Article
Pharmacology & Pharmacy
Ran Joo Choi, Siti Zuraidah Mohamad Zobir, Ben Alexander-Dann, Nitin Sharma, Marcella K. L. Ma, Brian Y. H. Lam, Giles S. H. Yeo, Weidong Zhang, Tai-Ping Fan, Andreas Bender
Summary: Shexiang Baoxin Pill (SBP) promotes angiogenesis through the synergistic effects of ginsenosides Rb2 and Rg3, which activate the PI3K/Akt and MAPK/ERK signaling pathways to enhance endothelial cell proliferation and tube formation. The study also suggests that SBP, via Rb2 and Rg3, utilizes the CXCR1/2 CXCL8 (IL8)-mediated pathways to achieve its proangiogenic effects and protect the cardiovascular system.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Integrative & Complementary Medicine
Yuan Liang, Tiehua Zhang, Siyuan Jing, Peng Zuo, Tiezhu Li, Yongjun Wang, Shaochen Xing, Jie Zhang, Zhengyi Wei
Summary: 20(S)-Rg3, a triterpenoid saponin, was confirmed to be an EGFR-TKI and play a key role in regulating the EGFR/Ras/Raf/MEK/ERK signal pathway. It can inhibit A549 cell proliferation by blocking the cell cycle at the G0/G1 phase through downregulating CDK2, Cyclin A2, and Cyclin E1.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2021)
Article
Genetics & Heredity
Pan Wang, Congcong Tang, Yannan Liu, Jing Yang, Daidi Fan
Summary: This study successfully expressed a thermostable β-glycosidase from Sulfolobus solfataricus in Pichia pastoris and secreted it into fermentation broth. The optimized enzyme showed the highest catalytic efficiency at 80°C and pH 6.0, and its activity was significantly enhanced in the presence of Li+. The recombinant enzyme could completely convert the ginsenoside substrate to the rare ginsenoside Compound K and exhibited extraordinary tolerance against high substrate concentrations.
Article
Microbiology
Geyuan Qi, Baoyu Ji, Yanan Zhang, Luqi Huang, Juan Wang, Wenyuan Gao
Summary: This study investigates the interaction between medicinal plants and microorganisms to screen suitable microbial strains for large-scale production of ginsenoside Rg3. The results show that the method of screening dominant strains in soil is reliable, and the highest yield of Rg3 is achieved through fermentation optimization and co-fermentation with other microorganisms. This research provides theoretical and technical support for the industrial production of ginsenoside Rg3 using microbiology.
MICROBIOLOGICAL RESEARCH
(2022)
Article
Plant Sciences
Longhai Jin, Jinping Liu, Shu Wang, Linxian Zhao, Jiannan Li
Summary: This study developed a Rg3-loaded hydrogel for treating perianal ulcers, which showed significant efficacy in inhibiting inflammation, promoting ulcer healing, and could be a potential candidate for perianal ulcer treatment.
JOURNAL OF GINSENG RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Qiong Lai, Fu-Ming Liu, Wang-Lin Rao, Guang-Ying Yuan, Zhao-Yang Fan, Lu Zhang, Fei Fu, Jun-Ping Kou, Bo-Yang Yu, Fang Li
Summary: The study demonstrates that N-acetylglutamine may be a potential biomarker of HF, and its specific metabolic-degrading enzyme ACY1 could be a potential therapeutic target for the prevention and treatment of myocardial fibrosis during the development of HF. Rg3 attenuates myocardial fibrosis to ameliorate HF through increasing ACY1 expression and inhibiting TGF-beta 1/Smad3 pathway, providing references for further development of anti-fibrotic drugs for HF.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Chemistry, Applied
Xiong Guo, Fangfang Xiu, Hriday Bera, Yasir Faraz Abbasi, Yang Chen, Liangwei Si, Peixin Liu, Chunwei Zhao, Xing Tang, Yu Feng, Dongmei Cun, Xia Zhao, Mingshi Yang
Summary: A composite nanofiber dressing was developed to treat deep burn injuries, which effectively promoted wound healing and reduced scar formation. The dressing had a unique structure with the release of Rg3 to prevent excessive scar formation and demonstrated favorable cytocompatibility with cells. The experimental results showed that the dressing could accelerate epidermal wound closure in deep burn injuries and attenuate scar formation.
