Article
Food Science & Technology
Catrin Herpich, Bastian Kochlik, Ulrike Hass, Daniela Weber, Tilman Grune, Kristina Norman
Summary: The study found that in older women, adiponectin levels increased after glucose intake and decreased after high-fat intake; the adiponectin response was associated with the type of dietary challenge, age, and FGF21 response; age-group differences were partly due to metabolic parameters and oxidative stress.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Nutrition & Dietetics
Ying Zhang, Wenwen Gu, Xin Zhao, Le Shan, Zixuan Zhang, Xinhong Wu, Xinbao Zhang, Yanning Cao, Zhongna Sang
Summary: This study assessed iodine loss in breast milk among Chinese lactating women and found that the appropriate dietary intake of iodine is approximately 260 μg/day, which is higher than the previous recommendation.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Katharina Diana Seibt, Morteza Hosseini Ghaffari, Theresa Scheu, Christian Koch, Helga Sauerwein
Summary: The study characterized the oxidative status of Holstein heifer calves fed with milk replacer for 14 weeks, showing changes in oxidative status with age and confirming the benefits of a high feeding plane for welfare and development.
Review
Neurosciences
Jacqueline P. Robbins, Egle Solito
Summary: This review examines the quality of studies and evidence base for the ketogenic and calorie restriction diets in common neuropsychiatric conditions. It discusses the cellular mechanisms mediating the effects of these dietary interventions on brain health and summarizes the clinical evidence for these diets in specific patient populations. The review also provides suggestions to improve future research studies' clinical translation.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Agriculture, Multidisciplinary
Ling Mo, Chaochao Zhao, Bo Huang, Jiawei Niu, Siyan Hong, Jingjing Li, Yintao Lin, Fengqiong Qin
Summary: Intake of oxidized milk during pregnancy may increase the risk of liver and kidney injury in male offspring by interfering with amino acid and energy metabolism, leading to oxidative stress and inflammation.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Agriculture, Dairy & Animal Science
Sarah H. White-Springer, Kelly R. Vineyard, Jan Kivipelto, Lori K. Warren
Summary: This study aimed to investigate the effects of dietary n-3 fatty acid supplementation on antioxidant status and lipid peroxidation in horses. The results showed that supplementation with n-3 fatty acids did not reduce serum vitamin E or Se, but actually elevated vitamin E status and helped lower serum triglycerides and F2-isoprostanes.
JOURNAL OF ANIMAL SCIENCE
(2021)
Article
Nutrition & Dietetics
Wenxing Guo, Wen Wu, Min Gao, Ying Yang, Elizabeth N. Pearce, Shaohan Li, Zhiyuan Ren, Naifan Zhang, Kexin Zhang, Ziyun Pan, Wanqi Zhang
Summary: This study assessed the characteristics and predictors of breast milk iodine concentration (BMIC). The study found that BMIC before breastfeeding is generally higher than after breastfeeding, and morning BMIC is most correlated with the prior day's iodine intake. Breast milk samples taken in the afternoon or after midnight were found to be most representative of the day's BMIC. Maternal total iodine intake and urine iodine were significantly associated with BMIC, and 24-h urinary iodine excretion was the best predictor.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Ying Zhang, Xin Zhao, Le Shan, Xiaomin Jia, Jie Liu, Wenwen Gu, Zixuan Zhang, Xinbao Zhang, Zhongna Sang
Summary: This study found that breast milk iodine concentration (BMIC) varies in a V shaped curve over 24 hours, and suggests that breast milk samples should be collected between 08:00 and 12:00 for evaluating the iodine status of lactating women.
JOURNAL OF NUTRITION
(2023)
Article
Agriculture, Dairy & Animal Science
C. Q. Tan, J. Y. Li, Y. C. Ji, Y. Y. Yang, X. C. Zhao, M. X. Chen, Z. Q. Xin, L. J. Wen, Z. Y. Cui, G. Shu, Q. Y. Jiang
Summary: This study found that adding yeast extract (YE) to sow diets can increase feed intake, reduce body weight loss during lactation, and positively impact nucleotide concentrations in milk, potentially promoting piglet growth. Furthermore, YE can enhance antioxidant capacity in both sows and piglets.
