Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 7, Issue 47, Pages 26307-26314Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.5b09129
Keywords
electrochemiluminescence; silver nanoclusters; synergistic quenching effect; resonance energy transfer; microRNA detection
Funding
- National Natural Science Foundation of China [21535003, 21475058, 21135003]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
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In this work, oligonudeotide-encapusulated silver nanodusters were applied in the electrochemiluminescence (ECL) system of CdS nanocrystals (NCs)/ K2S2O8 based on dual ECL quenching effects. We found that the ECL emission of CdS NCs matched well with the absorption band of oligonucleotide encapsulated Ag nano clusters, which could act as the energy acceptor of CdS NCs ECL so as to lead to an effective ECL resonance energy transfer (RET). On the other hand, the Ag nanodusters could also catalyze electrochemical reduction of K2S2O8, resulting in increased consumption of ECL coreactant near the working electrode and decreased ECL intensity from CdS NCs. On the basis of the dual ECL quenching effects, a sensitive ECL biosensor for detection of microRNA was successfully achieved with a wide linear range from 10 fM to 100 pM.
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