Brain Stem NOS and ROS in Neural Mechanisms of Hypertension

Angiotensin II type 2 receptor-coupled nitric oxide production modulates free radical availability and voltage-gated Ca2+ currents in NTS neurons

(2012) Gang Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Redox-Sensitive Oxidation and Phosphorylation of PTEN Contribute to Enhanced Activation of PI3K/Akt Signaling in Rostral Ventrolateral Medulla and Neurogenic Hypertension in Spontaneously Hypertensive Rats

(2012) Kay L.H. Wu et al.   ANTIOXIDANTS & REDOX SIGNALING

Angiotensin-Generated Reactive Oxygen Species in Brain and Pathogenesis of Cardiovascular Diseases

(2012) Samuel H.H. Chan et al.   ANTIOXIDANTS & REDOX SIGNALING

Renin activates PI3K-Akt-eNOS signalling through the angiotensin AT1 and Mas receptors to modulate central blood pressure control in the nucleus tractus solitarii

(2012) Wen-Han Cheng et al.   BRITISH JOURNAL OF PHARMACOLOGY

Reduction of Nitric Oxide-Mediated γ-Amino Butyric Acid Release in Rostral Ventrolateral Medulla Is Involved in Superoxide-Induced Sympathoexcitation of Hypertensive Rats

(2012) Keisuke Shinohara et al.   CIRCULATION JOURNAL

Sympathoinhibition caused by orally administered telmisartan through inhibition of the AT1 receptor in the rostral ventrolateral medulla of hypertensive rats

(2012) Takuya Kishi et al.   HYPERTENSION RESEARCH

Inhibition of Oxidative Stress in Rostral Ventrolateral Medulla Improves Impaired Baroreflex Sensitivity in Stroke-Prone Spontaneously Hypertensive Rats

(2012) Kiyohiro Ogawa et al.   International Heart Journal

Brain stem oxidative stress and its associated signaling in the regulation of sympathetic vasomotor tone

(2012) Samuel H. H. Chan et al.   JOURNAL OF APPLIED PHYSIOLOGY

Uncoupling of eNOS causes superoxide anion production and impairs NO signaling in the cerebral microvessels of hph-1 mice

(2012) Anantha Vijay R. Santhanam et al.   JOURNAL OF NEUROCHEMISTRY

Neuroinflammation and oxidative stress in rostral ventrolateral medulla contribute to neurogenic hypertension induced by systemic inflammation

(2012) Kay LH Wu et al.   Journal of Neuroinflammation

Superoxide anions modulate the effects of angiotensin-(1–7) in the rostral ventrolateral medulla on cardiac sympathetic afferent reflex and sympathetic activity in rats

(2012) P. Li et al.   NEUROSCIENCE

Oxidative stress in the brain causes hypertension via sympathoexcitation

(2012) Takuya Kishi et al.   Frontiers in Physiology

Activation of Central Angiotensin Type 2 Receptors Suppresses Norepinephrine Excretion and Blood Pressure in Conscious Rats

(2011) Juan Gao et al.   AMERICAN JOURNAL OF HYPERTENSION

Imbalance of central nitric oxide and reactive oxygen species in the regulation of sympathetic activity and neural mechanisms of hypertension

(2011) Yoshitaka Hirooka et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Reactive Oxygen Species and Endothelial Function - Role of Nitric Oxide Synthase Uncoupling and Nox Family Nicotinamide Adenine Dinucleotide Phosphate Oxidases

(2011) Augusto C. Montezano et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Chronic exercise modulates RAS components and improves balance between pro- and anti-inflammatory cytokines in the brain of SHR

(2011) Deepmala Agarwal et al.   BASIC RESEARCH IN CARDIOLOGY

Nitric oxide signaling: Classical, less classical, and nonclassical mechanisms

(2011) Antonio Martínez-Ruiz et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cross talk between mitochondria and NADPH oxidases

