Statins as Regulators of Redox State in the Vascular Endothelium: Beyond Lipid Lowering

The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials

(2013)   LANCET

Statin Therapy and Outcome After Ischemic Stroke

(2013) Danielle Ní Chróinín et al.   STROKE

Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials

(2013) S.-K. Myung et al.   BMJ-British Medical Journal

Meta-analysis of the effects of statin therapy on endothelial function in patients with diabetes mellitus

(2012) Lin Zhang et al.   ATHEROSCLEROSIS

Subcellular Localization of Oxidants and Redox Modulation of Endothelial Nitric Oxide Synthase

(2012) Bradley A. Maron et al.   CIRCULATION JOURNAL

Statins and vein graft failure in coronary bypass surgery

(2012) Marios Margaritis et al.   CURRENT OPINION IN PHARMACOLOGY

Simvastatin Decreases Free Radicals Formation in the Human Abdominal Aortic Aneurysm Wall via NF-κB

(2012) A. Piechota-Polanczyk et al.   EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY

Actions of “antioxidants” in the protection against atherosclerosis

(2012) Maria E. Lönn et al.   FREE RADICAL BIOLOGY AND MEDICINE

Essential Role of MicroRNA-155 in Regulating Endothelium-Dependent Vasorelaxation by Targeting Endothelial Nitric Oxide Synthase

(2012) Hai-Xiang Sun et al.   HYPERTENSION

Vascular COX-2 Modulates Blood Pressure and Thrombosis in Mice

(2012) Y. Yu et al.   Science Translational Medicine

Translating the effects of statins: From redox regulation to suppression of vascular wall inflammation

(2012) A. S. Antonopoulos et al.   THROMBOSIS AND HAEMOSTASIS

Endothelial Nox4 NADPH Oxidase Enhances Vasodilatation and Reduces Blood Pressure In Vivo

(2011) Robin Ray et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Rapid, Direct Effects of Statin Treatment on Arterial Redox State and Nitric Oxide Bioavailability in Human Atherosclerosis via Tetrahydrobiopterin-Mediated Endothelial Nitric Oxide Synthase Coupling

(2011) Charalambos Antoniades et al.   CIRCULATION

AHA/ACCF Secondary Prevention and Risk Reduction Therapy for Patients With Coronary and Other Atherosclerotic Vascular Disease: 2011 Update

(2011) Sidney C. Smith et al.   CIRCULATION

Acute simvastatin increases endothelial nitric oxide synthase phosphorylation via AMP-activated protein kinase and reduces contractility of isolated rat mesenteric resistance arteries

(2011) Luciana V. Rossoni et al.   CLINICAL SCIENCE

Intensive statin therapy compared with moderate dosing for prevention of cardiovascular events: a meta-analysis of >40 000 patients

(2011) Edward J. Mills et al.   EUROPEAN HEART JOURNAL

Rosuvastatin attenuates monocrotaline-induced pulmonary hypertension via regulation of Akt/eNOS signaling and asymmetric dimethylarginine metabolism

(2011) Yingzi Pei et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Beneficial vasoactive endothelial effects of fluvastatin: focus on prostacyclin and nitric oxide

(2011) Cristine Skogastierna et al.   HEART AND VESSELS

Myocardial Redox State Predicts In-Hospital Clinical Outcome After Cardiac Surgery

(2011) Charalambos Antoniades et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The effect of simvastatin on asymmetric dimethylarginine and flow-mediated vasodilation after optimizing the LDL level — A randomized, placebo-controlled study

(2011) Lyudmila G. Vladimirova-Kitova et al.   VASCULAR PHARMACOLOGY

Induction of Endothelial Nitric Oxide Synthase, SIRT1, and Catalase by Statins Inhibits Endothelial Senescence Through the Akt Pathway

(2010) Hidetaka Ota et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway

(2010) Shin Makabe et al.   ATHEROSCLEROSIS

Differential metabolic effects of distinct statins

(2010) Kwang Kon Koh et al.   ATHEROSCLEROSIS

Simvastatin lowers reactive oxygen species level by Nrf2 activation via PI3K/Akt pathway

(2010) Dionysios Chartoumpekis et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Atorvastatin Reduces Plaque Vulnerability in an Atherosclerotic Rabbit Model by Altering the 5-Lipoxygenase Pathway

(2010) Guangyi Zhou et al.   CARDIOLOGY

Crosstalk of reactive oxygen species and NF-κB signaling

(2010) Michael J Morgan et al.   CELL RESEARCH

Preoperative Atorvastatin Treatment in CABG Patients Rapidly Improves Vein Graft Redox State by Inhibition of Rac1 and NADPH-Oxidase Activity

