Article
Biochemistry & Molecular Biology
Hyunsu Choi, Seung-Shin Yu, Jiwon Choi, Choung-Soo Kim
Summary: This study used rabbit and rat models and found that the c-Met agonistic antibody showed promise for promoting muscle regeneration in vocal fold palsy, providing a new strategy for treating vocal fold atrophy and glottic insufficiency.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Lilin Li, Jeonghwan Lee, Ara Cho, Jin Hyuk Kim, Wonmin Ju, Jung Nam An, Jeong Hwan Park, Shi Mao Zhu, Junghun Lee, Seung-Shin Yu, Chun Soo Lim, Dong Ki Kim, Yon Su Kim, Seung Hee Yang, Jung Pyo Lee
Summary: The study investigated the role of cMet agonistic antibody in preventing kidney fibrosis during the transition from acute kidney injury to chronic kidney disease. By decreasing inflammatory response and inhibiting the TGF-β/Smad pathway, cMet Ab successfully prevented fibrosis response in models of kidney fibrosis.
Article
Multidisciplinary Sciences
Takafumi I. Furuyama, Takafumi Shigeyama, Munenori Ono, Sachiko Yamaki, Kohta Kobayasi, Nobuo Kato, Ryo Yamamoto
Summary: This study investigates the relationship between vocalizations and aggressive behaviors in Mongolian gerbils during same-sex resident-intruder tests. The results show that different sexes and sexual experience affect vocalizations and aggressive responses in encounters. High-frequency vocalizations are associated with non-agonistic interactions, while low-frequency vocalizations are associated with agonistic interactions, predominantly observed in encounters involving multiparous females.
Article
Gastroenterology & Hepatology
Kuai Ma, Weitao Que, Xin Hu, Wen-Zhi Guo, Er-li Gu, Liang Zhong, Virginia Morello, Manuela Cazzanti, Paolo Michieli, Terumi Takahara, Xiao-Kang Li
Summary: The study investigated the effect of the MET-agonistic antibody 71D6 on liver regeneration in a mouse model of SFSS. The results showed that 71D6 administration reduced mouse mortality, promoted liver regeneration, and accelerated the resolution of hepatic fibrosis. These findings suggest that activating the MET pathway via an hepatocyte growth factor-mimetic antibody may be beneficial in patients with SFSS and other liver disorders.
LIVER TRANSPLANTATION
(2022)
Article
Zoology
Sarah Richdon, Eluned Price, Dominic Wormell, Gareth Jones, Grainne McCabe
Summary: This study observed male Livingstone's fruit bats and found that they have a stable linear dominance hierarchy. Older, higher-ranking males initiated the most agonistic interactions with lower-ranking males.
Article
Surgery
Min-Ha Choi, Tae-Sik Jang, Hyeonwoo Kim, Inhoe Ku, Junghun Lee, Jae-Gyun Jeong, Sunyoung Kim, Ji-Ung Park
Summary: This study investigates the use of a tyrosine kinase Met agonistic monoclonal antibody to improve diabetic wound healing. The results show that the agonist reduces inflammatory cell infiltration and promotes collagen synthesis.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
Article
Oncology
Marta Compte, Seandean L. Harwood, Ainhoa Erce-Llamazares, Antonio Tapia-Galisteo, Eduardo Romero, Irene Ferrer, Eva M. Garrido-Martin, Ana B. Enguita, Maria C. Ochoa, Belen Blanco, Marta Oteo, Nekane Merino, Daniel Nehme-Alvarez, Oana Hangiu, Carmen Dominguez-Alonso, Manuela Zonca, Angel Ramirez-Fernandez, Francisco J. Blanco, Miguel A. Morcillo, Ines G. Munoz, Ignacio Melero, Jose L. Rodriguez-Peralto, Luis Paz-Ares, Laura Sanz, Luis Alvarez-Vallina
Summary: The researchers developed a humanized EGFR-specific 4-1BB-agonistic trimerbody, which showed significant antitumor activity in a wide range of human tumors without hepatotoxicity. Combining the trimerbody with a PD-L1 blocker led to increased IFN gamma secretion and resulted in tumor regression in aggressive triple-negative breast cancer humanized mice.
CLINICAL CANCER RESEARCH
(2021)
Article
Biology
Yu-Young Tsai, Chiu-Lun Shen, D. Dhananjaya, Ching-Yen Tsai, Woan-Yuh Tarn
Summary: Knockout of the RBM4 gene leads to foliation defects in the cerebellum and delayed motor learning in mice, which are similar to neurotrophin deficiency. RBM4 promotes the expression of BDNF and enhances BDNF-TrkB signaling. Prenatal supplementation with a TrkB agonist rescues cerebellar malformation and improves motor learning in RBM4 knockout mice.
