Review
Cell Biology
Zhi Lin, Fei Long, Rui Kang, Daniel J. Klionsky, Minghua Yang, Daolin Tang
Summary: This article provides a comprehensive summary of the latest research on the role and potential mechanisms of different lipids in regulating regulated cell death processes, including apoptosis, necroptosis, pyroptosis, ferroptosis, and autophagy.
Article
Cell Biology
Baijie Jin, Jing Ren, Jinzi Chen, Zimei Dong, Guangwen Chen, Dezeng Liu
Summary: This study identifies three autophagy-related (Atg) genes from Dugesia japonica and examines their roles in planarian regeneration. The research shows that these genes are involved in autophagy and regeneration processes, and their knockdown leads to different effects on planarians, suggesting a link between autophagy, proliferation, and cell death during regeneration.
CELL AND TISSUE RESEARCH
(2022)
Article
Genetics & Heredity
Qinghua Wang, Lijuan Xie, Yixuan Wang, Baijie Jin, Jing Ren, Zimei Dong, Guangwen Chen, Dezeng Liu
Summary: This study investigates the roles of HSP70s in planarian regeneration and finds that Djhsp70s are not only conserved in cytoprotection, but also play a role in maintaining homeostasis and regulating cell proliferation and apoptosis during regeneration.
Article
Biochemistry & Molecular Biology
Qing-Xin Ji, Fei-Yan Zeng, Jian Zhou, Wen-Bin Wu, Xu-Jie Wang, Zhen Zhang, Guo-Yan Zhang, Jie Tong, Di-Yang Sun, Jia-Bao Zhang, Wen-Xiang Cao, Fu-Ming Shen, Jin-Jian Lu, Dong-Jie Li, Pei Wang
Summary: This study explores the potential role of ferroptosis in smooth muscle cell (SMC) phenotypic switch and neointimal formation. It found that ferroptotic stress is triggered in dedifferentiated SMCs and arterial neointimal tissue. Inhibition of ferroptosis delays SMC phenotype switch and arterial remodeling, while ferroptosis stress directly triggers SMC dedifferentiation.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Multidisciplinary Sciences
Andy Chan, Sophia Ma, Bret J. Pearson, Danny Chan
Summary: The extracellular matrix plays a crucial role in the maintenance, regeneration, and differentiation of stem cells within their niche. By studying the collagen gene family in the freshwater planarian Schmidtea mediterranea, researchers have identified a key gene, col4-1, which influences the proliferation of neoblasts. Furthermore, evidence suggests that an interaction between type IV collagen, the discoidin domain receptor, and neuregulin-7 regulate the balance of symmetric and asymmetric division of neoblasts through the NRG-7/EGFR pathway.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Pharmacology & Pharmacy
Srimanta Patra, Prakash P. Praharaj, Amruta Singh, Sujit K. Bhutia
Summary: SIRT1 plays a significant role in cancer regulation by regulating cellular localization and deacetylation activity. Its multifactorial role in autophagy regulates cancer-associated cellular phenotypes, aiding cellular survival and cell death. SIRT1-mediated deacetylation of autophagy-related genes and associated signaling mediators controls carcinogenesis.
DRUG DISCOVERY TODAY
(2023)
Review
Biochemistry & Molecular Biology
Jun Huang, Zaoshang Chang, Quzhe Lu, Xuedong Chen, Masoud Najafi
Summary: Cancer resistance to therapy is a significant challenge in cancer treatment, involving reduced induction of cell death and decreased response to anti-tumor immunity. Nobiletin can induce endogenous ROS generation, leading to damage to critical macromolecules and ultimately cell death. Additionally, NOB can induce cancer cell killing by modulating multiple mechanisms of cell death.
