Journal
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
Volume 171, Issue 7, Pages 1639-1657Publisher
SPRINGER
DOI: 10.1007/s12010-013-0448-z
Keywords
Resveratrol; RVS(a); EMSA; NFkB; Molecular docking; Dynamics simulations
Funding
- Department of Biotechnology (DBT) Bioinformatics Infrastructure Facility (BIF) [BT/BI/25/2001/2006]
- UGC [F.4-2/2006 (BSR)/13-843/2013 (BSR)]
- ICMR [45/20/2011-BMS/BIF]
Ask authors/readers for more resources
Resveratrol (RVS) is a naturally occurring antioxidant, able to display an array of biological activities. In the present investigation, a new derivative of RVS, RVS(a), was synthesized, and its biological activity was determined on U937 cells. It was observed that RVS(a) showed pronounced activity on U937 cells than RVS. RVS(a) is able to induce apoptosis in tumor cell lines through subsequent DNA fragmentation. From the EMSA results, it was evident that RVS(a) was able to suppress the activity of NFkB by interfering its DNA binding ability. Furthermore, the molecular interaction analysis (docking and dynamics) stated that RVS(a) has strong association with the IkB-alpha site of NFkB compared with RVS; this binding nature of RVS(a) might be prevent the NFkB binding ability with DNA. The present findings represent the potential activity of propynyl RVS on U937 cells and signifying it as a one of putative chemotherapeutic drugs against cancer.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available