morphology could be controlled by adjusting the temperature and Ca/Mn ratio. The optical and magnetic properties of the nanoparticles were studied using UV-Vis absorption and SQUID, respectively. XRD and Raman spectroscopy were used to analyze the microstructural changes associated with particle stoichiometry, and the stability of the nanoparticles in physiological pH was tested using DLS. The nanoparticles exhibited high magnetization and heating efficiency under alternating magnetic field conditions, making them suitable for biomedical applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Ren Hao Soon, Zhen Yin, Metin Alp Dogan, Nihal Olcay Dogan, Mehmet Efe Tiryaki, Alp Can Karacakol, Asli Aydin, Pouria Esmaeili-Dokht, Metin Sitti
Summary: This article presents a pangolin-inspired bi-layered soft robot design that achieves heating >70 degrees C at distances >5cm without compromising compliance and safety, thus providing a new option for biomedical applications.
NATURE COMMUNICATIONS
(2023)
Review
Medicine, Research & Experimental
Mohd Hasan Mujahid, Tarun Kumar Upadhyay, Fahad Khan, Pratibha Pandey, Moon Nyeo Park, Amit Baran Sharangi, Mohd Saeed, Vijay J. Upadhye, Bonglee Kim
Summary: Nanotechnology is a multidisciplinary field that includes various scientific areas such as chemistry, material science, physics, biomedicine, biology, and engineering. Metal nanohybrids with unique properties, particularly metal and metal oxide nanoparticles, have shown great potential in nanoscience and biomedical research. The synthesis of these nanohybrids involves physical, chemical, and biological methods to control their physiochemical properties at the nano level. They have applications in gene delivery, theranostics, catalysis, and environmental pollution control. Proteomics and transcriptomics approaches have been used to study their mechanisms of action, and limitations of these nanohybrids have also been discussed. Overall, this manuscript provides a comprehensive review of metallic and metallic oxide nanohybrids and their multifunctional role in various biomedical applications.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Biochemistry & Molecular Biology
Alireza Ghasempour, Hamideh Dehghan, Mehrnaz Ataee, Bozhi Chen, Zeqiang Zhao, Mahsa Sedighi, Xindong Guo, Mohammad-Ali Shahbazi
Summary: Cadmium sulfide nanoparticles (CdS NPs) are widely used in nanobiotechnology due to their unique properties and have applications in biosensors, bioimaging, and antibacterial and anticancer applications. Biogenic synthesis is a preferred method for producing CdS NPs due to its efficiency, environmental friendliness, and biocompatibility. The size and coating of CdS NPs play a crucial role in their biomedical activities, and there is a need for further in vivo studies to reduce toxicity. This review discusses synthesis methods, characterization, and applications of CdS NPs in the biomedical field.
Article
Chemistry, Multidisciplinary
Mylla C. Ferreira, Bruno Pimentel, Vivian Andrade, Vladimir Zverev, Radel R. Gimaev, Andrei S. Pomorov, Alexander Pyatakov, Yulia Alekhina, Aleksei Komlev, Liudmila Makarova, Nikolai Perov, Mario S. Reis
Summary: By studying the relationship between the heating power and nanoparticle size in magnetic oxides, it was found that particles of intermediate size have the highest heat transfer efficiency in the heating mechanism.
Article
Chemistry, Multidisciplinary
Armando Ramos-Sebastian, So-Jung Gwak, Sung Hoon Kim
Summary: Magnetic microrobots are highly promising for biomedical applications, but magnetic actuation alone is not enough. This study introduces a multimodal electromagnetic system that enables various modes of locomotion and heating control of magnetic microrobots, as well as the manipulation of magnetic nanoparticles.
Article
Biophysics
Mounika Choppadandi, Khyati Parmar, K. Srinivasa Rao, K. H. Rao, Aditya Singh, Hemant Kumar, Aditya Teja Guduru, Amit Shard, Govinda Kapusetti
Summary: In this study, cobalt-zinc nanoferrites (MNPs) with a tunable heating profile were loaded with Doxorubicin (DOX) through surface conjugation technique. The MNPs exhibited superparamagnetism and enhanced saturation magnetization, and could maintain a therapeutic temperature for an indefinite amount of time. In vitro experiments showed that DOX-Cs-MNPs caused substantial apoptosis in MCF-7 cells, suggesting their potential for clinical applications.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Agriculture, Dairy & Animal Science
Aleksandra Orzolek, Katarzyna T. Rafalska, Wiktoria A. Otowska, Wladyslaw Kordan, Anna J. Korzekwa, Krzysztof Kozlowski
Summary: The addition of zinc nanoparticles to semen extender reduces sperm motility and mitochondrial membrane potential, while maintaining sperm viability. In contrast, adding manganese nanoparticles improves membrane integrity and mitochondrial activity, with the highest SOD activity observed.
