Journal
APPLIED OPTICS
Volume 51, Issue 14, Pages 2713-2721Publisher
OPTICAL SOC AMER
DOI: 10.1364/AO.51.002713
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Funding
- American Heart Association (AHA) [10POST3640010]
- NSF [PHY0957468]
- Division Of Physics
- Direct For Mathematical & Physical Scien [0957468] Funding Source: National Science Foundation
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Myocardial infarction, caused by a major blockage of a coronary artery, creates a border zone (BZ) between perfused and nonperfused tissue, which is believed to be the origin of fatal cardiac arrhythmias. We used a combination of optical clearing and polarization-sensitive optical coherence tomography to visualize a three-dimensional organization of the BZ in isolated rabbit hearts (n = 5) at the microscopic level with a high spatial resolution. We found that the BZ has a complex three-dimensional structure with nonperfused areas penetrating into perfused tissue with finger-like projections. These fingers may play an important role in the initiation and maintenance of ventricular arrhythmias. (C) 2012 Optical Society of America
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