Article
Gastroenterology & Hepatology
Davide Roccarina, Laura Iogna Prat, Giada Pallini, Marta Guerrero Misas, Elena Buzzetti, Francesca Saffioti, Francesco M. Arico, Anna Mantovani, Evangelia Koutli, Atul Goyale, Matteo Rosselli, Tu Vinh Luong, Massimo Pinzani, Emmanuel A. Tsochatzis
Summary: This study compared liver stiffness measurements between ElastPQ and F-TE in patients with NAFLD, showing excellent correlation between the two techniques, especially for lower LSM. ElastPQ demonstrated similar diagnostic accuracy to F-TE in staging liver fibrosis in patients with available liver histology.
LIVER INTERNATIONAL
(2022)
Article
Medicine, General & Internal
Dongmin Choo, Kyung Sook Shin, Ji Hye Min, Sun-kyoung You, Kyung-Hee Kim, Jeong Eun Lee
Summary: This study assessed the diagnostic performance of elastography point quantification (ElastPQ), transient elastography (TE), and aspartate aminotransferase-to-platelet count ratio index (APRI) for the staging of liver fibrosis in patients with chronic viral hepatitis. It found that ElastPQ showed similar diagnostic accuracy to TE and was more accurate than APRI.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ilias Gatos, Spyros Yarmenitis, Ioannis Theotokas, John Koskinas, Emmanuel Manesis, Spyros P. Zoumpoulis, Pavlos S. Zoumpoulis
Summary: This study evaluates the performance of a recently introduced commercial alternative of ultrasound elastography (USE) called Visual Transient Elastography (ViTE) for the diagnosis of chronic liver disease (CLD). The results show that ViTE performs comparably to established USE methods in staging CLD.
EUROPEAN JOURNAL OF RADIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Alexander Chaidez, Zhaoxing Pan, Shikha S. Sundaram, Julia Boster, Mark Lovell, Ronald J. Sokol, Cara L. Mack
Summary: Vibration controlled transient elastography (Fibroscan) can be used to predict the severity of liver fibrosis and steatosis. This study investigated the correlation between FibroScan measurements and liver histologic features in pediatric nonalcoholic fatty liver disease (NAFLD). The study also assessed the predictive capacity of the FibroScan-aspartate aminotransferase (FAST) score in pediatric NAFLD.
HEPATOLOGY COMMUNICATIONS
(2022)
Article
Immunology
Maria Pokorska-Spiewak, Anna Dobrzeniecka, Marta Lipinska, Anna Tomasik, Malgorzata Aniszewska, Magdalena Marczynska
Summary: The study found that significant liver fibrosis may occur in teenagers with CHC, including cirrhosis, and serum biomarkers correlate positively with liver stiffness measurement.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2021)
Article
Multidisciplinary Sciences
Fei Chen, Yaning Yao, Zhen Li, Long Deng, Ruiling He
Summary: This study aimed to develop a prediction model based on individual bile acid (BA) profiles to identify compensated advanced chronic liver disease (cACLD). The study found that the content of individual BA in the serum increased significantly with the degree of fibrosis, especially glycine-conjugated BA and taurine-conjugated BA. The optimized random forest (RF) and support vector machine (SVM) models successfully distinguished patients with cACLD caused by hepatitis B virus (HBV). This study provides a new tool for identifying cACLD and improving the management of patients with chronic liver disease.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Anya Mezina, Arunkumar Krishnan, Tinsay A. Woreta, Kevin B. Rubenstein, Eric Watson, Po-Hung Chen, Carla Rodriguez-Watson
Summary: This study investigates the changes in liver stiffness measured by transient elastography (TE) in a large cohort of US patients with chronic hepatitis C (CHC), and compares the differences between patients treated with direct-acting antiviral (DAA) therapy and untreated patients.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Article
Gastroenterology & Hepatology
A. ElShahawy, M. S. El-Raziky, S. A. Sharaf, A. Elsharkawy, A. Enayet, H. Taher
Summary: This study aimed to assess the accuracy of APRI, HA, and TE in liver biopsy for children with chronic viral hepatitis. The results showed that APRI, HA, and TE are reliable indicators for detecting the presence of fibrosis, and TE is the only method to differentiate mild cases from those with significant fibrosis.