COMMUNICATIONS BIOLOGY
(2023)
Article
Fisheries
Ronick Spenly Shadrack, Ishikawa Manabu, Saichiro Yokoyama
Summary: This study showed that integrating different probiotic bacteria strains into the feed of juvenile Amberjack can significantly improve the physiological condition of fish, with the single strain Bacillus amyloliquefaciens (BA) showing the most positive effects on condition factor and length weight relationship coefficient. However, feeding different diets did not significantly affect growth parameters, feed utilization, and whole body composition of fish. More research is recommended to further explore the dietary effects of single strain (BA) and mix strain (SF + BM + LP) on fish growth and health.
AQUACULTURE REPORTS
(2021)
Article
Multidisciplinary Sciences
Hanlin Lu, Peidong Yuan, Xiaoping Ma, Xiuxin Jiang, Shaozhuang Liu, Chang Ma, Sjaak Philipsen, Qunye Zhang, Jianmin Yang, Feng Xu, Cheng Zhang, Yun Zhang, Wencheng Zhang
Summary: ACE inhibitors are commonly used to treat cardiovascular diseases and promote angiogenesis. This study reveals that endothelial USP7-Sp1/Sp3-Notch1 signaling plays a central role in pathophysiological angiogenesis in response to ACE inhibitor treatment.
NATURE COMMUNICATIONS
(2023)
Article
Biology
Xiaojie Yu, Sonya James, James H. Felce, Blanka Kellermayer, David A. Johnston, H. T. Claude Chan, Christine A. Penfold, Jinny Kim, Tatyana Inzhelevskaya, C. Ian Mockridge, Yasunori Watanabe, Max Crispin, Ruth R. French, Patrick J. Duriez, Leon R. Douglas, Martin J. Glennie, Mark S. Cragg
Summary: The study demonstrated that agonists with greater activity induced higher density receptor clustering and specific super-structures as opposed to simply larger receptor clusters.
COMMUNICATIONS BIOLOGY
(2021)
Article
Biology
Jeong-Kyu Han, Sun-Ho Kwon, Yong Gyu Kim, Jaeyong Choi, Jong-Il Kim, Yong-Seok Lee, Sang-Kyu Ye, Sang Jeong Kim
Summary: This study reveals the molecular and cellular mechanisms of cerebellar cortex modulating fear memory through the signaling of STAT3 in Purkinje cells. Deletion of STAT3 leads to transcriptional changes in PCs, affecting the expression of glutamate receptors and ultimately impacting fear memory. Fear conditioning induces different synaptic changes in STAT3 knockout mice and WT mice, resulting in depression and potentiation respectively.
Article
Marine & Freshwater Biology
J. Landa, M. Korta, A. Iriondo, J. Fontenla, R. Gancedo, M. Reparaz, L. Rodriguez-Fernandez, I. Loureiro, A. Gomez, B. Castro, A. Antolinez, I. Bruno, E. Abad, C. Hernandez
Summary: The study investigated the somatic parameters of megrim, an economically important flatfish species, over a multiyear period. The research identified a clear seasonal pattern in the condition factor and determined appropriate parameters for stock assessment. This study is of significant importance for deepening our understanding of the species and improving fishery management.
