Iron–Sulfur Clusters: Biogenesis, Molecular Mechanisms, and Their Functional Significance

The Disulfide Relay of the Intermembrane Space of Mitochondria: An Oxygen-Sensing System?

(2010) Karl Bihlmaier et al.   Annals of the New York Academy of Sciences

Structural Basis for the Disulfide Relay System in the Mitochondrial Intermembrane Space

(2010) Toshiya Endo et al.   ANTIOXIDANTS & REDOX SIGNALING

Oxidative Protein Folding in the Mitochondrial Intermembrane Space

(2010) Dionisia P. Sideris et al.   ANTIOXIDANTS & REDOX SIGNALING

Monothiol glutaredoxin Grx5 interacts with Fe–S scaffold proteins Isa1 and Isa2 and supports Fe–S assembly and DNA integrity in mitochondria of fission yeast

(2010) Kyoung-Dong Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Frataxin, a molecule of mystery: trading stability for function in its iron-binding site: Figure 1

(2010) Darius J. R. Lane et al.   BIOCHEMICAL JOURNAL

Chloroplast DnaJ-like proteins 3 and 4 (CDJ3/4) fromChlamydomonas reinhardtiicontain redox-active Fe–S clusters and interact with stromal HSP70B

(2010) Karolin V. Dorn et al.   BIOCHEMICAL JOURNAL

Human Iron−Sulfur Cluster Assembly, Cellular Iron Homeostasis, and Disease

(2010) Hong Ye et al.   BIOCHEMISTRY

SufU Is an Essential Iron-Sulfur Cluster Scaffold Protein in Bacillus subtilis

(2010) A. G. Albrecht et al.   JOURNAL OF BACTERIOLOGY

Glutaredoxin 5 deficiency causes sideroblastic anemia by specifically impairing heme biosynthesis and depleting cytosolic iron in human erythroblasts

(2010) Hong Ye et al.   JOURNAL OF CLINICAL INVESTIGATION

Plant glutaredoxins: pivotal players in redox biology and iron-sulphur centre assembly

(2010) Nicolas Rouhier   NEW PHYTOLOGIST

Hypoxia-regulated microRNA-210 modulates mitochondrial function and decreases ISCU and COX10 expression

(2010) Z Chen et al.   ONCOGENE

The evolution, metabolism and functions of the apicoplast

(2010) L. Lim et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

A Novel Role for Arabidopsis Mitochondrial ABC Transporter ATM3 in Molybdenum Cofactor Biosynthesis

(2010) J. Teschner et al.   PLANT CELL

Involvement of AtNAP1 in the regulation of chlorophyll degradation in Arabidopsis thaliana

(2010) Tomohiro Nagane et al.   PLANTA

MicroRNA-210 Regulates Mitochondrial Free Radical Response to Hypoxia and Krebs Cycle in Cancer Cells by Targeting Iron Sulfur Cluster Protein ISCU

(2010) Elena Favaro et al.   PLoS One

Nitric oxide and frataxin: two players contributing to maintain cellular iron homeostasis

(2009) Leonor Ramirez et al.   ANNALS OF BOTANY

New insights into ferritin synthesis and function highlight a link between iron homeostasis and oxidative stress in plants

(2009) Jean-Francois Briat et al.   ANNALS OF BOTANY

A Disruption in Iron-Sulfur Center Biogenesis via Inhibition of Mitochondrial Dithiol Glutaredoxin 2 May Contribute to Mitochondrial and Cellular Iron Dysregulation in Mammalian Glutathione-Depleted Dopaminergic Cells: Implications for Parkinson's Disease

(2009) Donna W. Lee et al.   ANTIOXIDANTS & REDOX SIGNALING

IscA/SufA paralogues are required for the [4Fe-4S] cluster assembly in enzymes of multiple physiological pathways inEscherichia coliunder aerobic growth conditions

(2009) Guoqiang Tan et al.   BIOCHEMICAL JOURNAL

Iron-binding activity in yeast frataxin entails a trade off with stability in the α1/β1 acidic ridge region