(2011) Sergey Dikalov   FREE RADICAL BIOLOGY AND MEDICINE

Autonomic-Immune-Vascular Interaction

(2011) Jasenka Zubcevic et al.   HYPERTENSION

Contribution of Central Nervous System Endothelial Nitric Oxide Synthase to Neurohumoral Activation in Heart Failure Rats

(2011) Vinicia C. Biancardi et al.   HYPERTENSION

Angiotensin II–Induced Hypertension Is Modulated by Nuclear Factor-κB in the Paraventricular Nucleus

(2011) Jeffrey P. Cardinale et al.   HYPERTENSION

Oxidative stress in the cardiovascular center has a pivotal role in the sympathetic activation in hypertension

(2011) Yoshitaka Hirooka   HYPERTENSION RESEARCH

Importance of rostral ventrolateral medulla neurons in determining efferent sympathetic nerve activity and blood pressure

(2011) Hiroo Kumagai et al.   HYPERTENSION RESEARCH

The Functional Role of PI3K in Maintenance of Blood Pressure and Baroreflex Suppression in (mRen2)27 and mRen2.Lewis Rat

(2011) Exazevia M Logan et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Oxidative stress in the rostral ventrolateral medulla modulates excitatory and inhibitory inputs in spontaneously hypertensive rats

(2011) Masaaki Nishihara et al.   JOURNAL OF HYPERTENSION

ACE2-Mediated Reduction of Oxidative Stress in the Central Nervous System Is Associated with Improvement of Autonomic Function

(2011) Huijing Xia et al.   PLoS One

Upregulation of AT1R and iNOS in the Rostral Ventrolateral Medulla (RVLM) Is Essential for the Sympathetic Hyperactivity and Hypertension in the 2K-1C Wistar Rat Model

(2010) E. B. de Oliveira-Sales et al.   AMERICAN JOURNAL OF HYPERTENSION

Downregulated Kv4.3 expression in the RVLM as a potential mechanism for sympathoexcitation in rats with chronic heart failure

(2010) Lie Gao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Enhanced angiotensin II-mediated central sympathoexcitation in streptozotocin-induced diabetes: role of superoxide anion

(2010) Kaushik P. Patel et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

The attenuation of central angiotensin II-dependent pressor response and intra-neuronal signaling by intracarotid injection of nanoformulated copper/zinc superoxide dismutase

(2010) Erin G. Rosenbaugh et al.   BIOMATERIALS

Therapeutic effect of enhancing endothelial nitric oxide synthase (eNOS) expression and preventing eNOS uncoupling

(2010) Ulrich Förstermann et al.   BRITISH JOURNAL OF PHARMACOLOGY

Losartan improved respiratory function and coenzyme Q content in brain mitochondria of young spontaneously hypertensive rats

(2010) Z. Sumbalová et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Oxidative Stress and Central Cardiovascular Regulation

(2010) Yoshitaka Hirooka et al.   CIRCULATION JOURNAL

Angiotensin II Inhibits Neuronal Nitric Oxide Synthase Activation Through the ERK1/2-RSK Signaling Pathway to Modulate Central Control of Blood Pressure

(2010) Wen-Han Cheng et al.   CIRCULATION RESEARCH

Transcriptional Upregulation of Brain-Derived Neurotrophic Factor in Rostral Ventrolateral Medulla by Angiotensin II

(2010) Samuel H.H. Chan et al.   CIRCULATION RESEARCH

Therapeutic Targeting of Mitochondrial Superoxide in Hypertension

(2010) Anna E. Dikalova et al.   CIRCULATION RESEARCH

Angiotensin-Converting Enzyme 2: Central Regulator for Cardiovascular Function

(2010) Huijing Xia et al.   CURRENT HYPERTENSION REPORTS

Pluronic-modified superoxide dismutase 1 attenuates angiotensin II-induced increase in intracellular superoxide in neurons

