Mitochondrial Morphology in Metabolic Diseases

Human MIEF1 recruits Drp1 to mitochondrial outer membranes and promotes mitochondrial fusion rather than fission

(2011) Jian Zhao et al.   EMBO JOURNAL

MiD49 and MiD51, new components of the mitochondrial fission machinery

(2011) Catherine S Palmer et al.   EMBO REPORTS

Mitofusin-2 Maintains Mitochondrial Structure and Contributes to Stress-Induced Permeability Transition in Cardiac Myocytes

(2011) K. N. Papanicolaou et al.   MOLECULAR AND CELLULAR BIOLOGY

Control of Mitochondrial Morphology Through Differential Interactions of Mitochondrial Fusion and Fission Proteins

(2011) Pinwei Huang et al.   PLoS One

Mitochondrial dysfunction in the type 2 diabetic heart is associated with alterations in spatially distinct mitochondrial proteomes

(2010) Erinne R. Dabkowski et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Increased propensity for cell death in diabetic human heart is mediated by mitochondrial-dependent pathways

(2010) Ethan J. Anderson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Mitochondrial Dynamics in Diabetes

(2010) Yisang Yoon et al.   ANTIOXIDANTS & REDOX SIGNALING

High-Glucose Stimulation Increases Reactive Oxygen Species Production Through the Calcium and Mitogen-Activated Protein Kinase-Mediated Activation of Mitochondrial Fission

(2010) Tianzheng Yu et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondria in the diabetic heart

(2010) H. Bugger et al.   CARDIOVASCULAR RESEARCH

Inhibiting Mitochondrial Fission Protects the Heart Against Ischemia/Reperfusion Injury

(2010) Sang-Bing Ong et al.   CIRCULATION

A Lethalde NovoMutation in the Middle Domain of the Dynamin-related GTPase Drp1 Impairs Higher Order Assembly and Mitochondrial Division

(2010) Chuang-Rung Chang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells

(2010) Hidenori Otera et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model

(2010) R. Scott Rector et al.   JOURNAL OF HEPATOLOGY

Mitochondrial dysfunction during in vitro hepatocyte steatosis is reversed by omega-3 fatty acid–induced up-regulation of mitofusin 2

(2010) Yong Zhang et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Conformational changes in Dnm1 support a contractile mechanism for mitochondrial fission

(2010) Jason A Mears et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Mutation in the Mitochondrial Fission Gene Dnm1l Leads to Cardiomyopathy

(2010) Houman Ashrafian et al.   PLoS Genetics

Enhanced apoptotic propensity in diabetic cardiac mitochondria: influence of subcellular spatial location

(2009) Courtney L. Williamson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Tissue-Specific Remodeling of the Mitochondrial Proteome in Type 1 Diabetic Akita Mice

(2009) H. Bugger et al.   DIABETES

Mitochondrial Networking Protects  -Cells From Nutrient-Induced Apoptosis

(2009) A. J.A. Molina et al.   DIABETES

SLP-2 is required for stress-induced mitochondrial hyperfusion

(2009) Daniel Tondera et al.   EMBO JOURNAL

MAPL is a new mitochondrial SUMO E3 ligase that regulates mitochondrial fission

(2009) Emélie Braschi et al.   EMBO REPORTS

Synergistic effect of cAMP and palmitate in promoting altered mitochondrial function and cell death in HepG2 cells

(2009) Linxia Zhang et al.   EXPERIMENTAL CELL RESEARCH

SUMOylation of the mitochondrial fission protein Drp1 occurs at multiple nonconsensus sites within the B domain and is linked to its activity cycle

(2009) Claudia Figueroa-Romero et al.   FASEB JOURNAL

Palmitate Induces Insulin Resistance in H4IIEC3 Hepatocytes through Reactive Oxygen Species Produced by Mitochondria

(2009) Seiji Nakamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of OPA1 processing and mitochondrial fusion bym-AAA protease isoenzymes and OMA1

(2009) Sarah Ehses et al.   JOURNAL OF CELL BIOLOGY

Inducible proteolytic inactivation of OPA1 mediated by the OMA1 protease in mammalian cells

(2009) Brian Head et al.   JOURNAL OF CELL BIOLOGY

The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice

(2009) Junko Wakabayashi et al.   JOURNAL OF CELL BIOLOGY

Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models

(2009) Craig Brooks et al.   JOURNAL OF CLINICAL INVESTIGATION

Substrate-Specific Derangements in Mitochondrial Metabolism and Redox Balance in the Atrium of the Type 2 Diabetic Human Heart

(2009) Ethan J. Anderson et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice

(2009) Naotada Ishihara et al.   NATURE CELL BIOLOGY

S-Nitrosylation of Drp1 Mediates β-Amyloid-Related Mitochondrial Fission and Neuronal Injury

(2009) Dong-Hyung Cho et al.   SCIENCE

Daily exercise increases hepatic fatty acid oxidation and prevents steatosis in Otsuka Long-Evans Tokushima Fatty rats

(2008) R. Scott Rector et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Diabetic cardiomyopathy-associated dysfunction in spatially distinct mitochondrial subpopulations

(2008) Erinne R. Dabkowski et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The cytoprotective actions of long-chain mono-unsaturated fatty acids in pancreatic β-cells

(2008) Noel G. Morgan et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Mitochondrial fission mediates high glucose-induced cell death through elevated production of reactive oxygen species

(2008) Tianzheng Yu et al.   CARDIOVASCULAR RESEARCH

Type 1 Diabetic Akita Mouse Hearts Are Insulin Sensitive but Manifest Structurally Abnormal Mitochondria That Remain Coupled Despite Increased Uncoupling Protein 3

(2008) H. Bugger et al.   DIABETES

Intracellular Angiotensin II Production in Diabetic Rats Is Correlated With Cardiomyocyte Apoptosis, Oxidative Stress, and Cardiac Fibrosis

(2008) V. P. Singh et al.   DIABETES

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

(2008) Gilad Twig et al.   EMBO JOURNAL

The mitochondrial outer membrane protein hFis1 regulates mitochondrial morphology and fission through self-interaction

(2008) Madhavika N. Serasinghe et al.   EXPERIMENTAL CELL RESEARCH

Fatty acids as modulators of the cellular production of reactive oxygen species

(2008) Peter Schönfeld et al.   FREE RADICAL BIOLOGY AND MEDICINE

The lysosomal-mitochondrial axis in free fatty acid-induced hepatic lipotoxicity

(2008) ZhengZheng Li et al.   HEPATOLOGY

CaM kinase Iα–induced phosphorylation of Drp1 regulates mitochondrial morphology

(2008) Xiao-Jian Han et al.   JOURNAL OF CELL BIOLOGY

Cessation of daily exercise dramatically alters precursors of hepatic steatosis in Otsuka Long-Evans Tokushima Fatty (OLETF) rats

(2008) R. Scott Rector et al.   JOURNAL OF PHYSIOLOGY-LONDON

The Novel Tail-anchored Membrane Protein Mff Controls Mitochondrial and Peroxisomal Fission in Mammalian Cells

(2008) Shilpa Gandre-Babbe et al.   MOLECULAR BIOLOGY OF THE CELL

Mitofusin 2 tethers endoplasmic reticulum to mitochondria

(2008) Olga Martins de Brito et al.   NATURE