Snake venom toxin from Vipera lebetina turanica sensitizes cancer cells to TRAIL through ROS- and JNK-mediated upregulation of death receptors and downregulation of survival proteins

Snake venom toxin from vipera lebetina turanicainduces apoptosis of colon cancer cells via upregulation of ROS- and JNK-mediated death receptor expression

(2012) Mi Hee Park et al.   BMC CANCER

Cardamonin sensitizes tumour cells to TRAIL through ROS- and CHOP-mediated up-regulation of death receptors and down-regulation of survival proteins

(2011) Vivek R Yadav et al.   BRITISH JOURNAL OF PHARMACOLOGY

Combined modality therapy with TRAIL or agonistic death receptor antibodies

(2011) Hope M. Amm et al.   CANCER BIOLOGY & THERAPY

c-Jun NH2-terminal kinase-dependent upregulation of DR5 mediates cooperative induction of apoptosis by perifosine and TRAIL

(2011) Lei Fu et al.   Molecular Cancer

Anti-cancer effect of bee venom toxin and melittin in ovarian cancer cells through induction of death receptors and inhibition of JAK2/STAT3 pathway

(2011) Miran Jo et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

TNFR1 and TNFR2 regulate the extrinsic apoptotic pathway in myeloma cells by multiple mechanisms

(2011) H Rauert et al.   Cell Death & Disease

From Toxins Targeting Ligand Gated Ion Channels to Therapeutic Molecules

(2011) Adak Nasiripourdori et al.   Toxins

Tocotrienols induce apoptosis in breast cancer cell lines via an endoplasmic reticulum stress-dependent increase in extrinsic death receptor signaling

(2010) Sook Kyung Park et al.   BREAST CANCER RESEARCH AND TREATMENT

ROS and CHOP Are Critical for Dibenzylideneacetone to Sensitize Tumor Cells to TRAIL through Induction of Death Receptors and Downregulation of Cell Survival Proteins

(2010) Sahdeo Prasad et al.   CANCER RESEARCH

Celastrol, a Triterpene, Enhances TRAIL-induced Apoptosis through the Down-regulation of Cell Survival Proteins and Up-regulation of Death Receptors

(2010) Bokyung Sung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ursolic Acid, a Pentacyclin Triterpene, Potentiates TRAIL-induced Apoptosis through p53-independent Up-regulation of Death Receptors

(2010) Sahdeo Prasad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gossypol Induces Death Receptor-5 through Activation of the ROS-ERK-CHOP Pathway and Sensitizes Colon Cancer Cells to TRAIL

(2010) Bokyung Sung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quercetin enhances TRAIL-induced apoptosis in prostate cancer cells via increased protein stability of death receptor 5

(2010) Young-Hwa Jung et al.   LIFE SCIENCES

β-Ionone Enhances TRAIL-Induced Apoptosis in Hepatocellular Carcinoma Cells through Sp1-Dependent Upregulation of DR5 and Downregulation of NF-κB Activity

(2010) Mun-Ock Kim et al.   MOLECULAR CANCER THERAPEUTICS

Garcinol Potentiates TRAIL-Induced Apoptosis through Modulation of Death Receptors and Antiapoptotic Proteins

(2010) Sahdeo Prasad et al.   MOLECULAR CANCER THERAPEUTICS

Snake venom toxin inhibits cell growth through induction of apoptosis in neuroblastoma cells

(2009) Mi Hee Park et al.   ARCHIVES OF PHARMACAL RESEARCH

Zerumbone Enhances TRAIL-Induced Apoptosis through the Induction of Death Receptors in Human Colon Cancer Cells: Evidence for an Essential Role of Reactive Oxygen Species

(2009) S. Yodkeeree et al.   CANCER RESEARCH

α7-Nicotinic receptor antagonists at the beginning of a clinical era for NSCLC and Mesothelioma?

(2009) Laura Paleari et al.   DRUG DISCOVERY TODAY

EGFR-targeted diphtheria toxin stimulates TRAIL killing of glioblastoma cells by depleting anti-apoptotic proteins

(2009) Henrick Horita et al.   JOURNAL OF NEURO-ONCOLOGY

Quercetin augments TRAIL-induced apoptotic death: Involvement of the ERK signal transduction pathway

(2008) Young-Ho Kim et al.   BIOCHEMICAL PHARMACOLOGY

Baicalein Overcomes Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand Resistance via Two Different Cell-Specific Pathways in Cancer Cells but not in Normal Cells

(2008) Hiroya Taniguchi et al.   CANCER RESEARCH

Melittin, a Major Component of Bee Venom, Sensitizes Human Hepatocellular Carcinoma Cells to Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)-induced Apoptosis by Activating CaMKII-TAK1-JNK/p38 and Inhibiting IκBα Kinase-NFκB

(2008) Chen Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

To kill a tumor cell: the potential of proapoptotic receptor agonists

(2008) Avi Ashkenazi et al.   JOURNAL OF CLINICAL INVESTIGATION

15-deoxy-Δ12,14-prostaglandin J2 up-regulates death receptor 5 gene expression in HCT116 cells: involvement of reactive oxygen species and C/EBP homologous transcription factor gene transcription

(2008) Rong-Ying Su et al.   MOLECULAR CANCER THERAPEUTICS

Honeybee venom induces calcium-dependent but caspase-independent apoptotic cell death in human melanoma A2058 cells

(2008) Wu-Chun Tu et al.   TOXICON