Valproic acid enhances fludarabine-induced apoptosis mediated by ROS and involving decreased AKT and ATM activation in B-cell-lymphoid neoplastic cells

Diverse Mechanisms of AKT Pathway Activation in Human Malignancy

(2013) Mitchell Cheung et al.   CURRENT CANCER DRUG TARGETS

Synergistic apoptotic response between valproic acid and fludarabine in chronic lymphocytic leukaemia (CLL) cells involves the lysosomal protease cathepsin B

(2013) J-Y Yoon et al.   Blood Cancer Journal

The B-cell receptor signaling pathway as a therapeutic target in CLL

(2012) J. A. Woyach et al.   BLOOD

Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes

(2011) Marcus Bantscheff et al.   NATURE BIOTECHNOLOGY

The PARP inhibitor olaparib induces significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo

(2010) V. J. Weston et al.   BLOOD

Effect of valproic acid on radiation-induced DNA damage in euchromatic and heterochromatic compartments

(2010) KN Harikrishnan et al.   CELL CYCLE

Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: a randomised, open-label, phase 3 trial

(2010) M Hallek et al.   LANCET

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

Epigenetic modulation of gene expression of human leukemia cell lines – induction of cell death and senescence

(2010) K. ELKNEROVA et al.   NEOPLASMA

Inhibition of histone deacetylase overcomes rapamycin-mediated resistance in diffuse large B-cell lymphoma by inhibiting Akt signaling through mTORC2

(2009) M. Gupta et al.   BLOOD

Phase II study of the histone deacetylase inhibitor MGCD0103 in patients with previously treated chronic lymphocytic leukaemia

(2009) Kristie A. Blum et al.   BRITISH JOURNAL OF HAEMATOLOGY

PCI-24781 Induces Caspase and Reactive Oxygen Species-Dependent Apoptosis Through NF- B Mechanisms and Is Synergistic with Bortezomib in Lymphoma Cells

(2009) S. Bhalla et al.   CLINICAL CANCER RESEARCH

Antileukemic activity of valproic acid in chronic lymphocytic leukemia B cells defined by microarray analysis

(2009) B Stamatopoulos et al.   LEUKEMIA

Treatment of elderly patients with chronic lymphocytic leukemia

(2009) Barbara Eichhorst et al.   LEUKEMIA & LYMPHOMA

Valproate synergizes with purine nucleoside analogues to induce apoptosis of B-chronic lymphocytic leukaemia cells

(2008) Amel Baya Bouzar et al.   BRITISH JOURNAL OF HAEMATOLOGY

Valproic acid enhances bosutinib cytotoxicity in colon cancer cells

(2008) Luca Mologni et al.   INTERNATIONAL JOURNAL OF CANCER

The role of TRAIL death receptors in the treatment of hematological malignancies

(2008) Elizabeth S. Henson et al.   LEUKEMIA & LYMPHOMA