Article
Polymer Science
Di Jia, Yui Tsuji, Mitsuhiro Shibayama, Murugappan Muthukumar
Summary: When long polymers are trapped in multiple entropic traps created by hydrogels, they are frozen into a nondiffusive topologically frustrated dynamical state (TFDS). The center of mass diffusion coefficient is zero in the TFDS regime, but the segmental dynamics of the macromolecule is active. It is found that the polydispersity in the number of monomers in the entropic traps is caused by conformational fluctuations.
Article
Polymer Science
Brittany K. Roopnarine, Spencer C. Schmidt, Kevin J. Maxwell, Svetlana Morozova
Summary: Understanding the transport and thermodynamics of polymers in confined spaces is beneficial for separation processes. By studying the diffusion coefficient of dextran and sodium polyacrylate in convex lens-induced confinement, we can gain insights into how these polymers interact and improve separation processes.
Review
Biotechnology & Applied Microbiology
Tassadit Ouidir, Bruno Gabriel, Yassine Nait Chabane
Summary: Biofilms, composed of bacteria in a sessile state within an extracellular matrix, are studied for their impact on various aspects of daily life. While the majority of research has focused on single-species biofilms, recent studies have shifted towards complex models that better approximate the natural environment. This review discusses examples of multispecies biofilms in different domains and highlights the need for multi-scale strategies to decipher this complex lifestyle.
JOURNAL OF BIOTECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Che-Hao Wu, Wenjing Meng, Masafumi Yoshio
Summary: Low-voltage-driven actuators based on photo-cross-linked ionic columnar liquid-crystalline polymer films integrating ionic liquids into nanoscale 1D channels have been shown to exhibit larger deformation and generated force compared to amorphous actuators. This concept opens up a promising pathway for electroactive actuator design by incorporating nanostructured components.
ACS MATERIALS LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Lijun Cai, Guopu Chen, Lingyu Sun, Shuangshuang Miao, Luoran Shang, Yuanjin Zhao, Lingyun Sun
Summary: A novel micromotor delivery system with rocket-like architecture and effervescent-tablets-derived fuel was developed for efficient oral macromolecule delivery. The micromotors, inspired by rockets, feature sharp needle tips for loading and efficient penetrating, and tail wings for loading effervescent powders and avoiding perforation. When exposed to a water environment, the effervescent fuel generates CO2 bubbles to propel the micromotors, allowing them to inject into the surrounding mucosa for drug release. These micromotors showed efficacy in regulating blood sugar glucose in a diabetic rabbit model, indicating their potential for clinical oral delivery of macromolecules.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Physical
L. Tonti, F. A. Garcia Daza, A. Patti
Summary: Applying an electric field to polarizable colloidal particles induces the formation of string-like clusters and alters the fluid mechanical and rheological properties. The dynamics of self-assembly and the viscoelastic response of the model fluid under the electric field are investigated using simulations and microrheology.
JOURNAL OF CHEMICAL PHYSICS
(2022)
Review
Chemistry, Multidisciplinary
Zhengrong Yin, Yaxi Liu, Annikaer Anniwaer, Yuan You, Jingmei Guo, Ying Tang, Lei Fu, Luyao Yi, Cui Huang
Summary: Oral biofilms, also known as dental plaque, are the main cause of oral and systemic diseases, posing serious health risks. Novel antimicrobial biomaterials with controllable fabrication and functionalization have shown promise. However, previous reviews have focused on the properties and effectiveness of these biomaterials, lacking attention to the design rationales tailored to different infection types and application scenarios. This review provides guidance on the design and application of antibiofilm biomaterials, discussing core strategies, advanced antibiofilm biomaterials, and future improvements.
ADVANCED MATERIALS
(2023)
Article
Physics, Fluids & Plasmas
Lazaro J. Perez, Tapomoy Bhattacharjee, Sujit S. Datta, Rishi Parashar, Nicole L. Sund
Summary: The study utilized a random walk particle-tracking approach to simulate bacterial transport in porous media, finding that the model efficiently captured the dynamics of bacterial spreading, including the impact of cell-cell interactions and pore confinement. The model is able to qualitatively reproduce observed directional persistence and provides a basis for studying bacterial dispersal in complex environments on a multiscale level.