BMC GASTROENTEROLOGY
(2022)
Article
Multidisciplinary Sciences
Philippe Garteiser, Gwenael Page, Gaspard d'Assignies, Helena S. Leitao, Valerie Vilgrain, Ralph Sinkus, Bernard E. Van Beers
Summary: The study aimed to evaluate the diagnostic value of multifrequency MR elastography in grading necro-inflammation in the liver. The multifrequency dispersion coefficient was found to be the most accurate in assessing necro-inflammatory activity, while the storage modulus was suitable for evaluating fibrosis.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Ditte Marie Kirkegaard-Klitbo, Flemming Bendtsen, Jens Lundgren, Robert J. de Knegt, Klaus Fuglsang Kofoed, Susanne Dam Nielsen, Thomas Benfield
Summary: The prevalence of elevated liver stiffness measurement (LSM) was higher in people with HIV compared to population controls. Factors independently associated with elevated LSM included older age, higher BMI, elevated ALT levels, previous exposure to didanosine, and positive HIV status.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Gastroenterology & Hepatology
Dong Ji, Yan Chen, Qinghua Shang, Huabao Liu, Lin Tan, Jing Wang, Yongping Chen, Qin Li, Qinghua Long, Laicheng Song, Li Jiang, Guangming Xiao, Zujiang Yu, Liang Chen, Xiaoyu Hu, Xiaodong Wang, Da Chen, Zhiqin Li, Zheng Dong, Guofeng Chen, Yongping Yang
Summary: The study aimed to assess the association between changes in liver stiffness measurement (LSM) and histological outcomes in chronic hepatitis B patients receiving entecavir-based therapy. LSM decrease of ≥30% was associated with regression of fibrosis, significant histological response, and alanine aminotransferase normalization, with a new on-treatment LSM cutoff value established for indicating significant histological response.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Lisa Hernandez Sampere, Johannes Vermehren, Victoria T. Muecke, Christiana Graf, Kai-Henrik Peiffer, Georg Dultz, Stefan Zeuzem, Oliver Waidmann, Natalie Filmann, Joerg Bojunga, Christoph Sarrazin, Mireen Friedrich-Rust, Marcus M. Muecke
Summary: The study demonstrates good comparability between point shear-wave elastography (pSWE) using acoustic radiation force impulse imaging and transient elastography (TE) in predicting liver-related events (LRE) in patients with chronic viral hepatitis, particularly those with chronic HCV. Further research is needed to confirm the findings and assess the prognostic value of these imaging techniques in other liver diseases.
HEPATOLOGY COMMUNICATIONS
(2021)
Article
Gastroenterology & Hepatology
Chun-Li Wang, Chien-Hao Huang, Victor Chien-Chia Wu, Chia-Ling Wu, Yu-Tung Huang, Shang-Hung Chang
Summary: This study investigated the prognostic effects of liver fibrosis and steatosis in patients with chronic hepatitis B or C. The results showed that increasing fibrosis severity was associated with higher risks of hepatic-related events, whereas the presence of steatosis had a protective effect. Cirrhosis was found to be an independent risk factor for mortality.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Medicine, General & Internal
Honore Tegwende Zougmore, Jean Francois David Cadranel, Gildas Fantognon, Badia Azzi, Ryad Smadhi, Jean Rene Ngele Efole, Samir Mrabti, Ratmony Heng, Marie Adrienne Ntsama, Mourad Medmoun, Firouzeh Kazerouni, Tristan Le Magoarou
Summary: This study evaluated the correlation between the measurements of liver fibrosis obtained by Shear Wave Elastography (SWE) and Fibroscan (FS) in patients with chronic liver diseases. The results showed that SWE technique was as efficient as FS for the evaluation of liver fibrosis. SWE allowed noninvasive evaluation of fibrosis for patients who couldn't undergo FS.
