Article
Pharmacology & Pharmacy
Xiuying Zhang, Qilei Chen, Jia Zhao, Wei Zhao, Ni Fan, Yu Wang, Hubiao Chen, Jianhui Rong
Summary: This study aimed to investigate the cardioprotective activity of the herbal medicine formula Baoyuan Decoction (BYD), identify the active compounds and molecular targets. The results showed that BYD effectively reduced infarct size and preserved cardiac functions. Network pharmacology analysis revealed that BYD might control cardiac inflammation through targeting the TNF-alpha/NF-kappa B pathway and other related pathways.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Environmental Sciences
Chiung-Ju Chen, Hung-Sheng Shang, Yuan-Li Huang, Ni Tien, Yung-Liang Chen, Sheng-Yao Hsu, Rick Sai-Chuen Wu, Chien-Lun Tang, Jin-Cherng Lien, Mei-Hui Lee, Hsu-Feng Lu, Te-Chun Hsia
Summary: We evaluated the antimetastasis activity of Bisdemethoxycurcumin (BDMC) in human glioblastoma (GBM) cells and found that BDMC may have the potential to inhibit cell migration and invasion in GBM by suppressing key signaling pathways involved in cell proliferation, uptake, and motility.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Medicine, Research & Experimental
Akiko Inujima, Keiichi Koizumi, Naotoshi Shibahara
Summary: Research on bioactive components of herbal medicines has traditionally focused on secondary metabolites of herbal plants, with limited information on primary metabolites. This study highlights the immunostimulatory effects of heat-resistant RNA in a decoction of Glycyrrhizae Radix, suggesting nucleic acids as a new research field in the bioactive components of herbal medicines. By activating specific pathways and inducing cytokine production, the RNA demonstrated potential for therapeutic applications.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Environmental Sciences
Ke-Cheng Zhu, Hua-Yang Guo, Liang Guo, Bao-Suo Liu, Nan Zhang, Shi-Gui Jiang, Dian-Chang Zhang
Summary: This study investigated the sequence features, expression levels, and regulatory mechanism of TNF alpha in golden pompano. The results showed that NF-kappa B positively regulates the transcription of TNF alpha by interacting with the promoter region of ToTNF alpha.
FRONTIERS IN MARINE SCIENCE
(2022)
Review
Endocrinology & Metabolism
Yue Wu, Yunjiao Yang, Lan Wang, Yiding Chen, Xuke Han, Lisha Sun, Huizhen Chen, Qiu Chen
Summary: Osteoporosis is a bone disease characterized by low bone quality and density, causing bone fragility and vulnerability to fractures. Increased osteoclast differentiation and activity contribute to bone loss, a common manifestation of osteoporosis. The TNF-a/NF-κB inflammatory pathway plays a key role in regulating osteoclast formation, along with the classical RANKL/RANK/OPG pathway. Probiotics, particularly Bifidobacterium, have shown potential beneficial effects on bone health by modulating this pathway. This review discusses the molecular mechanisms of the TNF-a/NF-κB pathway in osteoclast formation and explores the secretions produced by Bifidobacterium, providing new directions for future research.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Patricia Garcia-Fernandez, Colette Reinhold, Nurcan Ueceyler, Claudia Sommer
Summary: Polyneuropathy (PNP) refers to diseases of the peripheral nervous system, with 50% of cases presenting with neuropathic pain. Certain types of PNP show pain restricted to the distal leg skin, indicating a local regulatory process leading to pain. This study suggests that a pro-inflammatory pathway mediated by NF-κB may contribute to pain development in patients with painful PNP. Our findings support the hypothesis of local inflammatory processes involved in pain in PNP, and suggest disrupted anti-inflammatory pathways in inflammatory PNP involving TRPV1 and SIRT1.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Huanhuan Xu, Chunxia Gan, Zemin Xiang, Ting Xiang, Jin Li, Xueqin Huang, Xiangdong Qin, Titi Liu, Jun Sheng, Xuanjun Wang
Summary: The tumor necrosis factor alpha (TNF-a)-TNF-a receptor (TNFR) interaction is crucial in the development of autoimmune diseases like rheumatoid arthritis, making it an important target for drug discovery. This study found that (-)-Epigallocatechin-3-gallate (EGCG), a polyphenolic compound found in green tea, can bind to TNF-a, TNFR1, and TNFR2 and disrupt their interactions. This leads to inhibition of TNF-a-induced cell death and NF-kB signaling pathway, suggesting that regular consumption of EGCG in green tea could potentially be used as a therapeutic agent for TNF-a-associated diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Multidisciplinary Sciences
On-Yu Hong, Hye-Yeon Jang, Young-Rae Lee, Sung Hoo Jung, Hyun Jo Youn, Jong-Suk Kim
Summary: SIRT6 plays an important role in regulating breast cancer metastasis by suppressing MAPK phosphorylation and reducing NF-κB and AP-1 DNA activities, leading to downregulation of MMP-9 expression, thus inhibiting cancer cell invasion and migration.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Zhenzhen Yan, Jingwei Dai, Jiayue Wang, Qianxi Feng, Yaguang Wang, Tongye Han, Chen Wu
Summary: In this study, the post-translational modification of Tollip by ubiquitination was identified. Tollip interacts with RNF167 and RNF167 functions as the E3 ligase to attach poly-ubiquitin chains to Tollip. The ubiquitination of Tollip plays a crucial role in TNF-alpha signaling.