CARBOHYDRATE POLYMERS
(2023)
Article
Chemistry, Multidisciplinary
Ying Zhu, Jianming Liang, Caifang Gao, Anni Wang, Jiaxuan Xia, Chao Hong, Zhirong Zhong, Zhong Zuo, Jisu Kim, Hongwei Ren, Shiyi Li, Qi Wang, Fengxue Zhang, Jianxin Wang
Summary: The study found that using a liposomal system based on ginsenoside Rg3 can effectively improve the targeting of brain tumors, enhance the delivery of drugs, and play a beneficial role in anti-tumor treatment.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Cell Biology
Wei Liu, Sheng-Xiong Zhang, Bo Ai, Hua-Feng Pan, Dan Zhang, Yu Jiang, Lei-Hao Hu, Ling-Ling Sun, Zhe-Sheng Chen, Li-Zhu Lin
Summary: Ginsenoside Rg3, a compound derived from Panax ginseng, has shown dual effects on cancer cells with high concentrations inhibiting cell growth and low concentrations promoting mitochondrial biogenesis and function. These findings suggest a dose-dependent effect of Rg3 on tumor cell growth through mTORC1 and mitochondrial pathways.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Plant Sciences
Honglin Xu, Haifeng Miao, Guanghong Chen, Guoyong Zhang, Yue Hua, Yuting Wu, Tong Xu, Xin Han, Changlei Hu, Mingjie Pang, Leyi Tan, Bin Liu, Yingchun Zhou
Summary: This study found that Rg3 improves myocardial fibrosis and cardiac function by inhibiting the proliferation of cardiac fibroblasts and collagen deposition through inactivation of the TGFBR1 signaling pathway.
JOURNAL OF GINSENG RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Jiali Yang, Lifeng Zhang, Xiaojuan Peng, Shuai Zhang, Shuwen Sun, Qiteng Ding, Chuanbo Ding, Wencong Liu
Summary: The skin, as the largest organ in the human body, serves a protective role. Wound healing is a complex process that requires ideal wound dressings for promotion. Current wound dressings lack antibacterial properties and cannot effectively protect wounds from microbial infections, leading to delayed healing. However, ginsenoside Rg3-loaded polymer wound dressings have good biocompatibility and can effectively promote wound healing and reduce scar formation. This article focuses on the application and mechanism of ginsenoside Rg3-loaded dressings in wounds.
Review
Plant Sciences
Longxing Miao, Yijun Yang, Zhongwen Li, Zengjun Fang, Yongqing Zhang, Chun-chao Han
Summary: This paper provides an overview of the pharmacokinetics and pharmacological properties of Ginsenoside Rb2, as well as its mechanism of action in the prevention and treatment of various diseases. However, its clinical efficacy has not been evaluated and further research is needed.
JOURNAL OF GINSENG RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Siwen Zheng, Housheng Zheng, Rui Zhang, Xiangmin Piao, Junnan Hu, Yanzhu Zhu, Yingping Wang
Summary: This study demonstrates that ginsenoside Rb2 can improve the immune function that is declined in CTX-induced immunosuppressed mice, possibly through the regulation of cytokines and mRNA expression.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Yunhee Lee, Arum Park, Young-Jun Park, Haiyoung Jung, Tae-Don Kim, Ji-Yoon Noh, Inpyo Choi, Seungjin Lee, Suk Ran Yoon
Summary: G-Rg3 promotes NK cell cytotoxicity and activates the MAPK/ERK pathway. It increases the expression of NK-activating receptors and cytolytic molecules, while not affecting NK cell differentiation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Toxicology
Min Jiang, Yinxing Zhu, Hong Yu
Summary: 20(S)-Rg3 inhibits cell viability in ESCC by mediating miR-324-5p-targeted PSME3.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2021)