Article
Biochemistry & Molecular Biology
Lukuan Hou, Hai-Yan Tian, Li Wang, Zachary E. Ferris, Junfeng Wang, Mingwei Cai, Ethan A. Older, Manikanda Raja Keerthi Raja, Dan Xue, Wanyang Sun, Prakash Nagarkatti, Mitzi Nagarkatti, Hexin Chen, Daping Fan, Xiaoyu Tang, Jie Li
Summary: This study reports the discovery and isolation of SoLs from the opportunistic pathogen Chryseobacterium gleum DSM16776 and demonstrates their pro-inflammatory activity with mice primary macrophages. The study also identifies two enzymes involved in the biosynthesis of SoLs and suggests a wider distribution of SoL biosynthetic genes in other microbes. These findings may indicate a more comprehensive function of SoLs.
ACS CHEMICAL BIOLOGY
(2022)
Article
Microbiology
Andrea Foote, Kristin Schutz, Zirui Zhao, Pauline DiGianivittorio, Bethany R. Korwin-Mihavics, John J. LiPuma, Matthew J. Wargo
Summary: Biofilms in drinking water systems play important roles in human health, pipe corrosion, and water taste. This study investigates the enhanced biofilm formation of two common bacteria, Ralstonia insidiosa and Chryseobacterium gleum, in potable water systems. While the interaction between these two bacteria strains from the International Space Station leads to enhanced biofilm formation, this phenomenon is not commonly observed in other strains and species.
MICROBIOLOGY SPECTRUM
(2023)
Article
Nutrition & Dietetics
OEzlem OEzdemir Tozlu, Hasan Tuerkez, Ufuk Okkay, Onur Ceylan, Cemil Bayram, Ahmet Hacimueftueoglu, Adil Mardinoglu
Summary: This study aimed to investigate the potential neuroprotective effect of D-cycloserine and L-serine against aluminum chloride (AlCl3)-induced Alzheimer's disease (AD) in rats. The results showed that these two drugs improved neurodegeneration and oxidative damage caused by aluminum toxicity.
FRONTIERS IN NUTRITION
(2022)
Correction
Oncology
Zheqiong Tan, Yaru Zou, Man Zhu, Zhenzhao Luo, Tangwei Wu, Chao Zheng, Aqing Xie, Hui Wang, Shiqiang Fang, Shuiyi Liu, Yong Li, Zhongxin Lu
Summary: A correction has been made to this paper and can be accessed through the original article.
Article
Fisheries
Ramesh Chandra Malick, Basanta Kumar Das, Bibhuti Bhusan Pal, Asit Kumar Bera, Praveen Maurye, Amiya Kumar Sahoo
Summary: Globally, bacterial gill disease is a major problem for marine and freshwater fishes. This study focused on diseased Labeo rohita, Labeo catla and Oreochromis niloticus with gill discoloration, tail rot and skin ulcers, which are typical signs of bacterial gill disease, in East Kolkata Wetlands, India. Four isolates of Chryseobacterium gleum were identified as the responsible pathogens, and they showed complete resistance to multiple antibiotics. A challenge experiment confirmed the virulence of three isolates.
Article
Oncology
Zheqiong Tan, Yaru Zou, Man Zhu, Zhenzhao Luo, Tangwei Wu, Chao Zheng, Aqing Xie, Hui Wang, Shiqiang Fang, Shuiyi Liu, Yong Li, Zhongxin Lu
Summary: CPT1A is overexpressed in breast cancer and can be secreted out of breast cancer cells. Serum CPT1A levels are positively associated with breast cancer progression and metastasis, and show high diagnostic efficiency for breast cancer.
Article
Physiology
Mauro Parimbelli, Elena Pezzotti, Massimo Negro, Luca Calanni, Silvia Allemano, Marco Bernardi, Angela Berardinelli, Giuseppe D'Antona
Summary: In this study, a 14-year-old female with inherited CPTII deficiency underwent a 6-month unsupervised exercise training program consisting of interval and resistance exercises. The results showed that the high-intensity short-duration exercise improved metabolism and aerobic fitness in this specific case of CPTII deficiency, with no reported muscle pain or rhabdomyolysis during the observation period.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Yue Zheng, Xiao-Xiao Chen, Dong-Yang Zhang, Wen-Jin Wang, Kun Peng, Zhi-Yuan Li, Zong-Wan Mao, Cai-Ping Tan
Summary: We report a highly emissive rhodium(III) complex (Rh-Mito) as the mtDNA intercalator that specifically binds to mtDNA, causing cytoplasmic release of mtDNA fragments to activate the cGAS-STING pathway. Rh-Mito also activates mitochondrial retrograde signaling and alters nuclear genome methylation landscape to influence genes related to immune signaling pathways. Furthermore, ferritin-encapsulated Rh-Mito elicits potent anticancer activities and immune responses in vivo. This study provides insights into the development of biomacromolecule-targeted immunotherapeutic agents.