Article
Infectious Diseases
Haiyan Luo, Songxu Peng, Wenxian Ouyang, Yanfang Tan, Tao Jiang, Lian Tang, Shuangjie Li, Jun Qiu, Changci Zhou
Summary: This study compared the diagnostic value of transient elastography (TE) and multivariate indicators with liver biopsy for the detection of liver fibrosis in children with chronic hepatitis B (CHB). The results showed that TE had better diagnostic value for significant liver fibrosis compared to APRI and FIB-4.
BMC INFECTIOUS DISEASES
(2022)
Article
Medicine, General & Internal
Waled Mohsen, Patrick Chan, Michelle Whelan, Ann Glass, Marlize Mouton, Ernest Young, Quyen Tran, Sanjeev Arora, Scott Davison, Tenzin Lama, Cherry Cobrador, Miriam Levy
INTERNAL MEDICINE JOURNAL
(2019)
Editorial Material
Gastroenterology & Hepatology
Harry G. Crane, Scott A. Davison, Miriam T. Levy
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2020)
Article
Gastroenterology & Hepatology
Patrick P. Y. Chan, Miriam T. Levy, Nicholas Shackel, Scott A. Davison, Emilia Prakoso
HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL
(2020)
Article
Immunology
Timothy Papaluca, Stuart K. Roberts, Simone Strasser, Katherine A. Stuart, Geoffrey Farrell, Gerry MacQuillan, Gregory J. Dore, Amanda J. Wade, Jacob George, Simon Hazeldine, James O'Beirne, Alan Wigg, Leslie Fisher, Bruce McGarity, Rohit Sawhney, Marie Sinclair, James Thomas, Ivan Valiozis, Martin Weltman, Mark Wilson, Aidan Woodward, Golo Ahlenstiel, Mazhar Haque, Miriam Levy, Emily Prewett, William Sievert, Siddharth Sood, Edmund Tse, Zina Valaydon, Scott Bowden, Mark Douglas, Kate New, Jacinta O'Keefe, Margaret Hellard, Joseph Doyle, Mark Stoove, Alexander J. Thompson
Summary: This real-world study confirms the high efficacy of SOF/VEL/VOX for difficult-to-cure NS5A inhibitor experienced patients, particularly those with GT3 and cirrhosis, with an SVR12 rate of 85%. Treatment was generally well tolerated, but serious adverse events may occur in patients with advanced liver disease.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Gastroenterology & Hepatology
Homie Razavi, Sarah Blach, Devin Razavi-Shearers, Faisal Abaalkhail, Zaigham Abbas, Ayat Abdallah, Paulo Abrao Ferreira, Laith Jamal Abu Raddad, Danjuma Adda, Kosh Agarwal, Alessio Aghemo, Aijaz Ahmed, Said A. Al-Busafi, Waleed Al-hamoudi, Saad Al-Kaabi, Hamad Al-Romaihi, Badr Aljarallah, Khalid AlNaamani, Saleh Alqahtani, Khalid Alswat, Ibrahim Altraif, Tarik Asselah, Bruce Bacon, Fernando Bessone, Abdul Rahman Bizri, Tim Block, Ferruccio Bonino, Carlos Eduardo BranclaoMello, Kimberly Browny, Philip Bruggmann, Maurizia Rossana Brunetto, Maria Buti, Joaquin Cabezas, Jose Luis Calleja, Erika Castro Batanjer, Henry Lik-Yuen Chan, Henry Chang, Chien-Jen Chen, Peer Brehm Christensen, Wan-Long Chuang, Laura Cisneros, Chari Cohen, Massimo Colombo, Brian Conway, Curtis Cooper, Antonio Craxi, Javier Crespo, Esther Croes, Donna Cryer, Fernando Passos Cupertino de