Article
Multidisciplinary Sciences
Takeshi Kaida, Yoshiki Fujiyama, Takafumi Soeno, Mitsuo Yokota, Shuji Nakamoto, Takuya Goto, Akiko Watanabe, Kota Okuno, Yusuke Nie, Shiori Fujino, Kazuko Yokota, Hiroki Harada, Yoko Tanaka, Toshimichi Tanaka, Keigo Yokoi, Ken Kojo, Hirohisa Miura, Takahiro Yamanashi, Takeo Sato, Jiichiro Sasaki, Takafumi Sangai, Naoki Hiki, Yusuke Kumamoto, Takeshi Naitoh, Keishi Yamashita
Summary: This study examined the mRNA levels of CD44T, CD44V, and CD133 in 60 colon cancer patients using quantitative PCR. The results showed that CD44T and CD44V were highly expressed in primary tumors compared to non-cancerous mucosas, while CD133 expression was higher in non-cancerous mucosas and decreased in tumors. CD44V expression was significantly correlated with CD44T expression, but not with CD133. CD44V/CD44T expression was higher in right colon cancer than in left colon cancer, while CD133 expression showed no difference. In primary tumors, the mRNA expressions of CD44V/CD44T/CD133 were not correlated with aggressive phenotypes, but were significantly associated with less aggressive lymph node metastasis/distant metastasis. Moreover, CD44V and CD133 expressions were significantly decreased in liver metastasis compared to primary tumors.
Article
Oncology
Nicole I. Farber, Yimin Li, Roberto N. Solis, Joy Chen, Zahrah Masheeb, Machelle Wilson, Arnaud F. Bewley, Marianne Abouyared, Shyam Rao, Yi Rong, Andrew C. Birkeland
Summary: Due to the favorable prognosis of p16+ oropharyngeal squamous cell carcinoma, de-escalation therapy is being implemented more frequently, but there is still uncertainty regarding the best candidates for this treatment. This study aimed to establish the growth rates of primary tumors and lymph nodes in oropharyngeal squamous cell carcinoma and analyze their prognostic value. The results showed that the growth rates were independent factors and did not significantly impact prognosis.
Review
Immunology
Giovanni Monteleone, Claudia Maresca, Marco Colella, Teresa Pacifico, Daniele Congiu, Edoardo Troncone, Irene Marafini
Summary: This article reviews the current understanding of the involvement of interleukin-34 (IL-34) and its receptor, macrophage colony-stimulating factor-1 receptor (MCSF-1R), in colorectal cancer (CRC). It highlights the role of the IL-34/MCSF-1R axis in controlling tumor-associated macrophages (TAMs) and promoting cancer resistance to chemotherapy and immunotherapy. The findings suggest that targeting IL-34/MCSF-1R could be a potential therapeutic intervention in CRC.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shi-Wei He, Yuan Zhang, Lei Chen, Wei-Jie Luo, Xiao-Min Li, Yang Chen, Sheng-Yan Huang, Qing-Mei He, Xiao-Jing Yang, Ying-Qin Li, Na Liu, Yin Zhao, Jun Ma
Summary: The combination of gemcitabine and cisplatin significantly inhibits NPC cell proliferation and tumor growth by inducing cell cycle arrest, cell apoptosis, and DNA damage response, revealing the mechanisms of improving locoregionally advanced NPC with combined GEM and DDP induction chemotherapy.
Article
Cell Biology
Adam Lauko, Josephine Volovetz, Soumya M. Turaga, Defne Bayik, Daniel J. Silver, Kelly Mitchell, Erin E. Mulkearns-Hubert, Dionysios C. Watson, Kiran Desai, Manav Midha, Jing Hao, Kathleen McCortney, Alicia Steffens, Ulhas Naik, Manmeet S. Ahluwalia, Shideng Bao, Craig Horbinski, Jennifer S. Yu, Justin D. Lathia
Summary: This study uncovers a survival mechanism in glioblastoma cancer stem cells (CSCs) involving a cysteine protease inhibitor called SerpinB3. The inhibition of cell death by SerpinB3 is essential for CSC maintenance and tumor growth. Knockdown of SerpinB3 increases apoptosis and enhances the efficacy of radiation therapy.
Article
Oncology
Shao-Hao Chen, Long-Yao Xu, Yu-Peng Wu, Zhi-Bin Ke, Peng Huang, Fei Lin, Xiao-Dong Li, Xue-Yi Xue, Yong Wei, Qing-Shui Zheng, Ning Xu
Summary: This study found that tumor volume (TV) is associated with oncological outcomes of localized ccRCC, with high TV being an independent predictor of poor survival.
