DNA Double Strand Break Repair: A Radiation Perspective

PARP inhibition sensitizes childhood high grade glioma, medulloblastoma and ependymoma to radiation

(2015) Dannis Gilbert Van Vuurden et al.   Oncotarget

The Dual PI3K/mTOR Inhibitor NVP-BEZ235 Is a Potent Inhibitor of ATM- and DNA-PKCs-Mediated DNA Damage Responses

(2015) Bipasha Mukherjee et al.   NEOPLASIA

Cross-platform pathway-based analysis identifies markers of response to the PARP inhibitor olaparib

(2012) Anneleen Daemen et al.   BREAST CANCER RESEARCH AND TREATMENT

Targeting radiation-resistant hypoxic tumour cells through ATR inhibition

(2012) I M Pires et al.   BRITISH JOURNAL OF CANCER

Cytokine profile of conditioned medium from human tumor cell lines after acute and fractionated doses of gamma radiation and its effect on survival of bystander tumor cells

(2012) Sejal Desai et al.   CYTOKINE

The dynamics of Ku70/80 and DNA-PKcs at DSBs induced by ionizing radiation is dependent on the complexity of damage

(2012) Pamela Reynolds et al.   NUCLEIC ACIDS RESEARCH

Severe reaction to radiotherapy for breast cancer as the presenting feature of ataxia telangiectasia

(2011) P J Byrd et al.   BRITISH JOURNAL OF CANCER

Screening for large genomic rearrangements in the FANCA gene reveals extensive deletion in a Finnish breast cancer family

(2011) Szilvia Solyom et al.   CANCER LETTERS

Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications

(2011) S. E. Polo et al.   GENES & DEVELOPMENT

A putative “hepitype” in the ATM gene associated with chronic lymphocytic leukemia risk

(2011) Idoia Martín-Guerrero et al.   GENES CHROMOSOMES & CANCER

Repair of DNA damage induced by accelerated heavy ions-A mini review

(2011) Ryuichi Okayasu   INTERNATIONAL JOURNAL OF CANCER

Reactive oxygen species-induced release of signalling factors in irradiated cells triggers membrane signalling and calcium influx in bystander cells

(2011) Fiona M. Lyng et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

DNA Repair Biomarkers Predict Response to Neoadjuvant Chemoradiotherapy in Esophageal Cancer

(2011) Brian M. Alexander et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Association of BRCA1 and BRCA2 Mutations With Survival, Chemotherapy Sensitivity, and Gene Mutator Phenotype in Patients With Ovarian Cancer

(2011) Da Yang et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Critical Role of Monoubiquitination of Histone H2AX Protein in Histone H2AX Phosphorylation and DNA Damage Response

(2011) Ching-Yuan Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phase II, Open-Label, Randomized, Multicenter Study Comparing the Efficacy and Safety of Olaparib, a Poly (ADP-Ribose) Polymerase Inhibitor, and Pegylated Liposomal Doxorubicin in Patients WithBRCA1orBRCA2Mutations and Recurrent Ovarian Cancer

(2011) Stan B. Kaye et al.   JOURNAL OF CLINICAL ONCOLOGY

Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study

(2011) Karen A Gelmon et al.   LANCET ONCOLOGY

Role of oxidative stress and DNA damage in human carcinogenesis

(2011) Thomas B. Kryston et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

hSSB1 interacts directly with the MRN complex stimulating its recruitment to DNA double-strand breaks and its endo-nuclease activity

(2011) Derek J. Richard et al.   NUCLEIC ACIDS RESEARCH

Efficacy of CHK inhibitors as single agents in MYC-driven lymphoma cells

(2011) P T Ferrao et al.   ONCOGENE

Unrepaired clustered DNA lesions induce chromosome breakage in human cells

(2011) A. Asaithamby et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Poly(ADP-ribose) polymerase-1 mRNA expression in human breast cancer: a meta-analysis

(2010) Anthony Gonçalves et al.   BREAST CANCER RESEARCH AND TREATMENT

Mechanism of Radiosensitization by the Chk1/2 Inhibitor AZD7762 Involves Abrogation of the G2Checkpoint and Inhibition of Homologous Recombinational DNA Repair

(2010) Meredith A. Morgan et al.   CANCER RESEARCH

In vitro and In vivo Radiation Sensitization of Human Tumor Cells by a Novel Checkpoint Kinase Inhibitor, AZD7762