Article
Cell Biology
Pablo Coronel-Cordoba, M. Dolores Molina, Gemma Cardona, Susanna Fraguas, Eudald Pascual-Carreras, Emili Salo, Francesc Cebria, Teresa Adell
Summary: Fox genes, including the less characterized FoxK genes, play important roles in controlling various cellular processes. A recent study identified three foxK paralogs in the genome of Schmidtea mediterranea, showing that foxK1 inhibition affects regeneration of ectodermal tissues by influencing apoptosis. These results suggest that foxK1 is required for differentiation and maintenance of ectodermal tissues in planarians.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yael Dagan, Yarden Yesharim, Ashley R. Bonneau, Tamar Frankovits, Schraga Schwartz, Peter W. Reddien, Omri Wurtzel
Summary: m6A plays a critical role in the regulation of gene expression and chromatin modifications, contributing to the homeostasis and regeneration of planarian stem cells.
Review
Cell Biology
Xiao-yu Wu, Wen-Wen Xu, Xiang-kun Huan, Guan-nan Wu, Gang Li, Yu-Hong Zhou, Masoud Najafi
Summary: Resistance of cancer cells to anti-tumour agents is a major challenge in cancer treatment. Metformin, an antidiabetic drug, can enhance cell death mechanisms and play a key role in inducing cell death, thereby increasing the therapeutic efficiency of anti-cancer therapy.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Review
Engineering, Marine
Viviana Di Tuccio, Pasquale De Luca, Giovanna Romano
Summary: The sea urchin embryo is a widely used model system to study biological processes and investigate molecular and cellular responses to external stress factors. Programmed cell death (PCD) is a regulated molecular mechanism that plays a central role in tissue rearrangement and development, especially during metamorphosis, and is activated in response to abiotic stress. This review summarizes the current knowledge about the involvement of PCD processes in sea urchin embryos exposed to pollutants and provides information about the occurrence of physiological apoptosis during development.
JOURNAL OF MARINE SCIENCE AND ENGINEERING
(2023)
Review
Cell Biology
Juntao Cui, Suhan Zhao, Yinghui Li, Danyang Zhang, Bingjing Wang, Junxia Xie, Jun Wang
Summary: Regulated cell death (RCD) is a crucial process in maintaining tissue homeostasis and restoring biological balance, involving various forms of cell death with complex interactions. Understanding of the role of RCD in evolution, development, physiology, and disease is improving, with a focus on key mechanisms of RCD and its critical role in neurodegenerative diseases.
CELL COMMUNICATION AND SIGNALING
(2021)
Review
Oncology
Yifan Cheng, Misha Mao, Yong Lu
Summary: YAP plays a critical role in regulating tumor progression and is closely related to programmed cell death (PCD). YAP activity can be regulated by kinase cascade pathways and other proteins. It has been found that YAP can affect multiple forms of PCD and act as a bridge between different forms of PCD in tumor development.
BIOMARKER RESEARCH
(2022)
Review
Cell Biology
Angga Wiratama Lokeswara, Rabbania Hiksas, Rima Irwinda, Noroyono Wibowo
Summary: Preeclampsia, a common obstetrical complication, is linked to abnormal placental development and cellular health, with nutritional adequacy playing a crucial role. Cellular components' structural integrity affects physiological cell death mechanisms, while nutritional deficiencies can disrupt these processes, leading to poor trophoblast invasion and differentiation in preeclampsia.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Zoology
Jia-Jia Chen, Kai Lei
Summary: Planarians, the most primitive bilateral triploblastic animals, possess robust whole-body regeneration capacity, making them ideal model organisms for regenerative research. Recent studies have elucidated the cellular mechanisms underlying regeneration, particularly the role of stem cells in tissue homeostasis and regeneration.