(2009) Ana R. Correia et al.   BIOCHEMICAL JOURNAL

Chloroplast HCF101 is a scaffold protein for [4Fe-4S] cluster assembly

(2009) Serena Schwenkert et al.   BIOCHEMICAL JOURNAL

Iron−Sulfur Cluster Biosynthesis: Functional Characterization of the N- and C-Terminal Domains of Human NFU†

(2009) Yushi Liu et al.   BIOCHEMISTRY

A Complex between Biotin Synthase and the Iron−Sulfur Cluster Assembly Chaperone HscA That Enhances in Vivo Cluster Assembly

(2009) Michael R. Reyda et al.   BIOCHEMISTRY

Structure and Dynamics of the Iron−Sulfur Cluster Assembly Scaffold Protein IscU and Its Interaction with the Cochaperone HscB

(2009) Jin Hae Kim et al.   BIOCHEMISTRY

Iron−Sulfur Cluster Biosynthesis: Characterization of a Molten Globule Domain in Human NFU

(2009) Yushi Liu et al.   BIOCHEMISTRY

The SufBCD Fe−S Scaffold Complex Interacts with SufA for Fe−S Cluster Transfer

(2009) Harsimranjit K. Chahal et al.   BIOCHEMISTRY

Structural Basis for Delivery of the Intact [Fe2S2] Cluster by Monothiol Glutaredoxin

(2009) Thomas Iwema et al.   BIOCHEMISTRY

Stage- and tissue-specific expression of rice OsIsu1 gene encoding a scaffold protein for mitochondrial iron–sulfur-cluster biogenesis

(2009) Daisuke Tsugama et al.   BIOTECHNOLOGY LETTERS

Structural studies of the Enterococcus faecalis SufU [Fe-S] cluster protein

(2009) Gustavo P Riboldi et al.   BMC BIOCHEMISTRY

Clinical manifestation and a new ISCU mutation in iron–sulphur cluster deficiency myopathy

(2009) Gittan Kollberg et al.   BRAIN

MicroRNA-210 Controls Mitochondrial Metabolism during Hypoxia by Repressing the Iron-Sulfur Cluster Assembly Proteins ISCU1/2

(2009) Stephen Y. Chan et al.   Cell Metabolism

Small RNA-induced differential degradation of the polycistronic mRNA iscRSUA

(2009) Guillaume Desnoyers et al.   EMBO JOURNAL

Frataxin interacts with Isu1 through a conserved tryptophan in its β-sheet

(2009) Sébastien Leidgens et al.   HUMAN MOLECULAR GENETICS

Oligomeric Yeast Frataxin Drives Assembly of Core Machinery for Mitochondrial Iron-Sulfur Cluster Synthesis

(2009) Hongqiao Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dual Targeting of Nfs1 and Discovery of Its Novel Processing Enzyme, Icp55

(2009) Adi Naamati et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure-Function Relationship of the Chloroplastic Glutaredoxin S12 with an Atypical WCSYS Active Site

(2009) Jeremy Couturier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Integrated Approach for Experimental Target Identification of Hypoxia-induced miR-210

(2009) Pasquale Fasanaro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Iron–sulfur cluster biosynthesis: characterization of IscU–IscS complex formation and a structural model for sulfide delivery to the [2Fe–2S] assembly site

(2009) Manunya Nuth et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Molecular Dynamism of Fe–S Cluster Biosynthesis Implicated by the Structure of the SufC2–SufD2 Complex

(2009) Kei Wada et al.   JOURNAL OF MOLECULAR BIOLOGY

NativeEscherichia coliSufA, Coexpressed with SufBCDSE, Purifies as a [2Fe−2S] Protein and Acts as an Fe−S Transporter to Fe−S Target Enzymes

(2009) Vibha Gupta et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Overexpression of the yeast frataxin homolog (Yfh1): Contrasting effects on iron–sulfur cluster assembly, heme synthesis and resistance to oxidative stress

