Redox Balance in the Pathogenesis of Nonalcoholic Fatty Liver Disease: Mechanisms and Therapeutic Opportunities

Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis

(2010) Arun J. Sanyal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clinical trial: a nutritional supplement Viusid, in combination with diet and exercise, in patients with nonalcoholic fatty liver disease

(2009) E. VILAR GOMEZ et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Oxidative Stress-Mediated Mitochondrial Dysfunction Contributes to Angiotensin II-Induced Nonalcoholic Fatty Liver Disease in Transgenic Ren2 Rats

(2009) Yongzhong Wei et al.   AMERICAN JOURNAL OF PATHOLOGY

Increased Hepatic Myeloperoxidase Activity in Obese Subjects with Nonalcoholic Steatohepatitis

(2009) Sander S. Rensen et al.   AMERICAN JOURNAL OF PATHOLOGY

Asymmetrical dimethylarginine triggers lipolysis and inflammatory response via induction of endoplasmic reticulum stress in cultured adipocytes

(2009) Qiu Gen Zhou et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Myeloperoxidase: Molecular Mechanisms of Action and Their Relevance to Human Health and Disease

(2009) Betty S. van der Veen et al.   ANTIOXIDANTS & REDOX SIGNALING

Coenzyme Q10 supplementation lowers hepatic oxidative stress and inflammation associated with diet-induced obesity in mice

(2009) Florence M. Sohet et al.   BIOCHEMICAL PHARMACOLOGY

Study of Cytochrome P450 2E1 and its allele Variants in Liver Injury of Nondiabetic, Nonalcoholic Steatohepatitis Obese Women

(2009) NELSON M VARELA et al.   BIOLOGICAL RESEARCH

Prevention of Steatosis by Hepatic JNK1

(2009) Guadalupe Sabio et al.   Cell Metabolism

IRE-1 and HSP-4 Contribute to Energy Homeostasis via Fasting-Induced Lipases in C. elegans

(2009) Hyunsun Jo et al.   Cell Metabolism

Hepatocyte-Specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis and Inflammation

(2009) Aparna Purushotham et al.   Cell Metabolism

Soraphen, an inhibitor of the acetyl-CoA carboxylase system, improves peripheral insulin sensitivity in mice fed a high-fat diet

(2009) M. Schreurs et al.   DIABETES OBESITY & METABOLISM

Curcumin Eliminates Leptin’s Effects on Hepatic Stellate Cell Activation via Interrupting Leptin Signaling

(2009) Youcai Tang et al.   ENDOCRINOLOGY

PPARδ ligand L-165041 ameliorates Western diet-induced hepatic lipid accumulation and inflammation in LDLR−/− mice

(2009) Hyun-Joung Lim et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Curcumin ameliorates rabbits's steatohepatitis via respiratory chain, oxidative stress, and TNF-α

(2009) M. Carmen Ramirez-Tortosa et al.   FREE RADICAL BIOLOGY AND MEDICINE

SREBP-1c in nonalcoholic fatty liver disease induced by Western-type high-fat diet plus fructose in rats

(2009) Manuela Aragno et al.   FREE RADICAL BIOLOGY AND MEDICINE

c-Jun N-terminal Kinase-1 From Hematopoietic Cells Mediates Progression From Hepatic Steatosis to Steatohepatitis and Fibrosis in Mice

(2009) Yuzo Kodama et al.   GASTROENTEROLOGY

Zinc supplementation reverses alcohol-induced steatosis in mice through reactivating hepatocyte nuclear factor-4α and peroxisome proliferator-activated receptor-α

(2009) Xinqin Kang et al.   HEPATOLOGY

The plasma lipidomic signature of nonalcoholic steatohepatitis

(2009) Puneet Puri et al.   HEPATOLOGY

Maternal high-fat feeding primes steatohepatitis in adult mice offspring, involving mitochondrial dysfunction and altered lipogenesis gene expression

(2009) Kimberley D. Bruce et al.   HEPATOLOGY

Influence of inducible nitric oxide synthase polymorphisms in Japanese patients with non-alcoholic fatty liver disease

(2009) Masato Yoneda et al.   HEPATOLOGY RESEARCH

Hepatic VLDL assembly is disturbed in a rat model of nonalcoholic fatty liver disease: is there a role for dietary coenzyme Q?