ANIMAL FEED SCIENCE AND TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Tarek Khamis, Abdelalim F. Abdelalim, Ahmed A. Saeed, Nagah M. Edress, Alaa Nafea, Huda F. Ebian, Reem Algendy, Doaa M. Hendawy, Ahmed Hamed Arisha, Somia Hassan Abdallah
Summary: The study revealed that intraperitoneally transplanted Br-MSCs homed to the diabetic islet, improving fasting blood glucose, serum insulin level, and pancreatic oxidative stress, and modulated various molecular pathways involved in beta-cell dysfunction, indicating their potential as a new insight in beta cell regenerative therapy.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Pinghan Wang, Fangyi Long, Hong Lin, Ting Wang
Summary: Breast cancer, accounting for 11.7% of all newly diagnosed cancer cases, has become the leading cause of cancer worldwide. Naturally occurring dietary phytochemical compounds, such as curcumin and resveratrol, are considered promising agents for breast cancer prevention. Nuclear factor erythroid 2-related factor 2 (Nrf2) plays a key regulatory role in suppressing the accumulation of carcinogens, and its modulation by dietary phytochemicals appears to be a promising approach for breast cancer prevention.
Article
Nutrition & Dietetics
Pantea Nazeri, Zhale Tahmasebinejad, Mehdi Hedayati, Parvin Mirmiran, Fereidoun Azizi
Summary: The study found a positive association between breast milk iodine concentration and weight-for-length z-score of infants, potentially independent of growth- and obesity-related hormones. The specific mechanisms behind this relationship require further elucidation.
MATERNAL AND CHILD NUTRITION
(2021)
Article
Nutrition & Dietetics
Miho Kanazashi, Tadayuki Iida, Ryosuke Nakanishi, Masayuki Tanaka, Hiromi Ikeda, Naomi Takamiya, Noriaki Maeshige, Hiroyo Kondo, Tomohiko Nishigami, Toshihide Harada, Hidemi Fujino
Summary: This study examined the effects of Brazilian propolis on body fat mass, adiponectin levels, and reactive oxygen species in elderly females. 78 participants were randomly assigned to receive propolis or placebo for 12 weeks. The propolis group experienced a significant decrease in fat mass, an increase in adiponectin levels, and a decrease in oxidative stress, suggesting propolis supplementation may benefit elderly females.
Article
Oncology
Lisa B. B. Earnest-Noble, Dennis Hsu, Siyu Chen, Hosseinali Asgharian, Mandayam Nandan, Maria C. C. Passarelli, Hani Goodarzi, Sohail F. F. Tavazoie
Summary: This study reveals that two isoacceptor tRNAs that decode synonymous codons become modulated in opposing directions during breast cancer progression, affecting the translation and growth of breast cancer cells.
Article
Biochemistry & Molecular Biology
Susanne M. Henning, Jieping Yang, Ru-Po Lee, Jianjun Huang, Gail Thames, Michelle Korn, Dina Ben-Nissan, David Heber, Zhaoping Li
Summary: This pilot study demonstrates that ellagic acid and its metabolites are transferred from breast milk to nursing infants and affect the infant gut microbiome. The concentration of ellagic acid metabolites in breast milk increased over time, indicating potential neuroprotective, antioxidant, and anti-inflammatory health benefits for infants.
Article
Medicine, General & Internal
Pedro Pujante Alarcon, Edelmiro Luis Menendez Torre, Paula Morales Sanchez, Raul Rodriguez Escobedo, Santiago Conde Barreiro, Gemma Rojo Martinez, Elias Delgado Alvarez
Summary: This study aims to understand the prevalence of atherosclerotic cardiovascular diseases and heart failure in people diagnosed with diabetes in Spain during 2017, and compare them with those not diagnosed with diabetes. The results show that the risk of being diagnosed with acute myocardial infarction, stroke, peripheral artery disease, or heart failure is higher in diabetes patients aged over 35 compared to those without diabetes, and this risk is more pronounced in patients under 64 years of age. Moreover, females have a higher risk than males for all diagnoses except peripheral artery disease.
