Article
Biochemistry & Molecular Biology
Peiying Huang, Mengmeng Li, Qinglai Tang, Kang Jiang, Yuchao Luo
Summary: This study investigated the biological functions and mechanisms of circular RNA_0000523 (circ_0000523) in nasopharyngeal carcinoma (NPC). The results showed that circ_0000523 facilitates NPC progression through regulating the miR-1184/COL1A1 axis.
Article
Medicine, Research & Experimental
Enni Chen, Jiajia Huang, Miao Chen, Jiawei Wu, Puyun Ouyang, Xiaonan Wang, Dingbo Shi, Zhiqiao Liu, Wancui Zhu, Haohui Sun, Shanshan Yang, Baoyu Zhang, Wuguo Deng, Huijuan Qiu, Fangyun Xie
Summary: This study reveals that FLI1 regulates radiotherapy resistance in nasopharyngeal carcinoma (NPC) through the TIE1-mediated PI3K/AKT signaling pathway, suggesting that targeting the FLI1/TIE1 signaling pathway could be a potential therapeutic strategy to enhance the efficacy of radiotherapy in NPC.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Virology
Ye Wei, Shitong Lin, Wenhua Zhi, Tian Chu, Binghan Liu, Ting Peng, Miaochun Xu, Wencheng Ding, Canhui Cao, Peng Wu
Summary: Cervical carcinoma is a serious gynecological cancer with potential targets in the PI3K/AKT pathways. The study found that PIK3CA mutation is common in cervical carcinoma, and Alpelisib can inhibit the growth of PIK3CA-mutant cancer cells and enhance cisplatin efficacy. This study provides insights into the potential use of Alpelisib in precision medicine for cervical carcinoma.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Review
Medicine, General & Internal
Anna Starzynska, Aleksandra Sejda, Paulina Adamska, Giulia Marvaso, Monika Sakowicz-Burkiewicz, Lukasz Adamski, Barbara A. Jereczek-Fossa
Summary: Oral squamous cell carcinoma (OSCC) affects over 260,000 new cases annually worldwide. The molecular signaling pathway of phosphatidyl-inositol-3-kinase plays a vital role in OSCC progression. Mutations in PIK3CA, PTEN, and AKT genes may serve as prognostic factors and contribute to aggressive disease progression in OSCC.
ARCHIVES OF MEDICAL SCIENCE
(2021)
Article
Medicine, Research & Experimental
Li-Zhi Wu, You Zou, Bin-Ru Wang, Hai-Feng Ni, Yong-Gang Kong, Qing-Quan Hua, Shi-Ming Chen
Summary: Investigating the impact of CENP-N on the radiosensitivity of NPC cells, this study found that knockdown of CENP-N can enhance NPC radiosensitivity by inhibiting the AKT/mTOR pathway. The combination of CENP-N knockdown and radiotherapy showed significant suppression of proliferation, induction of apoptosis, and G2/M phase arrest in NPC cells, with increased levels of Bax and gamma H2AX proteins and decreased levels of Cyclin D1 protein.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Wu Wu, Xi Chen, Xin Liu, Hai-juan Bao, Qian-hui Li, Jing-yuan Xian, Bing-feng Lu, Yang Zhao, Shuo Chen
Summary: The expression level of SNORD60 in endometrial cancer tissues is significantly higher than that in normal tissues, and it promotes the development of endometrial cancer by modulating the PI3K/AKT/mTOR signaling pathway. SNORD60 might become a new biomarker and therapeutic target for endometrial cancer.
