Article
Medicine, General & Internal
J. Deanna Wilson, Kaleab Z. Abebe, Kevin Kraemer, Jane Liebschutz, Jessica Merlin, Elizabeth Miller, David Kelley, Julie Donohue
Summary: This study identified two trajectories of opioid prescribing patterns in opioid-naive youths, with high-risk trajectory associated with older age and longer, more potent initial prescriptions. Even short and low-dose opioid prescriptions can be associated with risks of persistent opioid use for youths.
Article
Multidisciplinary Sciences
Sarah M. Hartz, Robert C. Culverhouse, Carrie M. Mintz, Matthew S. Ellis, Zachary A. Kasper, Patricia Cavazos-Rehg, Richard A. Grucza, Laura J. Bierut, Theodore J. Cicero
Summary: Chronic pain is associated with opioid overdose, and incorporating treatment for chronic pain may reduce the occurrence of opioid overdoses.
Article
Medicine, General & Internal
Lynn M. Yee, Deborah Kacanek, Chase Brightwell, Lisa B. Haddad, Jennifer Jao, Kathleen M. Powis, Tzy-Jyun Yao, Emily Barr, Carly Broadwell, Suzanne Siminski, George R. Seage, Ellen G. Chadwick
Summary: This study evaluated trends in marijuana, alcohol, and opioid use during pregnancy and the first year postpartum among US people living with HIV, showing an increasing trend in marijuana use and stable patterns in alcohol and opioid use over the years.
Article
Pediatrics
Junhan Cho, Lorraine Kelley-Quon, Jessica L. Barrington-Trimis, Afton Kechter, Sarah Axeen, Adam M. Leventhal
Summary: The study found that adolescent nonmedical prescription opioid use is associated with behavioral health problems such as major depression, hypomania or mania, cannabis, alcohol, and other drug use problems. Adolescents with these issues were more likely to use nonmedical prescription opioids. Furthermore, the higher the comorbidity of behavioral health problems, the greater the risk of subsequent nonmedical prescription opioid use.
Article
Medicine, General & Internal
Pia M. Mauro, Sarah Gutkind, Erin M. Annunziato, Hillary Samples
Summary: In this cross-sectional study, low utilization of MOUD was found among people who may have needed treatment for OUD, especially adolescents and older adults. The high prevalence of contacts with the health care and legal systems suggests significant gaps in care delivery or linkage.
Article
Psychiatry
Matthew S. Ellis, Kevin Y. Xu, Vitor S. Tardelli, Thiago M. Fidalgo, Mance E. Buttram, Richard A. Grucza
Summary: Gabapentin is frequently used off-label in OUD treatment despite the lack of evidence supporting its use. This study found that although individuals receiving gabapentin were more likely to experience drug-related poisonings, there was no increased risk when gabapentin was used alongside buprenorphine.
Article
Public, Environmental & Occupational Health
Matthew S. Ellis, Zachary A. Kasper, Bryce Takenaka, Mance E. Buttram, Enbal Shacham
Summary: Coinciding with the rise in opioid use, the rates of sexually transmitted infections have reached historically high levels, emphasizing the need to understand the various pathways of disease spread. This study focused on transactional sex as a lesser known pathway and found that it is relatively common among individuals with opioid use disorder, especially sexual and gender minorities, and is associated with a higher lifetime prevalence of sexually transmitted infections. Therefore, sexual health screenings and sexually transmitted infection prevention/testing should be prioritized and integrated into the care of patients with opioid use disorder.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2023)
Article
Multidisciplinary Sciences
Jill A. Rabinowitz, Jin Jin, Sally I-Chun Kuo, Adrian Campos, Miguel E. Renteria, Andrew S. Huhn, Johannes Thrul, Beth A. Reboussin, Kelly Benke, Benjamin Domingue, Nicholas S. Ialongo, Brion S. Maher, Darlene Kertes, Vanessa Troiani, George Uhl
Summary: This study examined the association between polygenic risk scores (PRS) for lifetime cannabis and alcohol use and the misuse of opioids among an urban, African-American sample. The findings suggest that higher PRS for lifetime cannabis use, heavy drinking, and alcohol consumption are associated with an increased risk for opioid misuse. Additionally, there are significant sex differences in these associations.