Article
Dentistry, Oral Surgery & Medicine
Heitor Ceolin Araujo, Wilmer Ramirez Carmona, Camila Sato, Marcelo dos Santos Oliveira, Guilherme dos Santos Gomes Alves, Deborah Nunes Morato, Juliano Pelim Pessan, Douglas Roberto Monteiro
Summary: This study assessed the effects of chitosan (CS) on microcosm biofilms derived from saliva of patients with Candida-associated denture stomatitis. The results showed that CS has similar or superior effects to conventional active principles on important parameters of oral candidiasis microcosm biofilms, indicating its potential in improving the clinical condition of denture stomatitis patients.
JOURNAL OF DENTISTRY
(2022)
Article
Cell Biology
Peter Gennemark, Katrin Walter, Niclas Clemmensen, Dinko Rekic, Catarina A. M. Nilsson, Jane Knochel, Mikko Holtta, Linda Wernevik, Birgitta Rosengren, Dorota Kakol-Palm, Yanfeng Wang, Rosie Z. Yu, Richard S. Geary, Stan J. Riney, Brett P. Monia, Rikard Isaksson, Rasmus Jansson-Lofmark, Cristina S. J. Rocha, Daniel Linden, Eva Hurt-Camejo, Rosanne Crooke, Lloyd Tillman, Tina Ryden-Bergsten, Bjorn Carlsson, Ulf Andersson, Marie Elebring, Anna Tivesten, Nigel Davies
Summary: In this study, a chemically modified PCSK9 antisense oligonucleotide (ASO) with potential for oral delivery was developed and shown to effectively reduce LDL cholesterol levels. Animal experiments demonstrated liver targeting and significant reductions in PCSK9 and LDL cholesterol levels after oral administration.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Tian Zhang, Lingyun Xia, Zhejun Wang, Robert E. W. Hancock, Markus Haapasalo
Summary: DJK-5 treatment quickly killed biofilm bacteria and maintained a high level of dead bacteria for 1 week, while 1018 and CHX had less effective results, and the proportion of dead bacteria doubled within the first 7 days after exposure to CHX and 1018. The recovery time of biofilms was slow but similar after exposure to different treatments, with the recovery time after exposure to DJK-5 being longer.
JOURNAL OF ENDODONTICS
(2021)
Article
Polymer Science
Maxwell Smith, Ryan Poling-Skutvik, Ali H. Slim, Richard C. Willson, Jacinta C. Conrad
Summary: The study explores the coupling of dynamics between flexible viral nanoparticles and similarly sized polymer chains. It finds that the dynamics of viral nanoparticles in semidilute polymer solutions exhibit diffusive behavior, but with non-Gaussian displacement distributions. The long-time diffusion coefficients do not conform to existing models based on rodlike or spherical nanoparticles, instead collapsing as a function of the ratio of the polymer correlation length and an intermediate length scale between the virus radius and length, suggesting that the hydrodynamic coupling is affected by virus anisotropy and flexibility.
Article
Dentistry, Oral Surgery & Medicine
Min-Kyung Kang, Hee-Eun Kim
Summary: This study evaluated the remineralizing efficacy of fluoride using a pH-cycling model with oral microcosm biofilms. Results showed that the presence of biofilms significantly influenced fluoride remineralization on early carious lesions. The fluoride-treated group with oral biofilms experienced lower ΔΔF compared to the group without biofilms, highlighting the importance of considering biofilm presence in assessing fluoride efficacy.
JOURNAL OF DENTISTRY
(2021)
Article
Polymer Science
Brian G. Amsden
Summary: In this study, the use of the correlation length as the mesh size along with the obstruction model was found to yield the most consistent agreement between experimental data and model predictions, while the use of the mesh radius did not yield good agreement with the experimental data.