Barros, Moutaz Derbala, John Dillon, Wahid Doss, Xiaoguang Dou, Joseph Doyle, Ann-Sofi Duberg, Ellen Dugan, Rick Dunn, Geoffrey Dusheiko, Hisham El Khayat, Manal H. EI-Sayed, Ahad Eshraghian, Gamal Esmat, Rafael Esteban Mur, Sameera Ezzat, Karolin Falconer, Eduardo Fassio, Paulo Ferrinho, Steven Flamm, Robert Flisiak, Graham Foster, James Fung, Javier Garcia-Samaniego, Robert G. Gish, Fernando Goncales, Waldemar Halota, Waseem Hamoudi, Mohamed Hassany, Angelos Hatzakis, Susan Hay, Sayed Himatt, I. M. Hoepelman, Yao-Chun Hsu, Yee Tak Hui, Bela Hunyady, Ira Jacobson, Naveed Janjua, Harry Janssen, Peter Jarcuska, Kenneth Kabagambe, Tatsuya Kanto, Jia-Horng Kao, Sabahattin Kaymakoglu, David Kershenobich, Faryal Khamis, Dong Joon Kim, Young Kim, Loreta A. Kondili, Shyamasundaran KottiliI, Anna Kramvis, Marcelo Kugelmas, Masayuki Kurosaki, Karine Lacombe, Martin Lagging, WaiCheung Lao, Daniel Lavanchy, Jeffrey Lazarus, Alice Lee, Samual S. Lee, Miriam Levyl, Valentina Liakina, YoungSuk Lim, Shuang Liu, Willis Maddrey, Reza Malekzade, Rui Tato Marinho, Poonam Mathur, Mojca Maticic, Maria Cassia Mendes Correa, Jorge Mera, Shahin Merat, Sherif Mogawer, Rosmawati Mohamed, Beat Muellhaupti, David Muljono, Ibrahim Mostafa, Mendez Sanchez Nahum, Arif Nawaz, Francesco Negro, Michael Ninburg, Qing Ning, Boatemaa Ntiri-Reid, Pagbajabyn Nymadawa, Anne Oevrehus, Necati Ormeci, Mauricio Orrego, Alaa Osman, Tsendsuren Oyunsuren, Calvin Pant, Vassiliki Papaevangelou, George Papatheodoridis, Stephanie Popping, Papu Prasad, Rittoo Prithiviputh, Huma Qureshi, Alnoor Ramji, Kathryn Razavi-Shearer, Rajender Reddy, William Remak, Clemens Richter, Ezequiel Ridruejo, Geert Robaeys, Stuart Robert, Lewis Roberts, Francoise Roudot-Thoraval, Sammy Saab, Sanaa Said, Amjad Salamat, Faisal Sanai, Juan Francisco Sanchez-Avila, Eugene Schiff, Raymond Schinazi, Giada Sebastiani, Carole Seguin-Devaux, R. P. Shanmugam, Ala Sharara, Sonjelle Shilton, Daniel Shouval, William Sievert, Marieta Simonova, Amir Ali Sohrabpour, Mark Sonderup, Alejandro Soza, C. Wendy Spearman, Nancy Steinfurth, Mark Sulkowski, Soek-Siam Tan, Junko Tanaka, Dhondup Tashi, Hla-Hla Thein, Peyton Thompson, Ieva Tolmane, Mehlika Toy, Jonas Valantinas, David Van de Vijver, Patricia Velez-Moller, Adriana Vince, Imam Waked, Su Wang, Heiner Wedemeyer, Vincent Wong, Qing Xie, Seiji Yamada, Hwai- Yang, Kakharman Yesmembetov, Yusuf Yilmaz, Zobair Younossi, Ming-Lung Yu, Man-Fung Yuen, Cihan Yurdaydin, Aasim Yusuf, Amany Zekry, Stefan Zeuzem
Summary: The 69th World Health Assembly endorsed the goal to eliminate hepatitis infection as a public health threat by 2030, followed by global targets for the care and management of hepatitis B and hepatitis C infections. However, tracking countries' progress towards these elimination goals revealed limitations of existing targets and recommended changes to simplify and adjust the targets for better impact and recognition of countries' efforts.