ESTUARINE COASTAL AND SHELF SCIENCE
(2022)
Article
Multidisciplinary Sciences
Jamie L. Lim, Roy Augustinus, Jaap J. Plomp, Kasra Roya-Kouchaki, Dana L. E. Vergoossen, Yvonne Fillie-Grijpma, Josephine Struijk, Rachel Thomas, Daniela Salvatori, Christophe Steyaert, Christophe Blanchetot, Roeland Vanhauwaert, Karen Silence, Silvere M. van der Maarel, Jan J. Verschuuren, Maartje G. Huijbers
Summary: Muscle-specific kinase (MuSK) is crucial for neuromuscular junction (NMJ) function. Agonist monoclonal antibodies targeting MuSK Ig-like 1 domain showed potential in vitro, but failed to rescue myasthenia in vivo. Unexpectedly, MuSK agonists caused sudden death in male mice, hampering further development.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Takahisa Kawaguchi, Kazuhiro Hasegawa, Itaru Yasuda, Hirokazu Muraoka, Hiroyuki Umino, Hirobumi Tokuyama, Akinori Hashiguchi, Shu Wakino, Hiroshi Itoh
Summary: The study found that diabetes significantly affects PECs, including hypertrophy, increased vacuoles, and cell apoptosis. These changes in PECs were observed in diabetic mice and patients, suggesting a role for PECs in diabetic nephropathy.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Ana R. Goncalves, Carina Fernandes, Rita Pasion, Fernando Ferreira-Santos, Fernando Barbosa, Joao Marques-Teixeira
CLINICAL NEUROPHYSIOLOGY
(2018)
Article
Integrative & Complementary Medicine
Karine Silva, Mariely Lima, Andre Santos-Magalhaes, Carla Fafiaes, Liliana de Sousa
JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE
(2018)
Article
Geriatrics & Gerontology
Carina Fernandes, Rita Pasion, Ana R. Goncalves, Fernando Ferreira-Santos, Fernando Barbosa, Isabel P. Martins, Joao Marques-Teixeira
NEUROBIOLOGY OF AGING
(2018)
Article
Multidisciplinary Sciences
Ana R. Goncalves, Carina Fernandes, Rita Pasion, Fernando Ferreira-Santos, Fernando Barbosa, Joao Marques-Teixeira
Article
Anthropology
Karine Silva, Mariely Lima, Andre Santos-Magalhaes, Carla Fafiaes, Liliana de Sousa
Article
Behavioral Sciences
Carina Fernandes, A. R. Goncalves, R. Pasion, F. Ferreira-Santos, F. Barbosa, I. P. Martins, J. Marques-Teixeira
COGNITIVE AFFECTIVE & BEHAVIORAL NEUROSCIENCE
(2019)
Article
Neurosciences
C. Fernandes, A. R. Goncalves, R. Pasion, F. Ferreira-Santos, F. Barbosa, I. P. Martins, J. Marques-Teixeira
NEUROSCIENCE LETTERS
(2019)
Article
Behavioral Sciences
Joana Carvalheiro, Ana Seara-Cardoso, Ana Raquel Mesquita, Liliana de Sousa, Pedro Oliveira, Teresa Summavielle, Ana Magalhaes
JOURNAL OF COMPARATIVE PSYCHOLOGY
(2019)
Article
Agriculture, Dairy & Animal Science
Ana Catarina Vieira de Castro, Jennifer Barrett, Liliana de Sousa, I. Anna S. Olsson
APPLIED ANIMAL BEHAVIOUR SCIENCE
(2019)
Article
Multidisciplinary Sciences
Alexandre Azevedo, Liam Bailey, Victor Bandeira, Martin Dehnhard, Carlos Fonseca, Liliana de Sousa, Katarina Jewgenow
Correction
Multidisciplinary Sciences
Alexandre Azevedo, Liam Bailey, Victor Bandeira, Martin Dehnhard, Carlos Fonseca, Liliana de Sousa, Katarina Jewgenow
Review
Neurosciences
Helena Garcez, Carina Fernandes, Fernando Barbosa, Mariana R. Pereira, Celeste Silveira, Joao Marques-Teixeira, Ana R. Goncalves
PSYCHOPHARMACOLOGY
(2020)
Article
Behavioral Sciences
Sandra Duarte Cardoso, Ceres Berger Faraco, Liliana de Sousa, Goncalo Da Graca Pereira
Summary: The objective of this study was to evaluate the empathy of humans towards animals and humans towards humans in a sample of individuals who have adopted or relinquished a dog or a cat in Portugal. The study found high levels of human-animal empathy in the sample, with no significant differences between adopters and relinquishers. Furthermore, there was a significant link between human-human empathy and human-animal empathy.
JOURNAL OF VETERINARY BEHAVIOR-CLINICAL APPLICATIONS AND RESEARCH
(2022)
Article
Neurosciences
R. Pasion, C. Fernandes, A. R. Goncalves, F. Ferreira-Santos, R. Pascoa, F. Barbosa, J. Marques-Teixeira
SOCIAL NEUROSCIENCE
(2019)
Article
Psychiatry
Carina Fernandes, Ana Ribeiro Goncalves, Rita Pasion, Fernando Ferreira-Santos, Tiago Oliveira Paiva, Joana Melo e Castro, Fernando Barbosa, Isabel Pavao Martins, Joao Marques-Teixeira
TRENDS IN PSYCHIATRY AND PSYCHOTHERAPY
(2018)