Article
Chemistry, Inorganic & Nuclear
Rouiha Zohra, Souhaila Meneceur, Laouini Salah Eddine, Abderrhmane Bouafia, Hamdi Ali Mohammed, Gamil Gamal Hasan
Summary: An aqueous leaf extract of Ziziphus spina-Christi was used to synthesize MnO2 NPs and Zn/Mn2O4 NC. The synthesized nanoparticles were characterized using XRD, SEM, UV-vis, and FTIR, and their photocatalytic degradation efficiency was investigated. The study found that the biosynthesized MnO2 NPs and Zn/Mn2O4 NCs exhibited good efficacy in degrading azo dyes, making them cost-effective and eco-friendly materials.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Chemistry, Physical
Caio Jose Perecin, Xavier Pierre Marie Gratens, Valmir Antonio Chitta, Patricia Leo, Adriano Marim de Oliveira, Sergio Akinobu Yoshioka, Natalia Neto Pereira Cerize
Summary: Magnetite nanoparticles encapsulated with polymers were successfully synthesized using a nano spray drying technique. The encapsulated particles showed larger size and could be potentially applied as theragnostic agents. Characterization methods such as magnetic saturation and thermogravimetric analysis were used to understand the magnetic content in the materials.
Article
Thermodynamics
Mohamed S. A. Darwish, L. M. Al-Harbi, Ahmed Bakry
Summary: This study focuses on improving the heating performance and stability of nanoparticles for hyperthermia treatment. Magnetite nanoparticles and coated magnetite nanoparticles with polyvinyl alcohol were fabricated, and their self-heating properties and magnetic characteristics were studied. The results showed that the coated nanoparticles exhibited higher stability and magnetization, leading to improved heating performance for potential biomedical applications.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2022)
Article
Agriculture, Dairy & Animal Science
Hidayat Mohd Yusof, Nor'Aini Abdul Rahman, Rosfarizan Mohamad, Uswatun Hasanah Zaidan, Anjas Asmara Samsudin
Summary: Traditionally, higher levels of inorganic zinc (Zn) were added to broiler chicken diets to meet optimal body requirements, but this can lead to heavy metal contamination. Nanomaterial ZnO NPs have unique properties that increase nutrient utilization and improve broiler physiological function and production. This study found that dietary biosynthesized ZnO NPs increased Zn absorption in broiler chickens, improved tibia bone development, and enhanced antioxidative status in serum and liver tissue.
Article
Biochemistry & Molecular Biology
Cristina Chircov, Maria-Andreea Minca, Andreea Bianca Serban, Alexandra Catalina Birca, Georgiana Dolete, Vladimir-Lucian Ene, Ecaterina Andronescu, Alina-Maria Holban
Summary: This study aimed to develop zinc and/or cerium-substituted magnetite nanoparticles for medical applications. The nanostructures were evaluated using various analysis methods and subjected to antioxidant, anticancer, and antimicrobial tests. The results showed promising effects, including the inhibition of oxidative stress in normal cells, inhibition of cell proliferation in tumor cells, and antimicrobial activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Shihao Zhou, Xiangsi Wu, Hongxia Du, Zhangxing He, Xianming Wu, Xianwen Wu
Summary: In this study, layered delta-MnO2 with improved structural stability and enhanced ion migration rate was prepared by pre-intercalating Al3+. The material exhibited high reversible specific capacity and excellent stability in aqueous zinc ion batteries.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Alexandra Maier, Rogier van Oossanen, Gerard C. van Rhoon, Jean-Philippe Pignol, Iulian Dugulan, Antonia G. Denkova, Kristina Djanashvili
Summary: Heterostructured magnetic nanoparticles have great potential in biomedical applications due to their ability to express multiple functionalities in a single structure. Their magnetic properties are influenced by the morphology and composition of the nanoparticles, which in turn depend on the synthetic conditions. Incorporation of a non-magnetic heterometal also affects the final magnetic behavior. This study focuses on palladium/iron oxide nanoparticles for combined brachytherapy and MRI-guided hyperthermia of tumors. The synthetic mechanisms and their effects on the magnetic properties of the nanoparticles were investigated. The results revealed the most relevant synthetic parameters leading to promising performance in hyperthermia and MRI.
