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Targeting PI3K Signaling as a Therapeutic Approach for Colorectal Cancer

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Integrin α8β1 confers anoikis susceptibility to human intestinal epithelial crypt cells

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Should individual PI3 kinase isoforms be targeted in cancer?

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PIKKing on PKB: regulation of PKB activity by phosphorylation

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How adhesion signals reach a mitochondrial conclusion—ECM regulation of apoptosis

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Integrins and cell-fate determination

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Integrin signalling at a glance

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Intestinal epithelial cancer cell anoikis resistance: EGFR-mediated sustained activation of Src overrides Fak-dependent signaling to MEK/Erk and/or PI3-K/Akt-1

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Integrin-linked kinase regulates migration and proliferation of human intestinal cells under a fibronectin-dependent mechanism

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β1 integrin/Fak/Src signaling in intestinal epithelial crypt cell survival: integration of complex regulatory mechanisms

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The life of a cell: apoptosis regulation by the PI3K/PKB pathway

(2008) Vincent Duronio   BIOCHEMICAL JOURNAL

Cell Death in Mammalian Development

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Class I PI3K in oncogenic cellular transformation

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PI3K/Akt: getting it right matters

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Is Src the key to understanding metastasis and developing new treatments for colon cancer?

(2008) Jiezhong Chen   Nature clinical practice. Gastroenterology & hepatology