MOLECULAR CARCINOGENESIS
(2023)
Article
Immunology
Huageng Huang, Yuyi Yao, Xinyi Deng, Huawei Weng, Zegeng Chen, Le Yu, Zhao Wang, Xiaojie Fang, Huangming Hong, He Huang, Tongyu Lin
Summary: This study provides a comprehensive analysis of immunotherapy clinical trials in nasopharyngeal carcinoma (NPC) over the past 15 years. It reveals that NPC immunotherapy trials are predominantly exploratory and calls for more attention and concerted efforts to generate high-quality evidence and advance the clinical application of immunotherapy in NPC.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Jin Su, Shousen Hu, Shiping Ding, Kun Feng
Summary: This study reveals the functional importance of proteasome 26 S subunit ATPase 2 (PSMC2) in nasopharyngeal carcinoma and demonstrates its positive regulatory role in the AKT signaling pathway.
Article
Oncology
Xiaoqin Fan, Xina Xie, Ming Yang, Yujie Wang, Hanwei Wu, Tingting Deng, Xin Weng, Weiping Wen, Guohui Nie
Summary: This study revealed the significant role of YBX3 in the metastasis of nasopharyngeal carcinoma, showing that it inhibits epithelial-to-mesenchymal transition and MMP1 activation by regulating the PI3K/AKT signaling pathway. These findings suggest that YBX3 could be a potential therapeutic target for patients with NPC.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Hai-Long Li, Nian-Hua Deng, Xiu-Sheng He, Yue-Hua Li
Summary: This article primarily discusses the interactions between PI3K/AKT/mTOR signaling pathway and miRNAs in the pathology of nasopharyngeal carcinoma (NPC), as well as explores potential diagnostic biomarkers and therapeutic targets.
BIOMARKER RESEARCH
(2022)
Article
Medicine, General & Internal
Lin-Quan Tang, Xiao-Yun Li, Zhi-Ming Li, Zhi-Gang Liu, Miao-Zhen Lin, Huan Zhou, Qi-Wen Yu, Jian Zhou, Chong Zhao, Ze-Bin Chen, Xi-Cheng Wang, Jia-Yu Peng, Qiu-Yan Chen, Wen-Feng Fang, Yun-Peng Yang, Bei Zhang, Liang-Ping Xia, Pi-Li Hu, Wei-Han Hu, Yi-Jie Li, Hai-Qiang Mai, Xiu-Yu Cai
Summary: Apatinib combined with capecitabine shows promising efficacy as a second-line treatment option in pretreated platinum-refractory recurrent or metastatic nasopharyngeal carcinoma patients.
Article
Biotechnology & Applied Microbiology
Li-Zhi Wu, Mao-Ling Huang, Cheng-Lin Qi, Li-Jun Shen, You Zou, Rui Yang, Jian-Fei Sheng, Shi-Ming Chen
Summary: Overexpression of Notch2 can increase the radiosensitivity of NPC cells by inhibiting the AKT/mTOR pathway, leading to enhanced apoptosis and cell cycle arrest in G2/M phase.
Article
Pharmacology & Pharmacy
Jianbin Zhang, Yan Jiang, Ye Yu, Jiangping Li
Summary: This study evaluated the combination of TORC1/2 inhibitor sapanisertib and chemotherapy drug cisplatin for nasopharyngeal carcinoma (NPC) treatment. The results showed that sapanisertib effectively decreased NPC cell viability and proliferation, and acted synergistically with cisplatin to induce cell arrest and apoptosis. Sapanisertib had minimal effects on normal cells and also reduced NPC cell migration. These findings were evident in both in vitro and in vivo models.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zhi-Jie Liu, Li-Sheng Zheng, Chang-Zhi Li, Li-Xia Peng, Yan Mei, Yan-Hong Lang, Liang Xu, Dong-Fang Meng, Xing-Si Peng, Ming-Dian Wang, De-Huan Xie, Ling-Ling Guo, Liu-Yan Ding, Bi-Jun Huang, Chao-Nan Qian
Summary: In this study, it was found that downregulation of Cystatin A (CSTA) was associated with metastasis in nasopharyngeal carcinoma (NPC) tissues. Functional assays showed that CSTA inhibited the motility and metastasis of NPC cells. Mechanistically, CSTA interacted with METTL3 to promote the degradation of NKX3-1 and LHPP, thereby suppressing AKT signaling. Our findings suggest that targeting the CSTA-METTL3-NKX3-1/LHPP-AKT axis could be a potential therapeutic strategy for inhibiting NPC metastasis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Yu Qin, Jennifer R. Wang, Ying Wang, Priyanka Iyer, Gilbert J. Cote, Naifa L. Busaidy, Ramona Dadu, Mark Zafereo, Michelle D. Williams, Renata Ferrarotto, G. Brandon Gunn, Peng Wei, Keyur Patel, Marie-Claude Hofmann, Maria E. Cabanillas
Summary: This study demonstrates the value of cfDNA gene mutation analysis in aiding early diagnosis and treatment selection for ATC patients. High concordance rates were observed between the mutations detected in cfDNA and those from tumor tissue sequencing. Patients with a PIK3CA mutation in cfDNA had worse overall survival, while BRAFi therapy significantly improved survival outcomes for ATC patients.