Article
Materials Science, Multidisciplinary
Tsuyoshi Yamaminami, Satoshi Ota, Suko Bagus Trisnanto, Mamoru Ishikawa, Tsutomu Yamada, Takashi Yoshida, Keiji Enpuku, Yasushi Takemura
Summary: The study measured the frequency dependence of magnetization of magnetic nanoparticles under different AC fields to examine the linear and nonlinear magnetization responses. Two methods were used to evaluate the AC susceptibility, with differences observed in the estimated values at different field intensities. Understanding the difference between the two methods is important for optimizing material and field conditions for hyperthermia treatment.
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
(2021)
Article
Polymer Science
Shinichiro Kano, Kengo Takagi, Tsuyoshi Yamaminami, Yasushi Takemura, Shin-ichi Yusa
Summary: In this study, pH- and thermoresponsive poly(N,N-dimethylaminoethyl methacrylate) was grafted onto the surface of superparamagnetic iron oxide Resovist via atom transfer radical polymerization, resulting in different zeta potential and physical properties of PDMA@Rv under different acidic conditions. Moreover, PDMA@Rv was observed to form aggregates above pH 7, indicating a lower critical solution temperature behavior.
Article
Physics, Applied
Suko Bagus Trisnanto, Tamon Kasajima, Taiju Akushichi, Yasushi Takemura
Summary: This study achieved a harmonic-rich signal by utilizing linear magnetization responses of magnetic nanoparticles, providing a new approach for magnetic particle imaging. By using a magnetoresistive sensor, the research team proposed a strategy to exploit the linear responses of tracers, resulting in high-contrast images of a solid ferucarbotran phantom and bringing new expectations for clinical use of MPI.
APPLIED PHYSICS EXPRESS
(2021)
Article
Energy & Fuels
Xiaoya Sun, Haruchika Iijima, Stefano Saggini, Yasushi Takemura
Summary: This paper presents a new method of generating electricity using a Wiegand sensor, aiming to produce a stable DC voltage of 5 V for use in self-powered devices and battery-less modules. A self-oscillating boost converter circuit is designed and verified to boost the pulse voltage generated from the Wiegand sensor, successfully obtaining a stable 5 V output voltage. Quantitative analysis reveals a suitable voltage-current range for application in self-powered devices and battery-less modules.
Article
Physics, Applied
Suko Bagus Trisnanto, Yasushi Takemura
Summary: The coexisting Neel and Brownian relaxation behaviors of magnetic nanoclusters in a viscous medium result in a highly nonlinear field-dependent magnetization response. Spectroscopic susceptometry and static magnetometry were used to assess the frequency-dependent complex magnetic susceptibility and predict effective core sizes, respectively. The different estimates of the effective Neel relaxation time constant from frequency-dependent and static magnetization responses indicate the activation energies limiting the relaxation behavior of magnetic nanoclusters.
JOURNAL OF APPLIED PHYSICS
(2021)
Article
Chemistry, Physical
Tomoaki Nakamura, Hiroki Tanaka, Tomofumi Horiuchi, Tsutomu Yamada, Yasushi Takemura
Summary: The Wiegand wire demonstrates fast magnetization reversal and large Barkhausen jumps in the magnetically soft region, with significant differences between surface and cross-section magnetization reversals possibly due to the low coercivity of the outer surface layer.
Article
Engineering, Electrical & Electronic
Seiya Tanaka, Satoshi Ota, Harutoyo Hirano, Masato Futagawa, Yasushi Takemura
Summary: This study investigates the harmonic components of signals derived from magnetization of magnetic nanoparticles in MPI, and proposes a new analytical method to improve resolution by considering the ratio of the third harmonic to the second harmonic. The study also discusses the important issues related to even harmonics in the application of MPI for diagnostics in the human body.
