Synthetic lethality of PARP inhibition in BRCA-network disrupted tumor cells is associated with interferon pathway activation and enhanced by interferon-γ

Poly(ADP-Ribose) polymerase (PARP) inhibitors: Exploiting a synthetic lethal strategy in the clinic

(2011) Timothy A. Yap et al.   CA-A CANCER JOURNAL FOR CLINICIANS

PARP inhibitors stumble in breast cancer

(2011) Malini Guha   NATURE BIOTECHNOLOGY

Iniparib plus Chemotherapy in Metastatic Triple-Negative Breast Cancer

(2011) Joyce O'Shaughnessy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nonhomologous end joining drives poly(ADP-ribose) polymerase (PARP) inhibitor lethality in homologous recombination-deficient cells

(2011) A. G. Patel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The PARP inhibitor olaparib induces significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo

(2010) V. J. Weston et al.   BLOOD

BRCA1 and BRCA2: breast/ovarian cancer susceptibility gene products and participants in DNA double-strand break repair

(2010) P. J. O'Donovan et al.   CARCINOGENESIS

Guiding the “misguided” - functional conditioning of dendritic cells for the DC-based immunotherapy against tumours

(2010) Fang-Ping Huang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Interferon-Lambda: A New Addition to an Old Family

(2010) Raymond P. Donnelly et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

IFN  Restores Breast Cancer Sensitivity to Fulvestrant by Regulating STAT1, IFN Regulatory Factor 1, NF- B, BCL2 Family Members, and Signaling to Caspase-Dependent Apoptosis

(2010) Y. Ning et al.   MOLECULAR CANCER THERAPEUTICS

ATM Deficiency Sensitizes Mantle Cell Lymphoma Cells to Poly(ADP-Ribose) Polymerase-1 Inhibitors

(2010) C. T. Williamson et al.   MOLECULAR CANCER THERAPEUTICS

Identification and SAR of novel pyrrolo[1,2-a]pyrazin-1(2H)-one derivatives as inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1)

(2009) Giovanna Pescatore et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Conditional interleukin-12 gene therapy promotes safe and effective antitumor immunity

(2009) H Komita et al.   CANCER GENE THERAPY

Regulation of apoptosis by type III interferons

(2008) W. Li et al.   CELL PROLIFERATION

A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor

(2008) Nicholas C Turner et al.   EMBO JOURNAL

 -H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin

(2008) A. Kinner et al.   NUCLEIC ACIDS RESEARCH