JOURNAL OF VIRAL HEPATITIS
(2021)
Article
Gastroenterology & Hepatology
David Stephen Prince, Joseph Louis Pipicella, Melissa Fraser, Frank Alvaro, Michael Maley, Hong Foo, Paul MacConachie Middleton, Scott Anthony Davison, Greg John Dore, Geoff William McCaughan, Miriam Tania Levy
Summary: The study evaluated the effectiveness of an automated Emergency Department (ED) screening service in identifying and engaging patients with hepatitis C (HCV). Results showed that the screening was successful in identifying a significant number of HCV patients and achieving linkage to care, with high rates of successful care among viraemic patients. Opt-out consent and automation were found to be effective in removing obstacles to testing.
JOURNAL OF VIRAL HEPATITIS
(2021)
Review
Gastroenterology & Hepatology
Norah A. Terrault, Miriam T. Levy, Ka Wang Cheung, Gonzague Jourdain
Summary: The management of viral hepatitis in pregnancy requires special consideration due to the unique characteristics of each hepatitis virus and their impact on maternal and infant outcomes. Preventing mother-to-child transmission is crucial in reducing the global burden of chronic viral hepatitis.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2021)
Letter
Gastroenterology & Hepatology
Miriam T. Levy, Norah A. Terrault
JOURNAL OF VIRAL HEPATITIS
(2021)
Article
Gastroenterology & Hepatology
Ian Lockart, Behzad Hajarizadeh, Maryam Alavi, Scott Davison, Emilia Prakoso, Miriam T. Levy, Jacob George, Gregory J. Dore, Mark Danta
Summary: The study indicates that patients with HCV-related HCC who have achieved HCV cure before HCC diagnosis have improved overall survival compared with patients who were viraemic at diagnosis, showing a positive impact of HCV cure on the survival of HCV-related HCC patients.
JOURNAL OF VIRAL HEPATITIS
(2021)
Article
Medicine, General & Internal
John S. Lubel, Stuart K. Roberts, Simone Strasser, Alexander J. Thompson, Jennifer Philip, Mark Goodwin, Stephen Clarke, Darrell H. G. Crawford, Miriam T. Levy, Nick Shackel
Summary: Hepatocellular carcinoma (HCC) is a major cause of cancer deaths globally and in Australia. Most Australians diagnosed with HCC die of the cancer or liver disease. This consensus statement aims to simplify HCC patient management, reduce clinical variation, and improve outcomes for patients.
MEDICAL JOURNAL OF AUSTRALIA
(2021)
Letter
Gastroenterology & Hepatology
Norah A. Terrault, Ka Wang Cheung, Miriam T. Levy, Gonzague Jourdain
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Ian Lockart, Behzad Hajarizadeh, Niamh Buckley, Scott Davison, Emilia Prakoso, Miriam T. Levy, Jacob George, Gregory J. Dore, Mark Danta
Summary: The study suggests that hepatitis C virus-related HCC survival has improved in the DAA era, while the survival rates for HBV-HCC and non-viral HCC remained stable. HBV-HCC exhibited better survival compared to HCV-HCC in 2008-2014, but this difference disappeared in 2015-2019.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Editorial Material
Gastroenterology & Hepatology
Miriam T. Levy, Angela Kashuba, Edward Gane
Summary: This article is connected to the papers by Kayes et al.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Gastroenterology & Hepatology
David Stephen Prince, Julia Di Girolamo, Joseph Louis Pipicella, Melissa Bagatella, Tahrima Kayes, Frank Alvaro, Michael Maley, Hong Foo, Paul MacConachie Middleton, Miriam Tania Levy
Summary: This study aims to evaluate the cost of an emergency department (ED) screening program called SEARCH and make improvements to enhance efficiency and reduce cost. The findings from sensitivity analysis suggest that ED screening is an affordable strategy for hepatitis C virus (HCV) case detection and elimination.
CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Elizabeth R. O'Brien, Michelle C. Whelan, Tenzin Lama, Miriam Levy
Summary: The study aimed to determine hepatitis C virus (HCV) treatment rates among newly diagnosed cases in South Western Sydney, NSW, Australia. Only 47% of patients who were indicated for treatment received antiviral medication within 12 months of diagnosis, with 22% lost to follow-up and 18% showing RNA negativity.
PUBLIC HEALTH RESEARCH & PRACTICE
(2021)