Journal
APPLIED PHYSICS LETTERS
Volume 94, Issue 17, Pages -Publisher
AMER INST PHYSICS
DOI: 10.1063/1.3126039
Keywords
bubbles; cellular biophysics; diseases; gelatin; phantoms; ultrasonic arrays; ultrasonic focusing; ultrasonic therapy
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Targeted microbubbles bind specifically to molecular markers of diseases and their unique acoustic signature is used to image cellular processes in vivo. The ability of time-reversal processing to focus waves through heterogeneities on such targeted microbubbles is demonstrated. For this purpose, microbubbles were deposited on a gelatin phantom and their specific signal was recorded by a high intensity ultrasonic array. The amplified time-reversed signal was re-emitted and shown to focus back in the region where the bound microbubbles were present. This proof of concept emphasizes that molecular-time-reversal focusing could guide energy deposition on early, diffuse, or metastatic disease.
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