Article
Medicine, Research & Experimental
Maria Molina-Vega, Maria J. Picon-Cesar, Carolina Gutierrez-Repiso, Andrea Fernandez-Valero, Fuensanta Lima-Rubio, Stella Gonzalez-Romero, Isabel Moreno-Indias, Francisco J. Tinahones
Summary: In women with gestational diabetes mellitus, treatment with metformin led to lower postprandial glycemia and less weight gain compared to treatment with insulin. There were also changes in the composition of gut microbiota, with a decrease in Firmicutes and Peptostreptococcaceae abundance and an increase in Proteobacteria and Enterobacteriaceae abundance in the metformin group. Predicted metabolic pathways related to propionate degradation and ubiquinol biosynthesis were more prevalent in the metformin group. Further studies are needed to understand how these changes impact metabolic control during and after pregnancy.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Endocrinology & Metabolism
Silvia Patricia Alonso, Sergio Valdes, Cristina Maldonado-Araque, Ana Lago, Pilar Ocon, Alfonso Calle, Luis Castano, Elias Delgado, Edelmiro Menendez, Josep Franch-Nadal, Sonia Gaztambide, Juan Girbes, Felipe Chaves, Sara Garcia-Serrano, Eva Garcia-Escobar, Jose Carlos Fernandez-Garcia, Gabriel Olveira, Natalia Colomo, Gemma Rojo-Martinez
Summary: The study found that the thyroid hormone resistance index is associated with the risk of all-cause mortality in the adult population of Spain.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Teresa Maria Linares-Pineda, Hatim Boughanem, Carolina Gutierrez-Repiso, Manuel Macias-Gonzalez, Eduardo Andres-Leon, Gemma Rojo-Martinez, Sergio Valdes, Francisco J. Tinahones, Sonsoles Morcillo
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Surgery
Carolina Gutierrez-Repiso, Lourdes Garrido-Sanchez, Juan Alcaide-Torres, Isabel Cornejo-Pareja, Luis Ocana-Wilhelmi, Eduardo Garcia-Fuentes, Isabel Moreno-Indias, Francisco J. Tinahones
Summary: This study found that the composition of the gut microbiota before surgery may impact the outcomes of bariatric surgery. The Prevotella-to-Bacteroides ratio could serve as a predictive tool for weight loss trajectory. Early after surgery, patients who experienced successful weight loss showed an enrichment in taxa related to beneficial effects on host metabolism.
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2022)
Article
Biochemistry & Molecular Biology
Jose Ignacio Martinez-Montoro, Mar Quesada-Molina, Carolina Gutierrez-Repiso, Patricia Ruiz-Limon, Alba Subiri-Verdugo, Francisco J. Tinahones, Isabel Moreno-Indias
Summary: The antioxidant capacity of beer polyphenols may induce positive shifts in gut microbiota composition, and some of the observed changes may be related to metabolic status.
Article
Nutrition & Dietetics
Concepcion Santiago-Fernandez, Cristina Rodriguez-Diaz, Ailec Ho-Plagaro, Carolina Gutierrez-Repiso, Wilfredo Oliva-Olivera, Flores Martin-Reyes, Virginia Mela, Rocio Bautista, Monicas Tome, Josefa Gomez-Maldonado, Francisco J. Tinahones, Eduardo Garcia-Fuentes, Lourdes Garrido-Sanchez
Summary: This study found that extra virgin olive oil (EVOO) and sunflower oil (SO) have different effects on the miRNA composition of endothelial cell-derived extracellular vesicles (EVs). These EVs can regulate the transcriptomic profile of smooth muscle cells (SMCs), which plays a role in the development of atherosclerosis.
FRONTIERS IN NUTRITION
(2022)
Article
Environmental Sciences
Sergio Valdes, Viyey Doulatram-Gamgaram, Cristina Maldonado-Araque, Ana Lago-Sampedro, Eva Garcia-Escobar, Sara Garcia-Serrano, Marta Garcia-Vivanco, Luis Garrido Juan, Mark Richard Theobald, Victoria Gil, Fernando Martin-Llorente, Pilar Ocon, Alfonso Calle-Pascual, Luis Castano, Elias Delgado, Edelmiro Menendez, Josep Franch-Nadal, Sonia Gaztambide, Joan Girbes, F. Javier Chaves, Jose L. Galan-Garcia, Gabriel Aguilera-Venegas, Carolina Gutierrez-Repiso, Jose Carlos Fernandez-Garcia, Natalia Colomo, Federico Soriguer, Eduardo Garcia-Fuentes, Gemma Rojo-Martinez
Summary: This study evaluated the association between exposure to air pollutants and thyroid function parameters in a nationwide sample of Spanish adults. The results showed a significant negative correlation between PM2.5 concentrations and FT4 and FT3 levels, as well as a significant association between PM2.5 concentrations and the odds of presenting high TSH, lower FT4, and low FT3 levels. NO2 concentrations showed no association with thyroid hormone levels.
