Inhibition of the JAK/STAT pathway with ruxolitinib overcomes cisplatin resistance in non-small-cell lung cancer NSCLC

A phase II study of cisplatin with intravenous and oral vinorelbine as induction chemotherapy followed by concomitant chemoradiotherapy with oral vinorelbine and cisplatin for locally advanced non-small cell lung cancer

(2014) Delphine Lerouge et al.   BMC CANCER

Critical role of FANCC in JAK2 V617F mutant-induced resistance to DNA cross-linking drugs

(2013) Fumihito Ueda et al.   CELLULAR SIGNALLING

Genomic Landscape of Non-Small Cell Lung Cancer in Smokers and Never-Smokers

(2012) Ramaswamy Govindan et al.   CELL

Antitumor activity of motesanib alone and in combination with cisplatin or docetaxel in multiple human non–small-cell lung cancer xenograft models

(2012) Angela Coxon et al.   Molecular Cancer

Arctigenin enhances chemosensitivity of cancer cells to cisplatin through inhibition of the STAT3 signaling pathway

(2011) Xiangyang Yao et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Cisplatin as an Anti-Tumor Drug: Cellular Mechanisms of Activity, Drug Resistance and Induced Side Effects

(2011) Ana-Maria Florea et al.   Cancers

Identification and functional analysis of genes which confer resistance to cisplatin in tumor cells

(2010) Zchong-Zcho Wu et al.   BIOCHEMICAL PHARMACOLOGY

Defining the role of the JAK-STAT pathway in head and neck and thoracic malignancies: Implications for future therapeutic approaches

(2010) Stephen Y. Lai et al.   DRUG RESISTANCE UPDATES

Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008

(2010) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

STI571 sensitizes breast cancer cells to 5-fluorouracil, cisplatin and camptothecin in a cell type-specific manner

(2009) Jonathan T. Sims et al.   BIOCHEMICAL PHARMACOLOGY

Cucurbitacin B Induces Apoptosis by Inhibition of the JAK/STAT Pathway and Potentiates Antiproliferative Effects of Gemcitabine on Pancreatic Cancer Cells

(2009) N. H. Thoennissen et al.   CANCER RESEARCH

The polycythemia vera-associated Jak2 V617F mutant induces tumorigenesis in nude mice

(2009) Miyuki Abe et al.   INTERNATIONAL IMMUNOPHARMACOLOGY