Article
Oncology
Stephanie P. L. Saw, Win Pin Ng, Siqin Zhou, Gillianne G. Y. Lai, Aaron C. Tan, Mei -Kim Ang, Wan-Teck Lim, Ravindran Kanesvaran, Quan Sing Ng, Amit Jain, Wan Ling Tan, Tanujaa Rajasekaran, Johan W. K. Chan, Yi Lin Teh, Mengyuan Pang, Jia-Chi Yeo, Angela Takano, Boon-Hean Ong, Eng-Huat Tan, Sze Huey Tan, Anders J. Skanderup, Daniel S. W. Tan
Summary: The aim of this study was to compare the prognostic value of programmed death-ligand 1 (PD-L1) score in early-stage epidermal growth factor receptor (EGFR)-mutated and EGFR-wildtype non-small cell lung cancer (NSCLC). The results showed that PD-L1 > 1% was an independent predictor of worse prognosis in EGFR-mutated NSCLC and was associated with inferior disease-free survival (DFS) regardless of EGFR status. Therefore, PD-L1 score should be evaluated as a risk stratification factor in prospective adjuvant studies among EGFR-mutated NSCLC.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Oncology
K. Yeoh, Y. Wu, S. Chakraborty, G. Elhusseiny, S. Gondhowiardjo, N. Joseph, A. W. M. Lee, H. H. Loong, S. C. Msadabwe-Chikuni, B. F. Tan, A. V. Ospina, T. Roques, H. M. Shum, E. K. Yeoh
Summary: The study investigated the resilience of health systems in maintaining cancer services during the COVID-19 pandemic. It revealed that underlying weaknesses of health systems were exacerbated by the pandemic, and universal adaptive strategies were not applicable to all systems. Common issues were identified, such as the lack of contingency plan for pandemics and inadequate financial policies for cancer patients. The study recommends effective pandemic control approaches, strong health systems, adaptable response strategies, and preparedness for future public health emergencies to enhance the resilient capacity of cancer care.
Editorial Material
Oncology
Aaron C. Tan, Keigo Kobayashi, Stephanie P. L. Saw, Daniel S. W. Tan, Darren Wan-Teck Lim
EXPERT REVIEW OF ANTICANCER THERAPY
(2023)
Editorial Material
Oncology
Wan Ling Tan, Darren Wan-Teck Lim
JOURNAL OF THORACIC ONCOLOGY
(2023)
Review
Oncology
Brian Sheng Yep Yeo, Harris Jun Jie Muhammad Danial Song, Yoke Lim Soong, Melvin Lee Kiang Chua, Mei-Kim Ang, Darren Wan Teck Lim, Anna See, Chwee Ming Lim
Summary: This study aims to summarize the evidence on the use of anti-PD1 antibodies in recurrent and/or metastatic nasopharyngeal cancer patients and compare their effectiveness with chemotherapy. The results show that anti-PD1 antibodies have significant activity in the treatment of these patients. Combination therapy with gemcitabine and cisplatin enhances the efficacy of treatment.
