Review
Cell Biology
Juan Rodriguez, Tao Li, Yiran Xu, Yanyan Sun, Changlian Zhu
Summary: This review focuses on the molecular mechanisms of hypoxic-ischemic encephalopathy, specifically highlighting the importance of apoptosis-inducing factor. Understanding the roles of this factor is crucial for developing more effective treatments for perinatal brain injury. Additionally, the interaction of apoptosis-inducing factor with other proteins may provide promising therapeutic targets for improving outcomes after perinatal brain injury.
NEURAL REGENERATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Wojciech Trybus, Ewa Trybus, Teodora Krol
Summary: This study evaluated the effects of combining emodin with vinblastine on cervical cancer cells. The combination increased oxidative stress, mitotic catastrophe, and apoptosis, potentially offering a promising approach for anticancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Congcong Wang, Jiaying He, Tongfei Xu, Hongyu Han, Zhimin Zhu, Lingxue Meng, Qihua Pang, Ruifang Fan
Summary: The analogues of BPA, BPS and BPB, may induce oxidative stress and apoptosis in neuroblastoma cells, with males being more susceptible to BPs. Interestingly, BPS shows lower neurotoxic effects compared to BPA and BPB with BPA having a significantly higher impact on IMR-32 cells than on SK-N-SH cells.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Jing Guo, Chang-Guo Min, Kai-Yan Zhang, Cheng-Lin Zhan, Yu-Chan Wang, Sheng-Kui Hou, Xin Ma, Wen-Fa Lu
Summary: TBBPA exposure impaired oocyte maturation and developmental competence by disrupting both nuclear and cytoplasmic maturation of the oocyte, which might have been caused by oxidative stress induced by mitochondrial dysfunction.
Article
Environmental Sciences
Weiqi Sun, Zhijing Ni, Rui Li, Xiuli Chang, Weihua Li, Mingjun Yang, Zhijun Zhou
Summary: The study showed that flurochloridone induces apoptosis in TM4 cells through the mitochondrial apoptotic pathway, accompanied by accumulation of ROS, depolarization of the mitochondrial membrane potential, etc. Pretreatment with the ROS scavenger NAC significantly alleviated flurochloridone-induced cell apoptosis and MMP depolarization.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Review
Medicine, General & Internal
Lena Wischhof, Enzo Scifo, Dan Ehninger, Daniele Bano
Summary: Apoptosis-inducing factor (AIF) is a flavoprotein located in the mitochondrial intermembrane space, playing diverse roles in cellular physiology. This review focuses on AIF's contribution to chromatin condensation during cell death and its involvement in pathogenic mechanisms of inherited metabolic diseases. The study highlights AIF's role in promoting mitochondrial oxidative phosphorylation (OXPHOS) system for cell survival and discusses its potential therapeutic implications.
Article
Pharmacology & Pharmacy
Xia Gan, Mingyi Nie, Siying Cai, Yonghong Liu, Fan Zhang, Xiaotao Feng, Yunqiu Li, Bin Yang, Xueni Wang
Summary: Oxidative stress can either promote tumor development or induce cell death. Dankasterone A, derived from the fungus Talaromyces purpurogenu, has shown potential as an anti-prostate cancer compound. It was found to be cytotoxic to prostate cancer cells and inhibited cell proliferation and migration. Dankasterone A induced apoptosis by triggering intense oxidative stress, leading to the release of reactive oxygen species and upregulation of HO-1 protein expression. The anti-prostate cancer effects of Dankasterone A were also confirmed in a zebrafish xenograft tumor model.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Environmental Sciences
Xin-Le Lai, Wen-Jie Xiong, Li-Shu Li, Meng-Fan Lan, Jin-Xin Zhang, Yu-Ting Zhou, Dong Niu, Xing Duan
Summary: Zinc, an essential trace mineral, plays a critical role in various cellular processes. Zinc deficiency in patients with polycystic ovary syndrome (PCOS) has been found to affect the reproductive system, particularly oocyte quality. This study established an in vitro model to investigate the regulatory function of zinc in porcine oocyte maturation. The results showed that zinc deficiency disrupted meiotic progress and cytoskeleton structure, impaired mitochondrial function, perturbed cytosolic Ca2+ homeostasis, and induced mitophagy in porcine oocytes.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Biochemistry & Molecular Biology
Kana Yokoo, Yoshinari Yamamoto, Takuya Suzuki
Summary: Ammonia impairs TJ barrier in Caco-2 cells by increasing oxidative stress, leading to mitochondrial dysfunction, which may precede the ammonia-induced oxidative stress.