ENVIRONMENTAL HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Maria Molina-Vega, Maria Jose Picon-Cesar, Fuensanta Lima-Rubio, Carolina Gutierrez-Repiso, Teresa Maria Linares-Pineda, Maria Suarez-Arana, Ana Maria Fernandez-Ramos, Francisco J. Tinahones, Sonsoles Morcillo
Summary: Vitamin D deficiency is common in pregnant women and is associated with a higher risk of gestational diabetes mellitus (GDM). In this study, it was found that pregnant women who required insulin for GDM had higher levels of vitamin D compared to those who did not require insulin and healthy controls at postpartum and 1 year after birth.
Article
Endocrinology & Metabolism
Jose Ignacio Martinez-Montoro, Marta Generoso-Pinar, Luis Ocana-Wilhelmi, Carolina Gutierrez-Repiso, Ana Sanchez-Garcia, Rocio Soler-Humanes, Jose Luis Fernandez-Serrano, Pilar Sanchez-Gallego, Jose M. Martinez-Moreno, Eduardo Garcia-Fuentes, Francisco J. Tinahones, Lourdes Garrido-Sanchez
Summary: This study investigated the impact of preoperative clinical and biochemical parameters on the remission of Type 2 diabetes (T2DM) after metabolic surgery. The results showed that patients who did not experience T2DM remission after surgery had longer diabetes duration, higher levels of glycated hemoglobin (HbA1c), and were more likely to use insulin, antihypertensive drugs, and lipid-lowering therapies. Additionally, preexisting hypertension, hypercholesterolemia, and longer diabetes duration were independent predictors of T2DM persistence after metabolic surgery.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Biochemistry & Molecular Biology
Teresa Maria Linares-Pineda, Nerea Pena-Montero, Carolina Gutierrez-Repiso, Fuensanta Lima-Rubio, Antonio Sanchez-Pozo, Francisco J. Tinahones, Maria Molina-Vega, Maria Jose Picon-Cesar, Sonsoles Morcillo
Summary: Gestational diabetes mellitus (GDM) increases the risk of metabolic disorders in pregnant women and their offspring. This study aims to identify epigenetic marks related to the development of GDM. DNA methylation patterns from 32 pregnant women, 16 with GDM and 16 without GDM, were analyzed. Differential methylated positions and annotated genes were identified, with a significant relationship found between certain genes and carbohydrate metabolism. Furthermore, a correlation was observed between specific methylation positions and biochemical variables during pregnancy and postpartum. These findings suggest a potential role of epigenetic mechanisms in GDM and related metabolic changes.
Article
Endocrinology & Metabolism
Teresa Maria Linares-Pineda, Carolina Gutierrez-Repiso, Nerea Pena-Montero, Maria Molina-Vega, Fuensanta Lima Rubio, Maria Suarez Arana, Francisco J. Tinahones, Maria Jose Picon-Cesar, Sonsoles Morcillo
Summary: There is increasing interest in developing markers for detecting pancreatic beta cell death to improve early diagnosis and treatment response in diabetes, particularly in type 1 diabetes. Early detection of beta cell death would also benefit other types of diabetes.
DIABETOLOGY & METABOLIC SYNDROME
(2023)
Article
Endocrinology & Metabolism
Enrique Ozcariz, Montse Guardiola, Nuria Amigo, Gemma Rojo-Martinez, Sergio Valdes, Pere Rehues, Lluis Masana, Josep Ribalta
Summary: The aim of this study was to combine nuclear magnetic resonance-based metabolomics and machine learning to identify a glucose-independent molecular signature associated with future type 2 diabetes development. A metabolomic analysis was performed on serum samples from individuals in the Di@bet.es study, revealing lipoprotein and glycoprotein profiles as well as 15 low molecular weight metabolites that were related to the development of type 2 diabetes. Machine learning models also highlighted the roles of inflammation and muscle as independent factors in the development of type 2 diabetes.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
