Review
Obstetrics & Gynecology
Yushuang Zheng, Donglu Li, Xinran Li, Aman Zheng, Fan Wang
Summary: This paper reports two cases of fetomaternal hemorrhage with unknown causes. Emergency caesarean sections were performed for non-reassuring fetal status and neonatal blood transfusion was administered. Fetomaternal hemorrhage was confirmed via maternal Kleihauer-Betke test. The study found parenchymal pallor, increased nucleated red blood cells (nRBCs), and syncytial knots (SKs) in the placentas, which are compatible with fetal anemia. Immunohistochemical staining indicated VEGF, CD34, and CD31 expression in the endothelial cells of the capillaries, characteristic of massive FMH placenta. This article also reviews the particular histopathological changes in FHM placenta according to the placental lesion classification system.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Developmental Biology
Amine Bouachba, Fabienne Allias, Beatrice Nadaud, Jerome Massardier, Yahia Mekki, Maude Bouscambert Duchamp, Benoit De L. A. Fourniere, Cyril Huissoud, Alexis Trecourt, Sophie Collardeau-Frachon
Summary: The study reported 5 cases of poor fetal outcomes in pregnant women with COVID-19, including 3 fetal deaths and 2 extreme premature neonates. All placentas showed massive perivillous fibrin deposition and large intervillous thrombi, associated with strong SARS-CoV-2 expression in trophoblast and RT-PCR positivity for the virus in amniotic fluid or placenta samples.
Article
Medicine, General & Internal
Andrea Marzullo, Emmanuela Vitelli, Gerardo Cazzato, Margherita Fanelli, Giuseppe Ingravallo, Antonella Vimercati, Roberta Rossi, Leonardo Resta
Summary: This study retrospectively analyzed 2063 placentas and identified 70 placentas affected by angiodysplasia. The analysis found a significant association between placental angiodysplasia and neonatal outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Obstetrics & Gynecology
Julian K. Christians
Summary: Fetal sex impacts pregnancy complications and long-term health effects of prenatal environment, with placenta playing a crucial role. Sexual dimorphism may affect gene expression, responses to nutrient supply, and histopathology, but there is no clear pattern supporting the hypothesis that one sex is more responsive. More robust statistical approaches are needed to test for sex-dependent effects in order to reduce spurious results.
REPRODUCTIVE SCIENCES
(2022)
Article
Obstetrics & Gynecology
Daniel Tairy, Eran Weiner, Letizia Schreiber, Hadas Miremberg, Liat Gindes, Roni Hochman, Jacob Bar, Michal Kovo
Summary: Anterior placenta previa is associated with adverse maternal and neonatal outcomes, lower placental weights, and an increased rate of malperfusion lesions. Abnormal placentation in scarred uterine walls may impact placental function.
REPRODUCTIVE SCIENCES
(2021)
Article
Developmental Biology
Anat Shmueli, Liat Mor, Ophir Blickstein, Rinat Sela, Eran Weiner, Noa Gonen, Letizia Schreiber, Michal Levy
Summary: Late fetal growth restriction (FGR) is associated with mild growth restriction and normal or mild abnormal doppler flows. Abnormal cerebroplacental ratio (CPR) in late FGR is reflected in placental vascular malperfusion lesions, resulting in adverse maternal and neonatal outcomes.
Article
Microbiology
Mercedes M. Burucua, Maria A. Risalde, Felipe A. Cheuquepan, Silvina Quintana, Sandra E. Perez, German J. Canton, Dadin P. Moore, Anselmo C. Odeon, Irene Agullo-Ros, Maria Valeria Scioli, Claudio Barbeito, Eleonora L. Morrell, Maia S. Marin
Summary: This study investigated the immune response in bovine placentas and fetal lungs infected with BoAHV-1. The results revealed mild inflammatory responses in infected tissues, with high expression levels of inducible nitric oxide synthase, tumor necrosis factor-alpha, and cyclooxeganse-2. The findings provide strong evidence of an early immune response to BoAHV-1 infection in the fetus.
VETERINARY MICROBIOLOGY
(2023)
Article
Pediatrics
Gloria Brembilla, Andrea Righini, Barbara Scelsa, Gianluca Lista, Marina Balestriero, Elena Cesari, Francesca Maria Castoldi, Martina Di Stasi, Chiara Ciardi, Elisa Ligato, Emanuela Taricco, Irene Cetin
Summary: This study found that FGR plays an additional role in determining brain impairment compared to prematurity. Infants with FGR showed smaller cerebral parenchymal areas than preterm controls. There was a positive correlation between the parenchyma area and cognitive score, emphasizing the importance of early structural dimensional MRI evaluation in identifying high-risk infants, even in the absence of overt brain lesions.
