Journal
ANTIVIRAL RESEARCH
Volume 85, Issue 2, Pages 346-353Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.antiviral.2009.10.014
Keywords
Diammonium glycyrrhizinate; Lithium chloride; Pseudorabies virus (PrV); Apoptosis
Categories
Funding
- National Natural Science Foundation of China [30700590]
- Ministry of Education of China [N0706019]
- Heilongjiang Provincial Science and Technology Department [LC06C01]
- Harbin Science and Technology Bureau [2006RFLXN004]
- Northeast Agricultural University, China [CXZ0081]
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Diammonium glycyrrhizin (DG), a salt from glycyrrhizinate (GL) that is a major active component of licorice root extract with various pharmacological activities was investigated for its inhibitory effect on pseudorabies virus (PrV) infection. In parallel, lithium chloride (LiCl), a chemical reagent with potential antiviral activity was compared with DG for their inhibitory ability against PrV infection in vitro. Virus plaque-reduction assays, PCR and RT-PCR analysis indicated that both drugs inhibited cell infection by PrV. Moreover, addition of the drugs resulted in fewer apoptotic cells during PrV infection. (C) 2009 Elsevier B.V. All rights reserved.
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