Review
Biochemistry & Molecular Biology
Tapan Behl, Rashita Makkar, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Gokhan Zengin, Simona Bungau, Felicia Liana Andronie-Cioara, Mihai Alexandru Munteanu, Mihaela Cristina Brisc, Diana Uivarosan, Ciprian Brisc
Summary: The human body is complex and comprises various living cells and extracellular material forming tissues, organs, and organ systems. While most human cells turnover regularly, postmitotic nerve cells have the exceptional ability to regenerate and sustain throughout an individual's life to safeguard the central nervous system's functioning. Neurodegenerative diseases, such as Parkinson's and Alzheimer's disease, result from factors like oxidative stress, cell death, and neuroinflammation, causing neuronal degradation and impacting the quality of life for millions worldwide.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Siyuan He, Xiaoqian Yu, Daxin Cui, Yin Liu, Shanshan Yang, Hongmei Zhang, Wanxin Hu, Zhiguang Su
Summary: Pancreatic NF-Y might play an essential role in regulating b-cell compensation under metabolic stress caused by insulin resistance in obesity. NF-Y deletion in b-cells worsened glucose intolerance and b-cell dysfunction, leading to increased apoptosis and reactive oxygen species production. This study provides insights into the mechanism of b-cell compensation in obesity-related type 2 diabetes.
CHINESE MEDICAL JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Kakali Bhadra
Summary: This article reviews the alternative pathways of cancer cell death targeted by anticancer drug molecules, providing a molecular basis for new strategies in cancer treatment. Many drugs can effectively induce cell death through targeting the caspase-independent cell death pathway, which is significant for cancer therapy.
Article
Biochemistry & Molecular Biology
Anwesha Bandyopadhyay, Sudip Kumar Ghosh
Summary: Our study shows the presence of a AIF-like protein in a caspase-deficient protozoan, suggesting the occurrence of apoptosis in unicellular organisms. The protein migrates to the nucleus upon stress and is involved in chromatin degradation and condensation. Down-regulating its expression attenuates apoptotic features, while over-expression enhances them. The widely-used drug metronidazole induces similar AIF-mediated cell death, indicating it as a probable mechanism of amoebicidal action. The occurrence of apoptosis in unicellular organisms may signify altruistic death that benefits the population health.
MOLECULAR MICROBIOLOGY
(2023)
Review
Dermatology
Yi Lin, Yuecen Ding, Yue Wu, Yiwen Yang, Ziqi Liu, Leihong Xiang, Chengfeng Zhang
Summary: Vitiligo is a depigmentary disorder caused by mitochondrial alterations and downregulation of Nrf2. The abnormal mitochondria lead to melanocyte loss, while Nrf2 plays a critical role in maintaining mitochondrial homeostasis.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Nonhlakanipho F. Sangweni, Phiwayinkosi V. Dludla, Nireshni Chellan, Lawrence Mabasa, Jyoti R. Sharma, Rabia Johnson
Summary: The study found that DMSO concentrations lower than 0.5% can enhance respiratory control ratio and cellular viability in cardiomyoblasts, while exposure to 3.7% DMSO increases apoptosis in cardiomyoblasts due to mitochondrial dysfunction and oxidative stress. In cancer cells, DMSO at concentrations equal to or higher than 0.009 reduces maximal respiratory capacity and ATP-linked respiration, leading to increased ROS production and apoptosis. Surprisingly, 0.001% DMSO exposure resulted in increased proliferative activity in cancer cells. These findings suggest caution when using DMSO in cancer cells, while demonstrating no cytotoxic effects or therapeutic benefits at concentrations equal to or lower than 0.5% in cardiomyoblasts.