(2009) Alexandra Seguin et al.   MITOCHONDRION

Function and biogenesis of iron–sulphur proteins

(2009) Roland Lill   NATURE

Bacterial frataxin CyaY is the gatekeeper of iron-sulfur cluster formation catalyzed by IscS

(2009) Salvatore Adinolfi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An Allelic Mutant Series of ATM3 Reveals Its Key Role in the Biogenesis of Cytosolic Iron-Sulfur Proteins in Arabidopsis

(2009) D. G. Bernard et al.   PLANT PHYSIOLOGY

Dual Localized AtHscB Involved in Iron Sulfur Protein Biogenesis in Arabidopsis

(2009) Xiang Ming Xu et al.   PLoS One

Cannabinoid-induced conditioned place preference in the spontaneously hypertensive rat–an animal model of attention deficit hyperactivity disorder

(2009) Pablo Pandolfo et al.   PSYCHOPHARMACOLOGY

Hereditary Sideroblastic Anemias: Pathophysiology, Diagnosis, and Treatment

(2009) Clara Camaschella   SEMINARS IN HEMATOLOGY

Glutaredoxins: roles in iron homeostasis

(2009) Nicolas Rouhier et al.   TRENDS IN BIOCHEMICAL SCIENCES

Iron-Sulfur (Fe/S) Protein Biogenesis: Phylogenomic and Genetic Studies of A-Type Carriers

(2009) Daniel Vinella et al.   PLoS Genetics

Splice Mutation in the Iron-Sulfur Cluster Scaffold Protein ISCU Causes Myopathy with Exercise Intolerance

(2008) Fanny Mochel et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Maturation of Iron-Sulfur Proteins in Eukaryotes: Mechanisms, Connected Processes, and Diseases

(2008) Roland Lill et al.   Annual Review of Biochemistry

Iron-Based Redox Switches in Biology

(2008) F. Wayne Outten et al.   ANTIOXIDANTS & REDOX SIGNALING

Complementary roles of SufA and IscA in the biogenesis of iron–sulfur clusters inEscherichia coli

(2008) Jianxin Lu et al.   BIOCHEMICAL JOURNAL

Solution Structure of the Iron−Sulfur Cluster Cochaperone HscB and Its Binding Surface for the Iron−Sulfur Assembly Scaffold Protein IscU†‡

(2008) Anna K. Füzéry et al.   BIOCHEMISTRY

Studies on the Mechanism of Catalysis of Iron−Sulfur Cluster Transfer from IscU[2Fe2S] by HscA/HscB Chaperones†

(2008) Francesco Bonomi et al.   BIOCHEMISTRY

Characterization of Quinolinate Synthases fromEscherichia coli,Mycobacterium tuberculosis, andPyrococcus horikoshiiIndicates That [4Fe-4S] Clusters Are Common Cofactors throughout This Class of Enzymes†

(2008) Allison H. Saunders et al.   BIOCHEMISTRY

Assembly of Nitrogenase MoFe Protein†

(2008) Yilin Hu et al.   BIOCHEMISTRY

Regulation of the Activity ofEscherichia coliQuinolinate Synthase by Reversible Disulfide-Bond Formation†

(2008) Allison H. Saunders et al.   BIOCHEMISTRY

Glutaredoxin systems

(2008) Christopher Horst Lillig et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The Erv1–Mia40 disulfide relay system in the intermembrane space of mitochondria

(2008) Kai Hell   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Iron-Sulfur Cluster Biogenesis Systems and their Crosstalk

(2008) Xiang Ming Xu et al.   CHEMBIOCHEM

Characterization of l-aspartate oxidase and quinolinate synthase from Bacillus subtilis

(2008) Ilaria Marinoni et al.   FEBS Journal

Nitric oxide accumulation is required to protect against iron-mediated oxidative stress in frataxin-deficient Arabidopsis plants

(2008) Mariana Martin et al.   FEBS LETTERS

The [4Fe-4S] cluster of quinolinate synthase fromEscherichia coli: Investigation of cluster ligands

(2008) Carine Rousset et al.   FEBS LETTERS

Genome Analysis of Chlamydomonas reinhardtii Reveals The Existence of Multiple, Compartmentalized Iron-Sulfur Protein Assembly Machineries of Different Evolutionary Origins