Article
Nanoscience & Nanotechnology
Camila Leiva-Sabadini, Simon Alvarez, Nelson P. Barrera, Christina M. A. P. Schuh, Sebastian Aguayo
Summary: The study aims to characterize the molecular and nanomechanical properties of honey-derived EVs to elucidate their antibacterial effects, and to determine their differential antibiofilm activity against oral streptococci. The molecular analysis identified important exosome markers and antibacterial molecules in the EVs, while nanomechanical characterization showed their potential impact on altering cell wall elasticity. The differential effects of honey-derived EVs on different oral streptococci could provide a novel strategy for modulating biofilm formation in dental caries.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Microbiology
Breana Pabst, Betsey Pitts, Ellen Lauchnor, Philip S. Stewart
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2016)
Letter
Dermatology
G. A. Okoye, N. Vlassova, O. Olowoyeye, A. Agostinho, G. James, P. S. Stewart, S. Leung, G. Lazarus
BRITISH JOURNAL OF DERMATOLOGY
(2017)
Article
Cell Biology
Garth A. James, Alice Ge Zhao, Marcia Usui, Robert A. Underwood, Hung Nguyen, Haluk Beyenal, Elinor deLancey Pulcini, Alessandra Agostinho Hunt, Hans C. Bernstein, Philip Fleckman, John Olerud, Kerry S. Williamson, Michael J. Franklin, Philip S. Stewart
WOUND REPAIR AND REGENERATION
(2016)
Article
Biotechnology & Applied Microbiology
Philip S. Stewart, Tianyu Zhang, Ruifang Xu, Betsey Pitts, Marshall C. Walters, Frank Roe, Judith Kikhney, Annette Moter
NPJ BIOFILMS AND MICROBIOMES
(2016)
Article
Infectious Diseases
Garth A. James, Laurent Chesnel, Laura Boegli, Elinor deLancey Pulcini, Steve Fisher, Philip S. Stewart
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2018)
Article
Multidisciplinary Sciences
Manu N. Capoor, Filip Ruzicka, Jonathan E. Schmitz, Garth A. James, Tana Machackova, Radim Jancalek, Martin Smrcka, Radim Lipina, Fahad S. Ahmed, Todd F. Alamin, Neel Anand, John C. Baird, Nitin Bhatia, Sibel Demir-Deviren, Robert K. Eastlack, Steve Fisher, Steven R. Garfin, Jaspaul S. Gogia, Ziya L. Gokaslan, Calvin C. Kuo, Yu-Po Lee, Konstantinos Mavrommatis, Elleni Michu, Hana Noskova, Assaf Raz, Jiri Sana, A. Nick Shamie, Philip S. Stewart, Jerry L. Stonemetz, Jeffrey C. Wang, Timothy F. Witham, Michael F. Coscia, Christof Birkenmaier, Vincent A. Fischetti, Ondrej Slaby
Article
Biochemical Research Methods
Jeffrey W. Simkins, Philip S. Stewart, Joseph D. Seymour
JOURNAL OF MAGNETIC RESONANCE
(2018)
Article
Statistics & Probability
Albert E. Parker, Betsey Pitts, Lindsey Lorenz, Philip S. Stewart
JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION
(2018)
Article
Biotechnology & Applied Microbiology
D. Ausbacher, L. Lorenz, B. Pitts, P. S. Stewart, D. M. Goeres
LETTERS IN APPLIED MICROBIOLOGY
(2018)
Article
Immunology
Yilin Wu, Isaac Klapper, Philip S. Stewart
PATHOGENS AND DISEASE
(2018)
Article
Microbiology
Philip S. Stewart, Albert E. Parker
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2019)
Article
Microbiology
Fernanda Godoy-Santos, Betsey Pitts, Philip S. Stewart, Hilario C. Mantovani
Article
Radiology, Nuclear Medicine & Medical Imaging
Jeffrey W. Simkins, Philip S. Stewart, Sarah L. Codd, Joseph D. Seymour
MAGNETIC RESONANCE IN MEDICINE
(2019)
Article
Multidisciplinary Sciences
Raquel Ferrer-Espada, Hawraa Shahrour, Betsey Pitts, Philip S. Stewart, Susana Sanchez-Gomez, Guillermo Martinez-de-Tejada
SCIENTIFIC REPORTS
(2019)
Correction
Biotechnology & Applied Microbiology
Christine Rabinovitch, Philip S. Stewart
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2017)