Review
Oncology
Huan Yan, Jing-Ling Zhang, Kam-Tong Leung, Kwok-Wai Lo, Jun Yu, Ka-Fai To, Wei Kang
Summary: Gastric cancer is a highly life-threatening malignancy, particularly in Asian countries. Aberrant activation of G-protein-coupled receptors (GPCRs) and G proteins promotes the progression of gastric cancer. These activated GPCRs/G proteins can potentially serve as valuable biomarkers for early diagnosis and prognostic prediction, as well as therapeutic targets. This review summarizes the recent research progress of GPCRs and highlights their mechanisms in tumorigenesis, specifically in gastric cancer initiation and progression.
Article
Biochemistry & Molecular Biology
Lili Li, Xing-sheng Shu, Hua Geng, Jianming Ying, Lei Guo, Jie Luo, Tingxiu Xiang, Longtao Wu, Brigette B. Y. Ma, Anthony T. C. Chan, Xiaofeng Zhu, Richard F. Ambinder, Qian Tao
Summary: Peptides/small proteins encoded by noncanonical open reading frames (ORF) of previously claimed non-coding RNAs have important biological functions but are largely uncharacterized. In this study, we identified and validated a small protein SP0495 as a novel tumor suppressor, frequently inactivated by promoter methylation in multiple tumors. SP0495 functions as a phosphoinositide-binding protein, regulating AKT signaling activation and autophagy. It inhibits tumor cell growth and induces apoptosis, cell cycle arrest, senescence, and autophagy through multiple mechanisms, including the modulation of phosphoinositides turnover and autophagic/proteasomal degradation of autophagy regulators. SP0495 has the potential to be a biomarker for cancer diagnosis and prognosis.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Health Care Sciences & Services
Chun Sing Lam, Keary Zhou, Herbert Ho-Fung Loong, Vincent Chi-Ho Chung, Chun-Kit Ngan, Yin Ting Cheung
Summary: This study utilized data from social media platforms and health forums to explore patients' use, interest, and perception of traditional, complementary, and integrative medicine (TCIM) for cancer care. The study found that patients commonly discuss the use of TCIM modalities for symptoms such as pain, anxiety and depression, and poor sleep. Positive and negative themes were identified, along with patients' perceptions of TCIM. The findings provide valuable insights for understanding patients' needs and concerns regarding TCIM and integrating it into cancer care.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Multidisciplinary Sciences
Darren Wan-Teck Lim, Hsiang-Fong Kao, Lisda Suteja, Constance H. Li, Hong Sheng Quah, Daniel Shao-Weng Tan, Sze-Huey Tan, Eng-Huat Tan, Wan-Ling Tan, Justina Nadia Lee, Felicia Yu-Ting Wee, Amit Jain, Boon-Cher Goh, Melvin L. K. Chua, Bin-Chi Liao, Quan Sing Ng, Ruey-Long Hong, Mei-Kim Ang, Joe Poh-Sheng Yeong, N. Gopalakrishna Iyer
Summary: This study reports the results of a clinical trial of dual PD-1 and CTLA-4 checkpoint blockade in patients with recurrent/metastatic EBV-positive nasopharyngeal carcinoma. Single-agent checkpoint inhibitor activity is limited in this cancer type, but the combination treatment shows increased activity. The results show that this combination therapy has good tolerability and better clinical response and progression-free survival in patients with low EBV-DNA levels.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Jun Ma, Sze Huey Tan, Daniel Xing Cheng Yin, Nguyen Tuan Anh Tran, Gek San Tan, Gillianne Geet Yi Lai, Mei-Kim Ang, Ravindran Kanesvaran, Amit Jain, Tanujaa Rajasekaran, Eng-Huat Tan, Tony Kiat Hon Lim, Daniel Shao-Weng Tan, Darren Wan-Teck Lim, Quan Sing Ng, Wan Ling Tan
Summary: This study retrospectively examined the performance of osimertinib in the second/subsequent line treatment of lung cancer patients. The results showed that osimertinib had good efficacy in the second-line setting and there was heterogeneity in T790M expression between plasma and tumor tissue, indicating that plasma T790M testing may not fully predict the efficacy of osimertinib.