IEEE TRANSACTIONS ON MAGNETICS
(2022)
Article
Physics, Applied
Suko Bagus Trisnanto, Tamon Kasajima, Taiju Akushichi, Yasushi Takemura
Summary: Analyzing the spatial distribution of stray field from magnetic nanoparticles is crucial for designing and optimizing magnetometric systems in clinical magnetic particle imaging scanners. In this study, a magnetoresistive sensor was used to directly measure the stray field from a commercial magnetic nanoparticle suspension under a static field. The results show that the spatial distribution of the stray field is correlated with the geometry of the sample.
JOURNAL OF APPLIED PHYSICS
(2022)
Article
Chemistry, Physical
Liang Jiang, Chao Yang, Zenglu Song, Yasushi Takemura
Summary: This study aims to elucidate the magnetization reversal in the Wiegand wire by using a first-order reversal curve (FORC) diagram method. The results demonstrate a significant magnetization reversal in various components of the wire under an applied magnetic field.
Article
Chemistry, Physical
Guorong Sha, Chao Yang, Zenglu Song, Yasushi Takemura
Summary: This study analyzed the magnetic properties of Wiegand wires at various lengths using first-order reversal curves (FORCs) and evaluated the FORC diagram. The unique magnetization reversal feature and the polarity of FORC distribution were clarified.
Article
Nanoscience & Nanotechnology
Ruixuan Yao, Yasushi Takemura, Tsuyoshi Uchiyama
Summary: This study proposes a new method of driving MI sensors with low power consumption using a Wiegand sensor. The characteristics of an MI sensor driven by low-frequency pulses were investigated, and it was concluded that fast rise time pulses with small excitation current are necessary for inducing a significant MI effect. The newly designed MI sensor exhibited good output linearity and significantly reduced power consumption, making it suitable for various applications including bio-magnetic field measurements and vehicle detection.
Article
Nanoscience & Nanotechnology
Suko Bagus Trisnanto, Tamon Kasajima, Taiju Akushichi, Yasushi Takemura
Summary: Implementing low ac excitation fields in clinical magnetic particle imaging (MPI) system is critical to avoid magnetostimulation effects. In this study, an array of ultrasensitive MR sensors was used to detect sub-pT magnetic signal and obtain its spatial distribution. The sensitivity of each sensor was increased to 20 mV pT(-1) at 10 kHz with a 0.25 pT noise level. The MR sensor array demonstrated usability for low-field MPI system in mapping high-contrast field images and detecting stray fields of iron oxide nanoparticles.
Article
Engineering, Electrical & Electronic
Federico Iob, Stefano Saggini, Mario Ursino, Yasushi Takemura
Summary: During the last decade, biomedical devices have become increasingly powerful and versatile, with subcutaneous devices being one of the most invasive and innovative applications. Managing the battery of subcutaneous devices presents a significant challenge as they can only be handled through surgery, making wireless charging the only feasible option. However, unlike consumer devices, the energy delivered to subcutaneous systems necessarily goes through the human body and tissues, requiring the maximization of energy delivery while ensuring human safety. This article proposes a novel architecture for low-power wireless charging using a Wiegand sensor as a transducer, fulfilling both electrical and medical requirements within an ultralow-power IC prototype.
IEEE JOURNAL OF EMERGING AND SELECTED TOPICS IN POWER ELECTRONICS
(2023)
Article
Chemistry, Physical
Liang Jiang, Chao Yang, Zenglu Song, Yasushi Takemura
Summary: Wiegand wires are unique ferromagnetic materials that exhibit rapid magnetization reversal and a large Barkhausen jump under an applied field. This study investigates the magnetic structure and magnetization process of Wiegand wires with different diameters. Hysteresis loops and theoretical models were used to reveal the magnetic properties of the wires.
Article
Chemistry, Multidisciplinary
Ji-Wook Kim, Dan Heo, Jie Wang, Hyung-Sub Kim, Satoshi Ota, Yasushi Takemura, Chulhaeng Huh, Seongtae Bae
Summary: In magnetic nanofluid hyperthermia, the use of pseudo-single domain-SPNP can significantly enhance the intrinsic loss power, making it a promising agent for clinically safe treatment.