Article
Medicine, General & Internal
Lauren Klein Warren, Joella Adams, Georgiy Bobashev
Summary: Although opioid misuse has been decreasing among US youths and adolescents in recent years, it is unclear what has contributed to this trend and how this trend differs by age group and sex over time. This study aimed to identify trends in opioid misuse among youths and young adults across different age groups, birth cohorts, and sexes. The findings suggest that high school-aged individuals consistently misused fewer opioids in later pseudocohorts overall and by sex, and sex differences in opioid rates diminished in later pseudocohorts.
Article
Public, Environmental & Occupational Health
Kerry L. Beckman, Emily C. Williams, Paul L. Hebert, Madeline C. Frost, Anna D. Rubinsky, Eric J. Hawkins, Alyson J. Littman, Keren Lehavot
Summary: This study examines the association between military sexual trauma and opioid use disorder and high-risk opioid prescription, with a focus on the potential moderation by gender. The results indicate that military sexual trauma is significantly associated with a higher risk of opioid use disorder and high-risk opioid prescription, particularly in men.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2022)
Article
Pediatrics
Emilie Bruzelius, Natalie S. Levy, Mayumi Okuda, Shakira F. Suglia, Silvia S. Martins
Summary: This study aimed to test the impact of prescription drug monitoring programs (PDMPs) on child maltreatment prevalence. The results found evidence supporting a reduction in maltreatment prevalence at the state level, particularly in cases of neglect and physical abuse, and this effect may be especially significant for American Indian/Alaskan Native children.
JOURNAL OF PEDIATRICS
(2022)
Article
Health Care Sciences & Services
Binh Nguyen, Chenyue Zhao, Eric Bailly, Winnie Chi
Summary: This study examines the characteristics of patients initiating buprenorphine treatment via telehealth and its association with treatment outcomes and health outcomes. The findings suggest that telehealth-initiated buprenorphine treatment is associated with reduced opioid overdose rate and improved patient engagement.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Wilson M. Compton, Rita J. Valentino, Robert L. DuPont
Summary: The U.S. opioid crisis is not limited to opioids, but also involves multiple substances. The overlap of different substances contributes to increased morbidity and mortality, and may have unique effects. Addressing the overlap between opioids and other substances is essential to maximize benefits in prevention, treatment, overdose reversal, public health surveillance, and research.
MOLECULAR PSYCHIATRY
(2021)
Article
Multidisciplinary Sciences
Hsueh-Han Yeh, Cathryn Peltz-Rauchman, Christine C. C. Johnson, Pamala A. A. Pawloski, David Chesla, Stephen C. C. Waring, Alan B. B. Stevens, Mara Epstein, Christine Joseph, Lisa R. R. Miller-Matero, Hongsheng Gui, Amy Tang, Eric Boerwinkle, Mine Cicek, Cheryl R. R. Clark, Elizabeth Cohn, Kelly Gebo, Roxana Loperena, Kelsey Mayo, Stephen Mockrin, Lucila Ohno-Machado, Sheri Schully, Andrea H. H. Ramirez, Jun Qian, Brian K. K. Ahmedani
Summary: This study uses data from the All of Us research program to estimate the prevalence of opioid use among diverse populations in the US and investigate its association with sociodemographic characteristics. The study finds that the lifetime prevalence of street opioids is 4% and the nonmedical use of prescription opioids is 9%. Men have higher odds of lifetime opioid use but reduced odds of current nonmedical use of prescription opioids. Foreign-born participants have reduced risks of opioid use compared to US-born participants.
Article
Substance Abuse
Scott E. Hadland, Sarah M. Bagley, Mam Jarra Gai, Joel J. Earlywine, Samantha F. Schoenberger, Jake R. Morgan, Joshua A. Barocas
Summary: Among US youth, complications after an initial opioid prescription appear to be relatively rare and are associated with mood/anxiety disorders, substance use, comorbid substance use disorders, and prescriptions involving long-acting opioids or long durations.