Article
Biochemistry & Molecular Biology
Zhenzhen Yan, Jingwei Dai, Jiayue Wang, Qianxi Feng, Yaguang Wang, Tongye Han, Chen Wu
Summary: In this study, ubiquitination was identified as a post-translational modification on Tollip, and RNF167 was found to be the potential E3 ligase for Tollip. Tollip's ubiquitination plays a crucial role in TNF-a signaling.
Article
Pharmacology & Pharmacy
Weiwei Yuan, Jinxi Huang, Shanshan Hou, Huahua Li, Liangyu Bie, Beibei Chen, Gaofeng Li, Yang Zhou, Xiaobing Chen
Summary: The study found that pretreatment of gastric cancer cells with triptolide can enhance its anti-tumor effect. This effect is dependent on the disruption of the H19/miR-204-5p/NF-kappa B/FLIP axis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Aline de Oliveira Rezende, Rafaella Santos Saboia, Adeliane Castro da Costa, Diana Messala Pinheiro da Silva Monteiro, Adrielle Zagmignan, Luis Angelo Macedo Santiago, Rafael Cardoso Carvalho, Paulo Vitor Soeiro Pereira, Ana Paula Junqueira-Kipnis, Eduardo Martins de Sousa
Summary: This study investigated the association of HIF-1 alpha expression and related mechanisms with latent or active tuberculosis infection. The results showed that IL-15 expression was higher in individuals with LTBI, while IL-18 and TNF-alpha expression were similar between LTBI and TB groups. Additionally, patients with active TB had higher serum 25(OH)D3 levels and expression of IL-6, HIF1A, and A20. The study also found that PBMCs from individuals with LTBI showed decreased NF-kappa B phosphorylation and increased TNF-alpha production after HIF-1 alpha blockade.
Article
Immunology
Chang-hong Li, Zhen-zhen Ma, Lei-lei Jian, Xin-yu Wang, Lin Sun, Xiang-yuan Liu, Zhong-qiang Yao, Jin-xia Zhao
Summary: Iguratimod has been shown to inhibit osteoclast formation and bone resorption by interfering with signaling pathways, preventing bone loss in animal models. It also dampened TNF-alpha-induced osteoclastogenesis and disrupted nuclear translocation, providing promising evidence for its therapeutic application against RA and bone loss prevention.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sho Inoue, Yuki Inahashi, Makoto Itakura, Gen Inoue, Kyoko Muneshige, Tomoyasu Hirose, Masato Iwatsuki, Masashi Takaso, Masayuki Miyagi, Kentaro Uchida
Summary: This study found that Medermycin (MED) can reduce inflammatory reactions in synovial cells and inhibit the expression of proinflammatory cytokines. Further experiments demonstrated that MED can also inhibit the activation of NF?B and Akt, thereby modulating the inflammatory response. These results highlight the potential therapeutic value of MED in managing inflammatory conditions in osteoarthritis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Mona G. Elhadidy, Eman Mohamad El Nashar, Mansour A. Alghamdi, Shereen M. Samir
Summary: The study discovered a new gastroprotective effect of zeaxanthin (ZE) against stress-induced gastritis in rats, primarily through its antioxidative and anti-inflammatory effects, demonstrated in the regulation of the MMP-9 and HIF-1 alpha signaling pathways.