(2009) Ainara Cano et al.   JOURNAL OF APPLIED PHYSIOLOGY

GRP78 expression inhibits insulin and ER stress–induced SREBP-1c activation and reduces hepatic steatosis in mice

(2009) Hélène L. Kammoun et al.   JOURNAL OF CLINICAL INVESTIGATION

Silybin, a component of sylimarin, exerts anti-inflammatory and anti-fibrogenic effects on human hepatic stellate cells

(2009) Marco Trappoliere et al.   JOURNAL OF HEPATOLOGY

Enhanced free cholesterol, SREBP-2 and StAR expression in human NASH

(2009) Francisco Caballero et al.   JOURNAL OF HEPATOLOGY

Glucosamine-induced endoplasmic reticulum stress attenuates apolipoprotein B100 synthesis via PERK signaling

(2009) Wei Qiu et al.   JOURNAL OF LIPID RESEARCH

Probiotics Reduce the Inflammatory Response Induced by a High-Fat Diet in the Liver of Young Rats

(2009) Emanuela Esposito et al.   JOURNAL OF NUTRITION

Nitric Oxide and Redox Regulation in the Liver: Part I. General Considerations and Redox Biology in Hepatitis

(2009) Diana L. Diesen et al.   JOURNAL OF SURGICAL RESEARCH

Curcumin eliminates oxidized LDL roles in activating hepatic stellate cells by suppressing gene expression of lectin-like oxidized LDL receptor-1

(2009) Qiaohua Kang et al.   LABORATORY INVESTIGATION

Curcumin limits the fibrogenic evolution of experimental steatohepatitis

(2009) Francesco Vizzutti et al.   LABORATORY INVESTIGATION

Association between angiotensin II type 1 receptor polymorphisms and the occurrence of nonalcoholic fatty liver disease

(2009) Masato Yoneda et al.   LIVER INTERNATIONAL

Reduced endoplasmic reticulum luminal calcium links saturated fatty acid-mediated endoplasmic reticulum stress and cell death in liver cells

(2009) Yuren Wei et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Non-alcoholic fatty liver disease from pathogenesis to management: an update

(2009) G. Musso et al.   Obesity Reviews

Regulatory enzymes of mitochondrial β-oxidation as targets for treatment of the metabolic syndrome

(2009) M. Schreurs et al.   Obesity Reviews

Nitrative and Oxidative Stress in Toxicology and Disease

(2009) Ruth A. Roberts et al.   TOXICOLOGICAL SCIENCES

Increased hepatic oxidative metabolism distinguishes the action of Peroxisome proliferator-activated receptor δ from Peroxisome proliferator-activated receptor γ in the ob/ob mouse

(2009) Lee D Roberts et al.   Genome Medicine

Resveratrol improves non-alcoholic fatty liver disease by activating AMP-activated protein kinase

(2008) Jing SHANG et al.   ACTA PHARMACOLOGICA SINICA

Angiotensin receptor blockers in the treatment of NASH/NAFLD: Could they be a first-class option?

(2008) Eugen Florin Georgescu   ADVANCES IN THERAPY

Nitric Oxide Plays a Crucial Role in the Development/Progression of Nonalcoholic Steatohepatitis in the Choline-Deficient, l-Amino Acid-Defined Diet-Fed Rat Model

(2008) Koji Fujita et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Cytokines in the Pathogenesis of Fatty Liver and Disease Progression to Steatohepatitis: Implications for Treatment

(2008) Christine Carter-Kent et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Increased Hepatic and Circulating Interleukin-6 Levels in Human Nonalcoholic Steatohepatitis

(2008) Anna Wieckowska et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

The lowering of hepatic fatty acid uptake improves liver function and insulin sensitivity without affecting hepatic fat content in humans

(2008) Sara Rigazio et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Association of liver disease with postprandial large intestinal triglyceride-rich lipoprotein accumulation and pro/antioxidant imbalance in normolipidemic non-alcoholic steatohepatitis

(2008) Giovanni Musso et al.   ANNALS OF MEDICINE

Association between PPARGC1A polymorphisms and the occurrence of nonalcoholic fatty liver disease (NAFLD)

(2008) Masato Yoneda et al.   BMC GASTROENTEROLOGY

Resveratrol inhibits nonalcoholic fatty liver disease in rats

(2008) Luis Bujanda et al.   BMC GASTROENTEROLOGY

Alternative M2 Activation of Kupffer Cells by PPARδ Ameliorates Obesity-Induced Insulin Resistance

(2008) Justin I. Odegaard et al.   Cell Metabolism

Dephosphorylation of Translation Initiation Factor 2α Enhances Glucose Tolerance and Attenuates Hepatosteatosis in Mice

(2008) Seiichi Oyadomari et al.   Cell Metabolism

Endoplasmic Reticulum Stress Is Reduced in Tissues of Obese Subjects After Weight Loss

(2008) M. F. Gregor et al.   DIABETES

Obese Mice Lacking Inducible Nitric Oxide Synthase Are Sensitized to the Metabolic Actions of Peroxisome Proliferator-Activated Receptor-  Agonism