Article
Chemistry, Physical
Duncan Schwaller, Senem Yilmazer, Alain Carvalho, Dominique Collin, Philippe J. Mesini
Summary: Gels of edible oils, known as oleogels, are developed to replace solid fats and reduce the risk of coronary disease. A low molecular weight organogelator (LMWO) called N-palmitoyl-l-phenylalanine (Palm-Phe) forms gels at a concentration of 1 wt% in rapeseed oil. The gel exhibits two transitions upon heating, including a gel-gel transition between two polymorphic gels.
Article
Medicine, Research & Experimental
Moriah J. Hovde, Danielle E. Bolland, Aryna Armand, Emily Pitsch, Clare Bakker, Amanda J. Kooiker, Joseph J. Provost, Roxanne A. Vaughan, Mark A. Wallert, James D. Foster
Summary: This study demonstrates for the first time that NHE1 is palmitoylated in both cells and rat tissue, and that its palmitoylation status is associated with the regulation of intracellular pH, stress fiber formation, and cell migration. Furthermore, it is shown that LPA stimulates NHE1 palmitoylation, and pretreatment with 2BP inhibits LPA-induced increase in intracellular pH. These findings highlight the significance of palmitoylation in the regulation of NHE1 and other control/signaling proteins.
Article
Infectious Diseases
M. Ali, H. Alsoub
Summary: Chryseobacterium gleum is a Gram-negative aerobic bacillus that commonly causes device-associated infections. Risk factors for C. gleum bacteremia include long hospital stays and indwelling devices. Rapid identification and antimicrobial susceptibility testing are essential for guiding therapy due to the inherent resistance of C. gleum to beta-lactam antibiotics.
NEW MICROBES AND NEW INFECTIONS
(2021)
Article
Medicine, General & Internal
Fnu Amisha, Tyler Fugere, Jose Caceres, Juan Carlos Rico Crescencio, Nathan Falls
Summary: Chryseobacterium species are emerging as opportunistic bacterial pathogens in hospital settings, particularly affecting debilitated or immunosuppressed patients. The challenges in diagnosis and treatment are exacerbated by their ability to form biofilms and resist broad-spectrum antimicrobials, prompting the need for further clinical studies.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Chemistry, Medicinal
Nunzio Antonio Cacciola, Fabrizia Sepe, Salvatore Fioriniello, Orsolina Petillo, Sabrina Margarucci, Marcello Scivicco, Gianfranco Peluso, Anna Balestrieri, Giovanna Bifulco, Brunella Restucci, Lorella Severino
Summary: Canine mammary tumors (CMTs) are common in intact female dogs. In addition to surgery, other therapies may benefit these patients. Exploring new treatments for CMT is promising in veterinary oncology.
Article
Nutrition & Dietetics
Cheng Luo, Hongjie Liu, Xiaoqian Wang, Lili Xia, Hanqiu Huang, Xiaoling Peng, Chao Xia, Liegang Liu
Summary: Individual plasma odd-chain SFAs and VLSFAs showed associations with favorable blood lipids and insulin resistance, and were inversely associated with the odds of type 2 diabetes (T2D). Additionally, individuals with GA and AA genotypes of the SPTLC3 gene rs680379 polymorphism had decreased odds of T2D compared to GG genotype carriers. Further investigations are needed to confirm these findings.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Review
Clinical Neurology
Pooja Patnaik Kuppili, Vikas Menon, Gopinath Sathyanarayanan, Siddharth Sarkar, Chittaranjan Andrade
Summary: This study found that d-Cycloserine did not show significant efficacy in treating negative, cognitive, or positive symptoms of schizophrenia. Additionally, there was no significant improvement in early treatment outcomes.
