Withaferin A induces apoptosis in human melanoma cells through generation of reactive oxygen species and down-regulation of Bcl-2

Reactive oxygen species, cellular redox systems, and apoptosis

(2010) Magdalena L. Circu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Notch-1 Inhibition by Withaferin-A: A Therapeutic Target against Colon Carcinogenesis

(2010) S. Koduru et al.   MOLECULAR CANCER THERAPEUTICS

Targeting mitochondria for cancer therapy

(2010) Simone Fulda et al.   NATURE REVIEWS DRUG DISCOVERY

Use of Human Cancer Cell Lines Mitochondria to Explore the Mechanisms of BH3 Peptides and ABT-737-Induced Mitochondrial Membrane Permeabilization

(2010) Nelly Buron et al.   PLoS One

Withaferin A targets heat shock protein 90 in pancreatic cancer cells

(2009) Yanke Yu et al.   BIOCHEMICAL PHARMACOLOGY

Withaferin A sensitizes TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of death receptor 5 and down-regulation of c-FLIP

(2009) Tae-Jin Lee et al.   FREE RADICAL BIOLOGY AND MEDICINE

Pharmacological screening and enzymatic assays for apoptosis

(2009) Anne-Sophie Belzacq-Casagrande   Frontiers in Bioscience-Landmark

Withaferin A induces apoptosis by activating p38 mitogen-activated protein kinase signaling cascade in leukemic cells of lymphoid and myeloid origin through mitochondrial death cascade

(2008) Chandan Mandal et al.   APOPTOSIS

Induction of apoptosis by withaferin A in human leukemia U937 cells through down-regulation of Akt phosphorylation

(2008) Jung Hwa Oh et al.   APOPTOSIS

Withaferin A Causes FOXO3a- and Bim-Dependent Apoptosis and Inhibits Growth of Human Breast Cancer Cells In vivo

(2008) S. D. Stan et al.   CANCER RESEARCH

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

(2008) G Kroemer et al.   CELL DEATH AND DIFFERENTIATION

Expression and Function of Bcl-2 Proteins in Melanoma

(2008) Jurgen Eberle et al.   CURRENT GENOMICS

Systemic therapy for metastatic malignant melanoma - from deeply disappointing to bright future?

(2008) Paul Lorigan et al.   EXPERIMENTAL DERMATOLOGY

Reactive oxygen species: an Achilles’ heel of melanoma?

(2008) John P Fruehauf et al.   Expert Review of Anticancer Therapy

Glutathione Depletion and Disruption of Intracellular Ionic Homeostasis Regulate Lymphoid Cell Apoptosis

(2008) Rodrigo Franco et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins

(2008) J. E. Chipuk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of BSO (L-buthionine-S,R-sulfoximine)-induced cytotoxic effects in neuroblastoma

(2007) Barbara Marengo et al.   FREE RADICAL BIOLOGY AND MEDICINE