(2010) Xiang Yi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Association of endothelial nitric oxide synthase and mitochondrial dysfunction in the hippocampus of scrapie-infected mice

(2010) Jeong-Ho Park et al.   HIPPOCAMPUS

Brain Perivascular Macrophages and the Sympathetic Response to Inflammation in Rats After Myocardial Infarction

(2010) Yang Yu et al.   HYPERTENSION

Oral Intake of Rosiglitazone Promotes a Central Antihypertensive Effect Via Upregulation of Peroxisome Proliferator-Activated Receptor-γ and Alleviation of Oxidative Stress in Rostral Ventrolateral Medulla of Spontaneously Hypertensive Rats

(2010) Samuel H.H. Chan et al.   HYPERTENSION

Brain Microglial Cytokines in Neurogenic Hypertension

(2010) Peng Shi et al.   HYPERTENSION

Angiotensin II Type 1 Receptor–Activated Caspase-3 Through Ras/Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase in the Rostral Ventrolateral Medulla Is Involved in Sympathoexcitation in Stroke-Prone Spontaneously Hypertensive Rats

(2010) Takuya Kishi et al.   HYPERTENSION

Reactive oxygen species and vascular biology: implications in human hypertension

(2010) Rhian M Touyz et al.   HYPERTENSION RESEARCH

Point: Chronic Activation of the Sympathetic Nervous System is the Dominant Contributor to Systemic Hypertension

(2010) Murray Esler et al.   JOURNAL OF APPLIED PHYSIOLOGY

Sympathoinhibition Induced by Centrally Administered Atorvastatin Is Associated With Alteration of NAD(P)H and Mn Superoxide Dismutase Activity in Rostral Ventrolateral Medulla of Stroke-Prone Spontaneously Hypertensive Rats

(2010) Takuya Kishi et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Centrally administered lipopolysaccharide elicits sympathetic excitation via NAD(P)H oxidase-dependent mitogen-activated protein kinase signaling

(2010) Zhi-Hua Zhang et al.   JOURNAL OF HYPERTENSION

Central antioxidant therapy inhibits parasympathetic baroreflex control in conscious rats

(2010) Marcelo Franchini Giusti et al.   NEUROSCIENCE LETTERS

Sympathetic Nervous System Overactivity and Its Role in the Development of Cardiovascular Disease

(2010) Simon C. Malpas   PHYSIOLOGICAL REVIEWS

Reactive oxygen species in rostral ventrolateral medulla modulate cardiac sympathetic afferent reflex in rats

(2009) M.-K. Zhong et al.   Acta Physiologica

Oxidative Stress in the Sympathetic Premotor Neurons Contributes to Sympathetic Activation in Renovascular Hypertension

(2009) E. B. Oliveira-Sales et al.   AMERICAN JOURNAL OF HYPERTENSION

Nitric oxide in rostral ventrolateral medulla regulates cardiac-sympathetic reflexes: role of synthase isoforms

(2009) Zhi-Ling Guo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Regulation of central angiotensin type 1 receptors and sympathetic outflow in heart failure

(2009) Irving H. Zucker et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Cardiovascular responses to hydrogen peroxide into the nucleus tractus solitarius

(2009) Leonardo Máximo Cardoso et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Reactive oxygen and nitrogen species regulate inducible nitric oxide synthase function shifting the balance of nitric oxide and superoxide production

(2009) Jian Sun et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Effect of CoQ homologues on reactive oxygen generation by mitochondria

(2009) Isuke Imada et al.   BIOFACTORS

Brain nuclear factor-kappa B activation contributes to neurohumoral excitation in angiotensin II-induced hypertension

(2009) Y.-M. Kang et al.   CARDIOVASCULAR RESEARCH

Transcriptional Upregulation of Mitochondrial Uncoupling Protein 2 Protects Against Oxidative Stress-Associated Neurogenic Hypertension