ZOOLOGICAL RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Gustavo Rodriguez-Esteban, Alejandro Gonzalez-Sastre, Jose Ignacio Rojo-Laguna, Emili Salo, Josep F. Abril
Article
Developmental Biology
Alejandro Gonzalez-Sastre, Nidia De Sousa, Teresa Adell, Emili Salo
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
(2017)
Editorial Material
Immunology
Oscar Gutierrez-Gutierrez, Daniel A. Felix, Cristina Gonzalez-Estevez
Review
Cell Biology
Daniel A. Felix, Oscar Gutierrez-Gutierrez, Lilia Espada, Anne Thems, Cristina Gonzalez-Estevez
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2019)
Article
Developmental Biology
Alejandro Gonzalez-Sastre, Ma Dolores Molina, Emili Salo
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
(2012)
Article
Developmental Biology
Cristina Gonzalez-Estevez, Daniel A. Felix, Gustavo Rodriguez-Esteban, A. Aziz Aboobaker
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
(2012)
Article
Multidisciplinary Sciences
Maria Emilia Isolani, Josep F. Abril, Emili Salo, Paolo Deri, Anna Maria Bianucci, Renata Batistoni
Article
Genetics & Heredity
Maria Almuedo-Castillo, Xenia Crespo, Florian Seebeck, Kerstin Bartscherer, Emili Salo, Teresa Adell
Article
Biotechnology & Applied Microbiology
Teresa Adell, Emili Salo, Jack J. W. A. van Loon, Gennaro Auletta
BIOMED RESEARCH INTERNATIONAL
(2014)
Article
Cell & Tissue Engineering
Marta Iglesias, Daniel A. Felix, Oscar Gutierrez-Gutierrez, Maria del Mar De Miguel-Bonet, Sounak Sahu, Beatriz Fernandez-Varas, Rosario Perona, A. Aziz Aboobaker, Ignacio Flores, Cristina Gonzalez-Estevez
Editorial Material
Cell Biology
Cristina Gonzalez-Estevez
Article
Cell Biology
Paul M. Jordan, Jana Gerstmeier, Simona Pace, Rossella Bilancia, Zhigang Rao, Friedemann Boerner, Laura Miek, Oscar Gutierrez-Gutierrez, Vandana Arakandy, Antonietta Rossi, Armando Ialenti, Cristina Gonzalez-Estevez, Bettina Loeffler, Lorena Tuchscherr, Charles N. Serhan, Oliver Werz
Article
Biochemistry & Molecular Biology
Oscar Gutierrez-Gutierrez, Daniel A. Felix, Alessandra Salvetti, Elias M. Amro, Anne Thems, Stefan Pietsch, Andreas Koeberle, K. Lenhard Rudolph, Cristina Gonzalez-Estevez
Summary: Planarians can endure starvation by maintaining adult stem cell pools and regenerative capacity. TRiC/CCT subunits play a crucial role in maintaining regeneration under starvation conditions by modulating the unfolded protein response and maintaining ATP levels.
Article
Multidisciplinary Sciences
Maria Thuermer, Andre Gollowitzer, Helmut Pein, Konstantin Neukirch, Elif Gelmez, Lorenz Waltl, Natalie Wielsch, Rene Winkler, Konstantin Loeser, Julia Grander, Madlen Hotze, Sonke Harder, Annika Doeding, Martina Messner, Fabiana Troisi, Maximilian Ardelt, Hartmut Schlueter, Johanna Pachmayr, Oscar Gutierrez-Gutierrez, Karl Lenhard Rudolph, Kathrin Thedieck, Ulrike Schulze-Spaete, Cristina Gonzalez-Estevez, Christian Kosan, Ales Svatos, Marcel Kwiatkowski, Andreas Koeberle
Summary: The study reveals that PI(18:1/18:1) is a signaling lipid derived from SCD1 that connects fatty acid unsaturation with stress responses, regulating stress adaption, protecting against cell death, and promoting proliferation.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Sarmistha Deb, Daniel A. Felix, Philipp Koch, Maharshi Krishna Deb, Karol Szafranski, Katrin Buder, Mara Sannai, Marco Groth, Joanna Kirkpatrick, Stefan Pietsch, Andre Gollowitzer, Alexander Gross, Philip Riemenschneider, Andreas Koeberle, Cristina Gonzalez-Estevez, Karl Lenhard Rudolph
Summary: The study identifies Tnfaip2 and Smed-exoc3 as key regulators of lipid metabolism, essential for ESC differentiation and planarian organ maintenance. Tnfaip2 knockout impairs ESC differentiation, while depletion of Smed-exoc3 affects tissue homeostasis and regeneration in planarians.