(2010) J. B. Mitchell et al.   CLINICAL CANCER RESEARCH

Tumor Growth Inhibition by Olaparib in BRCA2 Germline-Mutated Patient-Derived Ovarian Cancer Tissue Xenografts

(2010) U. Kortmann et al.   CLINICAL CANCER RESEARCH

Targeting Hypoxic Cells through the DNA Damage Response

(2010) M. Olcina et al.   CLINICAL CANCER RESEARCH

The influence of heterochromatin on DNA double strand break repair: Getting the strong, silent type to relax

(2010) Aaron A. Goodarzi et al.   DNA REPAIR

ATM Deficiency Sensitizes Mantle Cell Lymphoma Cells to Poly(ADP-Ribose) Polymerase-1 Inhibitors

(2010) C. T. Williamson et al.   MOLECULAR CANCER THERAPEUTICS

Delayed repair of radiation induced clustered DNA damage: Friend or foe?

(2010) Laura J. Eccles et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Spatiotemporal characterization of ionizing radiation induced DNA damage foci and their relation to chromatin organization

(2010) S.V. Costes et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

(2010) Peter Bouwman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

hSSB1 rapidly binds at the sites of DNA double-strand breaks and is required for the efficient recruitment of the MRN complex

(2010) Derek J. Richard et al.   NUCLEIC ACIDS RESEARCH

ATM Activation by Oxidative Stress

(2010) Z. Guo et al.   SCIENCE

Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining

(2009) Brandi L. Mahaney et al.   BIOCHEMICAL JOURNAL

Molecular analysis of Ku redox regulation

(2009) Sara M Bennett et al.   BMC MOLECULAR BIOLOGY

Death receptor pathways mediate targeted and non-targeted effects of ionizing radiations in breast cancer cells

(2009) Audrey Luce et al.   CARCINOGENESIS

Mutational analysis of FANCL , FANCM and the recently identified FANCI suggests that among the 13 known Fanconi Anemia genes, only FANCD1/BRCA2 plays a major role in high-risk breast cancer predisposition

(2009) María J. García et al.   CARCINOGENESIS

Dose response and kinetics of foci disappearance following exposure to high- and low-LET ionizing radiation

(2009) Rasa Ugenskiene et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

A novel Chk inhibitor, XL-844, increases human cancer cell radiosensitivity through promotion of mitotic catastrophe

(2009) Oliver Riesterer et al.   INVESTIGATIONAL NEW DRUGS

MRE11-RAD50-NBS1 Complex Dictates DNA Repair Independent of H2AX

(2009) Jingsong Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Poly(ADP-Ribose) Polymerase in Tumors fromBRCAMutation Carriers

(2009) Peter C. Fong et al.   NEW ENGLAND JOURNAL OF MEDICINE

Artemis is a negative regulator of p53 in response to oxidative stress

(2009) X Zhang et al.   ONCOGENE

Exomic Sequencing Identifies PALB2 as a Pancreatic Cancer Susceptibility Gene

(2009) S. Jones et al.   SCIENCE

ATM Acts Downstream of ATR in the DNA Damage Response Signaling of Bystander Cells

(2008) S. Burdak-Rothkamm et al.   CANCER RESEARCH

Breaching the DNA damage checkpoint via PF-00477736, a novel small-molecule inhibitor of checkpoint kinase 1

(2008) A. Blasina et al.   MOLECULAR CANCER THERAPEUTICS

Single-stranded DNA-binding protein hSSB1 is critical for genomic stability

(2008) Derek J. Richard et al.   NATURE

Identification of Holliday junction resolvases from humans and yeast

(2008) Stephen C. Y. Ip et al.   NATURE

Expression of the BRCA1-interacting protein Brip1/BACH1/FANCJ is driven by E2F and correlates with human breast cancer malignancy

(2008) G Eelen et al.   ONCOGENE

Repair of HZE-Particle-Induced DNA Double-Strand Breaks in Normal Human Fibroblasts

(2008) Aroumougame Asaithamby et al.   RADIATION RESEARCH

MMEJ repair of double-strand breaks (director’s cut): deleted sequences and alternative endings

(2008) Mitch McVey et al.   TRENDS IN GENETICS