Journal
IUBMB LIFE
Volume 67, Issue 8, Pages 589-600Publisher
WILEY
DOI: 10.1002/iub.1392
Keywords
myostatin; skeletal muscle; muscle wasting; cancer cachexia; sarcopenia; insulin resistance
Categories
Funding
- National Research Foundation (NRF)
- NMRC (BnB), Singapore
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Myostatin is a secreted growth and differentiation factor that belongs to the TGF- superfamily. Myostatin is predominantly synthesized and expressed in skeletal muscle and thus exerts a huge impact on muscle growth and function. In keeping with its negative role in myogenesis, myostatin expression is tightly regulated at several levels including epigenetic, transcriptional, post-transcriptional, and post-translational. New revelations regarding myostatin regulation also offer mechanisms that could be exploited for developing myostatin antagonists. Increasingly, it is becoming clearer that besides its conventional role in muscle, myostatin plays a critical role in metabolism. Hence, molecular mechanisms by which myostatin regulates several key metabolic processes need to be further explored. (C) 2015.
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