JOURNAL OF NEURAL TRANSMISSION
(2021)
Article
Chemistry, Applied
Ganesh A. Bathe, Mandar S. Bhagat, Bhushan L. Chaudhari
JOURNAL OF SURFACTANTS AND DETERGENTS
(2018)
Article
Biotechnology & Applied Microbiology
J. J. Ahire, N. U. Mokashe, B. L. Chaudhari
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2019)
Article
Chemistry, Physical
Kiran S. Dalal, Yogesh B. Wagh, Yogesh A. Tayade, Dipak S. Dalal, Bhushan L. Chaudhari
Article
Green & Sustainable Science & Technology
Chandrashekhar K. Patil, Harishchandra D. Jirimali, Jayasinh S. Paradeshi, Bhushan L. Chaudhari, Prakash K. Alagi, Sung Chul Hong, Vikas V. Gite
Article
Chemistry, Multidisciplinary
Kiran S. Dalal, Swapnil A. Padvi, Yogesh B. Wagh, Dipak S. Dalal, Bhushan L. Chaudhari
Article
Food Science & Technology
Lalit R. Chopade, Jayasinh S. Paradeshi, Kalpesh P. Amrutkar, Bhushan L. Chaudhari
LWT-FOOD SCIENCE AND TECHNOLOGY
(2019)
Article
Biochemical Research Methods
Sandip Patil, Bhushan Bhadane, Leena Shirsath, Ravindra Patil, Bhushan Chaudhari
PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY
(2019)
Article
Chemistry, Applied
Chandrashekhar K. Patil, Harishchandra D. Jirimali, Jayasinh S. Paradeshi, Bhushan L. Chaudhari, Vikas V. Gite
PROGRESS IN ORGANIC COATINGS
(2019)
Article
Chemistry, Applied
Chandrashekhar K. Patil, Harishchandra D. Jirimali, Mahendra S. Mahajan, Jayasinh S. Paradeshi, Bhushan L. Chaudhari, Vikas V. Gite
REACTIVE & FUNCTIONAL POLYMERS
(2019)
Article
Biotechnology & Applied Microbiology
Nayna D. Patil, Lalit R. Chopade, Ketan P. Narkhede, Bhushan L. Chaudhari, Raghunath T. Mahajan
BIOTECHNOLOGY PROGRESS
(2020)
Article
Biochemistry & Molecular Biology
Sandip P. Patil, Leena P. Shirsath, Bhushan L. Chaudhari
Summary: A halotolerant bacterium isolated from dental caries was found to produce the enzyme hyaluronidase, which showed high activity and stability at pH 7.0 and 40 degrees C, as well as in 2M NaCl solution. The enzyme exhibited wide substrate specificity with hyaluronic acid as the best substrate.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Applied
Chandrashekhar K. Patil, Harishchandra D. Jirimali, Jayasinh S. Paradeshi, Bhushan L. Chaudhari, Prakash K. Alagi, Pramod P. Mahulikar, Sung Chul Hong, Vikas V. Gite
Summary: In this study, algae oil was chemically transformed into polyols and incorporated into polyurethane coatings. The resulting PUs demonstrated excellent physical and chemical properties, showcasing the high potential of environmentally friendly renewable resources for various applications.
PROGRESS IN ORGANIC COATINGS
(2021)
Article
Chemistry, Physical
Kiran S. Dalal, Mangal A. Chaudhari, Dipak S. Dalal, Bhushan L. Chaudhari
Summary: A novel biosynthetic route for the synthesis of kojic acid derivatives was developed efficiently with the use of lipase from Aspergillus niger, achieving high conversion rates (82-95%) in aqueous medium. The lipase was reused for three consecutive cycles without significant loss of activity, indicating the potential of this bioprocess to replace chemical catalytic processes.
CATALYSIS COMMUNICATIONS
(2021)
Article
Biotechnology & Applied Microbiology
Mahesh P. Patil, Jayesh J. Ahire, Ulhas K. Patil, Bharat Bhushan, Bhushan L. Chaudhari
Summary: The study demonstrated that Lactobacillus helveticus CD6 effectively reduces weight gain and hyperlipidemia induced by a high-fat diet while maintaining normal liver histology. The strain shows promise for developing functional foods for individuals with dyslipidemia after further human studies.
Article
Biochemistry & Molecular Biology
Kiran S. Dalal, Yogesh A. Tayade, Yogesh B. Wagh, Dipak S. Dalal, Bhushan L. Chaudhari
Summary: A novel method for the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives via lipase from Aspergillus niger-catalyzed multicomponent reaction has been reported. The method shows high efficiency, environmental friendliness, simple workup procedure, and good yield (70-86%). It has the potential to replace traditional chemical synthesis routes for nitrogen-containing heterocyclic compounds.
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
(2022)