Article
Veterinary Sciences
Hsi-Tien Wu, Ya-Wen Chuang, Cheng-Pu Huang, Ming-Huang Chang
EXPERIMENTAL ANIMALS
(2018)
Article
Biotechnology & Applied Microbiology
Cheng-Han Huang, Yi-Ming Huang, Yung-Sheng Tseng, Wei-Chi Lee, Jui-Te Wu, Zhi-Jia Zheng, Hsi-Tien Wu
AFRICAN JOURNAL OF BIOTECHNOLOGY
(2011)
Article
Biochemistry & Molecular Biology
Yu Chia Liu, Win Yu Lin, Ya Ru Jhang, Sing Hui Huang, Chean Ping Wu, Hsi Tien Wu
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2011)
Article
Biochemistry & Molecular Biology
Hung-Chuan Pan, Hsi-Tien Wu, Fu-Chou Cheng, Cheng-Hsu Chen, Meei-Ling Sheu, Chun-Jung Chen
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2009)
Article
Biochemistry & Molecular Biology
Chung-Shen Wu, Wei-Tin Kuo, Chia-Yu Chang, Jun-Yi Kuo, Yi-Ting Tsai, Su-May Yu, Hsi-Ten Wu, Peng-Wen Chen
PLANT MOLECULAR BIOLOGY
(2014)
Article
Agriculture, Dairy & Animal Science
H. T. Wu, C. K. Chou, Y. C. Hung, C. K. Yu
REPRODUCTION IN DOMESTIC ANIMALS
(2010)
Article
Cell Biology
Hung-Chiuan Chen, Suresh Awale, Chean-Ping Wu, Hu-Hui Lee, Hsi-Tien Wu
CELL BIOLOGY INTERNATIONAL
(2020)
Article
Green & Sustainable Science & Technology
Chiu-Mei Kuo, Yu-Ling Sun, Cheng-Han Lin, Chao-Hsu Lin, Hsi-Tien Wu, Chih-Sheng Lin
Summary: Microalgae-based carbon dioxide biofixation and biorefinery are efficient methods of CO2 reduction, considered promising platforms for sustainable energy and environmental development. This review discusses factors influencing microalgae CO2 biofixation and the diversified applications of microalgal biomass in biorefinery.
Article
Medicine, General & Internal
Wen-Yeh Hsieh, Cheng-Han Lin, Tzu-Ching Lin, Chao-Hsu Lin, Hui-Fang Chang, Chin-Hung Tsai, Hsi-Tien Wu, Chih-Sheng Lin
Summary: The COVID-19 pandemic, caused by SARS-CoV-2, poses a significant challenge to the global healthcare system. Early detection and treatment of infected cases are crucial, with rapid and cost-effective immunoassays like LFIA being utilized for quick and large-scale testing.
Article
Physiology
Cheng-Pu Huang, Keng-Chia Hsu, Chean-Ping Wu, Hsi-Tien Wu
Summary: This study compared the growth rate, differentiation ability, and purity of adipose-derived stem cells (ADSCs) and bone marrow stem cells (BMSCs) using a transgenic mouse model. The results showed that ADSCs had a higher proliferation rate and purity than BMSCs, and ADSCs also exhibited a better capacity for osteogenic differentiation.
CHINESE JOURNAL OF PHYSIOLOGY
(2022)
Article
Agricultural Engineering
Chiu-Mei Kuo, Tsung-Hsien Lin, Yi-Chun Yang, Wen-Xin Zhang, Jinn-Tsyy Lai, Hsi-Tien Wu, Jo-Shu Chang, Chih-Sheng Lin
BIORESOURCE TECHNOLOGY
(2017)
Article
Agriculture, Dairy & Animal Science
HT Wu, CK Chou, MC Huang
ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES
(2004)
Article
Developmental Biology
HT Wu, CS Lin, MC Huang
REPRODUCTION FERTILITY AND DEVELOPMENT
(2003)
Article
Agriculture, Dairy & Animal Science
HT Wu, CK Chou, CS Lin, MC Huang
REPRODUCTION IN DOMESTIC ANIMALS
(2003)