3-Nitro-naphthalimide and nitrogen mustard conjugate NNM-25 induces hepatocellular carcinoma apoptosis via PARP-1/p53 pathway

NPC-16, a novel naphthalimide–polyamine conjugate, induced apoptosis and autophagy in human hepatoma HepG2 cells and Bel-7402 cells

(2010) Song-qiang Xie et al.   APOPTOSIS

Coordination of the Nuclear and Cytoplasmic Activities of p53 in Response to DNA Damage

(2010) Tian Pu et al.   BIOPHYSICAL JOURNAL

Pre-clinical and clinical evaluation of PARP inhibitors as tumour-specific radiosensitisers

(2010) C. Powell et al.   CANCER TREATMENT REVIEWS

Alkylation DNA damage in combination with PARP inhibition results in formation of S-phase-dependent double-strand breaks

(2010) Michelle L. Heacock et al.   DNA REPAIR

Requirement for NBS1 in the S phase checkpoint response to DNA methylation combined with PARP inhibition

(2010) Julie K. Horton et al.   DNA REPAIR

Sensitization to Radiation and Alkylating Agents by Inhibitors of Poly(ADP-ribose) Polymerase Is Enhanced in Cells Deficient in DNA Double-Strand Break Repair

(2010) D. A. Loser et al.   MOLECULAR CANCER THERAPEUTICS

Developing better treatments in hepatocellular carcinoma

(2010) Austin Duffy et al.   Expert Review of Gastroenterology & Hepatology

Naphthalimides and Azonafides as Promising Anti-Cancer Agents

(2009) Laurent Ingrassia et al.   CURRENT MEDICINAL CHEMISTRY

Poly(ADP-ribose) polymerase inhibitors in cancer treatment: A clinical perspective

(2009) Shahneen K. Sandhu et al.   EUROPEAN JOURNAL OF CANCER

Activated monocytes in peritumoral stroma of hepatocellular carcinoma promote expansion of memory T helper 17 cells

(2009) Dong-Ming Kuang et al.   HEPATOLOGY

Knockdown of Caveolin-1 by siRNA Inhibits the Transformation of Mouse Hepatoma H22 Cells In Vitro and In Vivo

(2009) Shujing Wang et al.   OLIGONUCLEOTIDES

Conjugation of substituted naphthalimides to polyamines as cytotoxic agents targeting the Akt/mTOR signal pathway

(2009) Zhi-yong Tian et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis, cytotoxicity and apoptosis of naphthalimide polyamine conjugates as antitumor agents

(2008) Zhi-yong Tian et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Development of PARP inhibitors in oncology

(2008) Jordi Rodon et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS