Article
Biochemistry & Molecular Biology
Chrysostomos Avgeros, Aikaterini Patsatsi, Dimitrios Dimitriadis, Andigoni Malousi, Triantafyllia Koletsa, Despoina Papathemeli, Antonia Syrnioti, Paraskevi Avgerou, Elizabeth Lazaridou, Georgios Tzimagiorgis, Elisavet Georgiou
Summary: This study evaluates the plasma levels of miR-146a and miR-155 in Mycosis Fungoides (MF) patients and investigates their association with SNPs of their genes. The results show that the plasma levels of miR-146a and miR-155 are significantly higher in MF patients compared to controls, especially in early and advanced stages. miR-155 levels are significantly higher in patients with skin tumors or erythroderma. The presence of specific SNPs is associated with the expression of miRs and potentially with disease susceptibility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Chairmandurai Aravindraja, Syam Jeepipalli, Krishna Mukesh Vekariya, Ruben Botello-Escalante, Edward K. L. Chan, Lakshmyya Kesavalu
Summary: This study aimed to investigate the global miRNA expression kinetics during the progression of periodontitis in mice infected with T. denticola. The results showed that T. denticola infection led to bacterial colonization and increased alveolar bone resorption. A total of 70 miRNAs with differential expression were identified, and miR-486, miR-126-3p, and miR-126-5p were found to be potential invasive biomarkers of T. denticola in periodontal disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Prasenjit Mitra, Taru Goyal, Preeti Singh, Shailja Sharma, Praveen Sharma
Summary: The study found that miR-155 and miR-221 were significantly upregulated in occupationally lead-exposed workers, while miR-20b showed no significant difference. These miRNAs have the potential to trigger various genes and cellular pathways, highlighting the importance of miRNA dysregulation in the systemic effects of lead toxicity.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Review
Immunology
Salar Pashangzadeh, Morteza Motallebnezhad, Fatemeh Vafashoar, Azadeh Khalvandi, Nazanin Mojtabavi
Summary: miRNAs, especially miR-155, play crucial roles in immune system regulation, and their altered expression and function may contribute to vulnerability to autoimmune diseases and significant dysfunction of the immune system.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Genetics & Heredity
Anna Mizielska, Iga Dziechciowska, Radoslaw Szczepanski, Malgorzata Cisek, Malgorzata Dabrowska, Jan Slezak, Izabela Kosmalska, Marta Rymarczyk, Klaudia Wilkowska, Barbara Jacczak, Ewa Toton, Natalia Lisiak, Przemyslaw Kopczynski, Blazej Rubis
Summary: One of the most innovative medical trends is personalized therapy, which focuses on detecting unique features of cancer cells. The miRNA family may serve as good prognostic and diagnostic markers for breast cancer. This study evaluated changes in selected miRNA levels in breast cancer cell lines treated with doxorubicin or cisplatin, and identified potential miRNAs that respond to these treatments.
Article
Chemistry, Analytical
Fatemeh Khosravi, Mahdi Rahaie, Mohammad Reza Ghaani, Mostafa Azimzadeh, Ebrahim Mostafavi
Summary: Electrochemical nanobiosensors have revolutionized medical diagnosis with their enhanced sensitivity provided by the utilized nanomaterials. In this study, a novel sensitive electrochemical nanobiosensor for miR-155, a biomarker for early breast cancer detection, was introduced. The nanobiosensor utilized a combination of Fe-Ni@rGO, GQD-Ag, and GNS nanomaterials to expand the surface area and conductivity of the electrode, resulting in high sensitivity and specificity for miR-155 detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Review
Biochemistry & Molecular Biology
Karina Maciak, Angela Dziedzic, Elzbieta Miller, Joanna Saluk-Bijak
Summary: miR-155 plays a crucial role in regulating inflammation and autoimmune responses in multiple sclerosis, impacting processes such as blood-brain barrier disruption and neuropathic pain. Its dysregulation has also been linked to neuropsychiatric symptoms associated with the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Da Wang, Fei Xiong, Guanhua Wu, Wenzheng Liu, Bing Wang, Yongjun Chen
Summary: The study found that in cholangiocarcinoma, miR-155-5p targets the 3' UTR of SOX1, activating the RAF/MEK/ERK pathway and promoting cancer progression.
CANCER CELL INTERNATIONAL
(2021)
Article
Pharmacology & Pharmacy
Stephanie He, Davindra Singh, Hossein Yusefi, Brandon Helfield
Summary: This study investigates the feasibility of delivering the angiogenesis-promoting miR-126 using ultrasound-stimulated microbubbles. The results show that by stimulating miR-126-decorated microbubbles, the intracellular levels of miR-126 can be increased while decreasing the expression of its target genes. This delivery method has the potential to stimulate therapeutic angiogenesis while minimizing endothelial damage.
Article
Cell Biology
Monika Adamowicz, Agnieszka Kempinska-Podhorodecka, Joanna Abramczyk, Jesus M. Banales, Piotr Milkiewicz, Malgorzata Milkiewicz
Summary: The expression of PPARα is reduced in the liver of patients with primary biliary cholangitis (PBC), likely due to overexpression of miR-155. Ursodeoxycholic acid (UDCA) effectively reduces the expression of miR-155, preventing the suppression of PPARα.
Review
Biochemistry & Molecular Biology
Owen Dawson, Anna Maria Piccinini
Summary: miRNA strand selection is an important process in miRNA regulation, and its selection and functionality are closely related to areas such as immunity and cancer.
Article
Neurosciences
Jakub Litak, Wieslawa Grajkowska, Jacek Bogucki, Pawel Kowalczyk, Alicja Petniak, Arkadiusz Podkowinski, Justyna Szumilo, Janusz Kocki, Jacek Rolinski, Mansur Rahnama-Hezavah, Marcin Roszkowski, Cezary Grochowski
Summary: High-grade pediatric glioma is a common malignancy in children. This study found a significant correlation between miR-155 concentration and PD-L1 expression in tumor tissue.
Article
Oncology
Naveen Challagundla, Reena Agrawal-Rajput
Summary: A novel approach of microRNA-induced trans-differentiation of macrophages to induced neuronal cells without exogenous use of transcription factors was reported. The reprogramming involved alteration of pluripotency genes and miRs, with functional and active neurons obtained, suggesting potential clinical applications.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Medicine, Research & Experimental
Mengdi Shang, Yiyang Wu, Yeyang Wang, Yanfei Cai, Jian Jin, Zhaoqi Yang
Summary: This study developed a strategy using nanoparticles to co-deliver antisense oligonucleotides and photosensitizers into tumor cells, effectively inhibiting proliferation and metastasis of triple negative breast cancer cells.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Veterinary Sciences
Sally Ibrahim, Mohamed Hedia, Mohamed O. Taqi, Mohamed K. Derbala, Karima Gh M. Mahmoud, Youssef Ahmed, Sayed Ismail, Mohamed El-Belely
Summary: The study revealed higher concentrations of IL-6, PGE(2), and PGF(2 alpha) in mares with endometritis compared to controls, with age having a significant impact on these concentrations. The expression levels of eca-miR-155, eca-miR-223, eca-miR-17, eca-miR-200a, and eca-miR-205 were higher in mares with endometritis, especially in older mares. This is the first study to show changes in cell free miRNA and serum inflammatory mediators during endometritis in mares, providing insights into the pathophysiology mechanisms of this condition in equine.
VETERINARY SCIENCES
(2021)
Article
Hematology
Maria Gluud, Emil M. H. Pallesen, Terkild B. Buus, Lise Mette Rahbek Gjerdrum, Lise M. Lindahl, Maria R. Kamstrup, Michael Bzorek, Maria Danielsen, Rikke Bech, Madalena N. Monteiro, Edda Blumel, Andreas Willerslev-Olsen, Anders Lykkebo-Valloe, Chella Krishna Vadivel, Thorbjorn Krejsgaard, Charlotte Menne Bonefeld, Carsten Geisler, Juergen C. Becker, Sergei B. Koralov, Lars Iversen, Thomas Litman, Anders Woetmann, Niels Odum
Summary: Cutaneous T-cell lymphoma (CTCL) is a devastating lymphoid malignancy characterized by the accumulation of malignant T cells in the dermis and epidermis. Skin lesions cause serious symptoms and increase the risk of bacterial infection. The study found that malignant T cells secrete cytokines that downregulate the expression of filaggrin and filaggrin-2, leading to compromised skin barrier. Treatment with JAK inhibitors can reverse this effect and increase filaggrin expression in patients with advanced CTCL.
Article
Dermatology
Lydia Ouchene, Anastasiya Muntyanu, Deborah Assayag, Evicka Veilleux, Andy Abril, Giovanni Ferrara, Elaine Yacyshyn, Christian A. Pineau, Elizabeth O'Brien, Murray Baron, Mohammed Osman, Robert Gniadecki, Elena Netchiporouk
Summary: This article introduces dermatologists to the noninfectious inflammatory skin diseases associated with pulmonary involvement and emphasizes the importance of screening and monitoring for lung disease in high-risk patients. It also highlights the need for dermatologists to recognize cutaneous manifestations of lung disease and refer patients to pulmonary specialists for appropriate treatment. The article emphasizes the common pulmonary complications and high mortality rates associated with autoimmune connective tissue diseases, sarcoidosis, vasculitis, and autoimmune blistering diseases.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Editorial Material
Dermatology
Melika Motamedi, Giovanni Ferrara, Elaine Yacyshyn, Mohammed Osman, Andy Abril, Samia Rahman, Elena Netchiporouk, Robert Gniadecki
Summary: Numerous inflammatory, neoplastic, and genetic skin disorders are associated with interstitial lung disease (ILD), the fibrosing inflammation of lung parenchyma that has significant morbidity and mortality. Therefore, the dermatologist plays a major role in the early detection and appropriate referral of patients at risk for ILD.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Review
Dermatology
Joseph F. Merola, Arthur Kavanaugh, Mark G. Lebwohl, Robert Gniadecki, Jashin J. Wu
Summary: Metabolic syndrome (MetS) is a common comorbidity of psoriasis that affects the efficacy and safety of psoriasis treatment. There is limited evidence on the efficacy of biologics in MetS patients, and the impact of obesity on treatment response further complicates interpretation of the effect of MetS. Special attention should be given to cardiovascular safety and exacerbation of related conditions in patients with concomitant MetS.
DERMATOLOGY AND THERAPY
(2022)
Article
Computer Science, Interdisciplinary Applications
Marleine Azar, Francois Lagace, Anastasiya Muntyanu, Elena Netchiporouk, Youwen Zhou, Charles Lynde, Linda Moreau, Steve Mathieu, Denis Sasseville, Rachel Asiniwasis, Neil H. Shear, Robert Gniadecki, Elham Rahme, Ivan V. Litvinov
Summary: This study examined the relationship between h-index and academic rank, sex, and other factors in dermatology in Canada. The results showed an increase in female dermatologists and found no association between h-index and sex.
Article
Allergy
Anders Boutrup Funch, Julie Friis Weber, Rebecca Kitt Davidson Lohmann, Veronika Mraz, Kelvin Yeung, Mia Hamilton Jee, Niels Odum, Anders Woetmann, Jeanne Duus Johansen, Carsten Geisler, Charlotte Menne Bonefeld
Summary: This study reveals that clinically relevant contact allergens can generate pathogenic, epidermal CD8(+) T-RM cells that recruit neutrophils following re-exposure to the allergen, but this response is normally suppressed by the induction of anti-inflammatory CD4(+) T cells.
CONTACT DERMATITIS
(2023)
Article
Biochemistry & Molecular Biology
Kelly Cristina Gomes Manfrere, Marina Passos Torrealba, Frederico Moraes Ferreira, Emanuella Sarmento Alho de Sousa, Denis Miyashiro, Franciane Mouradian Emidio Teixeira, Ricardo Wesley Alberca Custodio, Helder I. Nakaya, Yasmin Alefe Leuzzi Ramos, Mirian Nacagami Sotto, Anders Woetmann, Niels odum, Alberto Jose da Silva Duarte, Jose Antonio Sanches, Maria Notomi Sato
Summary: This study investigated the expression levels of inflammatory markers IL-1B and IL-18 in the skin, serum, blood cells, and lymph nodes of patients with Sezary syndrome, as potential markers of inflammasome activation. The findings showed compartmentalized expressions of IL-1B and IL-18, with increased expression of IL-1B in the epidermis and increased expression of IL-18 in the dermis. In advanced stages of the disease, enhanced expression of IL-18 and downregulation of IL-1B were observed in the lymph nodes. This study provided the first evidence of the imbalance of IL-1B and IL-18 in patients with Sezary syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dermatology
Aaron M. M. Drucker, Omer Kleiner, Rachael Manion, Anie Philip, Jan Dutz, Kathleen Barnard, Julie Fradette, Lucie Germain, Robert Gniadecki, Ivan Litvinov, Sarvesh Logsetty, Morris Manolson, P. Regine Mydlarski, Vincent Piguet, Debbie Ward, Youwen Zhou, An-Wen Chan
Summary: The Skin Investigation Network of Canada (SkIN Canada) identified the top ten research priorities for nine key skin conditions through surveys, scoping reviews, and workshops, emphasizing the importance of involving patients and healthcare providers.
JOURNAL OF CUTANEOUS MEDICINE AND SURGERY
(2023)
Article
Cell Biology
Robert Gniadecki, Sandra O'Keefe, Dylan Hennessey, Aishwarya Iyer
Summary: Ultraviolet radiation is a strong carcinogen responsible for most skin cancers. However, its role in the pathogenesis of mycosis fungoides (MF) is still controversial.
Article
Dermatology
Kim A. Papp, Barbara Melosky, Sandeep Sehdev, Sebastien J. Hotte, Jennifer R. Beecker, Mark G. Kirchhof, Irina Turchin, Jan P. Dutz, Melinda J. Gooderham, Robert Gniadecki, Chih-ho Hong, Jo Lambert, Charles W. Lynde, Vimal H. Prajapati, Ronald B. Vender
Summary: Patients with previously treated solid tumors may have an increased risk of cancer recurrence when treated with systemic therapies for psoriasis, but for patients with a good cancer prognosis, treating psoriasis with systemic therapies may offer quality-of-life benefits.
DERMATOLOGY AND THERAPY
(2023)
Article
Allergy
Veronika Mraz, Anders B. Funch, Mia H. Jee, Anne-Sofie O. Gadsboll, Julie F. Weber, Kelvin Yeung, Rebecca K. D. Lohmann, Alana Hawkes, Niels Odum, Anders Woetmann, Dianne Mckay, Deborah Witherden, Carsten Geisler, Charlotte M. Bonefeld
Summary: CD8(+) TRM cells play a key role in allergic contact dermatitis (ACD), and CD100 is an essential protein for the activation of CD8(+) TRM cells and the flare-up response of ACD.
CONTACT DERMATITIS
(2023)
Article
Allergy
Veronika Mraz, Rebecca K. D. Lohmann, Mandy Menzel, Alana Hawkes, Helen Vaher, Anders B. Funch, Mia H. Jee, Anne-Sofie o. Gadsboll, Julie F. Weber, Kelvin Yeung, Niels Odum, Anders Woetmann, Dianne Mckay, Deborah Witherden, Carsten Geisler, Charlotte M. Bonefeld
Summary: This study reveals the central role of JAML in CHS and suggests a potential new target for the treatment of ACD in humans.
CONTACT DERMATITIS
(2023)
Article
Oncology
Francois Lagace, Bibi Nuzha Noorah, Santina Conte, Lorena Alexandra Mija, Jasmine Chang, Leila Cattelan, Jonathan LeBeau, Joel Claveau, Irina Turchin, Wayne Gulliver, Robert Gniadecki, Elena Netchiporouk, Wilson H. Miller, Thomas G. Salopek, Elham Rahme, Sandra Pelaez, Ivan V. Litvinov
Summary: This study compared the differences in sun exposure, sun protection, and level of worry for cutaneous melanoma between high-incidence and low-incidence provinces in Atlantic Canada, as well as between different demographic groups. The findings identified significant differences across multiple variables, which will help guide future public health efforts in preventing and reducing the incidence of cutaneous melanoma in the communities.
Correction
Dermatology
Kim A. Papp, Jennifer Beecker, Curtis Cooper, Mark G. Kirchhof, Anton L. Pozniak, Juergen K. Rockstroh, Jan P. Dutz, Melinda J. Gooderham, Robert Gniadecki, Chih-ho Hong, Charles W. Lynde, Catherine Maari, Yves Poulin, Ronald B. Vender, Sharon L. Walmsley
DERMATOLOGY AND THERAPY
(2023)
Review
Oncology
Johanna Latzka, Chalid Assaf, Martine Bagot, Antonio Cozzio, Reinhard Dummer, Emmanuella Guenova, Robert Gniadecki, Emmilia Hodak, Constanze Jonak, Claus-Detlev Klemke, Robert Knobler, Stephen Morrris, Jan P. Nicolay, Pablo L. Ortiz-Romero, Evangelia Papadavid, Nicola Pimpinelli, Pietro Quaglino, Annamari Ranki, Julia Scarisbrick, Rudolf Stadler, Liisa Vakeva, Maarten H. Vermeer, Ulrike Wehkamp, Sean Whittaker, Rein Willemze, Franz Trautinger
Summary: This document provides an updated standard for the treatment of mycosis fungoides and Sezary syndrome (MF/SS), including treatment options for each disease stage. Skin-directed therapies are the most appropriate option for early-stage MF, while treatment options have expanded recently for advanced disease. Prognosis is still poor for most patients.
EUROPEAN JOURNAL OF CANCER
(2023)