(2008) P. Dallaire et al.   DIABETES

Increase in Endoplasmic Reticulum Stress-Related Proteins and Genes in Adipose Tissue of Obese, Insulin-Resistant Individuals

(2008) G. Boden et al.   DIABETES

Ezetimibe improves high fat and cholesterol diet-induced non-alcoholic fatty liver disease in mice

(2008) Shuqin Zheng et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Zinc Supplementation Inhibits Hepatic Apoptosis in Mice Subjected to a Long-Term Ethanol Exposure

(2008) Zhanxiang Zhou et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Oxidative and nitrative stress markers in glaucoma

(2008) Mutay Aslan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mechanisms of Hepatic Fibrogenesis

(2008) Scott L. Friedman   GASTROENTEROLOGY

P2X receptor-mediated visceral hyperalgesia in a rat model of chronic visceral hypersensitivity

(2008) G-Y Xu et al.   GUT

Retinol‐binding protein 4: A new marker of virus‐induced steatosis in patients infected with hepatitis c virus genotype 1

(2008) Salvatore Petta et al.   HEPATOLOGY

The lysosomal-mitochondrial axis in free fatty acid-induced hepatic lipotoxicity

(2008) ZhengZheng Li et al.   HEPATOLOGY

Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance

(2008) Rajat Singh et al.   HEPATOLOGY

Beyond insulin resistance: Innate immunity in nonalcoholic steatohepatitis

(2008) Jacquelyn J. Maher et al.   HEPATOLOGY

Transcription factor 7-like 2 polymorphism modulates glucose and lipid homeostasis, adipokine profile, and hepatocyte apoptosis in NASH

(2008) Giovanni Musso et al.   HEPATOLOGY

Phosphatase and tensin homolog (PTEN) regulates hepatic lipogenesis, microsomal triglyceride transfer protein, and the secretion of apolipoprotein B-containing lipoproteins

(2008) Wei Qiu et al.   HEPATOLOGY

Mitochondrial dysfunction contributes to the increased vulnerabilities of adiponectin knockout mice to liver injury

(2008) Mingyan Zhou et al.   HEPATOLOGY

Dietary cholesterol, rather than liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitis

(2008) Kristiaan Wouters et al.   HEPATOLOGY

Liver X receptor in cooperation with SREBP-1c is a major lipid synthesis regulator in nonalcoholic fatty liver disease

(2008) Nobito Higuchi et al.   HEPATOLOGY RESEARCH

Bezafibrate prevents hepatic stellate cell activation and fibrogenesis in a murine steatohepatitis model, and suppresses fibrogenic response induced by transforming growth factor-β1 in a cultured stellate cell line

(2008) Shigeru Nakano et al.   HEPATOLOGY RESEARCH

Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases

(2008) Bharat B. Aggarwal et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Regulation of ApoB Secretion by the Low Density Lipoprotein Receptor Requires Exit from the Endoplasmic Reticulum and Interaction with ApoE or ApoB

(2008) Daniel A. Blasiole et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodents

(2008) Tsuguhito Ota et al.   JOURNAL OF CLINICAL INVESTIGATION

Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice

(2008) Catherine Postic et al.   JOURNAL OF CLINICAL INVESTIGATION

Polaprezinc attenuates liver fibrosis in a mouse model of non-alcoholic steatohepatitis

(2008) Haruko Sugino et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Angiotensin II-induced non-alcoholic fatty liver disease is mediated by oxidative stress in transgenic TG(mRen2)27(Ren2) rats

(2008) Yongzhong Wei et al.   JOURNAL OF HEPATOLOGY

Chromium Alleviates Glucose Intolerance, Insulin Resistance, and Hepatic ER Stress in Obese Mice

(2008) Nair Sreejayan et al.   Obesity

Sirt1 protects against high-fat diet-induced metabolic damage

(2008) P. T. Pfluger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nutritional investigation of non-obese patients with non-alcoholic fatty liver disease: The significance of dietary cholesterol

(2008) Kenichiro Yasutake et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Regulation of Hepatic Lipogenesis by the Transcription Factor XBP1

(2008) A.-H. Lee et al.   SCIENCE

A Stress Signaling Pathway in Adipose Tissue Regulates Hepatic Insulin Resistance

(2008) G. Sabio et al.   SCIENCE

Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets

(2008) Bharat B. Aggarwal et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Alleviation of ischemia/reperfusion injury in ob/ob mice by inhibiting UCP-2 expression in fatty liver

(2008) Chi-Dan Wan et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Wnt antagonism inhibits hepatic stellate cell activation and liver fibrosis

(2007) Jason H. Cheng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Activation and Dysregulation of the Unfolded Protein Response in Nonalcoholic Fatty Liver Disease

(2007) Puneet Puri et al.   GASTROENTEROLOGY