PEDIATRIC RESEARCH
(2021)
Article
Education & Educational Research
Samantha Waugh, James Devin, Alfred King-Yin Lam, Vinod Gopalan
Summary: During the COVID-19 pandemic, Griffith University in Australia implemented online histopathology teaching, which was well received by students and led to improved learning outcomes compared to traditional face-to-face teaching methods.
BMC MEDICAL EDUCATION
(2022)
Article
Microbiology
Natalia Salomao, Kissila Rabelo, Elyzabeth Avvad-Portari, Carlos Basilio-de-Oliveira, Rodrigo Basilio-de-Oliveira, Fatima Ferreira, Luiz Ferreira, Thiara Manuele de Souza, Priscila Nunes, Monique Lima, Anna Paula Sales, Regina Fernandes, Luiz Jose de Souza, Laura Dias, Patricia Brasil, Flavia dos Santos, Marciano Paes
Summary: This study investigates the role of placenta in the transmission of CHIKV and the effects of infection on the maternal-fetal interface. Results show that CHIKV infection disrupts placental homeostasis, leading to histopathological alterations and increased cellularity and cytokine release, creating an altered and harmful environment for the pregnant woman and fetus.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Obstetrics & Gynecology
Kathy C. Matthews, Nathan S. Fox, Andrei Rebarber
Summary: In twin pregnancies, there is no association between FGR and PEC with abnormal placental histopathology. This indicates that the pathologic placental manifestations of these conditions may differ in twins, suggesting factors beyond those commonly described in singletons.
AMERICAN JOURNAL OF PERINATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Thijs W. de Vos, Dian Winkelhorst, Hans J. Baelde, Kyra L. Dijkstra, Rianne D. M. van Bergen, Lotte E. van der Meeren, Peter G. J. Nikkels, Leendert Porcelijn, C. Ellen van der Schoot, Gestur Vidarsson, Michael Eikmans, Rick Kapur, Carin van der Keur, Leendert A. Trouw, Dick Oepkes, Enrico Lopriore, Marie-Louise P. van der Hoorn, Manon Bos, Masja de Haas
Summary: This study found that untreated FNAIT cases showed more C4d deposition in the placenta, which may impact placental function and fetal growth. Histopathological examination revealed a certain proportion of placental delayed maturation in these cases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Gregory Verghese, Jochen K. Lennerz, Danny Ruta, Wen Ng, Selvam Thavaraj, Kalliopi P. Siziopikou, Threnesan Naidoo, Swapnil Rane, Roberto Salgado, Sarah E. Pinder, Anita Grigoriadis
Summary: Computational pathology refers to the use of deep learning techniques and algorithms to analyze and interpret histopathology images. Despite its promising potential, the integration of computational pathology in clinical settings is hindered by various obstacles, including operational, technical, regulatory, ethical, financial, and cultural challenges.
JOURNAL OF PATHOLOGY
(2023)
Article
Psychiatry
Cristina Cheroni, Sebastiano Trattaro, Nicolo Caporale, Alejandro Lopez-Tobon, Erika Tenderini, Sara Sebastiani, Flavia Troglio, Michele Gabriele, Raul Bardini Bressan, Steven M. Pollard, William T. Gibson, Giuseppe Testa
Summary: Brain organoids are important for understanding the molecular mechanisms of psychiatric and neurological conditions. In this study, the gene expression patterns of brain organoids from different protocols were compared to those of fetal cortex. The relevance of identified gene modules for neurodevelopmental disorders and psychiatric conditions was evaluated. The study also revealed a two-step differentiation process of brain organoids. The findings provide valuable insights into the modeling of human corticogenesis and its impact on neuropsychiatric outcomes.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Obstetrics & Gynecology
Clare B. O'Hare, Kathryn S. Mangin-Heimos, Hongjie Gu, Miranda Edmunds, Michael Bebbington, Caroline K. Lee, Mai He, Cynthia M. Ortinau
Summary: This study applied Amsterdam criteria to compare and evaluate the placental abnormalities in pregnancies with fetal congenital heart disease. The results indicate that delayed villous maturation and maternal vascular malperfusion are more common in pregnancies with fetal congenital heart disease, suggesting a potential association between placental maldevelopment and maternal factors.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