TRANSLATIONAL LUNG CANCER RESEARCH
(2023)
Article
Medicine, General & Internal
Nancy Y. Lee, Jonathan Harris, John Kim, Adam Garden, James Mechalakos, David G. Pfister, Anthony T. C. Chan, Kenneth Hu, A. Dimitrios Colevas, Steven Frank, George Shenouda, Voichita Bar-Ad, John N. Waldron, Paul M. Harari, Adam Raben, Pedro Torres-Saavedra, Quynh-Thu Le
Summary: The study aimed to assess the long-term toxic effects and clinical outcomes associated with adding bevacizumab, a vascular endothelial growth factor inhibitor, to standard chemoradiation for patients with nasopharyngeal carcinoma (NPC). The results showed favorable long-term outcomes and no severe adverse events when using bevacizumab in combination with chemoradiation. Further investigation may be warranted.
Review
Biochemistry & Molecular Biology
Kah Yee Goh, Terence You De Cheng, Su Chin Tham, Darren Wan-Teck Lim
Summary: Non-small cell lung cancer (NSCLC) is the dominant form of lung cancer and typically has a poor prognosis. Immunotherapy using immune checkpoint inhibitors (ICI) has shown superior efficacy compared to conventional chemotherapy for advanced NSCLC patients. However, there is a need for biomarkers to accurately predict immunotherapy response, as only a minority of patients benefit from this treatment. Liquid biopsy, which enables non-invasive sampling of blood-based biomarkers, allows for the dynamic monitoring of treatment response. This review summarizes the progress and challenges in identifying circulating biomarkers for predicting immunotherapy benefit in NSCLC patients.
Article
Oncology
Claire Petit, Anne Lee, Jun Ma, Benjamin Lacas, Wai Tong Ng, Anthony T. C. Chan, Ruey-Long Hong, Ming-Yuan Chen, Lei Chen, Wen-Fei Li, Pei-Yu Huang, Terence Tan, Roger K. C. Ngan, Guopei Zhu, Hai-Qiang Mai, Edwin P. Hui, George Fountzilas, Li Zhang, Alexandra Carmel, Dora L. W. Kwong, James Moon, Jean Bourhis, Anne Auperin, Jean-Pierre Pignon, Pierre Blanchard
Summary: This study updated the evaluation of chemotherapy for nasopharynx carcinoma through a network meta-analysis. The results showed that the addition of induction chemotherapy or adjuvant chemotherapy to chemoradiotherapy improved overall survival for patients with non-metastatic nasopharyngeal carcinoma compared to chemoradiotherapy alone.
Meeting Abstract
Oncology
P. L. S. Saw, G. S. Tan, A. Tan, G. Lai, W. C. Tan, E. H. Tan, M-K. Ang, D. W-T. Lim, R. Kanesvaran, Q. S. Ng, A. Jain, W. L. Tan, T. Rajasekaran, J. Chan, Y. L. Teh, S. H. Tan, T. K. H. Lim, D. S. W. Tan
JOURNAL OF THORACIC ONCOLOGY
(2023)
Article
Nutrition & Dietetics
Chun Sing Lam, Rong Hua, Yu Kang Wu, Ho Kee Koon, Keary Rui Zhou, Herbert Ho-Fung Loong, Vincent Chi-Ho Chung, Yin Ting Cheung
Summary: This study investigated the potential supplement-drug interactions involving the hepatic system and their associations with liver diseases among cancer patients. The results showed that approximately one-third of cancer patients who used supplements had a risk of potential interactions, but no significant association was observed between the use of these combinations and subsequent liver diseases.
CLINICAL NUTRITION ESPEN
(2023)