(2009) Samuel H.H. Chan et al.   CIRCULATION RESEARCH

Brain-Selective Overexpression of Human Angiotensin-Converting Enzyme Type 2 Attenuates Neurogenic Hypertension

(2009) Yumei Feng et al.   CIRCULATION RESEARCH

Atorvastatin Improves the Impaired Baroreflex Sensitivity via Anti-Oxidant Effect in the Rostral Ventrolateral Medulla of SHRSP

(2009) Takuya Kishi et al.   CLINICAL AND EXPERIMENTAL HYPERTENSION

Role of Inducible Nitric Oxide Synthase in Rostral Ventrolateral Medulla in Blood Pressure Regulation in Spontaneously Hypertensive Rats

(2009) Yoshikuni Kimura et al.   CLINICAL AND EXPERIMENTAL HYPERTENSION

Systemically administered tempol reduces neuronal activity in paraventricular nucleus of hypothalamus and rostral ventrolateral medulla in rats

(2009) Shun-Guang Wei et al.   JOURNAL OF HYPERTENSION

The multiple actions of NO

(2009) Yuansheng Gao   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Role of reactive oxygen species in brainstem in neural mechanisms of hypertension

(2008) Yoshitaka Hirooka   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Atorvastatin Reduces Oxidative Stress in the Rostral Ventrolateral Medulla of Stroke-Prone Spontaneously Hypertensive Rats

(2008) Takuya Kishi et al.   CLINICAL AND EXPERIMENTAL HYPERTENSION

Concepts of neural nitric oxide-mediated transmission

(2008) John Garthwaite   EUROPEAN JOURNAL OF NEUROSCIENCE

Injections of angiotensin-converting enzyme 2 inhibitor MLN4760 into nucleus tractus solitarii reduce baroreceptor reflex sensitivity for heart rate control in rats

(2008) Debra I. Diz et al.   EXPERIMENTAL PHYSIOLOGY

Mitochondrial Dysfunction and Mitochondrial-Produced Reactive Oxygen Species

(2008) Matthew C. Zimmerman et al.   HYPERTENSION

Oxidative Impairment of Mitochondrial Electron Transport Chain Complexes in Rostral Ventrolateral Medulla Contributes to Neurogenic Hypertension

(2008) Samuel H.H. Chan et al.   HYPERTENSION

High Salt Intake Enhances Blood Pressure Increase during Development of Hypertension via Oxidative Stress in Rostral Ventrolateral Medulla of Spontaneously Hypertensive Rats

(2008) Yasuaki Koga et al.   HYPERTENSION RESEARCH

Immunohistochemical assessment of cyclic guanosine monophosphate (cGMP) and soluble guanylate cyclase (sGC) within the rostral ventrolateral medulla

(2008) Kellysan Powers-Martin et al.   JOURNAL OF BIOMEDICAL SCIENCE

Azelnidipine Decreases Sympathetic Nerve Activity Via Antioxidant Effect in the Rostral Ventrolateral Medulla of Stroke-prone Spontaneously Hypertensive Rats

(2008) Satomi Konno et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Mitochondria-derived reactive oxygen species mediate sympathoexcitation induced by angiotensin II in the rostral ventrolateral medulla

(2008) Masatsugu Nozoe et al.   JOURNAL OF HYPERTENSION

Novel Nanomaterials for Clinical Neuroscience

(2008) Jamie L. Gilmore et al.   Journal of Neuroimmune Pharmacology

Simvastatin Inhibits Central Sympathetic Outflow in Heart Failure by a Nitric-Oxide Synthase Mechanism

(2008) L. Gao et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Mitochondrial Respiratory Enzyme Complexes in Rostral Ventrolateral Medulla as Cellular Targets of Nitric Oxide and Superoxide Interaction in the Antagonism of Antihypertensive Action of eNOS Transgene

(2008) L.-C. Kung et al.   MOLECULAR PHARMACOLOGY