(2008) J. Godman et al.   GENETICS

Iron-dependent regulation of frataxin expression: implications for treatment of Friedreich ataxia

(2008) K. Li et al.   HUMAN MOLECULAR GENETICS

Myopathy with lactic acidosis is linked to chromosome 12q23.3-24.11 and caused by an intron mutation in the ISCU gene resulting in a splicing defect

(2008) A. Olsson et al.   HUMAN MOLECULAR GENETICS

Assembly of the Iron-binding Protein Frataxin inSaccharomyces cerevisiaeResponds to Dynamic Changes in Mitochondrial Iron Influx and Stress Level

(2008) Oleksandr Gakh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NfuA, a New Factor Required for Maturing Fe/S Proteins inEscherichia coliunder Oxidative Stress and Iron Starvation Conditions

(2008) Sandra Angelini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Binding of Yeast Frataxin to the Scaffold for Fe-S Cluster Biogenesis, Isu

(2008) Tao Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biogenesis of Iron-Sulfur Clusters in Photosystem I

(2008) Zhao Jin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Essential Cytosolic Iron-Sulfur Protein Nbp35 Acts without Cfd1 Partner in the Green Lineage

(2008) Katrine Bych et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cellular and Mitochondrial Remodeling upon Defects in Iron-Sulfur Protein Biogenesis

(2008) Anja Hausmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Asymmetric Trimeric Architecture of [2Fe–2S] IscU: Implications for Its Scaffolding during Iron–Sulfur Cluster Biosynthesis

(2008) Yoshimitsu Shimomura et al.   JOURNAL OF MOLECULAR BIOLOGY

The Impact of O2 on the Fe–S Cluster Biogenesis Requirements of Escherichia coli FNR

(2008) Erin L. Mettert et al.   JOURNAL OF MOLECULAR BIOLOGY

BolA Inhibits Cell Elongation and Regulates MreB Expression Levels

(2008) Patrick Freire et al.   JOURNAL OF MOLECULAR BIOLOGY

Fe-S Cluster Assembly Pathways in Bacteria

(2008) C. Ayala-Castro et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Human Nbp35 Is Essential for both Cytosolic Iron-Sulfur Protein Assembly and Iron Homeostasis

(2008) O. Stehling et al.   MOLECULAR AND CELLULAR BIOLOGY

Dre2, a Conserved Eukaryotic Fe/S Cluster Protein, Functions in Cytosolic Fe/S Protein Biogenesis

(2008) Y. Zhang et al.   MOLECULAR AND CELLULAR BIOLOGY

Biogenesis of Fe/S proteins and pathogenicity: IscR plays a key role in allowing Erwinia chrysanthemi to adapt to hostile conditions

(2008) Gabriel Rincon-Enriquez et al.   MOLECULAR MICROBIOLOGY

Arabidopsis Stromal 70-kD Heat Shock Proteins Are Essential for Plant Development and Important for Thermotolerance of Germinating Seeds

(2008) P.-H. Su et al.   PLANT PHYSIOLOGY

Hydrogen peroxide scavenging rescues frataxin deficiency in a Drosophila model of Friedreich's ataxia

(2008) P. R. Anderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo iron-sulfur cluster formation

(2008) E. C. Raulfs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hydrodynamic characterization of the SufBC and SufCD complexes and their interaction with fluorescent adenosine nucleotides

(2008) Arsen Petrovic et al.   PROTEIN SCIENCE

Iron–sulfur cluster biogenesis and human disease

(2008) Tracey A. Rouault et al.   TRENDS IN GENETICS

High-quality homology models derived from NMR and X-ray structures of E. coli proteins YgdK and Suf E suggest that all members of the YgdK/Suf E protein family are enhancers of cysteine desulfurases

(2005) Gaohua Liu et al.   PROTEIN SCIENCE

Nifs and Sufs in malaria

(2003) K. E. S. Ellis et al.   MOLECULAR MICROBIOLOGY