Article
Biochemistry & Molecular Biology
Alex De Gregorio, Ewa Krystyna Krasnowska, Manuela Zonfrillo, Giampietro Ravagnan, Valentina Bordignon, Enzo Bonmassar, Maria Pia Fuggetta
Summary: This study investigates the effects of Polydatin (PD) on colon cancer. The results show that PD has antiproliferative and proapoptotic effects, reduces the production of immunosuppressive and proinflammatory cytokines, and decreases the expression of adhesion molecules on endothelial cells. These findings provide preclinical support for the use of PD as a therapeutic adjuvant in colon cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Wei Yang, Hong-Peng Dong, Peng Wang, Zhi-Gao Xu, Jiahuan Xian, Jiachen Chen, Hai Wu, Yang Lou, Dandan Lin, Bo Zhong
Summary: This study reveals the crucial role of IL-36 gamma and IL-36Ra in gut inflammation and tumorigenesis. IL-36 gamma promotes inflammation and colon cancer development, while IL-36Ra alleviates inflammation and inhibits tumor growth. Targeting the IL-36 gamma/IL-36Ra signal balance may provide a potential therapeutic strategy for inflammatory bowel disease and gastrointestinal cancers.
Article
Dermatology
Jack Lee, Vernon J. Forrester, Wendy M. Novicoff, Darren J. Guffey, Mark A. Russell
Summary: In a retrospective analysis of SCCs and basal cell carcinomas treated with Mohs surgery at a single institution, the study identified an association between surgical delays and tumor growth for higher-grade SCCs, suggesting potential clinical significance.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Article
Cell Biology
Hanmin Tang, Jing Wang, Xuehui Luo, Qi Wang, Jie Chen, Xinyue Zhang, Qiuting Li, Chengyi Gao, Yuesen Li, Suxia Han
Summary: The apoptosis-related gene prognostic index (ARGPI) can serve as a promising biomarker for determining the risk of colon cancer progression, as well as molecular and immune characteristics and chemotherapeutic benefit. Through molecular analysis, it is a reliable method to predict the prognosis of colon cancer patients and assist doctors in formulating more effective treatment strategies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Analytical
Lili Cong, Yu Tian, Zepeng Huo, Weiqing Xu, Chunxi Hou, Wei Shi, Weigang Wang, Chongyang Liang, Shuping Xu
Summary: This study introduces a microfluidic droplet-based fluorescence imaging platform for analyzing single cell-secreted VEGF, exploring cellular physiological clues at the single-cell level. By developing silica nanoparticle-based immunoprobes and conducting immunosandwich assays, the method demonstrates cellular heterogeneity in cytokine secretion.
ANALYTICAL CHEMISTRY
(2022)
Article
Microbiology
Zhen Li, Chao Shi, Jiawen Zheng, Yongjun Guo, Taibing Fan, Huan Zhao, Dongdong Jian, Xiaolei Cheng, Hao Tang, Jie Ma
Summary: This study revealed a correlation between bacterial communities in esophageal squamous cell carcinoma tissues and tumor progression and clinical characteristics, particularly the association of F. nucleatum abundance with metastatic potential. These findings suggest a potential method for predicting metastasis in esophageal cancer.
Article
Oncology
Anita L. Ray, Apryl S. Saunders, Robert A. Nofchissey, Megan A. Reidy, Maria Kamal, Megan R. Lerner, Kar-Ming Fung, Mark L. Lang, Joshua A. Hanson, Shaoxuan Guo, Maria G. Urdaneta-Perez, Samara E. Lewis, Michael Cloyde, Katherine T. Morris
Summary: This study investigates the role of G-CSF in colon cancer development and explores G-CSF inhibition as an immunotherapeutic strategy against metastatic colon cancer. The findings show that G-CSF and G-CSFR levels are higher in colon cancer patients compared to normal colon tissues from the same patient. Elevated serum G-CSF is associated with poor prognosis markers. Inhibition of G-CSF improves tumor microenvironment, increases survival, and enhances tumor-infiltrating T cell response, with greater effects observed in female mice.
CLINICAL CANCER RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
L. Xie, Z. Cong, S. Tang, M. Yang, Y. Li, C. Ren, Q. Chen, D. Lu, F. Wan, X. Zhang, S. Wu
Summary: This study introduces tumor cell-based microrobots loaded with oncolytic adenovirus and coated with Fe3O4 nanoparticles. These microrobots exhibit homologous adhesion, active virotherapy, and magnetic navigation capabilities. The replication of the infected virus inside the host cells allows for persistent and specific tumor infection and killing. The combination of magnetic propulsion and homologous binding greatly enhances the binding and penetration of the microrobots, improving their cell-killing efficacy.
MATERIALS TODAY CHEMISTRY
(2023)
Review
Oncology
Elena Russo, Remo Accorona, Oreste Iocca, Andrea Costantino, Luca Malvezzi, Fabio Ferreli, Ciro Franzese, Marta Scorsetti, Pasquale Capaccio, Giuseppe Mercante, Giuseppe Spriano, Armando De Virgilio
Summary: The study found that tumor volume is not a reliable prognostic factor in OPSCC, as there was no significant difference in overall survival and disease-free survival between high and low values of primary and nodal tumor volume.