(2010) C. Antoniades et al.   CIRCULATION

Therapeutic Targeting of Mitochondrial Superoxide in Hypertension

(2010) Anna E. Dikalova et al.   CIRCULATION RESEARCH

Fluvastatin upregulates endothelial nitric oxide synthase activity via enhancement of its phosphorylation and expression and via an increase in tetrahydrobiopterin in vascular endothelial cells

(2010) Chie Aoki et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Evidence of Pre-Procedural Statin Therapy

(2010) David E. Winchester et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Statin Adverse Effects

(2009) Beatrice A Golomb et al.   American Journal of Cardiovascular Drugs

Atorvastatin Inhibits gp91 phox Circulating Levels in Patients With Hypercholesterolemia

(2009) Pasquale Pignatelli et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Preoperative sCD40L Levels Predict Risk of Atrial Fibrillation After Off-Pump Coronary Artery Bypass Graft Surgery

(2009) C. Antoniades et al.   CIRCULATION

Induction of Prostacyclin by Steady Laminar Shear Stress Suppresses Tumor Necrosis Factor-α Biosynthesis via Heme Oxygenase-1 in Human Endothelial Cells

(2009) Luigia Di Francesco et al.   CIRCULATION RESEARCH

Association of plasma asymmetrical dimethylarginine (ADMA) with elevated vascular superoxide production and endothelial nitric oxide synthase uncoupling: implications for endothelial function in human atherosclerosis

(2009) C. Antoniades et al.   EUROPEAN HEART JOURNAL

Atorvastatin Prevents Endothelial Dysfunction in Mesenteric Arteries From Spontaneously Hypertensive Rats

(2009) Agostino Virdis et al.   HYPERTENSION

Asymmetric dimethylarginine (ADMA) as a prospective marker of cardiovascular disease and mortality—An update on patient populations with a wide range of cardiovascular risk

(2009) Rainer H. Böger et al.   PHARMACOLOGICAL RESEARCH

Pleiotropic Effect of Lovastatin , With and Without Cholestyramine , in the Post Coronary Artery Bypass Graft (Post CABG) Trial

(2008) Michael Domanski et al.   AMERICAN JOURNAL OF CARDIOLOGY

Randomized Placebo-Controlled Trial Assessing a Treatment Strategy Consisting of Pravastatin, Vitamin E, and Homocysteine Lowering on Plasma Asymmetric Dimethylarginine Concentration in Mild to Moderate CKD

(2008) Prabath W.B. Nanayakkara et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Flow-mediated dilation in patients with coronary artery disease is enhanced by high dose atorvastatin compared to combined low dose atorvastatin and ezetimibe: Results of the CEZAR study

(2008) Mir Abolfazl Ostad et al.   ATHEROSCLEROSIS

Evidence for Statin Pleiotropy in Humans

(2008) Ping-Yen Liu et al.   CIRCULATION

Effect of atorvastatin on plasma levels of asymmetric dimethylarginine in patients with non-ischaemic heart failure

(2008) Joanna M. Young et al.   EUROPEAN JOURNAL OF HEART FAILURE

Distinct roles of Nox1 and Nox4 in basal and angiotensin II-stimulated superoxide and hydrogen peroxide production

(2008) S DIKALOV et al.   FREE RADICAL BIOLOGY AND MEDICINE

Anti-hypertensive effects of Rosuvastatin are associated with decreased inflammation and oxidative stress markers in hypertensive rats

(2008) Pierre Sicard et al.   FREE RADICAL RESEARCH

Temporal Gene Expression Analysis of Human Coronary Artery Endothelial Cells Treated With Simvastatin

(2008) LI QIN ZHANG et al.   GENE EXPRESSION

Short Term Fluvastatin Treatment Lowers Serum Asymmetric Dimethylarginine Levels in Patients With Metabolic Syndrome

(2008) Aytekin Oguz et al.   International Heart Journal

Phosphorylation of Endothelial Nitric-oxide Synthase Regulates Superoxide Generation from the Enzyme

(2008) Chun-An Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calcium-Dependent NOX5 Nicotinamide Adenine Dinucleotide Phosphate Oxidase Contributes to Vascular Oxidative Stress in Human Coronary Artery Disease

(2008) Tomasz J. Guzik et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Biomarkers in Heart Failure

(2008) Eugene Braunwald   NEW ENGLAND JOURNAL OF MEDICINE

Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein

(2008) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mechanisms underlying recoupling of eNOS by HMG-CoA reductase inhibition in a rat model of streptozotocin-induced diabetes mellitus

(2007) Philip Wenzel et al.   ATHEROSCLEROSIS

Improvement of age-related endothelial dysfunction by simvastatin: effect on NO and COX pathways

(2005) Maria Álvarez De Sotomayor et al.   BRITISH JOURNAL OF PHARMACOLOGY